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Ctip (human)

Overview Ctip a transcription factor containing C2H2 zinc fingers. May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein. Abundantly expressed in brain and the immune system and associated with immune system malignancies. Ionizing radiation induces its hyperphosphorylation and dissociation from BRCA1 in an ATM-dependent manner. Note: This description may include information from UniProtKB. Protein type: EC 3.1.-.-; Transcription, coactivator/corepressor Cellular Component: transcriptional repressor complex; nucleus Molecular Function: protein binding; single-stranded DNA specific endodeoxyribonuclease activity; damaged DNA binding Biological Process: regulation of transcription from RNA polymerase II promoter; meiosis; mitosis; cell division; blastocyst hatching; negative regulation of transcription from RNA polymerase II promoter; DNA repair; G2/M transition DNA damage checkpoint; cell cycle checkpoint; double-strand break repair via homologous recombination; G1/S transition of mitotic cell cycle Reference #:  Q99708 (UniProtKB) Alt. Names/Synonyms: CtBP-interacting protein; CTIP; RBBP-8; RBBP8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; retinoblastoma-interacting myosin-like; Retinoblastoma-interacting protein and myosin-like; RIM Gene Symbols: RBBP8 Molecular weight: 101,942 Da Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Ctip 2L4Z - A=641-685 (human)

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	Sites Implicated In
cell cycle regulation: S327‑p, T847‑p chromatin organization, altered: T847‑p molecular association, regulation: S327‑p, S664‑p, S745‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S10-p	ISGSSCGsPNSADTs
0	1		S17-p	sPNSADTssDFKDLW
0	1		S18-p	PNSADTssDFKDLWT
0	4		S233-p	DTYDQSQsPMAKAHG
0	2		K314	RFSDSTSKtPPQEEL
0	1		T315-p	FSDSTSKtPPQEELP
0	2		S326-p	EELPTRVssPVFGAT
2	7		S327-p	ELPTRVssPVFGATS
0	1		S349-p	LNTSLSPsLLQPGKK
0	3		T361-p	GKKKHLKtLPFSNTC
0	1		T450-p	RTSKRKKtEEESEHE
0	5		Y522-p	KFRQVTLyEALKTIP
0	2		S555-p	DSPGEPCsQECIILQ
0	2		I586	EENAVFKIPLRPREs
0	2		P590	VFKIPLRPREsLETE
0	6		S593-p	IPLRPREsLETENVL
0	1		T596	RPREsLETENVLDDI
1	0		S664-p	IDPGADLsQYKMDVT
0	1		S679-p	VIDTKDGsQSKLGGE
0	3		S723-p	EERKMNDsLEDMFDR
1	1		S745-p	SCLADSFsQAADEEE
1	1		T847-p	FRYIPPNtPENFWEV
1	0		T859-p	WEVGFPStQTCMERG
0	1		C875	IKEDLDPCPRPKRRQ

	Ctip iso3
S10	ISGSSCGSPNSADTS
S17	SPNSADTSSDFKDLW
S18	PNSADTSSDFKDLWT
S233	DTYDQSQSPMAKAHG
K314	RFSDSTSKTPPQEEL
T315	FSDSTSKTPPQEELP
S326	EELPTRVSSPVFGAT
S327	ELPTRVSSPVFGATS
S349	LNTSLSPSLLQPGKK
T361	GKKKHLKTLPFSNTC
T450	RTSKRKKTEEESEHE
Y522	KFRQVTLYEALKTIP
S555	DSPGEPCSQECIILQ
I586	EENAVFKIPLRPRES
P590	VFKIPLRPRESLETE
S593	IPLRPRESLETENVL
T596	RPRESLETENVLDDI
S664	IDPGADLSQYKMDVT
S679	VIDTKDGSQSKLGGE
S723	EERKMNDSLEDMFDR
S745	SCLADSFSQAADEEE
-	gap
-	under review
-	gap

	mouse
S10	ISGSGCGSPNSADAS
S17	SPNSADASNDFKELW
N18	PNSADASNDFKELWT
S233-p	DTCDQNHsPLSKICE
K314-a	RFSDSASktPPQEFT
T315-p	FSDSASktPPQEFTT
S325	QEFTTRASsPVFGAT
S326-p	EFTTRASsPVFGATS
S348	LNTSFSPSLLDIGKK
T360	GKKNLLKTAPFSNIA
T449	KASKRKRTEEESEHA
Y521	KLKQATIYEALKPIP
C553	KDSWETYCLQPRSLQ
T584-p	EENPVFKtPPCsQEs
S588-p	VFKtPPCsQEsLEtE
S591-p	tPPCsQEsLEtENLF
T594-p	CsQEsLEtENLFGDV
S662	VDPGADLSQYKMDVT
S677	VIDTKDSSHSRLGGE
S720-p	GDIKMNDsLEDMFDR
S742	SCLADSFSQVPDEEE
T843	FRYIPPNTPENFWEV
T855	WEVGFPSTQTCLERG
S871-p	IKEDLDLsPRPKRRQ

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