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AID (human)

Overview AID Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family. Note: This description may include information from UniProtKB. Protein type: EC 3.5.4.5; Hydrolase Cellular Component: cytoplasm; exosome (RNase complex); nucleus Molecular Function: protein binding; zinc ion binding; cytidine deaminase activity Biological Process: somatic diversification of immunoglobulins; B cell differentiation; isotype switching; mRNA processing Reference #:  Q9GZX7 (UniProtKB) Alt. Names/Synonyms: Activation-induced cytidine deaminase; AICDA; AID; ARP2; CDA2; Cytidine aminohydrolase; HIGM2; integrated into Burkitt's lymphoma cell line Ramos Gene Symbols: AICDA Molecular weight: 23,954 Da Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AID

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE 605257 605258  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: T27‑p, S38‑p enzymatic activity, inhibited: T27‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S3	_____MDSLLMNRRK
5	2		T27-p	WAKGRREtYLCYVVK
10	3		S38-p	YVVKRRDsATsFsLD
1	3		S41-p	KRRDsATsFsLDFGy
1	2		S43-p	RDsATsFsLDFGyLR
0	1		Y48-p	sFsLDFGyLRNKNGC
3	0		T140	GVQIAIMTFKDYFYC
0	1		Y146	MTFKDYFYCWNTFVE
0	1		K160-a	ENHERTFkAWEGLHE
1	2		Y184	RRILLPLYEVDDLRD

	mouse
S3-p	_____MDsLLMKQKK
T27-p	WAKGRHEtYLCYVVK
S38-p	YVVKRRDsATsCSLD
S41-p	KRRDsATsCSLDFGH
S43	RDsATsCSLDFGHLR
H48	sCSLDFGHLRNKSGC
T140-p	GVQIGIMtFKDYFYC
Y146	MtFKDYFYCWNTFVE
K160	ENRERTFKAWEGLHE
Y184-p	RRILLPLyEVDDLRD

	rat
-	gap
-	gap
S9	YVVKRRDSATSFSLD
S12	KRRDSATSFSLDFGH
S14	RDSATSFSLDFGHLR
H19	SFSLDFGHLRNKSGC
T111	GVQIGIMTFKDYFyC
Y117-p	MTFKDYFyCWNTFVE
K131	ENHERTFKAWEGLHE
Y155	RRILLPLYEVDDLRD

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