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Protein Page:
SLC25A4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC25A4 Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. Defects in SLC25A4 are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 2 (PEOA2). Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged- red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. Belongs to the mitochondrial carrier family. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Mitochondrial; Membrane protein, integral; Transporter
Cellular Component: mitochondrion; integral to plasma membrane; mitochondrial inner membrane; nucleus
Molecular Function: protein binding; adenine transmembrane transporter activity
Biological Process: adenine transport; apoptotic mitochondrial changes; mitochondrial genome maintenance; generation of precursor metabolites and energy; viral reproduction; transport; energy reserve metabolic process; transmembrane transport; regulation of insulin secretion
Reference #:  P12235 (UniProtKB)
Alt. Names/Synonyms: AAC1; Adenine nucleotide translocator 1; adenine nucleotide translocator 1 (skeletal muscle); adenine nucleotide translocator), member 4; ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; ADP/ATP translocase 1; ADT1; ANT; ANT 1; ANT1; heart/skeletal muscle ATP/ADP translocator; PEO2; PEO3; SLC25A4; solute carrier family 25 (mitochondrial carrier; Solute carrier family 25 member 4; T1
Gene Symbols: SLC25A4
Molecular weight: 33,064 Da
Basal Isoelectric point: 9.78  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below

SLC25A4

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: Y191‑p, Y195‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S7-p _MGDHAWsFLkDFLA
1 5 K10-ac DHAWsFLkDFLAGGV
0 2 K10 DHAWsFLKDFLAGGV
0 6 S22-p GGVAAAVskTAVAPI
1 2 K23-ac GVAAAVskTAVAPIE
0 1 K23 GVAAAVsKTAVAPIE
0 1 K23 GVAAAVsKTAVAPIE
0 5 K33-ac VAPIERVkLLLQVQH
0 3 K33-ub VAPIERVkLLLQVQH
0 5 S42-p LLQVQHAskQISAEK
0 2 K43-ac LQVQHAskQISAEKQ
0 3 K43-ub LQVQHAskQISAEKQ
0 2 K43-sc LQVQHAskQISAEKQ
0 10 K52-ac ISAEKQYkGIIDCVV
0 7 K52-m1 ISAEKQYkGIIDCVV
0 7 K52-m2 ISAEKQYkGIIDCVV
0 5 K52-m3 ISAEKQYkGIIDCVV
0 2 K63 DCVVRIPKEQGFLSF
0 2 K63-ub DCVVRIPkEQGFLSF
0 1 S69 PkEQGFLSFWRGNLA
0 29 Y81-p NLANVIRyFPtQALN
0 47 T84-p NVIRyFPtQALNFAF
0 205 K92-ac QALNFAFkDkYkQLF
0 2 K92-ub QALNFAFkDkYkQLF
0 14 K94-ac LNFAFkDkYkQLFLG
0 5 K96-ac FAFkDkYkQLFLGGV
0 2 K96-ub FAFkDkYkQLFLGGV
0 1 K96 FAFkDkYKQLFLGGV
0 1 K107 LGGVDRHKQFWRyFA
0 31 Y112-p RHKQFWRyFAGNLAS
0 2 K147 RLAADVGKGAAQREF
0 1 K147 RLAADVGKGAAQREF
0 12 K147-ub RLAADVGkGAAQREF
0 2 A149 AADVGkGAAQREFHG
0 4 A150 ADVGkGAAQREFHGL
0 2 K163 GLGDCIIKIFksDGL
0 2 K166-ac DCIIKIFksDGLRGL
0 1 K166 DCIIKIFKsDGLRGL
0 1 S167-p CIIKIFksDGLRGLy
0 1 Y174-p sDGLRGLyQGFNVSV
0 1 Y187-p SVQGIIIyRAAyFGV
1 352 Y191-p IIIyRAAyFGVyDTA
1 250 Y195-p RAAyFGVyDTAKGML
0 2 K263 DCWRKIAKDEGAKAF
0 1 K263 DCWRKIAKDEGAKAF
0 107 K272-ac EGAKAFFkGAWsNVL
0 4 K272-ub EGAKAFFkGAWsNVL
0 2 S276-p AFFkGAWsNVLRGMG
0 5 K295-ac LVLYDEIkKYV____
  mouse

 
S7-p _MGDQALsFLkDFLA
K10-ac DQALsFLkDFLAGGI
K10-ub DQALsFLkDFLAGGI
S22-p GGIAAAVskTAVAPI
K23-ac GIAAAVskTAVAPIE
K23-ub GIAAAVskTAVAPIE
K23-sc GIAAAVskTAVAPIE
K33-ac VAPIERVkLLLQVQH
K33-ub VAPIERVkLLLQVQH
S42-p LLQVQHAskQISAEK
K43 LQVQHAsKQISAEKQ
K43-ub LQVQHAskQISAEKQ
K43-sc LQVQHAskQISAEKQ
K52 ISAEKQYKGIIDCVV
K52-m1 ISAEKQYkGIIDCVV
K52 ISAEKQYKGIIDCVV
K52 ISAEKQYKGIIDCVV
K63-ac DCVVRIPkEQGFLsF
K63-ub DCVVRIPkEQGFLsF
S69-p PkEQGFLsFWRGNLA
Y81-p NLANVIRyFPtQALN
T84-p NVIRyFPtQALNFAF
K92-ac QALNFAFkDkYkQIF
K92-ub QALNFAFkDkYkQIF
K94-ac LNFAFkDkYkQIFLG
K96-ac FAFkDkYkQIFLGGV
K96-ub FAFkDkYkQIFLGGV
K96-sc FAFkDkYkQIFLGGV
K107 LGGVDRHKQFWRyFA
Y112-p RHKQFWRyFAGNLAS
K147-ac RLAADVGkGssQREF
K147-m1 RLAADVGkGssQREF
K147-ub RLAADVGkGssQREF
S149-p AADVGkGssQREFNG
S150-p ADVGkGssQREFNGL
K163-ac GLGDCLTkIFkSDGL
K166-ac DCLTkIFkSDGLKGL
K166-ub DCLTkIFkSDGLKGL
S167 CLTkIFkSDGLKGLY
Y174 SDGLKGLYQGFSVSV
Y187 SVQGIIIYRAAyFGV
Y191-p IIIYRAAyFGVyDTA
Y195-p RAAyFGVyDTAKGML
K263-ac DCWRKIAkDEGANAF
K263-ub DCWRKIAkDEGANAF
K272-ac EGANAFFkGAWsNVL
K272-ub EGANAFFkGAWsNVL
S276-p AFFkGAWsNVLRGMG
K295 LVLYDEIKKYV____
  rat

 
S7-p _MGDQALsFLkDFLA
K10-ac DQALsFLkDFLAGGI
K10 DQALsFLKDFLAGGI
S22-p GGIAAAVskTAVAPI
K23-ac GIAAAVskTAVAPIE
K23 GIAAAVsKTAVAPIE
K23 GIAAAVsKTAVAPIE
K33-ac VAPIERVkLLLQVQH
K33 VAPIERVKLLLQVQH
S42-p LLQVQHAskQISAEK
K43-ac LQVQHAskQISAEKQ
K43 LQVQHAsKQISAEKQ
K43 LQVQHAsKQISAEKQ
K52 ISAEKQYKGIIDCVV
K52 ISAEKQYKGIIDCVV
K52 ISAEKQYKGIIDCVV
K52 ISAEKQYKGIIDCVV
K63-ac DCVVRIPkEQGFLSF
K63 DCVVRIPKEQGFLSF
S69 PkEQGFLSFWRGNLA
Y81 NLANVIRYFPtQALN
T84-p NVIRYFPtQALNFAF
K92-ac QALNFAFkDkYkQIF
K92 QALNFAFKDkYkQIF
K94-ac LNFAFkDkYkQIFLG
K96-ac FAFkDkYkQIFLGGV
K96 FAFkDkYKQIFLGGV
K96 FAFkDkYKQIFLGGV
K107-ac LGGVDRHkQFWRyFA
Y112-p RHkQFWRyFAGNLAS
K147-ac RLAADVGkGssQREF
K147 RLAADVGKGssQREF
K147-ub RLAADVGkGssQREF
S149-p AADVGkGssQREFNG
S150-p ADVGkGssQREFNGL
K163-ac GLGDCLTkIFkSDGL
K166-ac DCLTkIFkSDGLKGL
K166 DCLTkIFKSDGLKGL
S167 CLTkIFkSDGLKGLY
Y174 SDGLKGLYQGFSVSV
Y187 SVQGIIIYRAAyFGV
Y191-p IIIYRAAyFGVyDTA
Y195-p RAAyFGVyDTAKGML
K263 DCWRKIAKDEGRKAF
K263 DCWRKIAKDEGRKAF
K272-ac EGRKAFFkGAWsNVL
K272 EGRKAFFKGAWsNVL
S276-p AFFkGAWsNVLRGMG
K295 LVLYDEIKKYV____
  pig

 
S7 _MSDQAWSFLKDFLA
K10 DQAWSFLKDFLAGGV
K10 DQAWSFLKDFLAGGV
S22-p GGVAAAIsKTAVAPI
K23 GVAAAIsKTAVAPIE
K23 GVAAAIsKTAVAPIE
K23 GVAAAIsKTAVAPIE
K33 VAPIERVKLLLQVRT
K33 VAPIERVKLLLQVRT
R42 LLQVRTARVRRGDAE
V43 LQVRTARVRRGDAEK
V43 LQVRTARVRRGDAEK
V43 LQVRTARVRRGDAEK
K53 GDAEKQYKGIIDCVV
K53 GDAEKQYKGIIDCVV
K53 GDAEKQYKGIIDCVV
K53 GDAEKQYKGIIDCVV
K64 DCVVRIPKEQGFLSF
K64 DCVVRIPKEQGFLSF
S70 PKEQGFLSFWRGNLA
Y82 NLANVIRYFPtQALN
T85-p NVIRYFPtQALNFAF
K93 QALNFAFKDKYKQIF
K93 QALNFAFKDKYKQIF
K95 LNFAFKDKYKQIFLG
K97 FAFKDKYKQIFLGGV
K97 FAFKDKYKQIFLGGV
K97 FAFKDKYKQIFLGGV
K108 LGGVDRHKQFWRYFA
Y113 RHKQFWRYFAGNLAS
K148 RLAADVGKGAAQREF
K148 RLAADVGKGAAQREF
K148 RLAADVGKGAAQREF
A150 AADVGKGAAQREFTG
A151 ADVGKGAAQREFTGL
K164 GLGNCLAKIFKSDGL
K167 NCLAKIFKSDGLRGL
K167 NCLAKIFKSDGLRGL
S168 CLAKIFKSDGLRGLY
Y175 SDGLRGLYQGFNVSV
Y188 SVQGIIIYRAAyFGV
Y192-p IIIYRAAyFGVyDTA
Y196-p RAAyFGVyDTAKGML
K264 DCWRKIAKDEGPKAF
K264 DCWRKIAKDEGPKAF
K273 EGPKAFFKGAWSNVL
K273 EGPKAFFKGAWSNVL
S277 AFFKGAWSNVLRGMG
K296 LVLYDEIKKYV____
  cow

 
S7 _MSDQALSFLKDFLA
K10 DQALSFLKDFLAGGV
K10 DQALSFLKDFLAGGV
S22 GGVAAAISKTAVAPI
K23 GVAAAISKTAVAPIE
K23 GVAAAISKTAVAPIE
K23 GVAAAISKTAVAPIE
K33 VAPIERVKLLLQVQH
K33 VAPIERVKLLLQVQH
S42 LLQVQHASKQISAEK
K43 LQVQHASKQISAEKQ
K43 LQVQHASKQISAEKQ
K43 LQVQHASKQISAEKQ
K52 ISAEKQYKGIIDCVV
K52 ISAEKQYKGIIDCVV
K52 ISAEKQYKGIIDCVV
K52 ISAEKQYKGIIDCVV
K63 DCVVRIPKEQGFLSF
K63 DCVVRIPKEQGFLSF
S69 PKEQGFLSFWRGNLA
Y81 NLANVIRYFPTQALN
T84 NVIRYFPTQALNFAF
K92 QALNFAFKDKYKQIF
K92 QALNFAFKDKYKQIF
K94 LNFAFKDKYKQIFLG
K96 FAFKDKYKQIFLGGV
K96 FAFKDKYKQIFLGGV
K96 FAFKDKYKQIFLGGV
K107 LGGVDRHKQFWRYFA
Y112 RHKQFWRYFAGNLAS
K147 RLAADVGKGAAQREF
K147 RLAADVGKGAAQREF
K147 RLAADVGKGAAQREF
A149 AADVGKGAAQREFTG
A150 ADVGKGAAQREFTGL
K163 GLGNCITKIFKSDGL
K166 NCITKIFKSDGLRGL
K166 NCITKIFKSDGLRGL
S167 CITKIFKSDGLRGLY
Y174 SDGLRGLYQGFNVSV
Y187 SVQGIIIYRAAYFGV
Y191 IIIYRAAYFGVYDTA
Y195 RAAYFGVYDTAKGML
K263 DCWRKIAKDEGPKAF
K263 DCWRKIAKDEGPKAF
K272 EGPKAFFKGAWSNVL
K272 EGPKAFFKGAWSNVL
S276 AFFKGAWSNVLRGMG
K295 LVLYDEIKKFV____
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