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Protein Page:
SMC2L1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMC2L1 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Belongs to the SMC family. SMC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 9q31.1
Cellular Component: nucleoplasm; nuclear chromosome; cytoplasm; condensin complex; condensed chromosome; nucleus; cytosol
Molecular Function: protein binding; protein heterodimerization activity; ATP binding
Biological Process: meiotic chromosome condensation; mitotic chromosome condensation; mitotic cell cycle; meiotic chromosome segregation; kinetochore organization and biogenesis
Reference #:  O95347 (UniProtKB)
Alt. Names/Synonyms: CAP-E; CAPE; Chromosome-associated protein E; FLJ10093; hCAP-E; SMC protein 2; SMC-2; SMC2; SMC2 (structural maintenance of chromosomes 2, yeast)-like 1; SMC2 structural maintenance of chromosomes 2-like 1; SMC2L1; structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E; structural maintenance of chromosomes 2; Structural maintenance of chromosomes protein 2; XCAP-E homolog
Gene Symbols: SMC2
Molecular weight: 135,656 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMC2L1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K12-ub SIILEGFkSYAQRTE
0 3 S60-p NLSQVRAsNLQDLVy
0 1 Y67-p sNLQDLVykNGQAGI
0 9 K68-ub NLQDLVykNGQAGIT
0 1 K114-ac VVIGGRNkYLINGVN
0 2 K114-ub VVIGGRNkYLINGVN
0 1 K196 EAKLKEIKTILEEEI
0 1 K209 EITPTIQKLKEERSS
0 1 K211 TPTIQKLKEERSSYL
0 1 K222-ac SSYLEYQkVMREIEH
0 1 Y237 LSRLYIAYQFLLAED
0 1 S249-p AEDTKVRsAEELKEM
0 1 S268-p IKLQEELsENDKKIK
0 1 T292-p EKRKDKEtGGILRSL
0 7 K320-ac SQSAFDLkkKNLACE
0 1 K320-sc SQSAFDLkkKNLACE
0 1 K321-ac QSAFDLkkKNLACEE
0 37 K330-ac NLACEESkRKELEkN
0 1 K336-ac SkRKELEkNMVEDSK
0 2 K343 kNMVEDSKTLAAkEK
0 1 K348-ac DSKTLAAkEKEVkKI
0 2 K348 DSKTLAAKEKEVkKI
0 1 K353-ac AAkEKEVkKITDGLH
0 1 K455 QEALEAVKRLKEKLE
0 1 R456 EALEAVKRLKEKLEA
0 1 K474 KLNYEENKEEsLLEK
0 1 S477 YEENKEESLLEKRRQ
0 1 S477-p YEENKEEsLLEKRRQ
0 1 S486-p LEKRRQLsRDIGRLK
0 1 K562-ub DTEVTGKkLLERGEL
0 1 T574-p GELKRRYtIIPLNKI
0 2 K677-ac QAASILTkFQELKDV
0 1 K677-ub QAASILTkFQELKDV
0 1 K768-ac NTKEIQRkAEEKYEV
0 1 Y773 QRkAEEKYEVLENKM
0 1 K792-ac AERERELkDAQKKLD
0 1 K813-ac DASSKKMkEKQQEVE
0 4 Y850 VNEAIKSYESQIEVM
0 1 K958-ac PNSAYDFkTNNPKEA
0 1 T1017-p NDKSKILttIEDLDQ
0 1 T1018-p DKSKILttIEDLDQk
0 2 K1025-ub tIEDLDQkKNQALNI
0 2 K1158-ac NNANVLFktkFVDGV
0 1 T1159-p NANVLFktkFVDGVS
0 1 K1160-ac ANVLFktkFVDGVST
0 1 K1160-ub ANVLFktkFVDGVST
  mouse

 
K12 SIILEGFKSYAQRTE
S60 NLSQVRASNLQDLVY
Y67 SNLQDLVYKNGQAGI
K68 NLQDLVYKNGQAGIT
K114 VVIGGRNKYLINGVN
K114 VVIGGRNKYLINGVN
K196-ac EAKLKEIkTILEEEI
K209-ac EITPTIQkLkEERSS
K211-ac TPTIQkLkEERSSYL
K222 SSYLEYQKVMREIEH
Y237-p LSRLYIAyQFLRAED
S249 AEDTKERSAGELKEM
S268 VNLQEVLSENEKKIK
T292 ERRKDKETGGKLKSL
K320-ac SQSAFDLkKKNLASE
K320 SQSAFDLKKKNLASE
K321 QSAFDLkKKNLASEE
K330 NLASEETKRKELQNS
N336 TKRKELQNSMAEDSK
K343 NSMAEDSKALAAKEK
K348 DSKALAAKEKEVKKI
K348 DSKALAAKEKEVKKI
K353 AAKEKEVKKITDGLH
K455-ac QDAFEAVkkAKEKLE
K456-ac DAFEAVkkAKEKLET
K474-ub KLNYEENkEEkLLEK
K477-ub YEENkEEkLLEKHRQ
K477 YEENkEEKLLEKHRQ
S486 LEKHRQLSRDINNLK
K562 DTEVTAKKLLEKGEL
T574 GELKRRYTIIPLNKI
K677 QAASILTKFQEVKDV
K677 QAASILTKFQEVKDV
K768 STKEIQKKAEEKyEA
Y773-p QKKAEEKyEALENKM
K792 AEREKELKDAQKKLD
K813 DASSKKMKEKQQEVE
Y850 VNEAIKAYEGQIEKM
K958 PNSAYDFKTNNPKEA
A1017 NDKSKILATIEDLDQ
T1018 DKSKILATIEDLDQK
K1025 TIEDLDQKKNQALNI
K1158 NNANVLFKTKFVDGV
T1159 NANVLFKTKFVDGVS
K1160 ANVLFKTKFVDGVST
K1160 ANVLFKTKFVDGVST
  rat

 
K12 SIILEGFKSYAQRTE
S60 NLSQVRASNLQDLVY
Y67 SNLQDLVYKNGQAGI
K68 NLQDLVYKNGQAGIT
K114 VVIGGRNKYLINGVN
K114 VVIGGRNKYLINGVN
K196 EAKLKEIKTILEEEI
K209 EITPTIQKLKEERSS
K211 TPTIQKLKEERSSYL
K222 SSYLEYQKVMREIEH
Y237 LSRLYIAYQFLLAED
S249 AEDTKERSAGELKEM
S268 LKLQEVLSENEKKIK
T292 EKRKDKETGGILRSL
K320 SQSAFDLKKKNLASE
K320 SQSAFDLKKKNLASE
K321 QSAFDLKKKNLASEE
K330 NLASEETKRKELEKN
K336 TKRKELEKNMAEDSk
K343-ub KNMAEDSkALAAkEK
K348 DSkALAAKEKEVKKL
K348-ub DSkALAAkEKEVKKL
K353 AAkEKEVKKLTDGLH
K455 QEAFEAVKKVKEKLE
K456 EAFEAVKKVKEKLET
K474 KLNYEDNKEERLLEK
R477 YEDNKEERLLEKHRQ
R477 YEDNKEERLLEKHRQ
S486 LEKHRQVSRDISNLK
K562 DTEVTGKKLLEKGEL
T574 GELKRRYTIIPLNKI
K677 QAASILTKFQELKDV
K677 QAASILTKFQELKDV
K768 NTKEIQKKAEEKYEA
Y773 QKKAEEKYEALENKM
K792 AEREKELKDAQKKLD
K813 DASSKKMKEKQQEVE
Y850-p VNEAIKAyEGQIEIM
K958 PNSAYDFKTNNPKEA
A1017 NDKSKILATIEDLDQ
T1018 DKSKILATIEDLDQK
K1025 TIEDLDQKKNQALNI
K1158 NNANVLFKTKFVDGV
T1159 NANVLFKTKFVDGVS
K1160 ANVLFKTKFVDGVST
K1160 ANVLFKTKFVDGVST
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