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TLR8 (human)

Overview TLR8 Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Receptor, misc. Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane Molecular Function: single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; receptor activity Biological Process: I-kappaB kinase/NF-kappaB cascade; response to virus; positive regulation of interferon-beta biosynthetic process; positive regulation of innate immune response; positive regulation of interleukin-8 biosynthetic process; innate immune response; positive regulation of interferon-alpha biosynthetic process; immunoglobulin mediated immune response; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process Reference #:  Q9NR97 (UniProtKB) Alt. Names/Synonyms: CD288; MGC119599; MGC119600; TLR8; Toll-like receptor 8 Gene Symbols: TLR8 Molecular weight: 119,828 Da Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states CST Pathways:  NF-kB Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TLR8 3W3G - A/B=27-827 (human) 3W3J - A/B=27-827 (human) 3W3K - A/B=27-827 (human) 3W3L - A/D/C/B=27-827 (human) 3W3M - A=27-827 (human) 3W3N - A/B=27-827 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3W3G 3W3J 3W3K 3W3L 3W3M 3W3N  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y64	VPQTVGKYVTELDLS
0	1		T66	QTVGKYVTELDLSDN
0	1		S368-p	RNFSKLLsLRALHLR
0	1		T762-p	ALETKTTtKLsMLEL
0	1		S765-p	TKTTtKLsMLELHGN
0	1		S874-p	VKGYRSLstsQTFyD
0	1		T875-p	KGYRSLstsQTFyDA
0	1		S876-p	GYRSLstsQTFyDAY
1	0		Y880-p	LstsQTFyDAYISyD
1	0		Y886-p	FyDAYISyDTKDASV
0	1		S935-p	IIDNLMQsINQsKKT
0	1		S939-p	LMQsINQsKKTVFVL
1	0		Y1030-p	LTENDSRyNNMYVDS

	mouse
Y64-p	VPQTIGKyVtNIDLS
T66-p	QTIGKyVtNIDLSDN
S363	SNFSKLRSLKKLHLR
T753	SLQTKMKTNLSILEL
S756	TKMKTNLSILELHGN
S865	LKGYRTSSTSQTFYD
T866	KGYRTSSTSQTFYDA
S867	GYRTSSTSQTFYDAY
Y871	SSTSQTFYDAYISYD
Y877	FYDAYISYDTKDASV
S926	IIDNLMQSINQSKKT
S930	LMQSINQSKKTIFVL
Y1021	LTENDSRYDDLYIDS

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