Binds preferentially single-stranded DNA and unwinds double stranded DNA. Belongs to the HMGB family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: chromosome; nucleus
Molecular Function: double-stranded DNA binding; chromatin binding; DNA bending activity
Biological Process: chromatin remodeling; negative regulation of B cell differentiation; negative regulation of myeloid cell differentiation; regulation of transcription, DNA-dependent; multicellular organismal development; DNA recombination
Alt. Names/Synonyms: High mobility group protein 2a; High mobility group protein 4; High mobility group protein B3; high-mobility group (nonhistone chromosomal) protein 4; high-mobility group box 3; HMG-2a; HMG-4; HMG2A; HMG4; HMGB3; MGC90319; non-histone chromosomal protein
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.