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Protein Page:
VDAC2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VDAC2 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. Interacts with hexokinases. Expressed in all tissues examined. Belongs to the eukaryotic mitochondrial porin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Channel, misc.; Mitochondrial
Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; nucleus
Molecular Function: protein binding; nucleotide binding; voltage-gated anion channel activity; porin activity
Biological Process: negative regulation of protein polymerization; transmembrane transport; anion transport
Reference #:  P45880 (UniProtKB)
Alt. Names/Synonyms: FLJ23841; hVDAC2; Outer mitochondrial membrane protein porin 2; VDAC-2; VDAC2; voltage-dependent anion channel 2; Voltage-dependent anion-selective channel protein 2
Gene Symbols: VDAC2
Molecular weight: 31,566 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VDAC2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K23 PSYADLGKAARDIFN
0 16 K31-ac AARDIFNkGFGFGLV
0 13 K31-ub AARDIFNkGFGFGLV
0 1 K31-sc AARDIFNkGFGFGLV
0 9 K39-ac GFGFGLVkLDVKtKs
0 2 K39-ub GFGFGLVkLDVKtKs
0 2 T44-p LVkLDVKtKsCsGVE
0 2 S46-p kLDVKtKsCsGVEFS
1 1 S48-p DVKtKsCsGVEFSts
0 1 T54-p CsGVEFStsGssNTD
0 1 S55-p sGVEFStsGssNTDT
0 1 S57-p VEFStsGssNTDTGK
0 2 S58-p EFStsGssNTDTGKV
0 7 K64 ssNTDTGKVtGtLET
0 1 T66-p NTDTGKVtGtLETkY
0 2 T68-p DTGKVtGtLETkYkW
0 11 K72-ac VtGtLETkYkWCEyG
0 3 K72-ub VtGtLETkYkWCEyG
0 22 K74-ac GtLETkYkWCEyGLT
0 2 K74-ub GtLETkYkWCEyGLT
0 27 Y78-p TkYkWCEyGLTFTEK
0 2 T112-p GLKLTFDttFsPNtG
0 4 T113-p LKLTFDttFsPNtGk
0 29 S115-p LTFDttFsPNtGkkS
0 6 T118-p DttFsPNtGkkSGKI
0 86 K120-ac tFsPNtGkkSGKIKS
0 21 K120-ub tFsPNtGkkSGKIKS
0 1 K120-sc tFsPNtGkkSGKIKS
0 7 K121-ub FsPNtGkkSGKIKSs
0 1 S128-p kSGKIKSsYKRECIN
0 1 K130 GKIKSsYKRECINLG
0 5 Y184-p RNNFAVGyRTGDFQL
0 1 T199 HTNVNDGTEFGGSIy
0 1 S204 DGTEFGGSIyQKVCE
0 13 Y206-p TEFGGSIyQKVCEDL
0 1 K235-ac TRFGIAAkYQLDPTA
0 1 K235-ub TRFGIAAkYQLDPTA
0 1 Y236 RFGIAAkYQLDPTAS
0 1 K247 PTASISAKVNNssLI
0 5 S251-p ISAKVNNssLIGVGY
0 3 S252-p SAKVNNssLIGVGYt
0 1 T259-p sLIGVGYtQtLRPGV
0 3 T261-p IGVGYtQtLRPGVKL
0 3 K277-ac LSALVDGkSINAGGH
0 2 K277 LSALVDGKSINAGGH
0 1 S278 SALVDGkSINAGGHk
0 22 K285-ub SINAGGHkVGLALEL
  mouse

 
K24-ub PPYADLGkAARDIFN
K32-ac AARDIFNkGFGFGLV
K32-ub AARDIFNkGFGFGLV
K32 AARDIFNKGFGFGLV
K40-ac GFGFGLVkLDVKTKS
K40-ub GFGFGLVkLDVKTKS
T45 LVkLDVKTKSCSGVE
S47 kLDVKTKSCSGVEFS
S49 DVKTKSCSGVEFSTS
T55 CSGVEFSTSGSSNTD
S56 SGVEFSTSGSSNTDT
S58 VEFSTSGSSNTDTGk
S59 EFSTSGSSNTDTGkV
K65-ub SSNTDTGkVSGTLET
S67 NTDTGkVSGTLETkY
T69 DTGkVSGTLETkYkW
K73-ac VSGTLETkYkWCEYG
K73-ub VSGTLETkYkWCEYG
K75-ac GTLETkYkWCEYGLT
K75-ub GTLETkYkWCEYGLT
Y79 TkYkWCEYGLTFTEK
T113-p GLKLTFDttFsPNtG
T114-p LKLTFDttFsPNtGk
S116-p LTFDttFsPNtGkkS
T119-p DttFsPNtGkkSGKI
K121-ac tFsPNtGkkSGKIKS
K121-ub tFsPNtGkkSGKIKS
K121 tFsPNtGKkSGKIKS
K122-ub FsPNtGkkSGKIKSA
A129 kSGKIKSAYkRECIN
K131-ac GKIKSAYkRECINLG
Y185 RSNFAVGYRTGDFQL
T200-p HTNVNNGtEFGGsIy
S205-p NGtEFGGsIyQKVCE
Y207-p tEFGGsIyQKVCEDF
K236 TRFGIAAKYQLDPTA
K236 TRFGIAAKYQLDPTA
Y237 RFGIAAKYQLDPTAS
K248-sc PTASISAkVNNsSLI
S252-p ISAkVNNsSLIGVGY
S253 SAkVNNsSLIGVGYT
T260 SLIGVGYTQtLRPGV
T262-p IGVGYTQtLRPGVKL
K278 LSALVDGKsFNAGGH
K278-ub LSALVDGksFNAGGH
S279-p SALVDGksFNAGGHk
K286-ub sFNAGGHkLGLALEL
  rat

 
K24 PPYADLGKAARDIFN
K32-ac AARDIFNkGFGFGLV
K32-ub AARDIFNkGFGFGLV
K32 AARDIFNKGFGFGLV
K40 GFGFGLVKLDVKTKS
K40 GFGFGLVKLDVKTKS
T45 LVKLDVKTKSCSGVE
S47 KLDVKTKSCSGVEFS
S49 DVKTKSCSGVEFSTS
T55 CSGVEFSTSGSSNTD
S56 SGVEFSTSGSSNTDT
S58 VEFSTSGSSNTDTGK
S59 EFSTSGSSNTDTGKV
K65 SSNTDTGKVSGTLET
S67 NTDTGKVSGTLETkY
T69 DTGKVSGTLETkYkW
K73-ac VSGTLETkYkWCEYG
K73 VSGTLETKYkWCEYG
K75-ac GTLETkYkWCEYGLT
K75 GTLETkYKWCEYGLT
Y79 TkYkWCEYGLTFTEK
T113 GLKLTFDTTFSPNTG
T114 LKLTFDTTFSPNTGk
S116 LTFDTTFSPNTGkKS
T119 DTTFSPNTGkKSGKI
K121-ac TFSPNTGkKSGKIKS
K121 TFSPNTGKKSGKIKS
K121 TFSPNTGKKSGKIKS
K122 FSPNTGkKSGKIKSA
A129 KSGKIKSAYKRECIN
K131 GKIKSAYKRECINLG
Y185 RSNFAVGYRTGDFQL
T200 HTNVNNGTEFGGSIy
S205 NGTEFGGSIyQKVCE
Y207-p TEFGGSIyQKVCEDF
K236 TRFGIAAKyQLDPTA
K236 TRFGIAAKyQLDPTA
Y237-p RFGIAAKyQLDPTAS
K248 PTASISAKVNNSSLI
S252 ISAKVNNSSLIGVGY
S253 SAKVNNSSLIGVGYT
T260 SLIGVGYTQTLRPGV
T262 IGVGYTQTLRPGVKL
K278-ac LSALVDGkSFNAGGH
K278 LSALVDGKSFNAGGH
S279 SALVDGkSFNAGGHk
K286-ub SFNAGGHkLGLALEL
  pig

 
K23 PSYADLGKAARDIFN
K31 AARDIFNKGFGFGLV
K31 AARDIFNKGFGFGLV
K31 AARDIFNKGFGFGLV
K39 GFGFGLVKLDVKTKS
K39 GFGFGLVKLDVKTKS
T44 LVKLDVKTKSCSGVE
S46 KLDVKTKSCSGVEFS
S48 DVKTKSCSGVEFSTS
T54 CSGVEFSTSGSSNTD
S55 SGVEFSTSGSSNTDT
S57 VEFSTSGSSNTDTGK
S58 EFSTSGSSNTDTGKV
K64 SSNTDTGKVTGTLET
T66 NTDTGKVTGTLETKY
T68 DTGKVTGTLETKYKW
K72 VTGTLETKYKWCEYG
K72 VTGTLETKYKWCEYG
K74 GTLETKYKWCEYGLT
K74 GTLETKYKWCEYGLT
Y78 TKYKWCEYGLTFTEK
T112 GLKLTFDTTFSPNTG
T113 LKLTFDTTFSPNTGK
S115 LTFDTTFSPNTGKKS
T118 DTTFSPNTGKKSGKI
K120 TFSPNTGKKSGKIKS
K120 TFSPNTGKKSGKIKS
K120 TFSPNTGKKSGKIKS
K121 FSPNTGKKSGKIKSS
S128 KSGKIKSSYKRECVN
K130 GKIKSSYKRECVNLG
Y184 RNNFAVGYRTGDFQL
T199 HTNVNDGTEFGGSIY
S204 DGTEFGGSIYQKVCE
Y206 TEFGGSIYQKVCEDL
K235 TRFGIAAKYQLDPTA
K235 TRFGIAAKYQLDPTA
Y236 RFGIAAKYQLDPTAS
K247 PTASISAKVNNssLI
S251-p ISAKVNNssLIGVGY
S252-p SAKVNNssLIGVGYT
T259 sLIGVGYTQTLRPGV
T261 IGVGYTQTLRPGVKL
K277 LSALVDGKSINAGGH
K277 LSALVDGKSINAGGH
S278 SALVDGKSINAGGHK
K285 SINAGGHKLGLALEL
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