a transcription factor containing C2H2 zinc fingers. May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein. Abundantly expressed in brain and the immune system and associated with immune system malignancies. Ionizing radiation induces its hyperphosphorylation and dissociation from BRCA1 in an ATM-dependent manner. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; EC 3.1.-.-
Molecular Function: protein binding; single-stranded DNA specific endodeoxyribonuclease activity; damaged DNA binding
Biological Process: regulation of transcription from RNA polymerase II promoter; mitosis; meiotic cell cycle; cell division; blastocyst hatching; negative regulation of transcription from RNA polymerase II promoter; G2/M transition DNA damage checkpoint; DNA repair; cell cycle checkpoint; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; G1/S transition of mitotic cell cycle
Alt. Names/Synonyms: CtBP-interacting protein; CTIP; RBBP-8; RBBP8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; retinoblastoma-interacting myosin-like; Retinoblastoma-interacting protein and myosin-like; RIM
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.