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Protein Page:
DFFA (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DFFA Inhibitor of the caspase-activated DNase (DFF40). Heterodimer of DFFA and DFFB. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Cellular Component: nucleoplasm; cytoplasm; nuclear chromatin; lipid particle; nucleus; cytosol
Molecular Function: protein binding
Biological Process: positive regulation of apoptosis; apoptosis; DNA fragmentation during apoptosis; cell structure disassembly during apoptosis
Reference #:  O00273 (UniProtKB)
Alt. Names/Synonyms: DFF-45; DFF1; DFF45; DFFA; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; ICAD; Inhibitor of CAD
Gene Symbols: DFFA
Molecular weight: 36,522 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DFFA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 10 S28-p CLLRRNYsREQHGVA
0 31 Y75-p TIVDDDDyFLCLPSN
0 10 S107-p DGGTAWIsQEsFDVD
0 3 S110-p TAWIsQEsFDVDETD
0 1 K189-u REEVRQSkQLLQLYL
0 5 K201-u LYLQALEkEGSLLSK
0 3 S232-p TGISRETssDVALAS
0 1 S233-p GISRETssDVALASH
0 1 T243-p ALASHILtALREKQA
0 1 K248 ILtALREKQAPELSL
0 6 S257 APELSLSSQDLELVT
0 1 S310-p LHSLRSIsASKAsPP
0 8 - gap
0 10 S315-p SIsASKAsPPGDLQN
0 13 K324-a PGDLQNPkRARQDPT
  DFFA iso2  
S28-p CLLRRNYsREQHGVA
Y75-p TIVDDDDyFLCLPSN
S107 DGGTAWISQESFDVD
S110 TAWISQESFDVDETD
K189 REEVRQSKQLLQLYL
K201 LYLQALEKEGSLLSK
S232 TGISRETSSDVALAS
S233 GISRETSSDVALASH
T243 ALASHILTALREkQA
K248-u ILTALREkQAPELSL
S257-p APELSLSsQDLEVGG
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S28-p CLLRRNHsRDQHGVA
Y75 TIVDDDDYFLCLPSN
S107 DGGTAWVSQEsFEAD
S110-p TAWVSQEsFEADEPD
K189 REEARQSKQLLELYL
K201 LYLQALEKEGNILSN
A232 TGVGREMASEVLLRS
S233 GVGREMASEVLLRSQ
T243 LLRSQILTTLKEKPA
K248 ILTTLKEKPAPELSL
S257 APELSLSSQDLESVS
S310 LHSLRNLSARRsPLP
S314-p RNLSARRsPLPGEPQ
- gap
K324 PGEPQRPKRAKRDSS
  DFFA iso2  
S28 CLLRRNHSRDQHGVA
Y75 TIVDDDDYFLCLPSN
S107 DGGTAWVSQESFEAD
S110 TAWVSQESFEADEPD
K189 REEARQSKQLLELYL
K201 LYLQALEKEGNILSN
A232 TGVGREMASEVLLRS
S233 GVGREMASEVLLRSQ
T243 LLRSQILTTLKEKPA
K248 ILTTLKEKPAPELSL
S257 APELSLSSQDLEVGK
- gap
- gap
- gap
- gap
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