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CRMP-2 (human)

Overview CRMP-2 a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)). Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Microtubule binding protein Cellular Component: protein complex; growth cone; mitochondrion; cell soma; dendrite; terminal button; cytosol Molecular Function: protein binding; dihydropyrimidinase activity; protein kinase binding Biological Process: response to drug; axon guidance; nervous system development; regulation of neuron differentiation; olfactory bulb development; response to amphetamine; positive regulation of glutamate secretion; synaptic vesicle transport; cytoskeleton organization and biogenesis; response to cocaine; signal transduction; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Reference #:  Q16555 (UniProtKB) Alt. Names/Synonyms: Collapsin response mediator protein 2; collapsin response mediator protein hCRMP-2; CRMP-2; CRMP2; DHPRP2; dihydropyrimidinase-like 2; dihydropyrimidinase-like 2 long form; Dihydropyrimidinase-related protein 2; DPYL2; DPYSL2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2; Unc-33-like phosphoprotein 2 Gene Symbols: DPYSL2 Molecular weight: 62,294 Da Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states CST Pathways:  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CRMP-2 2GSE - A/B/C/D=12-490 (human) 2VM8 - A/D/C/B=13-490 (human)

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	Sites Implicated In
cell motility, altered: Y479‑p, S522‑p cytoskeletal reorganization: Y479‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		Y3-p	_____MSyQGKKNIP
0	2		S14	KNIPRITSDRLLIkG
0	1		-	gap
0	1		-	gap
0	5		-	gap
0	4		-	gap
0	1		-	gap
0	1		-	gap
0	3		K20-u	TSDRLLIkGGKIVND
0	2		S30-p	KIVNDDQsFyADIYM
1	64		Y32-p	VNDDQsFyADIYMED
0	1		K56	LIVPGGVKtIEAHSR
0	1		T57-p	IVPGGVKtIEAHSRM
0	1		T74-p	PGGIDVHtRFQMPDQ
0	1		K146-u	VDISEWHkGIQEEME
0	1		T177	FKDRFQLTDCQIYEV
0	1		C179	DRFQLTDCQIYEVLS
0	1		Y182	QLTDCQIYEVLSVIR
0	1		K293	DGSHYWSKNWAkAAA
0	1		K297-u	YWSKNWAkAAAFVTS
0	2		K345-u	TAQKAVGkDNFTLIP
0	1		T358-p	IPEGTNGtEERMSVI
0	1		K368	RMSVIWDKAVVTGKM
0	1		K374	DKAVVTGKMDENQFV
0	2		A402	YPRKGRIAVGSDADL
0	1		S405	KGRIAVGSDADLVIW
0	13		K423-u	SVKTISAkTHNSSLE
0	129		Y431-p	THNSSLEyNIFEGME
0	1		T458	KIVLEDGTLHVTEGS
0	1		S465	TLHVTEGSGRYIPRk
0	6		K472-u	SGRYIPRkPFPDFVy
1	0		Y479-p	kPFPDFVyKRIKARS
0	1		K480	PFPDFVyKRIKARSR
0	1		K480	PFPDFVyKRIKARSR
0	351		Y499-p	RGVPRGLyDGPVCEV
0	5		S507-p	DGPVCEVsVtPktVt
0	1		S507	DGPVCEVSVtPktVt
7	59		T509-p	PVCEVsVtPktVtPA
0	5		K511-u	CEVsVtPktVtPAss
0	14		T512-p	EVsVtPktVtPAssA
13	46		T514-p	sVtPktVtPAssAkt
0	22		S517-p	PktVtPAssAktsPA
6	28		S518-p	ktVtPAssAktsPAk
0	1		K520-a	VtPAssAktsPAkQQ
0	12		K520-u	VtPAssAktsPAkQQ
0	24		T521-p	tPAssAktsPAkQQA
11	97		S522-p	PAssAktsPAkQQAP
0	1		K525-a	sAktsPAkQQAPPVR
0	8		K525	sAktsPAKQQAPPVR
0	9		S537-p	PVRNLHQsGFsLsGA
0	14		S540-p	NLHQsGFsLsGAQID
0	5		S542-p	HQsGFsLsGAQIDDN
0	2		T554-p	DDNIPRRttQRIVAP
7	8		T555-p	DNIPRRttQRIVAPP
0	1		R565	IVAPPGGRANITsLG
0	2		S570-p	GGRANITsLG_____

	CRMP-2 iso3
-	gap
-	gap
S27-p	FKNLGSGsPKPRQKF
S54-p	NKTIDFDsLSVGRGS
Y82-p	GPDPQPPysRQGRRA
S83-p	PDPQPPysRQGRRAG
S94-p	RRAGGEPsVEsGRKV
S97-p	GGEPsVEsGRKVEIR
K125	QSDRLLIKGGKIVND
S135	KIVNDDQSFYADIYM
Y137	VNDDQSFYADIYMED
K161	LIVPGGVKTIEAHSR
T162	IVPGGVKTIEAHSRM
T179	PGGIDVHTRFQMPDQ
K251	VDISEWHKGIQEEME
T282	FKDRFQLTDCQIYEV
C284	DRFQLTDCQIYEVLS
Y287	QLTDCQIYEVLSVIR
K398	DGSHYWSKNWAKAAA
K402	YWSKNWAKAAAFVTS
K450	TAQKAVGKDNFTLIP
T463	IPEGTNGTEERMSVI
K473	RMSVIWDKAVVTGKM
K479	DKAVVTGKMDENQFV
A507	YPRKGRIAVGSDADL
S510	KGRIAVGSDADLVIW
K528	SVKTISAKTHNSSLE
Y536	THNSSLEYNIFEGME
T563	KIVLEDGTLHVTEGS
S570	TLHVTEGSGRYIPRK
K577	SGRYIPRKPFPDFVY
Y584	KPFPDFVYKRIKARS
K585	PFPDFVYKRIKARSR
K585	PFPDFVYKRIKARSR
Y604	RGVPRGLYDGPVCEV
S612	DGPVCEVSVTPKTVT
S612	DGPVCEVSVTPKTVT
T614	PVCEVSVTPKTVTPA
K616	CEVSVTPKTVTPASS
T617	EVSVTPKTVTPASSA
T619	SVTPKTVTPASSAKT
S622	PKTVTPASSAKTSPA
S623	KTVTPASSAKTSPAK
K625	VTPASSAKTSPAKQQ
K625	VTPASSAKTSPAKQQ
T626	TPASSAKTSPAKQQA
S627	PASSAKTSPAKQQAP
K630	SAKTSPAKQQAPPVR
K630	SAKTSPAKQQAPPVR
S642	PVRNLHQSGFSLSGA
S645	NLHQSGFSLSGAQID
S647	HQSGFSLSGAQIDDN
T659	DDNIPRRTTQRIVAP
T660	DNIPRRTTQRIVAPP
R670	IVAPPGGRANITSLG
S675	GGRANITSLG_____

	mouse
Y3	_____MSYQGKKNIP
S14-p	KNIPRITsDRLLIkG
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K20-u	TsDRLLIkGGKIVND
S30-p	KIVNDDQsFyADIYM
Y32-p	VNDDQsFyADIYMED
K56-u	LIVPGGVkTIEAHSR
T57	IVPGGVkTIEAHSRM
T74	PGGIDVHTRFQMPDQ
K146-u	VDITEWHkGIQEEME
T177-p	FKDRFQLtDsQIyEV
S179-p	DRFQLtDsQIyEVLS
Y182-p	QLtDsQIyEVLSVIR
K293-u	DGSHYWSkNWAkAAA
K297-u	YWSkNWAkAAAFVTS
K345-u	TAQKAVGkDNFTLIP
T358	IPEGTNGTEERMSVI
K368-u	RMSVIWDkAVVTGkM
K374-u	DkAVVTGkMDENQFV
S402-p	YPRKGRIsVGsDADL
S405-p	KGRIsVGsDADLVIW
K423-u	SVKTISAkTHNSALE
Y431-p	THNSALEyNIFEGME
T458-p	KIVLEDGtLHVTEGs
S465-p	tLHVTEGsGRYIPRk
K472-u	sGRYIPRkPFPDFVY
Y479	kPFPDFVYkRIKARS
K480-a	PFPDFVYkRIKARSR
K480-u	PFPDFVYkRIKARSR
Y499-p	RGVPRGLyDGPVCEV
S507-p	DGPVCEVsVtPktVt
S507-g	DGPVCEVsVtPktVt
T509-p	PVCEVsVtPktVtPA
K511-u	CEVsVtPktVtPAss
T512-p	EVsVtPktVtPAssA
T514-p	sVtPktVtPAssAkt
S517-p	PktVtPAssAktsPA
S518-p	ktVtPAssAktsPAk
K520	VtPAssAKtsPAkQQ
K520-u	VtPAssAktsPAkQQ
T521-p	tPAssAktsPAkQQA
S522-p	PAssAktsPAkQQAP
K525	sAktsPAKQQAPPVR
K525-u	sAktsPAkQQAPPVR
S537-p	PVRNLHQsGFsLsGA
S540-p	NLHQsGFsLsGAQID
S542-p	HQsGFsLsGAQIDDN
T554-p	DDNIPRRttQRIVAP
T555-p	DNIPRRttQRIVAPP
R565-m1	IVAPPGGrANITSLG
S570	GGrANITSLG_____

	rat
Y3	_____MSYQGKKNIP
S14	KNIPRITSDRLLIkG
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K20-u	TSDRLLIkGGKIVND
S30	KIVNDDQSFyADIYM
Y32-p	VNDDQSFyADIYMED
K56	LIVPGGVKTIEAHSR
T57	IVPGGVKTIEAHSRM
T74	PGGIDVHTRFQMPDQ
K146	VDITEWHKGIQEEME
T177	FKDRFQLTDSQIYEV
S179	DRFQLTDSQIYEVLS
Y182	QLTDSQIYEVLSVIR
K293	DGSHYWSKNWAKAAA
K297	YWSKNWAKAAAFVTS
K345	TAQKAVGKDNFTLIP
T358	IPEGTNGTEERMSVI
K368	RMSVIWDKAVVTGKM
K374	DKAVVTGKMDENQFV
S402	YPRKGRISVGSDADL
S405	KGRISVGSDADLVIW
K423	SVKTISAKTHNSALE
Y431-p	THNSALEyNIFEGME
T458	KIVLEDGTLHVTEGS
S465	TLHVTEGSGRYIPRK
K472	SGRYIPRKPFPDFVY
Y479	KPFPDFVYKRIKARS
K480	PFPDFVYKRIKARSR
K480	PFPDFVYKRIKARSR
Y499-p	RGVPRGLyDGPVCEV
S507	DGPVCEVSVtPKTVt
S507	DGPVCEVSVtPKTVt
T509-p	PVCEVSVtPKTVtPA
K511	CEVSVtPKTVtPASs
T512	EVSVtPKTVtPASsA
T514-p	SVtPKTVtPASsAKT
S517	PKTVtPASsAKTsPA
S518-p	KTVtPASsAKTsPAK
K520	VtPASsAKTsPAKQQ
K520	VtPASsAKTsPAKQQ
T521	tPASsAKTsPAKQQA
S522-p	PASsAKTsPAKQQAP
K525	sAKTsPAKQQAPPVR
K525	sAKTsPAKQQAPPVR
S537	PVRNLHQSGFSLSGA
S540	NLHQSGFSLSGAQID
S542	HQSGFSLSGAQIDDN
T554	DDNIPRRTtQRIVAP
T555-p	DNIPRRTtQRIVAPP
R565	IVAPPGGRANITSLG
S570	GGRANITSLG_____

	chicken
Y3	_____MSYQGKKNIP
S14	KNIPRITSDRLLIKG
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K20	TSDRLLIKGGKIVND
S30	KIVNDDQSFYADIYM
Y32	VNDDQSFYADIYMED
K56	LIVPGGVKTIEAHGR
T57	IVPGGVKTIEAHGRM
T74	PGGIDVHTRFQMPEQ
K146	VDITEWHKGVQEEME
S177	FKDRFQLSDSQIYEV
S179	DRFQLSDSQIYEVLS
Y182	QLSDSQIYEVLSVIR
K293	DGSHYWSKNWAKAAA
K297	YWSKNWAKAAAFVTS
K345	TAQKAVGKDNFTLIP
T358	IPEGTNGTEERMSII
K368	RMSIIWDKAVVTGKM
K374	DKAVVTGKMDENQFV
A402	YPRKGRIAVGSDADL
S405	KGRIAVGSDADLVIW
K423	SVKTISAKTHNISLE
Y431	THNISLEYNIFEGME
N458	KIVLEDGNLHVTEGS
S465	NLHVTEGSGRYIPRK
K472	SGRYIPRKPFPDFVY
Y479	KPFPDFVYKRIKARS
K480	PFPDFVYKRIKARSR
K480	PFPDFVYKRIKARSR
Y499	RGVPRGLYDGPVCEV
S507	DGPVCEVSVTPKTVt
S507	DGPVCEVSVTPKTVt
T509	PVCEVSVTPKTVtPA
K511	CEVSVTPKTVtPASS
T512	EVSVTPKTVtPASSA
T514-p	SVTPKTVtPASSAKT
S517	PKTVtPASSAKTsPA
S518	KTVtPASSAKTsPAK
K520	VtPASSAKTsPAKQQ
K520	VtPASSAKTsPAKQQ
T521	tPASSAKTsPAKQQA
S522-p	PASSAKTsPAKQQAP
K525	SAKTsPAKQQAPPVR
K525	SAKTsPAKQQAPPVR
S537	PVRNLHQSGFSLSGA
S540	NLHQSGFSLSGAQID
S542	HQSGFSLSGAQIDDN
T554	DDNIPRRTtQRIVAP
T555-p	DNIPRRTtQRIVAPP
R565	IVAPPGGRANITSLG
S570	GGRANITSLG_____

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