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Protein Page:
AID (human)

Overview
AID Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; EC 3.5.4.5
Cellular Component: cytoplasm; exosome (RNase complex); nucleus
Molecular Function: protein binding; zinc ion binding; cytidine deaminase activity
Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; mRNA processing
Reference #:  Q9GZX7 (UniProtKB)
Alt. Names/Synonyms: Activation-induced cytidine deaminase; AICDA; AID; ARP2; CDA2; Cytidine aminohydrolase; HIGM2; integrated into Burkitt's lymphoma cell line Ramos
Gene Symbols: AICDA
Molecular weight: 23,954 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AID

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: T27‑p, S38‑p
enzymatic activity, inhibited: T27‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S3 _____MDSLLMNRRK
5 2 T27-p WAKGRREtYLCYVVK
10 3 S38-p YVVKRRDsATsFsLD
1 3 S41-p KRRDsATsFsLDFGY
1 2 S43-p RDsATsFsLDFGYLR
3 0 T140 GVQIAIMTFKDYFYC
1 2 Y184 RRILLPLYEVDDLRD
  mouse

 
S3-p _____MDsLLMKQKK
T27-p WAKGRHEtYLCYVVK
S38-p YVVKRRDsATsCSLD
S41-p KRRDsATsCSLDFGH
S43 RDsATsCSLDFGHLR
T140-p GVQIGIMtFKDYFYC
Y184-p RRILLPLyEVDDLRD
  rat

 
- gap
- gap
S9 YVVKRRDSATSFSLD
S12 KRRDSATSFSLDFGH
S14 RDSATSFSLDFGHLR
T111 GVQIGIMTFKDYFYC
Y155 RRILLPLYEVDDLRD
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