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Protein Page:
DYN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DYN1 a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; Motor protein; Microtubule binding protein; EC 3.6.5.5; Motility/polarity/chemotaxis; Vesicle protein
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: microtubule; membrane coat
Molecular Function: protein C-terminus binding; GTPase activity; identical protein binding; protein binding; GTP binding; protein complex binding; protein kinase binding
Biological Process: receptor-mediated endocytosis; endosome organization and biogenesis; GTP catabolic process; receptor internalization; endocytosis
Reference #:  Q05193 (UniProtKB)
Alt. Names/Synonyms: DNM; DNM1; DYN1; dynamin 1; Dynamin-1
Gene Symbols: DNM1
Molecular weight: 97,408 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DYN1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 87 Y80 LVNATTEYAEFLHCK
0 1 T92 HCKGKKFTDFEEVRL
0 2 Y125 VPINLRVYSPHVLNL
0 2 K206-ub RTIGVITkLDLMDEG
0 2 K223-ub ARDVLENkLLPLRRG
3 2 Y231-p LLPLRRGyIGVVNRS
0 1 K257 AALAAERKFFLSHPS
0 1 K299 TLPGLRNKLQSQLLS
0 1 S302 GLRNKLQSQLLSIEK
0 4 S306 KLQSQLLSIEKEVEE
0 1 K309 SQLLSIEKEVEEYKN
0 1 K315 EKEVEEYKNFRPDDP
0 1 K342 QFAVDFEKRIEGsGD
1 4 S347-p FEKRIEGsGDQIDTy
0 1 T353 GsGDQIDTyELSGGA
1 25 Y354-p sGDQIDTyELSGGAR
0 3 K376-ub RFPFELVkMEFDEKE
0 1 K382 VkMEFDEKELRREIS
0 1 T404 GIRTGLFTPDMAFEt
0 1 T411-p TPDMAFEtIVKKQVK
0 1 K414 MAFEtIVKKQVKKIR
0 1 S433-p KCVDMVIsELIstVR
0 1 S437-p MVIsELIstVRQCtK
0 1 T438-p VIsELIstVRQCtKK
0 1 T443-p IstVRQCtKKLQQYP
0 1 K445 tVRQCtKKLQQYPRL
0 1 Y449 CtKKLQQYPRLREEM
0 1 T511 NQMNKKKTsGNQDEI
1 7 S512-p QMNKKKTsGNQDEIL
0 1 K523-ub DEILVIRkGWLTINN
0 1 K535 INNIGIMKGGSKEYW
0 1 S538 IGIMKGGSKEYWFVL
0 1 Y563 DEEKEKKYMLSVDNL
0 2 S566 KEKKYMLSVDNLKLR
0 1 K571 MLSVDNLKLRDVEKG
3 0 Y597 NTEQRNVYkDYRQLE
0 1 K598-ac TEQRNVYkDYRQLEL
0 1 K635 ERVGDKEKASETEEN
0 2 S644 SETEENGSDSFMHSM
0 1 S650 GSDSFMHSMDPQLER
0 1 T676 YMAIVNKTVRDLMPK
7 37 S774-p SVPAGRRsPtssPtP
0 8 T776-p PAGRRsPtssPtPQR
0 3 S777-p AGRRsPtssPtPQRR
9 21 S778-p GRRsPtssPtPQRRA
1 16 T780-p RsPtssPtPQRRAPA
3 1 S795-p VPPARPGsRGPAPGP
0 1 R796 PPARPGsRGPAPGPP
0 1 S817 GGAPPVPSRPGAsPD
1 1 S822-p VPSRPGAsPDPFGPP
2 10 S851-p PSRSGQAsPSRPEsP
0 1 S853 RSGQAsPSRPEsPRP
4 6 S857-p AsPSRPEsPRPPFDL
  mouse

► Hide Isoforms
 
Y80-p LVNSTTEyAEFLHCK
T92-p HCKGKKFtDFEEVRL
Y125-p VPINLRVySPHVLNL
K206-ub RTIGVITkLDLMDEG
K223-ub ARDVLENkLLPLRRG
Y231-p LLPLRRGyIGVVNRS
K257-ub AALAAERkFFLSHPS
K299-ub TLPGLRNkLQsQLLs
S302-p GLRNkLQsQLLsIEk
S306-p kLQsQLLsIEkEVDE
K309-ub sQLLsIEkEVDEYkN
K315-ub EkEVDEYkNFRPDDP
K342-ub QFAVDFEkRIEGsGD
S347-p FEkRIEGsGDQIDTy
T353 GsGDQIDTyELSGGA
Y354-p sGDQIDTyELSGGAR
K376-ub RFPFELVkMEFDEkE
K382-ub VkMEFDEkELRREIS
T404 GIRTGLFTPDMAFET
T411 TPDMAFETIVKKQVK
K414 MAFETIVKKQVKKIR
S433 KCVDMVISELISTVR
S437 MVISELISTVRQCTK
T438 VISELISTVRQCTKK
T443 ISTVRQCTKKLQQyP
K445 TVRQCTKKLQQyPRL
Y449-p CTKKLQQyPRLREEM
T511-p NQMNKKKtsGNQDEI
S512-p QMNKKKtsGNQDEIL
K523 DEILVIRKGWLTINN
K535-ub INNIGIMkGGsKEYW
S538-p IGIMkGGsKEYWFVL
Y563-p DEEKEKKyMLsVDNL
S566-p KEKKyMLsVDNLkLR
K571-ub MLsVDNLkLRDVEKG
Y597 NTEQRNVYKDYRQLE
K598 TEQRNVYKDYRQLEL
K635-ub ERVGDKEkASETEEN
S644-p SETEENGsDSFMHsM
S650-p GsDSFMHsMDPQLER
T676-p YMAIVNKtVRDLMPK
S774-p SVPAGRRsPtssPtP
T776-p PAGRRsPtssPtPQR
S777-p AGRRsPtssPtPQRR
S778-p GRRsPtssPtPQRRA
T780-p RsPtssPtPQRRAPA
S795-p VPPARPGsrGPAPGP
R796-m1 PPARPGsrGPAPGPP
S817-p GGAPPVPsRPGASPD
S822 VPsRPGASPDPFGPP
S853 LGAWRLNSPQGKHEN
Q855 AWRLNSPQGKHENRA
E859 NSPQGKHENRAGKAR
  DYN1 iso3  
Y80 LVNSTTEYAEFLHCK
T92 HCKGKKFTDFEEVRL
Y125 VPINLRVYSPHVLNL
K206 RTIGVITKLDLMDEG
K223 ARDVLENKLLPLRRG
Y231 LLPLRRGYIGVVNRS
K257 AALAAERKFFLSHPS
K299 TLPGLRNKLQSQLLS
S302 GLRNKLQSQLLSIEK
S306 KLQSQLLSIEKEVDE
K309 SQLLSIEKEVDEYKN
K315 EKEVDEYKNFRPDDP
K342 QFAVDFEKRIEGSGD
S347 FEKRIEGSGDQIDTY
T353 GSGDQIDTYELSGGA
Y354 SGDQIDTYELSGGAR
K376 RFPFELVKMEFDEKE
K382 VKMEFDEKELRREIS
T404-p GIRTGLFtPDLAFEA
- gap
K414-ub LAFEATVkKQVQKLK
S433 KCVDMVVSELTSTIR
- gap
T438 VVSELTSTIRKCSEK
- gap
K445 TIRKCSEKLQQYPRL
Y449 CSEKLQQYPRLREEM
T511 NQMNKKKTSGNQDEI
S512 QMNKKKTSGNQDEIL
K523 DEILVIRKGWLTINN
K535 INNIGIMKGGSKEYW
S538 IGIMKGGSKEYWFVL
Y563 DEEKEKKYMLSVDNL
S566 KEKKYMLSVDNLKLR
K571 MLSVDNLKLRDVEKG
Y597 NTEQRNVYKDYRQLE
K598 TEQRNVYKDYRQLEL
K635 ERVGDKEKASETEEN
S644 SETEENGSDSFMHSM
S650 GSDSFMHSMDPQLER
T676 YMAIVNKTVRDLMPK
S774 SVPAGRRSPTSSPTP
T776 PAGRRSPTSSPTPQR
S777 AGRRSPTSSPTPQRR
S778 GRRSPTSSPTPQRRA
T780 RSPTSSPTPQRRAPA
S795 VPPARPGSRGPAPGP
R796 PPARPGSRGPAPGPP
S817 GGAPPVPSRPGASPD
S822 VPSRPGASPDPFGPP
- gap
- gap
- gap
  DYN1 iso4  
Y80 LVNSTTEYAEFLHCK
T92 HCKGKKFTDFEEVRL
Y125 VPINLRVYSPHVLNL
K206 RTIGVITKLDLMDEG
K223 ARDVLENKLLPLRRG
Y231 LLPLRRGYIGVVNRS
K257 AALAAERKFFLSHPS
K299 TLPGLRNKLQSQLLs
S302 GLRNKLQSQLLsIEK
S306-p KLQSQLLsIEKEVDE
K309 SQLLsIEKEVDEYKN
K315 EKEVDEYKNFRPDDP
K342 QFAVDFEKRIEGSGD
S347 FEKRIEGSGDQIDTY
T353 GSGDQIDTYELSGGA
Y354 SGDQIDTYELSGGAR
K376 RFPFELVKMEFDEKE
K382 VKMEFDEKELRREIS
T404 GIRTGLFTPDMAFET
T411 TPDMAFETIVKKQVK
K414 MAFETIVKKQVKKIR
S433 KCVDMVISELISTVR
S437 MVISELISTVRQCTK
T438 VISELISTVRQCTKK
T443 ISTVRQCTKKLQQYP
K445 TVRQCTKKLQQYPRL
Y449 CTKKLQQYPRLREEM
T511 NQMNKKKTsGNQDEI
S512-p QMNKKKTsGNQDEIL
K523 DEILVIRKGWLTINN
K535 INNIGIMKGGSKEYW
S538 IGIMKGGSKEYWFVL
Y563 DEEKEKKYMLSVDNL
S566 KEKKYMLSVDNLKLR
K571 MLSVDNLKLRDVEKG
Y597 NTEQRNVYKDYRQLE
K598 TEQRNVYKDYRQLEL
K635 ERVGDKEKASETEEN
S644 SETEENGSDSFMHSM
S650 GSDSFMHSMDPQLER
T676 YMAIVNKTVRDLMPK
S774-p SVPAGRRsPTSsPTP
T776 PAGRRsPTSsPTPQR
S777 AGRRsPTSsPTPQRR
S778-p GRRsPTSsPTPQRRA
T780 RsPTSsPTPQRRAPA
S795 VPPARPGSRGPAPGP
R796 PPARPGSRGPAPGPP
S817 GGAPPVPSRPGASPD
S822 VPSRPGASPDPFGPP
S851-p PSRSGQAsPsRPEsP
S853-p RSGQAsPsRPEsPRP
S857-p AsPsRPEsPRPPFDL
  DYN1 iso6  
Y80 LVNSTTEYAEFLHCK
T92 HCKGKKFTDFEEVRL
Y125 VPINLRVYSPHVLNL
K206 RTIGVITKLDLMDEG
K223 ARDVLENKLLPLRRG
Y231 LLPLRRGYIGVVNRS
K257 AALAAERKFFLSHPS
K299 TLPGLRNKLQSQLLs
S302 GLRNKLQSQLLsIEK
S306-p KLQSQLLsIEKEVDE
K309 SQLLsIEKEVDEYKN
K315 EKEVDEYKNFRPDDP
K342 QFAVDFEKRIEGSGD
S347 FEKRIEGSGDQIDTY
T353 GSGDQIDTYELSGGA
Y354 SGDQIDTYELSGGAR
K376 RFPFELVKMEFDEKE
K382 VKMEFDEKELRREIS
T404 GIRTGLFTPDMAFET
T411 TPDMAFETIVKKQVK
K414 MAFETIVKKQVKKIR
S433 KCVDMVISELISTVR
S437 MVISELISTVRQCTK
T438 VISELISTVRQCTKK
T443 ISTVRQCTKKLQQYP
K445 TVRQCTKKLQQYPRL
Y449 CTKKLQQYPRLREEM
T511 NQMNKKKTSGNQVIR
S512 QMNKKKTSGNQVIRK
K519 SGNQVIRKGWLTINN
K531 INNIGIMKGGSKEYW
S534 IGIMKGGSKEYWFVL
Y559 DEEKEKKYMLSVDNL
S562 KEKKYMLSVDNLKLR
K567 MLSVDNLKLRDVEKG
Y593 NTEQRNVYKDYRQLE
K594 TEQRNVYKDYRQLEL
K631 ERVGDKEKASETEEN
S640 SETEENGSDSFMHSM
S646 GSDSFMHSMDPQLER
T672 YMAIVNKTVRDLMPK
S770-p SVPAGRRsPTSsPTP
T772 PAGRRsPTSsPTPQR
S773 AGRRsPTSsPTPQRR
S774-p GRRsPTSsPTPQRRA
T776 RsPTSsPTPQRRAPA
S791 VPPARPGSRGPAPGP
R792 PPARPGSRGPAPGPP
S813 GGAPPVPSRPGASPD
S818 VPSRPGASPDPFGPP
S847-p PSRKGPAsPTRPAAP
T849 RKGPAsPTRPAAPRP
A853 AsPTRPAAPRPTEAP
  rat

► Hide Isoforms
 
Y80-p LVNSTTEyAEFLHCK
T92 HCKGKKFTDFEEVRL
Y125 VPINLRVYSPHVLNL
K206 RTIGVITKLDLMDEG
K223 ARDVLENKLLPLRRG
Y231-p LLPLRRGyIGVVNRS
K257 AALAAERKFFLSHPS
K299 TLPGLRNKLQSQLLS
S302 GLRNKLQSQLLSIEK
S306 KLQSQLLSIEKEVDE
K309 SQLLSIEKEVDEYKN
K315 EKEVDEYKNFRPDDP
K342 QFAVDFEKRIEGsGD
S347-p FEKRIEGsGDQIDty
T353-p GsGDQIDtyELSGGA
Y354-p sGDQIDtyELSGGAR
K376 RFPFELVKMEFDEKE
K382 VKMEFDEKELRREIS
T404 GIRTGLFTPDLAFEA
- gap
K414 LAFEATVKKQVQKLK
S433 KCVDMVVSELTSTIR
- gap
T438 VVSELTSTIRKCSEk
- gap
K445-ub TIRKCSEkLQQYPRL
Y449 CSEkLQQYPRLREEM
T511 NQMNKKKTSGNQDEI
S512 QMNKKKTSGNQDEIL
K523 DEILVIRKGWLTINN
K535 INNIGIMKGGSKEYW
S538 IGIMKGGSKEYWFVL
Y563 DEEKEKKYMLsVDNL
S566-p KEKKYMLsVDNLKLR
K571 MLsVDNLKLRDVEKG
Y597-p NTEQRNVykDYRQLE
K598-ac TEQRNVykDYRQLEL
K635 ERVGDKEKASETEEN
S644 SETEENGSDSFMHSM
S650 GSDSFMHSMDPQLER
T676 YMAIVNKTVRDLMPK
S774-p SVPAGRRsPTSsPTP
T776 PAGRRsPTSsPTPQR
S777 AGRRsPTSsPTPQRR
S778-p GRRsPTSsPTPQRRA
T780 RsPTSsPTPQRRAPA
S795-p VPPARPGsRGPAPGP
R796 PPARPGsRGPAPGPP
S817 GGAPPVPSRPGASPD
S822 VPSRPGASPDPFGPP
S851-p PSRSGQAsPSRPEsP
S853 RSGQAsPSRPEsPRP
S857-p AsPSRPEsPRPPFDL
  DYN1 iso2  
Y80 LVNSTTEYAEFLHCK
T92 HCKGKKFTDFEEVRL
Y125 VPINLRVYSPHVLNL
K206 RTIGVITKLDLMDEG
K223 ARDVLENKLLPLRRG
Y231 LLPLRRGYIGVVNRS
K257 AALAAERKFFLSHPS
K299 TLPGLRNKLQSQLLS
S302 GLRNKLQSQLLSIEK
S306 KLQSQLLSIEKEVDE
K309 SQLLSIEKEVDEYKN
K315 EKEVDEYKNFRPDDP
K342 QFAVDFEKRIEGSGD
S347 FEKRIEGSGDQIDTY
T353 GSGDQIDTYELSGGA
Y354 SGDQIDTYELSGGAR
K376 RFPFELVKMEFDEKE
K382 VKMEFDEKELRREIS
T404 GIRTGLFTPDLAFEA
- gap
K414 LAFEATVKKQVQKLK
S433 KCVDMVVSELTSTIR
- gap
T438 VVSELTSTIRKCSEK
- gap
K445 TIRKCSEKLQQYPRL
Y449 CSEKLQQYPRLREEM
T511 NQMNKKKTSGNQDEI
S512 QMNKKKTSGNQDEIL
K523 DEILVIRKGWLTINN
K535 INNIGIMKGGSKEYW
S538 IGIMKGGSKEYWFVL
Y563 DEEKEKKYMLSVDNL
S566 KEKKYMLSVDNLKLR
K571 MLSVDNLKLRDVEKG
Y597 NTEQRNVYKDYRQLE
K598 TEQRNVYKDYRQLEL
K635 ERVGDKEKASETEEN
S644 SETEENGSDSFMHSM
S650 GSDSFMHSMDPQLER
T676 YMAIVNKTVRDLMPK
S774-p SVPAGRRsPTSsPTP
T776 PAGRRsPTSsPTPQR
S777 AGRRsPTSsPTPQRR
S778-p GRRsPTSsPTPQRRA
T780 RsPTSsPTPQRRAPA
S795 VPPARPGSRGPAPGP
R796 PPARPGSRGPAPGPP
S817 GGAPPVPSRPGASPD
S822 VPSRPGASPDPFGPP
- gap
- gap
- gap
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