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Protein Page:
HLAC (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HLAC Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral
Cellular Component: Golgi membrane; phagocytic vesicle membrane; cell surface; integral to plasma membrane; early endosome membrane; extracellular region; plasma membrane; MHC class I protein complex
Molecular Function: peptide antigen binding; TAP binding; receptor binding
Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; regulation of immune response; antigen processing and presentation of peptide antigen via MHC class I; viral reproduction; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response
Reference #:  P30501 (UniProtKB)
Alt. Names/Synonyms: 1C02; class I MHC antigen HLA-B heavy chain; D6S204; FLJ27082; HLA class I antigen; HLA class I heavy chain; HLA class I histocompatibility antigen, C alpha chain; HLA class I histocompatibility antigen, Cw-1 alpha chain; HLA class I histocompatibility antigen, Cw-12 alpha chain; HLA class I histocompatibility antigen, Cw-14 alpha chain; HLA class I histocompatibility antigen, Cw-16 alpha chain; HLA class I histocompatibility antigen, Cw-17 alpha chain; HLA class I histocompatibility antigen, Cw-2 alpha chain; HLA class I histocompatibility antigen, Cw-4 alpha chain; HLA class I histocompatibility antigen, Cw-6 alpha chain; HLA class I histocompatibility antigen, Cw-7 alpha chain; HLA class I histocompatibility antigen, Cw-8 alpha chain; HLA-C; HLA-C (Cw*1201); HLA-Cw; HLA-Cw*050x; HLA-Cw12; HLA-JY3; HLAC; HLC-C; human leukocyte antigen-C alpha chain; leucocyte antigen C; leucocyte antigen Cw; leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C; major histocompatibility complex, class I, C; MHC class I antigen Cw*1; MHC class I antigen Cw*12; MHC class I antigen Cw*14; MHC class I antigen Cw*16; MHC class I antigen Cw*17; MHC class I antigen Cw*2; MHC class I antigen Cw*4; MHC class I antigen Cw*6; MHC class I antigen Cw*7; MHC class I antigen Cw*8; MHC class I antigen heavy chain HLA-C; MHC class I antigen HLA-C; MHC class I HLA-C; MHC class I HLA-Cw*0803; MHC class I protein HLA-C heavy chain; PSORS1
Gene Symbols: HLA-C
Molecular weight: 41,095 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
Select Structure to View Below

HLAC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T20 LSGALALTETWACSH
0 1 S28 ETWACSHSMRYFYTA
0 1 T55 AVGYVDDTQFVRFDS
0 1 Y83-p VEQEGPEyWDRETQk
0 1 K90-u yWDRETQkYNRQAQT
0 1 - gap
0 1 T97 kYNRQAQTDRVNLRK
0 10 K145-u DQSAYDGkDYIALNE
0 2 Y147 SAYDGkDYIALNEDL
0 1 S156 ALNEDLRSWTAADTA
0 1 - gap
0 4 K170-u AAQITQRkWEAAREA
0 1 Y183 EAEEWRAYLEGECVE
0 1 - gap
0 25 K200 RRYLENGKEKLQRAE
0 8 - gap
0 5 K210-u LQRAEHPkTHVTHHP
0 10 K267-u AGDGTFQkWAAVVVP
0 1 - gap
0 14 K341 RRKSSGGKGGSCSQA
0 2 - gap
0 39 - gap
0 2 S351 SCSQAASSNSAQGSD
0 6 - gap
0 9 - gap
0 16 S357 SSNSAQGSDESLIAS
0 22 S360 SAQGSDESLIASKA_
0 48 K365 DESLIASKA______
0 2 - gap
  HLAC iso2  
T20 LSGALALTETWACSH
S28 ETWACSHSMKYFFTS
T55 SVGYVDDTQFVRFDS
Y83 VEQEGPEYWDRETQK
K90 YWDRETQKYNRQAQT
- gap
T97 KYNRQAQTDRVSLRN
K145-u DQYAYDGkDYIALNE
Y147 YAYDGkDYIALNEDL
S156 ALNEDLRSWTAADTA
- gap
K170 AAQITQRKWEAAREA
Y183 EAEERRAYLEGTCVE
- gap
K200 RRYLENGKESLQRAE
S202 YLENGKESLQRAEHP
K210 LQRAEHPKTHVTHHP
K267 AGDGTFQKWAAVMVP
- gap
K341 RRKSSGGKGGSCSQA
- gap
- gap
S351 SCSQAASSNSAQGSD
- gap
- gap
S357 SSNSAQGSDESLIAS
S360 SAQGSDESLIASKA_
K365 DESLIASKA______
- gap
  HLAC iso5  
T20 LSGALALTETWACSH
S28 ETWACSHSMRYFYTA
T55 AVGYVDDTQFVQFDS
Y83 VEQEGPEYWDRETQK
K90 YWDRETQKYKRQAQT
K92 DRETQKYKRQAQTDR
T97 KYKRQAQTDRVNLRK
K145-u NQFAYDGkDyIALNE
Y147-p FAYDGkDyIALNEDL
S156 ALNEDLRSWTAADkA
K162-u RSWTAADkAAQITQR
K170 AAQITQRKWEAAREA
Y183 EAEQRRAYLEGTCVE
- gap
K200 RRYLENGKKTLQRAE
T202 YLENGKKTLQRAEHP
K210-u LQRAEHPkTHVTHHP
K267-u AGDGTFQkWAAVVVP
- gap
K341-u RRKSSGGkGGSCSQA
- gap
- gap
S351-p SCSQAASsNSAQGsD
- gap
- gap
S357-p SsNSAQGsDEsLIAC
S360-p SAQGsDEsLIACkA_
K365-u DEsLIACkA______
- gap
  HLAC iso7  
T20 LSGGLALTETWACSH
S28 ETWACSHSMRYFDTA
T55 SVGYVDDTQFVRFDS
Y83 VEQEGPEYWDRETQK
K90 YWDRETQKYKRQAQA
K92 DRETQKYKRQAQADR
- gap
K145 DQSAYDGKDYIALNE
Y147 SAYDGKDYIALNEDL
S156 ALNEDLRSWTAADTA
- gap
K170 AAQITQRKLEAARAA
Y183-p AAEQLRAyLEGTCVE
- gap
K200-u RRYLENGkEtLQRAE
T202-p YLENGkEtLQRAEPP
K210 LQRAEPPKTHVTHHP
K267-u AGDGTFQkWAAVVVP
- gap
K341-u RRKSSGGkGGSCSQA
- gap
- gap
S351 SCSQAACSNSAQGsD
- gap
- gap
S357-p CSNSAQGsDEsLITC
S360-p SAQGsDEsLITCkA_
K365-u DEsLITCkA______
- gap
  HLAC iso14  
T20 LSGALALTETWACSH
S28 ETWACSHSMRYFYTA
T55 AVGYVDDTQFVQFDS
Y83 VEQEGPEYWDRETQK
K90 YWDRETQKYKRQAQT
K92 DRETQKYKRQAQTDR
T97 KYKRQAQTDRVNLRK
K145 NQFAYDGKDYIALNE
Y147 FAYDGKDYIALNEDL
S156 ALNEDLRSWTAADKA
K162 RSWTAADKAAQITQR
K170 AAQITQRKWEAAREA
Y183 EAEQRRAYLEGTCVE
- gap
K200 RRYLENGKKTLQRAE
T202 YLENGKKTLQRAEHP
K210 LQRAEHPKTHVTHHP
K267 AGDGTFQKWAAVVVP
- gap
- gap
T351-p RSGVWPAtVPRALMS
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  HLAC iso15  
- gap
S3 _____SHSMRYFYTA
T30 AVGYVDDTQFVRFDS
Y58 VEQEGPEYWDRETQN
- gap
K67-u DRETQNYkRQAQTDR
T72 NYkRQAQTDRVNLRK
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  HLAC iso20  
T20 LSGGLALTETWACSH
S28 ETWACSHSMRYFDTA
T55 SVGYVDDTQFVRFDS
Y83 VEQEGPEYWDRETQK
K90 YWDRETQKYKRQAQA
K92 DRETQKYKRQAQADR
- gap
K145-u DQFAYDGkDYIALNE
Y147 FAYDGkDYIALNEDL
S156 ALNEDLRSWTAADTA
- gap
K170 AAQITQRKLEAARAA
Y183 AAEQDRAYLEGTCVE
- gap
K200 RRYLENGKKTLQRAE
T202 YLENGKKTLQRAEPP
K210 LQRAEPPKTHVTHHP
K267-u AGDGTFQkWAAVVVP
A270 GTFQkWAAVVVPSGQ
K341 RRKSSGGKGGSCSQA
- gap
- gap
S351 SCSQAACSNSAQGsD
- gap
- gap
S357-p CSNSAQGsDEsLITC
S360-p SAQGsDEsLITCKA_
K365 DEsLITCKA______
- gap
  mouse

► Hide Isoforms
 
A20 LAAALAPAQTRAGPH
S28 QTRAGPHSLRYFETV
T55 SVGYVDNTEFVRFDS
Y83 MEQEGPEYWERETQI
- gap
K92 ERETQIAKGNEQSFR
S97 IAKGNEQSFRVDLRT
- gap
Y147 FAYDGCDYIALNEDL
T156 ALNEDLKTWTAADMA
- gap
K170 AALITKHKWEQAGAA
Y183 AAERDRAYLEGTCVE
- gap
- gap
T202 YLELGNATLLHTDSP
K210 LLHTDSPKAHVTHHP
K267-u AGDGTFQkWASVVVP
S270 GTFQkWASVVVPLGK
K340 MRRNTGGKGGDYTLT
- gap
Y344 TGGKGGDYTLTPGSQ
- gap
S350 DYTLTPGSQSsEMsL
S352 TLTPGSQSsEMsLPD
S353-p LTPGSQSsEMsLPDC
S356-p GSQSsEMsLPDCKA_
K361 EMsLPDCKA______
- gap
  HLAC iso7  
T17 LAAALAPTQTRAGPH
S25 QTRAGPHSLRYFETA
T52 EVGYVDDTEFVRFDS
Y80 MEQVEPEYWEEQTQI
- gap
K89 EEQTQIAKGNEQRsR
S95-p AKGNEQRsRVNLRTA
R142 EQVAYDGRDYIALNE
Y144 VAYDGRDYIALNEDL
T153 ALNEDLKTWTAADMA
- gap
K167 AALITKHKWEQAGAA
Y180 AAERRRAYLEGTCVE
- gap
- gap
T199 YLELGNATLLRTDSP
K207 LLRTDSPKAHVTHHS
K264 AGDGTFQKWASVVVP
S267 GTFQKWASVVVPLGK
K337-u RRRNTGGkGGDyALA
- gap
Y341-p TGGkGGDyALAPGsQ
- gap
S347-p DyALAPGsQtsDLsL
T349-p ALAPGsQtsDLsLPD
S350-p LAPGsQtsDLsLPDC
S353-p GsQtsDLsLPDCKVM
K358 DLsLPDCKVMVHNPH
S366-p VMVHNPHsLA_____
  HLAC iso21  
T17 LAAALAPTQTRAGPH
S25 QTRAGPHSLRYFVTA
T52 EVGYVDDTEFVRFDS
Y80 MEQEGPEYWERETQK
K87 YWERETQKAKGNEQS
K89 ERETQKAKGNEQSFR
S94 KAKGNEQSFRVDLRT
- gap
Y144 YAYDGCDYIALNEDL
T153 ALNEDLKTWTAADMA
- gap
K167 AALITKHKWEQAGEA
Y180 EAERLRAYLEGTCVE
- gap
- gap
T199-p YLKNGNAtLLRTDSP
K207 LLRTDSPKAHVTHHS
K264 AGDGTFQKWASVVVP
S267 GTFQKWASVVVPLGK
K338-u RRRNTGGkGGDyALA
- gap
Y342-p TGGkGGDyALAPGsQ
- gap
S348-p DyALAPGsQtsDLsL
T350-p ALAPGsQtsDLsLPD
S351-p LAPGsQtsDLsLPDC
S354-p GsQtsDLsLPDCkVM
K359-u DLsLPDCkVMVHDPH
S367-p VMVHDPHsLA_____
  HLAC iso22  
T17 LAAALAPTQTRAGPH
S25 QTRAGPHSLRYFVTA
T52 AVGYVDDTQFVRFDS
Y80 MEQEGPEYWEEQTQR
R87 YWEEQTQRAKSDEQW
K89 EEQTQRAKSDEQWFR
- gap
R142 QQFAYDGRDYIALNE
Y144 FAYDGRDYIALNEDL
T153 ALNEDLKTWTAADTA
- gap
K167 AALITRRKWEQAGDA
Y180 DAEYYRAYLEGECVE
- gap
- gap
T199 YLELGNETLLRTDSP
K207 LLRTDSPKAHVTYHP
K264 AGDGTFQKWAAVVVP
- gap
K337-u MRRNTGGkGVNyALA
- gap
Y341-p TGGkGVNyALAPGsQ
- gap
S347-p NyALAPGsQtsDLsL
T349-p ALAPGsQtsDLsLPD
S350-p LAPGsQtsDLsLPDG
S353-p GsQtsDLsLPDGKVM
K358 DLsLPDGKVMVHDPH
S366-p VMVHDPHsLA_____
  HLAC iso23  
T20 LAAALGPTQTRAGSH
S28 QTRAGSHSLRYFVTA
T55 EVGYVDNTEFVRFDS
Y83 IEQEGPEYWERETRR
R90 YWERETRRAKGNEQS
K92 ERETRRAKGNEQSFR
S97 RAKGNEQSFRVDLRT
- gap
Y147 FAYDGCDYIALNEDL
T156 ALNEDLKTWTAADMA
- gap
K170 AAQITRRKWEQAGAA
Y183 AAERDRAYLEGECVE
- gap
- gap
T202-p YLKNGNAtLLRTDPP
K210 LLRTDPPKAHVTHHR
K267 AGDGTFQKWASVVVP
S270 GTFQKWASVVVPLGK
K343 RRRNTGGKGGDyALA
- gap
Y347-p TGGKGGDyALAPGsQ
- gap
S353-p DyALAPGsQssDMsL
S355-p ALAPGsQssDMsLPD
S356-p LAPGsQssDMsLPDC
S359-p GsQssDMsLPDCKV_
K364 DMsLPDCKV______
- gap
  HLAC iso25  
T17 LAVALAPTQTRAGPH
S25 QTRAGPHSLRYFYTT
T52 SVGYVDNTEFVRFDS
Y80 MEQEGPEYWERETQK
K87 YWERETQKSKGQKES
K89 ERETQKSKGQKESFR
S94 KSKGQKESFRVDLRT
R142 LQYAYDGRDYIALNE
Y144 YAYDGRDYIALNEDL
T153 ALNEDLKTWTAADMA
- gap
K167 AAQITRHKWEQAGAA
Y180 AAELYKAYLEGECVE
S188-p LEGECVEsLRRYLEL
- gap
T199 YLELGNATLLRTDSP
K207 LLRTDSPKAHVTHHS
K264 AGDGTFQKWASVVVP
S267 GTFQKWASVVVPLGK
K338-u RRRNTGGkGGDyALA
- gap
Y342-p TGGkGGDyALAPGsQ
- gap
S348-p DyALAPGsQtsDLsL
T350-p ALAPGsQtsDLsLPD
S351-p LAPGsQtsDLsLPDC
S354-p GsQtsDLsLPDCKA_
K359 DLsLPDCKA______
- gap
  HLAC iso26  
T20 LAAALAPTQTRAGPH
S28 QTRAGPHSMRYFETA
K55-u SVGYVDNkEFVRFDS
Y83 MEQEGPEYWERITQI
- gap
K92 ERITQIAKGQEQWFR
- gap
C145 EQFAYDGCDYIALNE
Y147 FAYDGCDYIALNEDL
T156 ALNEDLKTWTAADMA
- gap
K170-u AAQITRRkWEQAGAA
Y183 AAEYYRAYLEGECVE
- gap
- gap
T202-p YLKNGNAtLLRTDSP
K210 LLRTDSPKAHVTHHP
K267 AGDGTFQKWASVVVP
S270 GTFQKWASVVVPLGK
K340-u RRRNTGGkGGDyALA
- gap
Y344-p TGGkGGDyALAPGsQ
- gap
S350-p DyALAPGsQssEMsL
S352-p ALAPGsQssEMsLRD
S353-p LAPGsQssEMsLRDC
S356-p GsQssEMsLRDCKA_
K361 EMsLRDCKA______
- gap
  HLAC iso27  
T17 LAAALAPTQTRAGPH
S25 QTRAGPHSLRYFETA
T52 SVGYVDNTEFVRFDS
Y80 MEQEGPEYWERETQR
R87 YWERETQRAKGQEQS
K89 ERETQRAKGQEQSFR
S94 RAKGQEQSFRVDLRT
R142 QQHAYDGRDYIALNE
Y144 HAYDGRDYIALNEDL
T153 ALNEDLKTWTAADMA
- gap
K167 AALITKQKWEQAGAA
Y180 AAERLRAYLEGACVE
- gap
- gap
T199 YLERGNATLLRTDSP
K207 LLRTDSPKAHVTHHP
K264 AGDGTFQKWAsVVVP
S267-p GTFQKWAsVVVPRGK
K338 RRRNTGGKGGDYTLA
- gap
Y342 TGGKGGDYTLAPGSQ
- gap
S348 DYTLAPGSQSSDMSL
S350 TLAPGSQSSDMSLPD
S351 LAPGSQSSDMSLPDC
S354 GSQSSDMSLPDCKVM
K359 DMSLPDCKVMVDDPH
S367 VMVDDPHSLA_____
  rat

► Hide Isoforms
 
- gap
S4 ____GSHSLRYFVTA
T31 EVGYVDDTEFVRYDS
Y59 MEREGREYWERETRI
- gap
K68 ERETRIAKGNEQTFR
T73 IAKGNEQTFRENLRT
R121 EQFAYDGRDYIVLNE
Y123 FAYDGRDYIVLNEDL
T132 VLNEDLKTWTAADTA
- gap
K146 AARITRNKWDRAGVA
Y159 VAERHKAYLEGKCLE
S167 LEGKCLESLLRYLEL
K176 LRYLELGKETLLRSD
T178 YLELGKETLLRSDPP
K186 LLRSDPPKAHVTLHP
K243 AGDGTFQKWASVVVP
S246 GTFQKWASVVVPLGK
K321 RRRNTGGKVGVyAPA
- gap
Y325-p TGGKVGVyAPAPSRD
- gap
S334 PAPSRDSSESSDVSL
S336 PSRDSSESSDVSLSD
S337 SRDSSESSDVSLSDC
S340 SSESSDVSLSDCKA_
K345 DVSLSDCKA______
- gap
  HLAC iso1  
T20-p LAAALAPtQTRAGSH
S28-p QTRAGSHsMRYFDIA
T55 IVGYVDDTEFVRFDS
Y83 MEPEGPEYWEEQTRR
R90 YWEEQTRRAKEGEQT
K92 EEQTRRAKEGEQTFR
T97 RAKEGEQTFRVNLRT
R145 EQYAYDGRDYIALNE
Y147 YAYDGRDYIALNEDL
T156 ALNEDLKTWTAADFA
- gap
K170 AARISRNKWDQAGVA
Y183 VAERLRAYLEGECVE
- gap
K200 RRYLELGKETLLRSD
T202 YLELGKETLLRSDPP
K210 LLRSDPPKAHVTLHP
K267 AGDGTFQKWASVVVP
S270 GTFQKWASVVVPLGK
K345 RRRNTGGKGVYTPAP
- gap
Y348 NTGGKGVYTPAPGTD
- gap
S357 PAPGTDSSQSSDVSL
S359 PGTDSSQSSDVSLPD
S360 GTDSSQSSDVSLPDC
S363 SSQSSDVSLPDCKA_
K368 DVSLPDCKA______
- gap
  HLAC iso3  
T17 LAAALAPTQTQAGSH
S25 QTQAGSHSLRYFDIA
R52 IVGYVDDREVMRFDS
Y80 MEREGPEYWERQTRK
K87 YWERQTRKVKEKEQI
K89 ERQTRKVKEKEQIFR
- gap
R142 NQHAYDGRDyIALNE
Y144-p HAYDGRDyIALNEDL
T153-p ALNEDLKtWTAADTA
- gap
K167 AAQITKNKWERDGEA
Y180 EAERRRAYLEGECVE
- gap
K197 RSYLAPRKETLLRSD
T199 YLAPRKETLLRSDPP
K207 LLRSDPPKAHVTLHP
K264 AGDGTFQKWASVVVP
S267 GTFQKWASVVVPSGE
K345 RRRNTGGKGDYTPAR
- gap
Y348 NTGGKGDYTPARGRD
- gap
S357 PARGRDSSQSsDVsL
S359 RGRDSSQSsDVsLPD
S360-p GRDSSQSsDVsLPDC
S363-p SSQSsDVsLPDCKA_
K368 DVsLPDCKA______
- gap
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