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Protein Page:
FBL (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FBL Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Interacts with NOLC1. Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles that contain NHP2L1, FBL, NOP5 and NOP56, plus a guide RNA. It is associated with the U3, U8, U13, X and Y small nuclear RNAs. Component of several ribosomal and nucleolar protein complexes. Interacts with PRMT5 and UTP20. Interacts with DDX5. Belongs to the methyltransferase superfamily. Fibrillarin family. Note: This description may include information from UniProtKB.
Protein type: RNA processing; EC 2.1.1.-; Nucleolus; Methyltransferase; RNA binding protein
Cellular Component: Cajal body; granular component; membrane; nucleolus; nucleus
Molecular Function: protein binding; RNA binding
Biological Process: osteoblast differentiation; tRNA processing; snoRNA metabolic process; rRNA processing
Reference #:  P22087 (UniProtKB)
Alt. Names/Synonyms: 34 kDa nucleolar scleroderma antigen; 34-kD nucleolar scleroderma antigen; FBL; FBRL; FIB; FIB1; fibrillarin; FLRN; RNA, U3 small nucleolar interacting protein 1; RNU3IP1; rRNA 2'-O-methyltransferase fibrillarin
Gene Symbols: FBL
Molecular weight: 33,784 Da
Basal Isoelectric point: 10.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FBL

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S6-p __MKPGFsPRGGGFG
1 0 R8 MKPGFsPRGGGFGGr
1 0 R15 RGGGFGGRGGFGDRG
0 2 R15-m1 RGGGFGGrGGFGDRG
1 0 R21 GrGGFGDRGGRGGrG
1 0 R24 GFGDRGGRGGrGGFG
1 0 - gap
1 0 R27 DRGGRGGRGGFGGGr
0 1 R27-m1 DRGGRGGrGGFGGGr
0 5 R34-m1 rGGFGGGrGrGGGFR
1 0 R36-me GFGGGrGrGGGFRGR
0 1 R41 rGrGGGFRGRGRGGG
0 1 R43 rGGGFRGRGRGGGGG
0 4 R59 GGGGGGGRGGGGFHS
0 3 K102-ac GVFICRGkEDALVTk
0 2 K102-ub GVFICRGkEDALVTk
0 3 K109-ub kEDALVTkNLVPGEs
0 2 S116-p kNLVPGEsVyGEkRV
0 4 Y118-p LVPGEsVyGEkRVsI
0 7 K121-ac GEsVyGEkRVsIsEG
0 2 K121-ub GEsVyGEkRVsIsEG
0 1 K121-sc GEsVyGEkRVsIsEG
0 20 S124-p VyGEkRVsIsEGDDk
0 4 S126-p GEkRVsIsEGDDkIE
0 4 K131-ub sIsEGDDkIEYRAWN
0 1 K143-ub AWNPFRSkLAAAILG
0 2 K158-ub GVDQIHIkPGAKVLY
0 1 K205-ac RDLINLAkkRtNIIP
0 1 K205-ub RDLINLAkkRtNIIP
0 1 K206-ac DLINLAkkRtNIIPV
0 1 T208-p INLAkkRtNIIPVIE
0 1 K292 KMQQENMKPQEQLtL
0 2 K292-ub KMQQENMkPQEQLtL
0 1 T298-p MkPQEQLtLEPyERD
0 2 Y302-p EQLtLEPyERDHAVV
  mouse

 
S6 __MKPGFSPRGGGFG
R8 MKPGFSPRGGGFGGR
R15 RGGGFGGRGGFGDRG
R15 RGGGFGGRGGFGDRG
R21 GRGGFGDRGGRGGGR
R24 GFGDRGGRGGGRGGR
R28 RGGRGGGRGGRGGFG
R31 RGGGRGGRGGFGGGr
R31 RGGGRGGRGGFGGGr
R38-m1 RGGFGGGrGGFGGGG
F41 FGGGrGGFGGGGrGr
R46-m1 GGFGGGGrGrGGGGG
R48-m2 FGGGGrGrGGGGGGF
R64-m1 GRGGGGGrGGGFQSG
K108-ac GVFICRGkEDALVTk
K108 GVFICRGKEDALVTk
K115-ub kEDALVTkNLVPGES
S122 kNLVPGESVyGEkRV
Y124-p LVPGESVyGEkRVsI
K127 GESVyGEKRVsIsEG
K127-ub GESVyGEkRVsIsEG
K127 GESVyGEKRVsIsEG
S130-p VyGEkRVsIsEGDDk
S132-p GEkRVsIsEGDDkIE
K137-ub sIsEGDDkIEYRAWN
K149 AWNPFRSKLAAAILG
K164-ub GVDQIHIkPGAKVLY
K211 RDLINLAKKRTNIIP
K211 RDLINLAKKRTNIIP
K212 DLINLAKKRTNIIPV
T214 INLAKKRTNIIPVIE
K298-ac KMQQENMkPQEQLTL
K298-ub KMQQENMkPQEQLTL
T304 MkPQEQLTLEPYERD
Y308 EQLTLEPYERDHAVV
  rat

 
S6 __MKPGFSPrGGGFG
R8-m2 MKPGFSPrGGGFGGr
R15-m2 rGGGFGGrGGFGDrG
R15 rGGGFGGRGGFGDrG
R21-m2 GrGGFGDrGGrGGGr
R24-m2 GFGDrGGrGGGrGGr
R28-m2 rGGrGGGrGGrGGFG
R31-m2 rGGGrGGrGGFGGGR
R31 rGGGrGGRGGFGGGR
R38 rGGFGGGRGGFGGGG
F41 FGGGRGGFGGGGRGR
R46 GGFGGGGRGRGGGGG
R48 FGGGGRGRGGGGGGF
R64 GRGGGGGRGGGFQSG
K108-ac GVFICRGkEDALVTK
K108 GVFICRGKEDALVTK
K115 kEDALVTKNLVPGES
S122 KNLVPGESVYGEkRV
Y124 LVPGESVYGEkRVsI
K127-ac GESVYGEkRVsISEG
K127 GESVYGEKRVsISEG
K127 GESVYGEKRVsISEG
S130-p VYGEkRVsISEGDDK
S132 GEkRVsISEGDDKIE
K137 sISEGDDKIEYRAWN
K149 AWNPFRSKLAAAILG
K164 GVDQIHIKPGAKVLY
K211-ac RDLINLAkKRTNIIP
K211 RDLINLAKKRTNIIP
K212 DLINLAkKRTNIIPV
T214 INLAkKRTNIIPVIE
K298 KMQQENMKPQEQLTL
K298 KMQQENMKPQEQLTL
T304 MKPQEQLTLEPYERD
Y308 EQLTLEPYERDHAVV
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