Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
VDAC2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VDAC2 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. Interacts with hexokinases. Expressed in all tissues examined. Belongs to the eukaryotic mitochondrial porin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Channel, misc.; Mitochondrial
Chromosomal Location of Human Ortholog: 10q22
Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; nucleus
Molecular Function: protein binding; nucleotide binding; voltage-gated anion channel activity; porin activity
Biological Process: negative regulation of protein polymerization; transmembrane transport; anion transport
Reference #:  P45880 (UniProtKB)
Alt. Names/Synonyms: FLJ23841; hVDAC2; Outer mitochondrial membrane protein porin 2; VDAC-2; VDAC2; voltage-dependent anion channel 2; Voltage-dependent anion-selective channel protein 2
Gene Symbols: VDAC2
Molecular weight: 31,566 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VDAC2

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K23 PSYADLGKAARDIFN
0 17 K31-ac AARDIFNkGFGFGLV
0 13 K31-ub AARDIFNkGFGFGLV
0 1 K31-sc AARDIFNkGFGFGLV
0 10 K39-ac GFGFGLVkLDVKtKs
0 2 K39-ub GFGFGLVkLDVKtKs
0 2 T44-p LVkLDVKtKsCsGVE
0 2 S46-p kLDVKtKsCsGVEFS
1 1 S48-p DVKtKsCsGVEFSts
0 1 T54-p CsGVEFStsGssNTD
0 1 S55-p sGVEFStsGssNTDT
0 1 S57-p VEFStsGssNTDTGK
0 2 S58-p EFStsGssNTDTGKV
0 7 K64 ssNTDTGKVtGtLET
0 1 T66-p NTDTGKVtGtLETkY
0 2 T68-p DTGKVtGtLETkYkW
0 12 K72-ac VtGtLETkYkWCEyG
0 3 K72-ub VtGtLETkYkWCEyG
0 23 K74-ac GtLETkYkWCEyGLT
0 2 K74-ub GtLETkYkWCEyGLT
0 27 Y78-p TkYkWCEyGLTFTEK
0 1 T109-p ICQGLKLtFDttFsP
0 2 T112-p GLKLtFDttFsPNtG
0 4 T113-p LKLtFDttFsPNtGk
0 37 S115-p LtFDttFsPNtGkkS
0 7 T118-p DttFsPNtGkkSGKI
0 87 K120-ac tFsPNtGkkSGKIKS
0 21 K120-ub tFsPNtGkkSGKIKS
0 1 K120-sc tFsPNtGkkSGKIKS
0 7 K121-ub FsPNtGkkSGKIKSs
0 1 S128-p kSGKIKSsYKRECIN
0 1 K130 GKIKSsYKRECINLG
0 5 Y184-p RNNFAVGyRTGDFQL
0 1 T199 HTNVNDGTEFGGSIy
0 1 S204 DGTEFGGSIyQKVCE
0 13 Y206-p TEFGGSIyQKVCEDL
0 2 K235-ac TRFGIAAkYQLDPTA
0 1 K235-ub TRFGIAAkYQLDPTA
0 1 Y236 RFGIAAkYQLDPTAS
0 1 K247 PTASISAKVNNssLI
0 1 K247 PTASISAKVNNssLI
0 6 S251-p ISAKVNNssLIGVGY
0 4 S252-p SAKVNNssLIGVGYt
0 1 T259-p sLIGVGYtQtLRPGV
0 4 T261-p IGVGYtQtLRPGVKL
0 4 K277-ac LSALVDGkSINAGGH
0 2 K277 LSALVDGKSINAGGH
0 1 S278 SALVDGkSINAGGHk
0 22 K285-ub SINAGGHkVGLALEL
  VDAC2 iso1  
K38 PSYADLGKAARDIFN
K46 AARDIFNKGFGFGLV
K46 AARDIFNKGFGFGLV
K46 AARDIFNKGFGFGLV
K54-ac GFGFGLVkLDVKTKS
K54 GFGFGLVKLDVKTKS
T59 LVkLDVKTKSCSGVE
S61 kLDVKTKSCSGVEFS
S63 DVKTKSCSGVEFSTS
T69 CSGVEFSTSGSSNTD
S70 SGVEFSTSGSSNTDT
S72 VEFSTSGSSNTDTGK
S73 EFSTSGSSNTDTGKV
K79 SSNTDTGKVTGTLET
T81 NTDTGKVTGTLETKY
T83 DTGKVTGTLETKYkW
K87 VTGTLETKYkWCEYG
K87 VTGTLETKYkWCEYG
K89-ac GTLETKYkWCEYGLT
K89 GTLETKYKWCEYGLT
Y93 TKYkWCEYGLTFTEK
T124 ICQGLKLTFDTTFSP
T127 GLKLTFDTTFSPNTG
T128 LKLTFDTTFSPNTGk
S130 LTFDTTFSPNTGkKS
T133 DTTFSPNTGkKSGKI
K135-ac TFSPNTGkKSGKIKS
K135 TFSPNTGKKSGKIKS
K135 TFSPNTGKKSGKIKS
K136 FSPNTGkKSGKIKSS
S143 KSGKIKSSYKRECIN
K145 GKIKSSYKRECINLG
Y199 RNNFAVGYRTGDFQL
T214 HTNVNDGTEFGGSIY
S219 DGTEFGGSIYQKVCE
Y221 TEFGGSIYQKVCEDL
K250 TRFGIAAKYQLDPTA
K250 TRFGIAAKYQLDPTA
Y251 RFGIAAKYQLDPTAS
K262 PTASISAKVNNSSLI
K262 PTASISAKVNNSSLI
S266 ISAKVNNSSLIGVGY
S267 SAKVNNSSLIGVGYT
T274 SLIGVGYTQTLRPGV
T276 IGVGYTQTLRPGVKL
K292 LSALVDGKSINAGGH
K292 LSALVDGKSINAGGH
S293 SALVDGKSINAGGHK
K300 SINAGGHKVGLALEL
  VDAC2 iso2  
K12 PSYADLGKAARDIFN
K20 AARDIFNKGFGFGLV
K20 AARDIFNKGFGFGLV
K20 AARDIFNKGFGFGLV
K28-ac GFGFGLVkLDVKTKS
K28 GFGFGLVKLDVKTKS
T33 LVkLDVKTKSCSGVE
S35 kLDVKTKSCSGVEFS
S37 DVKTKSCSGVEFSTS
T43 CSGVEFSTSGSSNTD
S44 SGVEFSTSGSSNTDT
S46 VEFSTSGSSNTDTGK
S47 EFSTSGSSNTDTGKV
K53 SSNTDTGKVTGTLET
T55 NTDTGKVTGTLETKY
T57 DTGKVTGTLETKYkW
K61 VTGTLETKYkWCEYG
K61 VTGTLETKYkWCEYG
K63-ac GTLETKYkWCEYGLT
K63 GTLETKYKWCEYGLT
Y67 TKYkWCEYGLTFTEK
T98 ICQGLKLTFDTTFSP
T101 GLKLTFDTTFSPNTG
T102 LKLTFDTTFSPNTGk
S104 LTFDTTFSPNTGkKS
T107 DTTFSPNTGkKSGKI
K109-ac TFSPNTGkKSGKIKS
K109 TFSPNTGKKSGKIKS
K109 TFSPNTGKKSGKIKS
K110 FSPNTGkKSGKIKSS
S117 KSGKIKSSYKRECIN
K119 GKIKSSYKRECINLG
Y173 RNNFAVGYRTGDFQL
T188 HTNVNDGTEFGGSIY
S193 DGTEFGGSIYQKVCE
Y195 TEFGGSIYQKVCEDL
K224 TRFGIAAKYQLDPTA
K224 TRFGIAAKYQLDPTA
Y225 RFGIAAKYQLDPTAS
K236 PTASISAKVNNSSLI
K236 PTASISAKVNNSSLI
S240 ISAKVNNSSLIGVGY
S241 SAKVNNSSLIGVGYT
T248 SLIGVGYTQTLRPGV
T250 IGVGYTQTLRPGVKL
K266 LSALVDGKSINAGGH
K266 LSALVDGKSINAGGH
S267 SALVDGKSINAGGHK
K274 SINAGGHKVGLALEL
  mouse

 
K24-ub PPYADLGkAARDIFN
K32-ac AARDIFNkGFGFGLV
K32-ub AARDIFNkGFGFGLV
K32 AARDIFNKGFGFGLV
K40-ac GFGFGLVkLDVKTKS
K40-ub GFGFGLVkLDVKTKS
T45 LVkLDVKTKSCSGVE
S47 kLDVKTKSCSGVEFS
S49 DVKTKSCSGVEFSTS
T55 CSGVEFSTSGSSNTD
S56 SGVEFSTSGSSNTDT
S58 VEFSTSGSSNTDTGk
S59 EFSTSGSSNTDTGkV
K65-ub SSNTDTGkVSGTLET
S67 NTDTGkVSGTLETkY
T69 DTGkVSGTLETkYkW
K73-ac VSGTLETkYkWCEYG
K73-ub VSGTLETkYkWCEYG
K75-ac GTLETkYkWCEYGLT
K75-ub GTLETkYkWCEYGLT
Y79 TkYkWCEYGLTFTEK
T110 ICQGLKLTFDttFsP
T113-p GLKLTFDttFsPNtG
T114-p LKLTFDttFsPNtGk
S116-p LTFDttFsPNtGkkS
T119-p DttFsPNtGkkSGKI
K121-ac tFsPNtGkkSGKIKS
K121-ub tFsPNtGkkSGKIKS
K121 tFsPNtGKkSGKIKS
K122-ub FsPNtGkkSGKIKSA
A129 kSGKIKSAYkRECIN
K131-ac GKIKSAYkRECINLG
Y185 RSNFAVGYRTGDFQL
T200-p HTNVNNGtEFGGsIy
S205-p NGtEFGGsIyQKVCE
Y207-p tEFGGsIyQKVCEDF
K236 TRFGIAAKYQLDPTA
K236 TRFGIAAKYQLDPTA
Y237 RFGIAAKYQLDPTAS
K248 PTASISAKVNNsSLI
K248-sc PTASISAkVNNsSLI
S252-p ISAkVNNsSLIGVGY
S253 SAkVNNsSLIGVGYT
T260 SLIGVGYTQtLRPGV
T262-p IGVGYTQtLRPGVKL
K278 LSALVDGKsFNAGGH
K278-ub LSALVDGksFNAGGH
S279-p SALVDGksFNAGGHk
K286-ub sFNAGGHkLGLALEL
  rat

 
K24 PPYADLGKAARDIFN
K32-ac AARDIFNkGFGFGLV
K32-ub AARDIFNkGFGFGLV
K32 AARDIFNKGFGFGLV
K40-ac GFGFGLVkLDVKTKS
K40 GFGFGLVKLDVKTKS
T45 LVkLDVKTKSCSGVE
S47 kLDVKTKSCSGVEFS
S49 DVKTKSCSGVEFSTS
T55 CSGVEFSTSGSSNTD
S56 SGVEFSTSGSSNTDT
S58 VEFSTSGSSNTDTGK
S59 EFSTSGSSNTDTGKV
K65 SSNTDTGKVSGTLET
S67 NTDTGKVSGTLETkY
T69 DTGKVSGTLETkYkW
K73-ac VSGTLETkYkWCEYG
K73 VSGTLETKYkWCEYG
K75-ac GTLETkYkWCEYGLT
K75 GTLETkYKWCEYGLT
Y79 TkYkWCEYGLTFTEK
T110 ICQGLKLTFDTTFsP
T113 GLKLTFDTTFsPNTG
T114 LKLTFDTTFsPNTGk
S116-p LTFDTTFsPNTGkKS
T119 DTTFsPNTGkKSGKI
K121-ac TFsPNTGkKSGKIKS
K121 TFsPNTGKKSGKIKS
K121 TFsPNTGKKSGKIKS
K122 FsPNTGkKSGKIKSA
A129 KSGKIKSAYKRECIN
K131 GKIKSAYKRECINLG
Y185 RSNFAVGYRTGDFQL
T200 HTNVNNGTEFGGSIy
S205 NGTEFGGSIyQKVCE
Y207-p TEFGGSIyQKVCEDF
K236-ac TRFGIAAkyQLDPTA
K236 TRFGIAAKyQLDPTA
Y237-p RFGIAAkyQLDPTAS
K248-ac PTASISAkVNNSSLI
K248 PTASISAKVNNSSLI
S252 ISAkVNNSSLIGVGY
S253 SAkVNNSSLIGVGYT
T260 SLIGVGYTQTLRPGV
T262 IGVGYTQTLRPGVKL
K278-ac LSALVDGkSFNAGGH
K278 LSALVDGKSFNAGGH
S279 SALVDGkSFNAGGHk
K286-ub SFNAGGHkLGLALEL
  pig

 
K23 PSYADLGKAARDIFN
K31 AARDIFNKGFGFGLV
K31 AARDIFNKGFGFGLV
K31 AARDIFNKGFGFGLV
K39 GFGFGLVKLDVKTKS
K39 GFGFGLVKLDVKTKS
T44 LVKLDVKTKSCSGVE
S46 KLDVKTKSCSGVEFS
S48 DVKTKSCSGVEFSTS
T54 CSGVEFSTSGSSNTD
S55 SGVEFSTSGSSNTDT
S57 VEFSTSGSSNTDTGK
S58 EFSTSGSSNTDTGKV
K64 SSNTDTGKVTGTLET
T66 NTDTGKVTGTLETKY
T68 DTGKVTGTLETKYKW
K72 VTGTLETKYKWCEYG
K72 VTGTLETKYKWCEYG
K74 GTLETKYKWCEYGLT
K74 GTLETKYKWCEYGLT
Y78 TKYKWCEYGLTFTEK
T109 ICQGLKLTFDTTFSP
T112 GLKLTFDTTFSPNTG
T113 LKLTFDTTFSPNTGK
S115 LTFDTTFSPNTGKKS
T118 DTTFSPNTGKKSGKI
K120 TFSPNTGKKSGKIKS
K120 TFSPNTGKKSGKIKS
K120 TFSPNTGKKSGKIKS
K121 FSPNTGKKSGKIKSS
S128 KSGKIKSSYKRECVN
K130 GKIKSSYKRECVNLG
Y184 RNNFAVGYRTGDFQL
T199 HTNVNDGTEFGGSIY
S204 DGTEFGGSIYQKVCE
Y206 TEFGGSIYQKVCEDL
K235 TRFGIAAKYQLDPTA
K235 TRFGIAAKYQLDPTA
Y236 RFGIAAKYQLDPTAS
K247 PTASISAKVNNssLI
K247 PTASISAKVNNssLI
S251-p ISAKVNNssLIGVGY
S252-p SAKVNNssLIGVGYT
T259 sLIGVGYTQTLRPGV
T261 IGVGYTQTLRPGVKL
K277 LSALVDGKSINAGGH
K277 LSALVDGKSINAGGH
S278 SALVDGKSINAGGHK
K285 SINAGGHKLGLALEL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.