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Protein Page:
HMGB3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HMGB3 Binds preferentially single-stranded DNA and unwinds double stranded DNA. Belongs to the HMGB family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: chromosome; nucleus
Molecular Function: double-stranded DNA binding; DNA bending activity
Biological Process: multicellular organismal development; DNA recombination
Reference #:  O15347 (UniProtKB)
Alt. Names/Synonyms: High mobility group protein 2a; High mobility group protein 4; High mobility group protein B3; high-mobility group (nonhistone chromosomal) protein 4; high-mobility group box 3; HMG-2a; HMG-4; HMG2A; HMG4; HMGB3; MGC90319; non-histone chromosomal protein
Gene Symbols: HMGB3
Molecular weight: 22,980 Da
Basal Isoelectric point: 8.48  Predict pI for various phosphorylation states
Select Structure to View Below

HMGB3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K12-ac DPKKPKGkMsAYAFF
0 1 S14-p KKPKGkMsAYAFFVQ
0 1 K43-ac VNFAEFSkKCSERWK
0 1 K59-ac MSGKEKSkFDEMAKA
0 1 Y71-p AKADKVRyDREMKDy
0 10 Y78-p yDREMKDyGPAkGGK
0 1 K82-ac MKDyGPAkGGKKKKD
0 1 R95 KDPNAPKRPPsGFFL
0 3 S98-p NAPKRPPsGFFLFCs
0 2 S105-p sGFFLFCsEFRPKIk
0 1 K112-ub sEFRPKIkStNPGIs
0 1 S113 EFRPKIkStNPGIsI
0 3 T114-p FRPKIkStNPGIsIG
0 1 S119-p kStNPGIsIGDVAkk
0 1 K125 IsIGDVAKkLGEMWN
0 1 K125-ub IsIGDVAkkLGEMWN
0 2 K126-ub sIGDVAkkLGEMWNN
0 1 N135 GEMWNNLNDSEkQPY
0 1 K139-ac NNLNDSEkQPYITkA
0 1 K145-ac EkQPYITkAAKLKEK
0 1 K161-ac EKDVADYkSKGKFDG
0 1 K161-ub EKDVADYkSKGKFDG
0 1 K161-sc EKDVADYkSKGKFDG
0 1 K179-ac PAKVARKkVEEEDEE
  mouse

 
K12 DPKKPKGKMSAYAFF
S14 KKPKGKMSAYAFFVQ
K43 VNFAEFSKKCSERWK
K59 MSSKEKSKFDEMAKA
Y71 AKADKVRYDREMKDY
Y78 YDREMKDYGPAKGGK
K82 MKDYGPAKGGKKKKD
R95-m1 KDPNAPKrPPSGFFL
S98 NAPKrPPSGFFLFCS
S105 SGFFLFCSEFRPKIK
K112 SEFRPKIKstNPGIS
S113-p EFRPKIKstNPGISI
T114-p FRPKIKstNPGISIG
S119 KstNPGISIGDVAkK
K125-ac ISIGDVAkKLGEMWN
K125 ISIGDVAKKLGEMWN
K126 SIGDVAkKLGEMWNN
S135-p GEMWNNLsDNEKQPY
K139 NNLsDNEKQPYVTKA
K145 EKQPYVTKAAKLKEK
K161 EKDVADYKSKGKFDG
K161 EKDVADYKSKGKFDG
K161 EKDVADYKSKGKFDG
K179 PAKVARKKVEEEEEE
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