is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Note: This description may include information from UniProtKB.
Protein type: Ligase; EC 220.127.116.11; DNA repair, damage
Molecular Function: DNA binding; DNA ligase activity; DNA ligase (ATP) activity; metal ion binding; ATP binding
Biological Process: anatomical structure morphogenesis; V(D)J recombination; DNA strand elongation during DNA replication; DNA repair; lagging strand elongation; double-strand break repair via nonhomologous end joining; double-strand break repair via homologous recombination; telomere maintenance via semi-conservative replication; response to hydrogen peroxide; nucleotide-excision repair; base-excision repair; cell division; double-strand break repair; transcription-coupled nucleotide-excision repair; telomere maintenance via recombination; DNA ligation during DNA repair; nucleotide-excision repair, DNA gap filling; mitotic cell cycle; DNA metabolic process; telomere maintenance
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.