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Protein Page:
GLUD1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GLUD1 May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. Homohexamer. Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Energy Metabolism - nitrogen; EC 1.4.1.3; Oxidoreductase; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Amino Acid Metabolism - arginine and proline
Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm
Molecular Function: identical protein binding; protein binding; glutamate dehydrogenase activity; glutamate dehydrogenase [NAD(P)+] activity; GTP binding; ADP binding; ATP binding
Biological Process: glutamate catabolic process; positive regulation of insulin secretion; amino acid biosynthetic process; glutamate biosynthetic process
Reference #:  P00367 (UniProtKB)
Alt. Names/Synonyms: DHE3; GDH; GDH 1; GDH1; GLUD; GLUD1; glutamate dehydrogenase (NAD(P)+); glutamate dehydrogenase 1; Glutamate dehydrogenase 1, mitochondrial; MGC132003
Gene Symbols: GLUD1
Molecular weight: 61,398 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GLUD1
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S21 AGPAALGSASADSAA
0 4 K68-a EDDPNFFkMVEGFFD
0 6 S79-p GFFDRGAsIVEDkLV
0 11 K84-a GAsIVEDkLVEDLRT
0 2 K84-u GAsIVEDkLVEDLRT
0 54 R90 DkLVEDLRTRESEEQ
0 1 R90 DkLVEDLRTRESEEQ
0 3 K98-a TRESEEQkRNRVRGI
0 11 S128-p PIRRDDGsWEVIEGy
0 53 Y135-p sWEVIEGyRAQHSQH
0 1 K147 SQHRTPCKGGIRYST
0 1 T154 KGGIRYSTDVSVDEV
0 2 K162-a DVSVDEVkALASLMT
0 3 K162-u DVSVDEVkALASLMT
0 1 Y170-p ALASLMTyKCAVVDV
0 1 K171 LASLMTyKCAVVDVP
0 1 K183-a DVPFGGAkAGVkINP
0 1 K183 DVPFGGAKAGVkINP
0 10 K187-a GGAkAGVkINPkNYT
0 2 K191-u AGVkINPkNYTDNEL
0 1 K191 AGVkINPKNYTDNEL
0 2 K200-u YTDNELEkITRRFtM
1 2 T206-p EkITRRFtMELAkkG
0 5 K211-a RFtMELAkkGFIGPG
0 2 K212-u FtMELAkkGFIGPGI
0 1 T228 VPAPDMSTGEREMSW
0 1 K302-m1 MTPGFGDkTFVVQGF
0 1 K326 YLHRFGAKCIAVGES
0 1 K326 YLHRFGAKCIAVGES
0 12 K346-a NPDGIDPkELEDFkL
1 1 K346 NPDGIDPKELEDFkL
0 22 K352-a PkELEDFkLQHGSIL
1 1 K352 PkELEDFKLQHGSIL
0 2 K352-u PkELEDFkLQHGSIL
0 1 K363 GSILGFPKAkPYEGS
0 1 K363 GSILGFPKAkPYEGS
0 1 K365-a ILGFPKAkPYEGSIL
0 1 K365-u ILGFPKAkPYEGSIL
0 1 S384 DILIPAASEKQLTkS
0 2 K390-a ASEKQLTkSNAPRVK
0 2 K399-u NAPRVKAkIIAEGAN
0 1 K399 NAPRVKAKIIAEGAN
0 5 T409-p AEGANGPttPEADkI
0 26 T410-p EGANGPttPEADkIF
0 6 K415-a PttPEADkIFLERNI
0 3 K415-u PttPEADkIFLERNI
0 39 S450-p LKNLNHVsyGRLTFk
0 241 Y451-p KNLNHVsyGRLTFkY
0 14 K457-a syGRLTFkYERDSNy
0 1 K457 syGRLTFKYERDSNy
0 5 Y464-p kYERDSNyHLLMSVQ
0 1 K480-a SLERKFGkHGGTIPI
0 55 K503-a RISGASEkDIVHSGL
0 2 K503-u RISGASEkDIVHSGL
0 131 Y512-p IVHSGLAytMERSAR
0 83 T513-p VHSGLAytMERSARQ
0 25 K527-a QIMRTAMkyNLGLDL
0 3 Y528-p IMRTAMkyNLGLDLR
0 7 Y539-p LDLRTAAyVNAIEkV
0 36 K545-a AyVNAIEkVFKVYNE
0 2 K545-u AyVNAIEkVFKVYNE
0 1 K548 NAIEkVFKVYNEAGV
  mouse

 
S21-p AGPAALGsAAADSAA
K68-a EDDPNFFkMVEGFFD
S79-p GFFDRGAsIVEDkLV
K84-a GAsIVEDkLVEDLkT
K84 GAsIVEDKLVEDLkT
K90-a DkLVEDLkTRESEEQ
K90-u DkLVEDLkTRESEEQ
K98-a TRESEEQkRNRVRGI
S128-p PIRRDDGsWEVIEGy
Y135-p sWEVIEGyRAQHSQH
K147-u SQHRTPCkGGIRYSt
T154-p kGGIRYStDVSVDEV
K162-a DVSVDEVkALASLMT
K162-u DVSVDEVkALASLMT
Y170 ALASLMTYkCAVVDV
K171-u LASLMTYkCAVVDVP
K183-a DVPFGGAkAGVkINP
K183-u DVPFGGAkAGVkINP
K187-a GGAkAGVkINPkNYT
K191-u AGVkINPkNYTDNEL
K191-a AGVkINPkNYTDNEL
K200-u YTDNELEkITRRFTM
T206 EkITRRFTMELAkkG
K211-a RFTMELAkkGFIGPG
K212-u FTMELAkkGFIGPGI
T228-p VPAPDMStGEREMSW
K302 MTPGFGDKTFVVQGF
K326-a YLHRFGAkCVGVGES
K326-u YLHRFGAkCVGVGES
K346-a NPDGIDPkELEDFkL
K346 NPDGIDPKELEDFkL
K352-a PkELEDFkLQHGSIL
K352 PkELEDFKLQHGSIL
K352-u PkELEDFkLQHGSIL
K363 GSILGFPKAkVYEGS
K363-u GSILGFPkAkVYEGS
K365-a ILGFPkAkVYEGSIL
K365 ILGFPkAKVYEGSIL
S384-p DILIPAAsEKQLTkS
K390-a AsEKQLTkSNAPRVK
K399-u NAPRVKAkIIAEGAN
K399-a NAPRVKAkIIAEGAN
T409-p AEGANGPttPEADkI
T410-p EGANGPttPEADkIF
K415-a PttPEADkIFLERNI
K415-u PttPEADkIFLERNI
S450-p LKNLNHVsyGRLTFk
Y451-p KNLNHVsyGRLTFkY
K457-a syGRLTFkYERDSNY
K457-u syGRLTFkYERDSNY
Y464 kYERDSNYHLLMSVQ
K480 SLERKFGKHGGTIPV
K503-a RISGASEkDIVHSGL
K503-u RISGASEkDIVHSGL
Y512-p IVHSGLAytMERSAR
T513-p VHSGLAytMERSARQ
K527-a QIMRTAMkYNLGLDL
Y528 IMRTAMkYNLGLDLR
Y539 LDLRTAAYVNAIEkV
K545-a AYVNAIEkVFkVYNE
K545-u AYVNAIEkVFkVYNE
K548-a NAIEkVFkVYNEAGV
  rat

 
S21 AGPAALGSAAADSAA
K68 EDDPNFFKMVEGFFD
S79-p GFFDRGAsIVEDKLV
K84 GAsIVEDKLVEDLKT
K84 GAsIVEDKLVEDLKT
K90 DKLVEDLKTRENEEQ
K90 DKLVEDLKTRENEEQ
K98 TRENEEQKRNRVRGI
S128-p PIRRDDGsWEVIEGy
Y135-p sWEVIEGyRAQHSQH
K147 SQHRTPCKGGIRYST
T154 KGGIRYSTDVSVDEV
K162 DVSVDEVKALASLMT
K162 DVSVDEVKALASLMT
Y170 ALASLMTYKCAVVDV
K171 LASLMTYKCAVVDVP
K183 DVPFGGAKAGVKINP
K183 DVPFGGAKAGVKINP
K187 GGAKAGVKINPKNYT
K191 AGVKINPKNYTDNEL
K191 AGVKINPKNYTDNEL
K200 YTDNELEKITRRFtM
T206-p EKITRRFtMELAKKG
K211 RFtMELAKKGFIGPG
K212 FtMELAKKGFIGPGI
T228 VPAPDMSTGEREMSW
K302 MTPGLGDKTFVVQGF
K326 YLHRFGAKCVGVGES
K326 YLHRFGAKCVGVGES
K346-a NPDGIDPkELEDFkL
K346-m2 NPDGIDPkELEDFkL
K352 PkELEDFKLQHGSIL
K352-m2 PkELEDFkLQHGSIL
K352 PkELEDFKLQHGSIL
K363-a GSILGFPkAKVYEGS
K363 GSILGFPKAKVYEGS
K365 ILGFPkAKVYEGSIL
K365 ILGFPkAKVYEGSIL
S384 DILIPAASEKQLTKS
K390 ASEKQLTKSNAPRVK
K399 NAPRVKAKIIAEGAN
K399 NAPRVKAKIIAEGAN
T409 AEGANGPTTPEADkI
T410 EGANGPTTPEADkIF
K415-a PTTPEADkIFLERNI
K415 PTTPEADKIFLERNI
S450-p LKNLNHVsyGRLTFK
Y451-p KNLNHVsyGRLTFKY
K457 syGRLTFKYERDSNY
K457 syGRLTFKYERDSNY
Y464 KYERDSNYHLLMSVQ
K480 SLERKFGKHGGTIPV
K503 RISGASEKDIVHSGL
K503 RISGASEKDIVHSGL
Y512-p IVHSGLAyTMERSAR
T513 VHSGLAyTMERSARQ
K527 QIMRTAMKYNLGLDL
Y528 IMRTAMKYNLGLDLR
Y539 LDLRTAAYVNAIEkV
K545-a AYVNAIEkVFKVYNE
K545 AYVNAIEKVFKVYNE
K548 NAIEkVFKVYNEAGV
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