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Protein Page:
PPM1G (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PPM1G is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Protein type: Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; metal ion binding; protein serine/threonine phosphatase activity
Biological Process: protein amino acid dephosphorylation; cell cycle arrest
Reference #:  O15355 (UniProtKB)
Alt. Names/Synonyms: MGC1675; MGC2870; PP2C, gamma; PP2C-gamma; PP2CG; PP2CGAMMA; PPM1C; PPM1G; PPP2CG; Protein phosphatase 1C; Protein phosphatase 1G; protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform; protein phosphatase 2, catalytic subunit, gamma isoform; protein phosphatase 2C gamma isoform; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium-dependent 1 gamma; protein phosphatase, Mg2+/Mn2+ dependent, 1G
Gene Symbols: PPM1G
Molecular weight: 59,272 Da
Basal Isoelectric point: 4.28  Predict pI for various phosphorylation states
Select Structure to View Below

PPM1G
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 2 Y4-p ____MGAyLsQPNtV
0 1 S6-p __MGAyLsQPNtVKC
0 2 T10-p AyLsQPNtVKCSGDG
0 1 K92-u YKEGKLQkALEDAFL
0 5 K104-u AFLAIDAkLTTEEVI
0 1 K112 LTTEEVIKELAQIAG
0 1 K128 PTEDEDEKEKVADED
0 3 K166-u RYGQNCHkGPPHSks
0 1 K172-u HkGPPHSksGGGTGE
0 1 S173-p kGPPHSksGGGTGEE
1 37 S183-p GTGEEPGsQGLNGEA
0 3 S195-p GEAGPEDstREtPsQ
0 2 T196-p EAGPEDstREtPsQE
0 2 T199-p PEDstREtPsQENGP
1 6 S201-p DstREtPsQENGPtA
0 2 T207-p PsQENGPtAkAyTGF
0 11 K209-u QENGPtAkAyTGFSS
0 10 Y211-p NGPtAkAyTGFSSNS
0 2 K247-a SCSSASDkLPRVAKS
0 14 K247-u SCSSASDkLPRVAKS
0 1 S260-p KSKFFEDsEDEsDEA
0 1 S264-p FEDsEDEsDEAEEEE
0 3 K339-u VVALIRGkQLIVANA
0 1 K358-u CVVSEAGkALDMSYD
0 1 K383-a RIKNAGGkVTMDGRV
0 2 K383-u RIKNAGGkVTMDGRV
0 1 S397-p VNGGLNLsRAIGDHF
0 1 K409-u DHFYKRNkNLPPEEQ
0 1 S419-p PPEEQMIsALPDIKV
0 1 S517-p TAELQPEsGkRKLEE
0 61 K519-a ELQPEsGkRKLEEVL
0 11 K519-u ELQPEsGkRKLEEVL
0 5 S527-p RKLEEVLsTEGAEEN
0 6 K539-a EENGNSDkKKKAKRD
  mouse

 
Y4-p ____MGAyLSQPNtV
S6 __MGAyLSQPNtVKC
T10-p AyLSQPNtVKCSGDG
K92 YKEGKLQKALQDAFL
K104 AFLAIDAKLTTEEVI
K112-a LTTEEVIkELAQIAG
K128-a PTEDEDDkDKVADED
K166-u RYGQNCQkVPPHTKS
K172 QkVPPHTKSGIGTGD
S173 kVPPHTKSGIGTGDE
P183 GTGDEPGPQGLNGEA
P195 GEAGPEDPSRETPSQ
S196 EAGPEDPSRETPSQE
T199 PEDPSRETPSQENGP
S201 DPSRETPSQENGPTA
T207 PSQENGPTAKGHTGF
K209 QENGPTAKGHTGFSS
H211 NGPTAKGHTGFSSNS
K247 SCSSASDKLPRVAKS
K247-u SCSSASDkLPRVAKS
S260 KSKFFEDSEDESDEV
S264 FEDSEDESDEVEEEE
K336-u VVALIRGkQLIVANA
K355 CVVSEAGKALDMSYD
K380 RIKNAGGKVTMDGRV
K380-u RIKNAGGkVTMDGRV
S394 VNGGLNLSRAIGDHF
K406 DHFYKRNKNLPPQEQ
S416 PPQEQMISALPDIKV
S514 TVELQAESGkRKLEE
K516-a ELQAESGkRKLEEAL
K516 ELQAESGKRKLEEAL
S524-p RKLEEALsTEGAEDT
K536 EDTGNSDKKKAKRD_
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