a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)). Note: This description may include information from UniProtKB.
Protein type: Microtubule binding protein; Motility/polarity/chemotaxis
Molecular Function: dihydropyrimidinase activity; protein binding; protein kinase binding
Biological Process: response to drug; axon guidance; nervous system development; regulation of neuron differentiation; olfactory bulb development; response to amphetamine; positive regulation of glutamate secretion; synaptic vesicle transport; cytoskeleton organization and biogenesis; endocytosis; response to cocaine; signal transduction; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.