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Protein Page:
GLUD1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GLUD1 May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. Homohexamer. Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; EC 1.4.1.3; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Energy Metabolism - nitrogen; Amino Acid Metabolism - arginine and proline
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm
Molecular Function: identical protein binding; protein binding; glutamate dehydrogenase activity; GTP binding; glutamate dehydrogenase [NAD(P)+] activity; ADP binding; ATP binding
Biological Process: glutamate catabolic process; positive regulation of insulin secretion; glutamine metabolic process; glutamate biosynthetic process; amino acid biosynthetic process
Reference #:  P00367 (UniProtKB)
Alt. Names/Synonyms: DHE3; GDH; GDH 1; GDH1; GLUD; GLUD1; glutamate dehydrogenase (NAD(P)+); glutamate dehydrogenase 1; Glutamate dehydrogenase 1, mitochondrial; MGC132003
Gene Symbols: GLUD1
Molecular weight: 61,398 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GLUD1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S21 AGPAALGSASADSAA
0 5 K68-ac EDDPNFFkMVEGFFD
0 1 K68 EDDPNFFKMVEGFFD
0 10 S79-p GFFDRGAsIVEDkLV
0 12 K84-ac GAsIVEDkLVEDLRT
0 2 K84-ub GAsIVEDkLVEDLRT
0 2 K84 GAsIVEDKLVEDLRT
0 55 R90 DkLVEDLRTRESEEQ
0 1 R90 DkLVEDLRTRESEEQ
0 2 R90 DkLVEDLRTRESEEQ
0 1 S94 EDLRTRESEEQkRNR
0 4 K98-ac TRESEEQkRNRVRGI
0 1 K110 RGILRIIKPCNHVLS
0 1 S117 KPCNHVLSLSFPIRR
0 17 S128-p PIRRDDGsWEVIEGy
0 53 Y135-p sWEVIEGyRAQHSQH
0 1 K147 SQHRTPCKGGIRYST
0 1 S153 CKGGIRYSTDVsVDE
0 1 T154 KGGIRYSTDVsVDEV
0 3 S157-p IRYSTDVsVDEVkAL
0 3 K162-ac DVsVDEVkALASLMT
0 3 K162-ub DVsVDEVkALASLMT
0 2 K162 DVsVDEVKALASLMT
0 1 K171 LASLMTYKCAVVDVP
0 1 K183 DVPFGGAKAGVKINP
0 1 K183 DVPFGGAKAGVKINP
0 10 K187 GGAKAGVKINPkNYT
0 2 K187 GGAKAGVKINPkNYT
0 2 K191 AGVKINPKNYTDNEL
0 2 K191-ub AGVKINPkNYTDNEL
0 2 K191-sc AGVKINPkNYTDNEL
0 1 K200 YTDNELEKITRRFtM
0 2 K200-ub YTDNELEkITRRFtM
0 2 K200 YTDNELEKITRRFtM
1 2 T206-p EkITRRFtMELAkkG
0 5 K211-ac RFtMELAkkGFIGPG
0 2 K211-sc RFtMELAkkGFIGPG
1 0 K212 FtMELAkKGFIGPGI
0 2 K212-ub FtMELAkkGFIGPGI
0 2 S227-p DVPAPDMsTGEREMS
0 1 T228 VPAPDMsTGEREMSW
0 1 S270 GGIHGRISATGRGVF
0 1 K302-m1 MTPGFGDkTFVVQGF
0 1 K326 YLHRFGAKCIAVGES
0 1 K326 YLHRFGAKCIAVGES
0 1 K326 YLHRFGAKCIAVGES
0 2 S336-p AVGESDGsIWNPDGI
0 13 K346-ac NPDGIDPkELEDFkL
1 1 K346 NPDGIDPKELEDFkL
0 2 K346-sc NPDGIDPkELEDFkL
0 23 K352-ac PkELEDFkLQHGsIL
1 1 K352 PkELEDFKLQHGsIL
0 2 K352-ub PkELEDFkLQHGsIL
0 1 K352 PkELEDFKLQHGsIL
0 1 S357-p DFkLQHGsILGFPKA
0 2 K363 GsILGFPKAkPYEGs
0 1 K363 GsILGFPKAkPYEGs
0 1 K363 GsILGFPKAkPYEGs
0 1 K365 ILGFPKAKPYEGsIL
0 1 K365-ub ILGFPKAkPYEGsIL
0 1 K365 ILGFPKAKPYEGsIL
0 3 S370-p KAkPYEGsILEADCD
0 3 S384-p DILIPAAsEKQLTkS
0 2 K390-ac AsEKQLTkSNAPRVK
0 2 K390 AsEKQLTKSNAPRVK
0 2 K399 NAPRVKAKIIAEGAN
0 2 K399-ub NAPRVKAkIIAEGAN
0 6 T409-p AEGANGPttPEADkI
0 31 T410-p EGANGPttPEADkIF
0 7 K415-ac PttPEADkIFLERNI
0 3 K415-ub PttPEADkIFLERNI
0 2 K415-sc PttPEADkIFLERNI
0 44 S450-p LKNLNHVsyGRLTFk
0 242 Y451-p KNLNHVsyGRLTFkY
0 14 K457-ac syGRLTFkYERDSNy
0 1 K457 syGRLTFKYERDSNy
0 2 K457-sc syGRLTFkYERDSNy
0 5 Y464-p kYERDSNyHLLMSVQ
0 2 K480-ac SLERKFGkHGGTIPI
0 1 K480 SLERKFGKHGGTIPI
0 1 T484 KFGkHGGTIPIVPTA
0 1 T490 GTIPIVPTAEFQDRI
0 1 S498 AEFQDRISGASEkDI
0 1 S501 QDRISGASEkDIVHS
1 56 K503-ac RISGASEkDIVHSGL
0 2 K503-ub RISGASEkDIVHSGL
0 2 K503-sc RISGASEkDIVHSGL
0 1 S508 SEkDIVHSGLAytME
0 134 Y512-p IVHSGLAytMERSAR
0 83 T513-p VHSGLAytMERSARQ
0 26 K527-ac QIMRTAMkYNLGLDL
0 2 K527-sc QIMRTAMkYNLGLDL
0 37 K545-ac AYVNAIEkVFKVyNE
0 2 K545-ub AYVNAIEkVFKVyNE
0 2 K545-sc AYVNAIEkVFKVyNE
0 2 K548 NAIEkVFKVyNEAGV
0 2 K548 NAIEkVFKVyNEAGV
0 1 Y550-p IEkVFKVyNEAGVTF
  mouse

 
S21-p AGPAALGsAAADSAA
K68-ac EDDPNFFkMVEGFFD
K68-sc EDDPNFFkMVEGFFD
S79-p GFFDRGAsIVEDkLV
K84-ac GAsIVEDkLVEDLkT
K84 GAsIVEDKLVEDLkT
K84-sc GAsIVEDkLVEDLkT
K90-ac DkLVEDLkTREsEEQ
K90-ub DkLVEDLkTREsEEQ
K90-sc DkLVEDLkTREsEEQ
S94-p EDLkTREsEEQkRNR
K98-ac TREsEEQkRNRVRGI
K110-sc RGILRIIkPCNHVLs
S117-p kPCNHVLsLSFPIRR
S128-p PIRRDDGsWEVIEGy
Y135-p sWEVIEGyRAQHSQH
K147-ub SQHRTPCkGGIRYst
S153-p CkGGIRYstDVsVDE
T154-p kGGIRYstDVsVDEV
S157-p IRYstDVsVDEVkAL
K162-ac DVsVDEVkALASLMT
K162-ub DVsVDEVkALASLMT
K162-sc DVsVDEVkALASLMT
K171-ub LASLMTYkCAVVDVP
K183-ac DVPFGGAkAGVkINP
K183-ub DVPFGGAkAGVkINP
K187-ac GGAkAGVkINPkNYT
K187-sc GGAkAGVkINPkNYT
K191-ac AGVkINPkNYTDNEL
K191-ub AGVkINPkNYTDNEL
K191-sc AGVkINPkNYTDNEL
K200-ac YTDNELEkITRRFTM
K200-ub YTDNELEkITRRFTM
K200-sc YTDNELEkITRRFTM
T206 EkITRRFTMELAkkG
K211-ac RFTMELAkkGFIGPG
K211-sc RFTMELAkkGFIGPG
K212 FTMELAkKGFIGPGI
K212-ub FTMELAkkGFIGPGI
S227-p DVPAPDMstGEREMS
T228-p VPAPDMstGEREMSW
S270-p GGIHGRIsATGRGVF
K302 MTPGFGDKTFVVQGF
K326-ac YLHRFGAkCVGVGES
K326-ub YLHRFGAkCVGVGES
K326-sc YLHRFGAkCVGVGES
S336-p GVGESDGsIWNPDGI
K346-ac NPDGIDPkELEDFkL
K346 NPDGIDPKELEDFkL
K346-sc NPDGIDPkELEDFkL
K352-ac PkELEDFkLQHGsIL
K352 PkELEDFKLQHGsIL
K352-ub PkELEDFkLQHGsIL
K352-sc PkELEDFkLQHGsIL
S357-p DFkLQHGsILGFPkA
K363-ac GsILGFPkAkVYEGs
K363-ub GsILGFPkAkVYEGs
K363-sc GsILGFPkAkVYEGs
K365-ac ILGFPkAkVYEGsIL
K365 ILGFPkAKVYEGsIL
K365-sc ILGFPkAkVYEGsIL
S370-p kAkVYEGsILEADCD
S384-p DILIPAAsEKQLTkS
K390-ac AsEKQLTkSNAPRVK
K390-sc AsEKQLTkSNAPRVK
K399-ac NAPRVKAkIIAEGAN
K399-ub NAPRVKAkIIAEGAN
T409-p AEGANGPttPEADkI
T410-p EGANGPttPEADkIF
K415-ac PttPEADkIFLERNI
K415-ub PttPEADkIFLERNI
K415-sc PttPEADkIFLERNI
S450-p LKNLNHVsyGRLTFk
Y451-p KNLNHVsyGRLTFkY
K457-ac syGRLTFkYERDSNY
K457-ub syGRLTFkYERDSNY
K457-sc syGRLTFkYERDSNY
Y464 kYERDSNYHLLMSVQ
K480-ac SLERKFGkHGGtIPV
K480-sc SLERKFGkHGGtIPV
T484-p KFGkHGGtIPVVPtA
T490-p GtIPVVPtAEFQDRI
S498-p AEFQDRIsGAsEkDI
S501-p QDRIsGAsEkDIVHs
K503-ac RIsGAsEkDIVHsGL
K503-ub RIsGAsEkDIVHsGL
K503-sc RIsGAsEkDIVHsGL
S508-p sEkDIVHsGLAytME
Y512-p IVHsGLAytMERSAR
T513-p VHsGLAytMERSARQ
K527-ac QIMRTAMkYNLGLDL
K527-sc QIMRTAMkYNLGLDL
K545-ac AYVNAIEkVFkVYNE
K545-ub AYVNAIEkVFkVYNE
K545-sc AYVNAIEkVFkVYNE
K548-ac NAIEkVFkVYNEAGV
K548-sc NAIEkVFkVYNEAGV
Y550 IEkVFkVYNEAGVTF
  rat

 
S21 AGPAALGSAAADSAA
K68 EDDPNFFKMVEGFFD
K68 EDDPNFFKMVEGFFD
S79-p GFFDRGAsIVEDkLV
K84-ac GAsIVEDkLVEDLkT
K84 GAsIVEDKLVEDLkT
K84 GAsIVEDKLVEDLkT
K90-ac DkLVEDLkTRENEEQ
K90 DkLVEDLKTRENEEQ
K90 DkLVEDLKTRENEEQ
N94 EDLkTRENEEQKRNR
K98 TRENEEQKRNRVRGI
K110 RGILRIIKPCNHVLS
S117 KPCNHVLSLSFPIRR
S128-p PIRRDDGsWEVIEGy
Y135-p sWEVIEGyRAQHSQH
K147 SQHRTPCKGGIRYST
S153 CKGGIRYSTDVSVDE
T154 KGGIRYSTDVSVDEV
S157 IRYSTDVSVDEVkAL
K162-ac DVSVDEVkALASLMT
K162 DVSVDEVKALASLMT
K162 DVSVDEVKALASLMT
K171 LASLMTYKCAVVDVP
K183 DVPFGGAKAGVKINP
K183 DVPFGGAKAGVKINP
K187 GGAKAGVKINPkNYT
K187 GGAKAGVKINPkNYT
K191-ac AGVKINPkNYTDNEL
K191 AGVKINPKNYTDNEL
K191 AGVKINPKNYTDNEL
K200-ac YTDNELEkITRRFtM
K200 YTDNELEKITRRFtM
K200 YTDNELEKITRRFtM
T206-p EkITRRFtMELAkkG
K211-ac RFtMELAkkGFIGPG
K211 RFtMELAKkGFIGPG
K212-ac FtMELAkkGFIGPGI
K212 FtMELAkKGFIGPGI
S227 DVPAPDMSTGEREMS
T228 VPAPDMSTGEREMSW
S270 GGIHGRISATGRGVF
K302 MTPGLGDKTFVVQGF
K326 YLHRFGAKCVGVGES
K326 YLHRFGAKCVGVGES
K326 YLHRFGAKCVGVGES
S336 GVGESDGSIWNPDGI
K346-ac NPDGIDPkELEDFkL
K346-m2 NPDGIDPkELEDFkL
K346 NPDGIDPKELEDFkL
K352-ac PkELEDFkLQHGSIL
K352-m2 PkELEDFkLQHGSIL
K352 PkELEDFKLQHGSIL
K352 PkELEDFKLQHGSIL
S357 DFkLQHGSILGFPkA
K363-ac GSILGFPkAKVYEGS
K363 GSILGFPKAKVYEGS
K363 GSILGFPKAKVYEGS
K365 ILGFPkAKVYEGSIL
K365 ILGFPkAKVYEGSIL
K365 ILGFPkAKVYEGSIL
S370 kAKVYEGSILEADCD
S384 DILIPAASEKQLTkS
K390-ac ASEKQLTkSNAPRVK
K390 ASEKQLTKSNAPRVK
K399-ac NAPRVKAkIIAEGAN
K399 NAPRVKAKIIAEGAN
T409 AEGANGPTtPEADkI
T410-p EGANGPTtPEADkIF
K415-ac PTtPEADkIFLERNI
K415 PTtPEADKIFLERNI
K415 PTtPEADKIFLERNI
S450-p LKNLNHVsyGRLTFk
Y451-p KNLNHVsyGRLTFkY
K457-ac syGRLTFkYERDSNY
K457 syGRLTFKYERDSNY
K457 syGRLTFKYERDSNY
Y464 kYERDSNYHLLMSVQ
K480-ac SLERKFGkHGGTIPV
K480 SLERKFGKHGGTIPV
T484 KFGkHGGTIPVVPTA
T490 GTIPVVPTAEFQDRI
S498 AEFQDRISGASEkDI
S501 QDRISGASEkDIVHS
K503-ac RISGASEkDIVHSGL
K503 RISGASEKDIVHSGL
K503 RISGASEKDIVHSGL
S508 SEkDIVHSGLAyTME
Y512-p IVHSGLAyTMERSAR
T513 VHSGLAyTMERSARQ
K527-ac QIMRTAMkYNLGLDL
K527 QIMRTAMKYNLGLDL
K545-ac AYVNAIEkVFkVYNE
K545 AYVNAIEKVFkVYNE
K545 AYVNAIEKVFkVYNE
K548-ac NAIEkVFkVYNEAGV
K548 NAIEkVFKVYNEAGV
Y550 IEkVFkVYNEAGVTF
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