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Protein Page:
LIG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LIG1 is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Ligase; EC 6.5.1.1
Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; nucleolus; chromosome; nucleus
Molecular Function: DNA binding; DNA ligase activity; metal ion binding; DNA ligase (ATP) activity; ATP binding
Biological Process: anatomical structure morphogenesis; V(D)J recombination; DNA strand elongation during DNA replication; DNA repair; lagging strand elongation; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; telomere maintenance via semi-conservative replication; response to hydrogen peroxide; cell division; base-excision repair; nucleotide-excision repair; double-strand break repair; transcription-coupled nucleotide-excision repair; telomere maintenance via recombination; DNA ligation during DNA repair; mitotic cell cycle; nucleotide-excision repair, DNA gap filling; telomere maintenance; DNA metabolic process
Reference #:  P18858 (UniProtKB)
Alt. Names/Synonyms: DNA ligase 1; DNA ligase I; DNLI1; LIG1; ligase I, DNA, ATP-dependent; MGC117397; MGC130025; Polydeoxyribonucleotide synthase [ATP] 1; polydeoxyribonucleotide synthase ATP 1
Gene Symbols: LIG1
Molecular weight: 101,736 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below

LIG1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S51‑p
cell growth, altered: S51‑p, S66‑p, S76‑p, S91‑p
cytoskeletal reorganization: S51‑p
DNA repair, inhibited: S51‑p
intracellular localization: S51‑p, S66‑p, S76‑p, S91‑p
molecular association, regulation: S51‑p, S66‑p, S76‑p, S91‑p
phosphorylation: S91‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 1 S4-p ____MQRsIMSFFHP
0 1 K16 FHPKKEGKAKKPEKE
0 11 S47-p KEWNGVVsEsDsPVK
0 13 S49-p WNGVVsEsDsPVKRP
3 40 S51-p GVVsEsDsPVKRPGR
0 5 K59 PVKRPGRKAARVLGs
0 7 G65 RKAARVLGsEGEEED
4 34 S66-p KAARVLGsEGEEEDE
6 37 S76-p EEEDEALsPAKGQKP
0 14 P77 EEDEALsPAKGQKPA
0 2 L85 AKGQKPALDCSQVsP
0 1 V90 PALDCSQVsPPRPAt
3 8 S91-p ALDCSQVsPPRPAts
0 1 R94 CSQVsPPRPAtsPEN
0 2 T97-p VsPPRPAtsPENNAS
0 1 S98-p sPPRPAtsPENNASL
0 2 N102 PAtsPENNASLSDTS
0 1 S114 DTSPMDSSPSGIPKR
0 23 S141-p QEVLEEQsEDEDREA
0 1 S163-p EEETPKEsLtEAEVA
0 6 T165-p ETPKEsLtEAEVAtE
0 1 T171-p LtEAEVAtEKEGEDG
0 4 T182-p GEDGDQPttPPKPLK
0 19 T183-p EDGDQPttPPKPLKT
0 2 L188 PttPPKPLKTSKAEt
0 9 T190 tPPKPLKTSKAEtPt
0 1 - gap
1 28 T195-p LKTSKAEtPtEsVsE
1 7 T197-p TSKAEtPtEsVsEPE
0 3 S199-p KAEtPtEsVsEPEVA
0 22 S201-p EtPtEsVsEPEVAtK
0 1 T207-p VsEPEVAtKQELQEE
0 2 K219-ac QEEEEQTkPPRRAPk
0 1 K226-ub kPPRRAPkTLssFFt
0 7 S229-p RRAPkTLssFFtPRK
0 3 S230-p RAPkTLssFFtPRKP
1 83 T233-p kTLssFFtPRKPAVK
0 1 T311-p ARLRMVEtLsNLLRS
0 1 S313-p LRMVEtLsNLLRSVV
0 3 K356 VGDGVLLKAVAQATG
0 1 K376-ub VRAEAAEkGDVGLVA
0 1 K407-ub TASGVFSkFRDIARL
0 1 K422-ub TGSASTAkKIDIIKG
0 1 S437-p LFVACRHsEARFIAR
0 1 S445-p EARFIARsLsGRLRL
0 1 S447-p RFIARsLsGRLRLGL
0 3 S535-p LPEHCKLsPGIPLKP
0 1 T548-p KPMLAHPtRGISEVL
0 1 T595 SRNQEDNTGKYPDII
0 1 S603 GKYPDIISRIPKIKL
0 7 T639-p IQPFQVLtTRKRKEV
0 1 S714-p IAEFLEQsVKDSCEG
0 1 T798-p QAICKLGtGFsDEEL
0 3 S801-p CKLGtGFsDEELEEH
0 3 S819-p LKALVLPsPRPyVRI
0 1 Y823-p VLPsPRPyVRIDGAV
0 1 Y897-p SAQVACLyRKQsQIQ
0 1 S901-p ACLyRKQsQIQNQQG
0 4 - gap
0 7 - gap
0 25 S911-p QNQQGEDsGsDPEDt
0 35 S913-p QQGEDsGsDPEDty_
0 1 T918-p sGsDPEDty______
0 3 Y919-p GsDPEDty_______
  mouse

► Hide Isoforms
 
- gap
S4 ____MQRSIMSFFQP
K16-ac FQPTKEGkAKKPEKE
P47 KERNQVVPEsDsPVK
S49-p RNQVVPEsDsPVKRT
S51-p QVVPEsDsPVKRTGR
K59-ub PVKRTGRkVAQVLsC
S65-p RkVAQVLsCEGEDED
C66 kVAQVLsCEGEDEDE
G76 EDEDEAPGtPKVQKP
T77-p DEDEAPGtPKVQKPV
S85-p PKVQKPVsDSEQssP
S90-p PVsDSEQssPPsPDt
S91-p VsDSEQssPPsPDtC
S94-p SEQssPPsPDtCPEN
T97-p ssPPsPDtCPENsPV
C98 sPPsPDtCPENsPVF
S102-p PDtCPENsPVFNCSS
S114-p CSSPMDIsPSGFPKR
- gap
S161 EEETPKESLAEAEDI
- gap
K169 LAEAEDIKQKEEKEG
- gap
- gap
T186-p LIVPSEPtKsPEsVt
S188-p VPSEPtKsPEsVtLt
S191-p EPtKsPEsVtLtKTE
T193-p tKsPEsVtLtKTENI
T195-p sPEsVtLtKTENIPV
T197 EsVtLtKTENIPVCK
- gap
- gap
K218 PQEEEQSKPPARGAK
K225 KPPARGAKTLsSFFt
S228-p ARGAKTLsSFFtPRK
S229 RGAKTLsSFFtPRKP
T232-p KTLsSFFtPRKPAVK
T309 ARLKMVETLSNLLRS
S311 LKMVETLSNLLRSVV
K354-ub VGDGVLLkAVAQATG
K374 IRAEVAEKGDVGLVA
K405 TISGVFTKFCDIARL
K420 TGSASMAKKMDIIKG
S435 LFVACRHSEARYIAR
S443 EARYIARSLSGRLRL
S445 RYIARSLSGRLRLGL
S533 LPEHCKLSPGVPLKP
T546 KPMLAHPTRGVSEVL
T593-p SRNQEDNtGKYPDII
S601-p GKYPDIIsRIPKIKH
T637 IQPFQVLTTRKRKEV
S712 IAEFLEQSVKDSCEG
T796 QAICKLGTGFSDEEL
S799 CKLGTGFSDEELEEH
T817 LQALVLPTPRPYVRI
Y821 VLPTPRPYVRIDGAV
Y895 SNQVASLYRKQSQIQ
S899 ASLYRKQSQIQNQQs
S906-p SQIQNQQssDLDsDV
S907-p QIQNQQssDLDsDVE
- gap
S911-p QQssDLDsDVEDy__
- gap
Y916-p LDsDVEDy_______
  LIG1 iso3  
K9-ac RKKEQERkGETSAAN
S20 SAANMQRSIMSFFQP
K32 FQPTKEGKAKKPEKE
P63 KERNQVVPESDSPVK
S65 RNQVVPESDSPVKRT
S67 QVVPESDSPVKRTGR
K75 PVKRTGRKVAQVLSC
S81 RKVAQVLSCEGEDED
C82 KVAQVLSCEGEDEDE
G92 EDEDEAPGTPKVQKP
T93 DEDEAPGTPKVQKPV
S101 PKVQKPVSDSEQSSP
S106 PVSDSEQSSPPSPDT
S107 VSDSEQSSPPSPDTC
S110 SEQSSPPSPDTCPEN
T113 SSPPSPDTCPENSPV
C114 SPPSPDTCPENSPVF
S118 PDTCPENSPVFNCSS
S130 CSSPMDISPSGFPKR
- gap
S177 EEETPKESLAEAEDV
- gap
- under review  
- gap
- gap
T202 LIVPSEPTKSPESVT
S204 VPSEPTKSPESVTLT
S207 EPTKSPESVTLTKTE
T209 TKSPESVTLTKTENI
T211 SPESVTLTKTENIPV
T213 ESVTLTKTENIPVCK
- gap
- gap
K234 PQEEEQSKPPARGAK
K241 KPPARGAKTLSSFFT
S244 ARGAKTLSSFFTPRK
S245 RGAKTLSSFFTPRKP
T248 KTLSSFFTPRKPAVK
T325 ARLKMVETLSNLLRS
S327 LKMVETLSNLLRSVV
K370 VGDGVLLKAVAQATG
K390 IRAEVAEKGDVGLVA
K421 TISGVFTKFCDIARL
K436 TGSASMAKKMDIIKG
S451 LFVACRHSEARYIAR
S459 EARYIARSLSGRLRL
S461 RYIARSLSGRLRLGL
S549 LPEHCKLSPGVPLKP
T562 KPMLAHPTRGVSEVL
T609 SRNQEDNTGKYPDII
S617 GKYPDIISRIPKIKH
T653 IQPFQVLTTRKRKEV
S728 IAEFLEQSVKDSCEG
T812 QAICKLGTGFSDEEL
S815 CKLGTGFSDEELEEH
T833 LQALVLPTPRPYVRI
Y837 VLPTPRPYVRIDGAV
Y911 SNQVASLYRKQSQIQ
S915 ASLYRKQSQIQNQQS
S922 SQIQNQQSSDLDSDV
S923 QIQNQQSSDLDSDVE
- gap
S927 QQSSDLDSDVEDY__
- gap
Y932 LDSDVEDY_______
  rat

 
- gap
S4 ____MQRSIMSFFQP
K17 QPTTTEGKAKKPEKE
P48 KERNRAVPESDSPVK
S50 RNRAVPESDSPVKRP
S52 RAVPESDSPVKRPGR
K60 PVKRPGRKVAQVLss
S66-p RKVAQVLssEGEDED
S67-p KVAQVLssEGEDEDE
G77 EDEDEAPGtPQVQKP
T78-p DEDEAPGtPQVQKPV
S86 PQVQKPVSDSKQSSP
S91 PVSDSKQSSPPSPDS
S92 VSDSKQSSPPSPDSC
S95 SKQSSPPSPDSCPEN
S98 SSPPSPDSCPENSPV
C99 SPPSPDSCPENSPVF
S103 PDSCPENSPVFNCSP
S115 CSPSMDISPSGFPKR
- gap
S163 DPQTPPESLTEAEEV
T165 QTPPESLTEAEEVNQ
- under review  
T182 EQVEDQPTVPPEPTE
- gap
T188 PTVPPEPTESPESVT
S190 VPPEPTESPESVTLT
S193 EPTESPESVTLTKTE
T195 TESPESVTLTKTENI
T197 SPESVTLTKTENIPM
T199 ESVTLTKTENIPMCK
- gap
- gap
K220 PQEEEQSKPPARGAK
K227 KPPARGAKPLSSFFT
S230 ARGAKPLSSFFTPRK
S231 RGAKPLSSFFTPRKP
T234 KPLSSFFTPRKPAVK
T311 ARLKMVETLSNLLRS
S313 LKMVETLSNLLRSVV
K356 VGDGVLLKAVAQATG
K376 IRAEVAEKGDVGLVA
K407 TVSGVFTKFCDIARL
K422 TGSASMAKKMDIIKG
S437 LFVACRYSEARFIAR
S445 EARFIARSLSGRLRL
S447 RFIARSLSGRLRLGL
S535 LPEHCKLSPGVPLKP
T548 KPMLAHPTRGVREVL
S595 SRNQEDNSGKYPDII
S603 GKYPDIISRIPKIKH
T639 IQPFQVLTTRKRKEV
S714 IAEFLEQSVKDSCEG
T798 AAICKLGTGFSDEEL
S801 CKLGTGFSDEELEEH
T819 MQALLLPTPRPYVRI
Y823 LLPTPRPYVRIDGAV
Y897 SDQVASLYRKQSQIQ
S901 ASLYRKQSQIQNQQS
S908 SQIQNQQSSDLDsDV
S909 QIQNQQSSDLDsDVE
- gap
S913-p QQSSDLDsDVEDY__
- gap
Y918 LDsDVEDY_______
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