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Protein Page:
HSPA9B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HSPA9B Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Belongs to the heat shock protein 70 family. Note: This description may include information from UniProtKB.
Protein type: Heat shock protein; Chaperone; Nucleolus
Cellular Component: mitochondrion; cytoplasm; nucleolus
Molecular Function: protein binding; enzyme binding; unfolded protein binding; ATP binding
Biological Process: cellular protein metabolic process; protein folding; protein export from nucleus; protein targeting to mitochondrion; negative regulation of apoptosis
Reference #:  P38646 (UniProtKB)
Alt. Names/Synonyms: 75 kDa glucose regulated protein; 75 kDa glucose-regulated protein; CSA; GRP-75; GRP75; Heat shock 70 kDa protein 9; heat shock 70kD protein 9; heat shock 70kD protein 9B; heat shock 70kDa protein 9; heat shock 70kDa protein 9 (mortalin); HSPA9; HSPA9B; MGC4500; Mortalin; mortalin, perinuclear; mortalin-2; MOT; mot-2; MOT2; MTHSP75; p66-mortalin; PBP74; Peptide-binding protein 74; Stress-70 protein, mitochondrial
Gene Symbols: HSPA9
Molecular weight: 73,680 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HSPA9B

Protein Structure Not Found.


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Sites Implicated In
protein stabilization: T62‑p, S65‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S3-p _____MIsAsRAAAA
0 1 S5-p ___MIsAsRAAAARL
0 1 T22-p AAASRGPtAARHQDS
1 1 Y46-p RLVSRRDyASEAIKG
1 0 T62-p VVGIDLGtTNsCVAV
1 0 S65-p IDLGtTNsCVAVMEG
0 1 K76 VMEGKQAKVLENAEG
0 1 K76-sc VMEGKQAkVLENAEG
0 1 T87-p NAEGARTtPSVVAFT
0 1 K106 RLVGMPAKRQAVtNP
0 1 K106-sc RLVGMPAkRQAVtNP
0 1 T111-p PAkRQAVtNPNNTFy
0 2 Y118-p tNPNNTFyAtkRLIG
0 1 T120-p PNNTFyAtkRLIGRR
0 6 K121-ac NNTFyAtkRLIGRRy
0 4 K121-ub NNTFyAtkRLIGRRy
0 1 K121-sc NNTFyAtkRLIGRRy
0 5 Y128-p kRLIGRRyDDPEVQk
0 20 K135-ac yDDPEVQkDIkNVPF
0 1 K135-sc yDDPEVQkDIkNVPF
0 4 K138-ac PEVQkDIkNVPFkIV
0 1 K138-ub PEVQkDIkNVPFkIV
0 2 K138-sc PEVQkDIkNVPFkIV
0 2 K143-ac DIkNVPFkIVRASNG
0 9 K159-ac AWVEAHGkLysPsQI
0 3 Y161-p VEAHGkLysPsQIGA
0 3 S162-p EAHGkLysPsQIGAF
0 3 S164-p HGkLysPsQIGAFVL
0 1 - gap
0 1 K173 IGAFVLMKMkEtAEN
0 1 K175-sc AFVLMKMkEtAENyL
0 1 T177-p VLMKMkEtAENyLGH
0 1 Y181-p MkEtAENyLGHtAkN
0 1 T185-p AENyLGHtAkNAVIT
0 1 K187-sc NyLGHtAkNAVITVP
0 3 S200-p VPAYFNDsQRQAtkD
0 1 T205-p NDsQRQAtkDAGQIs
0 1 K206-ub DsQRQAtkDAGQIsG
0 2 K206-sc DsQRQAtkDAGQIsG
0 3 K206-ac DsQRQAtkDAGQIsG
0 2 S212-p tkDAGQIsGLNVLRV
0 2 K234-ac ALAYGLDkSEDKVIA
0 1 K234 ALAYGLDKSEDKVIA
0 1 K234-sc ALAYGLDkSEDKVIA
0 1 S253-p GGGTFDIsILEIQKG
0 1 K265 QKGVFEVKsTNGDTF
0 1 S266-p KGVFEVKsTNGDTFL
0 83 K288-ac ALLRHIVkEFkRETG
0 2 K288-sc ALLRHIVkEFkRETG
0 31 K291-ac RHIVkEFkRETGVDL
0 1 K291-sc RHIVkEFkRETGVDL
0 13 K300-ac ETGVDLTkDNMALQR
0 1 K300 ETGVDLTKDNMALQR
0 2 K300-sc ETGVDLTkDNMALQR
0 1 T333-p DINLPYLtMDsSGPK
0 1 S336-p LPYLtMDsSGPKHLN
0 2 S337 PYLtMDsSGPKHLNM
0 1 K345-ac GPKHLNMkLTRAQFE
0 1 K345-sc GPKHLNMkLTRAQFE
0 2 T356-p AQFEGIVtDLIRRtI
0 41 R360 GIVtDLIRRtIAPCQ
0 1 R360 GIVtDLIRRtIAPCQ
0 2 R360 GIVtDLIRRtIAPCQ
0 1 T362-p VtDLIRRtIAPCQkA
0 1 K368-ac RtIAPCQkAMQDAEV
0 1 K368-ub RtIAPCQkAMQDAEV
0 2 K368-sc RtIAPCQkAMQDAEV
0 1 K377-ac MQDAEVSksDIGEVI
0 1 K377-sc MQDAEVSksDIGEVI
0 3 S378-p QDAEVSksDIGEVIL
0 1 T390-p VILVGGMtRMPkVQQ
0 2 K394 GGMtRMPKVQQtVQD
0 1 K394-sc GGMtRMPkVQQtVQD
0 2 T398-p RMPkVQQtVQDLFGR
0 1 S408-p DLFGRAPsKAVNPDE
0 2 T462-p TKLINRNtTIPTkKS
0 3 K467 RNtTIPTKKSQVFST
0 2 K467-sc RNtTIPTkKSQVFST
0 1 K468 NtTIPTkKSQVFSTA
0 1 T480-p STAADGQtQVEIKVC
0 1 K498-ac REMAGDNkLLGQFtL
0 1 T504-p NkLLGQFtLIGIPPA
0 1 R513-m1 IGIPPAPrGVPQIEV
0 1 S533-p ANGIVHVsAKDKGTG
0 1 K555 QSSGGLSKDDIENMV
0 1 K563 DDIENMVKNAEkyAE
0 1 K563-sc DDIENMVkNAEkyAE
0 13 K567-ac NMVkNAEkyAEEDRR
0 1 K567-sc NMVkNAEkyAEEDRR
0 6 Y568-p MVkNAEkyAEEDRRK
0 2 K595-ac IIHDTETkMEEFkDQ
0 10 K600-ac ETkMEEFkDQLPADE
0 1 K600-sc ETkMEEFkDQLPADE
0 3 K610-ac LPADECNkLkEEIsK
0 8 K612-ac ADECNkLkEEIsKMR
0 1 K612-sc ADECNkLkEEIsKMR
0 1 S616-p NkLkEEIsKMRELLA
0 1 K625 MRELLARKDsETGEN
0 1 K625 MRELLARKDsETGEN
0 1 K625 MRELLARKDsETGEN
0 5 S627-p ELLARKDsETGENIR
0 1 T629 LARKDsETGENIRQA
0 1 S638 ENIRQAASSLQQASL
0 3 K646-ac SLQQASLkLFEMAyk
0 1 K646-ub SLQQASLkLFEMAyk
0 2 K646-sc SLQQASLkLFEMAyk
0 1 Y652-p LkLFEMAykKMASER
0 3 K653 kLFEMAyKKMASERE
0 1 K653-ub kLFEMAykKMASERE
0 1 K653-sc kLFEMAykKMASERE
0 1 K654 LFEMAykKMASEREG
0 1 S662-p MASEREGsGSSGTGE
0 3 K671-ac SSGTGEQkEDQkEEk
0 5 K675-ac GEQkEDQkEEkQ___
0 18 K678-ac kEDQkEEkQ______
  HSPA9B iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K19-ub QGGIMHQkQSREQLL
K126 MVMPVLMKMKETAEN
K128 MPVLMKMKETAENYL
T130 VLMKMKETAENYLGH
Y134 MKETAENYLGHTAKN
T138 AENYLGHTAKNAVIT
K140 NYLGHTAKNAVITVP
S153 VPAYFNDSQRQATKD
T158 NDSQRQATKDAGQIS
K159 DSQRQATKDAGQISG
K159 DSQRQATKDAGQISG
K159 DSQRQATKDAGQISG
S165 TKDAGQISGLNVLRA
K187 ALAYGLDKSEDKVIA
K187 ALAYGLDKSEDKVIA
K187 ALAYGLDKSEDKVIA
S206 GGGTFDISILEIQKG
K218 QKGVFEVKSTNGDTF
S219 KGVFEVKSTNGDTFL
K241 ALLRHIVKEFKRETG
K241 ALLRHIVKEFKRETG
K244 RHIVKEFKRETGVDL
K244 RHIVKEFKRETGVDL
K253 ETGVDLTKDNMALQR
K253 ETGVDLTKDNMALQR
K253 ETGVDLTKDNMALQR
T286 DINLPYLTMDSSGPK
S289 LPYLTMDSSGPKHLN
S290 PYLTMDSSGPKHLNM
K298 GPKHLNMKLTRAQFE
K298 GPKHLNMKLTRAQFE
T309 AQFEGIVTDLIRRTI
R313 GIVTDLIRRTIAPCQ
R313 GIVTDLIRRTIAPCQ
R313 GIVTDLIRRTIAPCQ
T315 VTDLIRRTIAPCQKA
K321 RTIAPCQKAMQDAEV
K321 RTIAPCQKAMQDAEV
K321 RTIAPCQKAMQDAEV
K330 MQDAEVSKSDIGEVI
K330 MQDAEVSKSDIGEVI
S331 QDAEVSKSDIGEVIL
T343 VILVGGMTRMPKVQQ
K347 GGMTRMPKVQQTVQD
K347 GGMTRMPKVQQTVQD
T351 RMPKVQQTVQDLFGR
S361 DLFGRAPSKAVNPDE
T415 TKLINRNTTIPTKKS
K420 RNTTIPTKKSQVFST
K420 RNTTIPTKKSQVFST
K421 NTTIPTKKSQVFSTA
T433 STAADGQTQVEIKVR
K451 REMAGDNKLLGQFTL
T457 NKLLGQFTLIGIPPA
R466 IGIPPAPRGVPQIEV
S486 ANGIVHVSAKDKGTG
K508 QSSGGLSKDDIENMV
K516 DDIENMVKNAEKYAE
K516 DDIENMVKNAEKYAE
K520 NMVKNAEKYAEEDRR
K520 NMVKNAEKYAEEDRR
Y521 MVKNAEKYAEEDRRK
K548 IIHDTETKMEEFKDQ
K553 ETKMEEFKDQLPADE
K553 ETKMEEFKDQLPADE
K563 LPADECNKLKEEISK
K565 ADECNKLKEEISKMR
K565 ADECNKLKEEISKMR
S569 NKLKEEISKMRELLA
K578 MRELLARKDSETGEN
K578 MRELLARKDSETGEN
K578 MRELLARKDSETGEN
S580 ELLARKDSETGENIR
T582 LARKDSETGENIRQA
S591 ENIRQAASSLQQASL
K599 SLQQASLKLFEMAYK
K599 SLQQASLKLFEMAYK
K599 SLQQASLKLFEMAYK
Y605 LKLFEMAYKKMASER
K606 KLFEMAYKKMASERE
K606 KLFEMAYKKMASERE
K606 KLFEMAYKKMASERE
K607 LFEMAYKKMASEREG
S615 MASEREGSGSSGTGE
K624 SSGTGEQKEDQKEEK
K628 GEQKEDQKEEKQ___
K631 KEDQKEEKQ______
  mouse

 
S3 _____MISASRAAAA
S5 ___MISASRAAAARL
A22 TAASRSPAAARPQDG
Y46 RFVSRRDYASEAIKG
T62 VVGIDLGTTNSCVAV
S65 IDLGTTNSCVAVMEG
K76-ac VMEGKQAkVLENAEG
K76-sc VMEGKQAkVLENAEG
T87-p NAEGARTtPSVVAFT
K106-ac RLVGMPAkRQAVTNP
K106-sc RLVGMPAkRQAVTNP
T111 PAkRQAVTNPNNTFY
Y118 TNPNNTFYATkRLIG
T120 PNNTFYATkRLIGRR
K121-ac NNTFYATkRLIGRRy
K121-ub NNTFYATkRLIGRRy
K121-sc NNTFYATkRLIGRRy
Y128-p kRLIGRRyDDPEVQk
K135-ac yDDPEVQkDTkNVPF
K135-sc yDDPEVQkDTkNVPF
K138-ac PEVQkDTkNVPFKIV
K138 PEVQkDTKNVPFKIV
K138-sc PEVQkDTkNVPFKIV
K143 DTkNVPFKIVRASNG
K159-ac AWVEAHGkLYSPSQI
Y161 VEAHGkLYSPSQIGA
S162 EAHGkLYSPSQIGAF
S164 HGkLYSPSQIGAFVL
- gap
K173-ac IGAFVLMkMkETAEN
K175-sc AFVLMkMkETAENYL
T177 VLMkMkETAENYLGH
Y181 MkETAENYLGHTAkN
T185 AENYLGHTAkNAVIT
K187-sc NYLGHTAkNAVITVP
S200 VPAYFNDSQRQATkD
T205 NDSQRQATkDAGQIS
K206 DSQRQATKDAGQISG
K206-sc DSQRQATkDAGQISG
K206-ac DSQRQATkDAGQISG
S212 TkDAGQISGLNVLRV
K234-ac ALAYGLDkSEDKVIA
K234-ub ALAYGLDkSEDKVIA
K234 ALAYGLDKSEDKVIA
S253 GGGTFDISILEIQKG
K265-sc QKGVFEVkSTNGDTF
S266 KGVFEVkSTNGDTFL
K288-ac ALLRHIVkEFkRETG
K288-sc ALLRHIVkEFkRETG
K291-ac RHIVkEFkRETGVDL
K291-sc RHIVkEFkRETGVDL
K300-ac ETGVDLTkDNMALQR
K300-ub ETGVDLTkDNMALQR
K300-sc ETGVDLTkDNMALQR
T333 DINLPYLTMDAsGPK
A336 LPYLTMDAsGPKHLN
S337-p PYLTMDAsGPKHLNM
K345 GPKHLNMKLTRAQFE
K345 GPKHLNMKLTRAQFE
T356 AQFEGIVTDLIkRTI
K360-ac GIVTDLIkRTIAPCQ
K360-ub GIVTDLIkRTIAPCQ
K360-sc GIVTDLIkRTIAPCQ
T362 VTDLIkRTIAPCQkA
K368 RTIAPCQKAMQDAEV
K368 RTIAPCQKAMQDAEV
K368-sc RTIAPCQkAMQDAEV
K377-ac MQDAEVSkSDIGEVI
K377-sc MQDAEVSkSDIGEVI
S378 QDAEVSkSDIGEVIL
T390 VILVGGMTRMPkVQQ
K394-ac GGMTRMPkVQQtVQD
K394 GGMTRMPKVQQtVQD
T398-p RMPkVQQtVQDLFGR
S408 DLFGRAPSKAVNPDE
T462 TKLINRNTTIPTkkS
K467-ac RNTTIPTkkSQVFST
K467-sc RNTTIPTkkSQVFST
K468-ub NTTIPTkkSQVFSTA
T480 STAADGQTQVEIKVC
K498 REMAGDNKLLGQFTL
T504 NKLLGQFTLIGIPPA
R513 IGIPPAPRGVPQIEV
S533 ANGIVHVSAKDKGTG
K555-ac QSSGGLSkDDIENMV
K563-ac DDIENMVkNAEkYAE
K563 DDIENMVKNAEkYAE
K567-ac NMVkNAEkYAEEDRR
K567 NMVkNAEKYAEEDRR
Y568 MVkNAEkYAEEDRRK
K595-ac IIHDTETkMEEFkDQ
K600-ac ETkMEEFkDQLPADE
K600 ETkMEEFKDQLPADE
K610-ac LPADECNkLkEEISK
K612-ac ADECNkLkEEISKMR
K612 ADECNkLKEEISKMR
S616 NkLkEEISKMRALLA
K625-ac MRALLAGkDsEtGEN
K625-ub MRALLAGkDsEtGEN
K625-sc MRALLAGkDsEtGEN
S627-p ALLAGkDsEtGENIR
T629-p LAGkDsEtGENIRQA
S638-p ENIRQAAsSLQQASL
K646-ac SLQQASLkLFEMAYk
K646 SLQQASLKLFEMAYk
K646-sc SLQQASLkLFEMAYk
Y652 LkLFEMAYkkMASER
K653-ac kLFEMAYkkMASERE
K653 kLFEMAYKkMASERE
K653-sc kLFEMAYkkMASERE
K654-ac LFEMAYkkMASEREG
S662 MASEREGSGSSGTGE
K671-ac SSGTGEQkEDQkEEk
K675-ac GEQkEDQkEEkQ___
K678-ac kEDQkEEkQ______
  rat

 
S3 _____MISASRAAAA
S5 ___MISASRAAAARL
A22 TTASRSPAAARHQDG
Y46 RFVSRRDYASEAIKG
T62 VVGIDLGTTNSCVAV
S65 IDLGTTNSCVAVMEG
K76 VMEGKQAKVLENAEG
K76 VMEGKQAKVLENAEG
T87 NAEGARTTPSVVAFT
K106 RLVGMPAKRQAVTNP
K106 RLVGMPAKRQAVTNP
T111 PAKRQAVTNPNNTFY
Y118 TNPNNTFYATKRLIG
T120 PNNTFYATKRLIGRR
K121 NNTFYATKRLIGRRY
K121 NNTFYATKRLIGRRY
K121 NNTFYATKRLIGRRY
Y128 KRLIGRRYDDPEVQK
K135 YDDPEVQKDTKNVPF
K135 YDDPEVQKDTKNVPF
K138 PEVQKDTKNVPFKIV
K138 PEVQKDTKNVPFKIV
K138 PEVQKDTKNVPFKIV
K143 DTKNVPFKIVRASNG
K159 AWVEAHGKLySPSQI
Y161-p VEAHGKLySPSQIGA
S162 EAHGKLySPSQIGAF
S164 HGKLySPSQIGAFVL
- gap
K173 IGAFVLMKMKETAEN
K175 AFVLMKMKETAENYL
T177 VLMKMKETAENYLGH
Y181 MKETAENYLGHTAKN
T185 AENYLGHTAKNAVIT
K187 NYLGHTAKNAVITVP
S200 VPAYFNDSQRQATKD
T205 NDSQRQATKDAGQIS
K206 DSQRQATKDAGQISG
K206 DSQRQATKDAGQISG
K206 DSQRQATKDAGQISG
S212 TKDAGQISGLNVLRV
K234 ALAYGLDKSEDKVIA
K234 ALAYGLDKSEDKVIA
K234 ALAYGLDKSEDKVIA
S253 GGGTFDISILEIQKG
K265 QKGVFEVKSTNGDTF
S266 KGVFEVKSTNGDTFL
K288 ALLRHIVKEFKRETG
K288 ALLRHIVKEFKRETG
K291 RHIVKEFKRETGVDL
K291 RHIVKEFKRETGVDL
K300 ETGVDLTKDNMALQR
K300 ETGVDLTKDNMALQR
K300 ETGVDLTKDNMALQR
T333 DINLPYLTMDASGPK
A336 LPYLTMDASGPKHLN
S337 PYLTMDASGPKHLNM
K345 GPKHLNMKLTRAQFE
K345 GPKHLNMKLTRAQFE
T356 AQFEGIVTDLIkRTI
K360-ac GIVTDLIkRTIAPCQ
K360 GIVTDLIKRTIAPCQ
K360 GIVTDLIKRTIAPCQ
T362 VTDLIkRTIAPCQKA
K368 RTIAPCQKAMQDREV
K368 RTIAPCQKAMQDREV
K368 RTIAPCQKAMQDREV
K377 MQDREVSKSDIGEVI
K377 MQDREVSKSDIGEVI
S378 QDREVSKSDIGEVIL
T390 VILVGGMTRMPKVQQ
K394 GGMTRMPKVQQTVQD
K394 GGMTRMPKVQQTVQD
T398 RMPKVQQTVQDLFGR
S408 DLFGRAPSKAVNPDE
T462 TKLINRNTTIPTKKS
K467 RNTTIPTKKSQVFST
K467 RNTTIPTKKSQVFST
K468 NTTIPTKKSQVFSTA
T480 STAADGQTQVEIKVC
K498 REMAGDNKLLGQFTL
T504 NKLLGQFTLIGIPPA
R513 IGIPPAPRGVPQIEV
S533 ANGIVHVSAKDKGTG
K555 QSSGGLSKDDIENMV
K563 DDIENMVKNAEKYAE
K563 DDIENMVKNAEKYAE
K567 NMVKNAEKYAEEDRR
K567 NMVKNAEKYAEEDRR
Y568 MVKNAEKYAEEDRRK
K595 IIHDTETKMEEFKDQ
K600 ETKMEEFKDQLPADE
K600 ETKMEEFKDQLPADE
K610 LPADECNKLKEEISK
K612 ADECNKLKEEISKMR
K612 ADECNKLKEEISKMR
S616 NKLKEEISKMRELLA
K625 MRELLARKDSETGEN
K625 MRELLARKDSETGEN
K625 MRELLARKDSETGEN
S627 ELLARKDSETGENIR
T629 LARKDSETGENIRQA
S638 ENIRQAASSLQQASL
K646 SLQQASLKLFEMAYK
K646 SLQQASLKLFEMAYK
K646 SLQQASLKLFEMAYK
Y652 LKLFEMAYKKMASER
K653 KLFEMAYKKMASERE
K653 KLFEMAYKKMASERE
K653 KLFEMAYKKMASERE
K654 LFEMAYKKMASEREG
S662 MASEREGSGSSSTGE
K671 SSSTGEQKEDQKEEK
K675 GEQKEDQKEEKQ___
K678 KEDQKEEKQ______
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