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TXN (human)

Overview TXN Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA- binding activity in a redox-dependent manner. Up-regulated by ionizing radiation. Belongs to the thioredoxin family. Note: This description may include information from UniProtKB. Cellular Component: nucleoplasm; mitochondrion; extracellular region; cytosol Molecular Function: protein binding; electron carrier activity; protein disulfide oxidoreductase activity; peptide disulfide oxidoreductase activity Biological Process: negative regulation of protein export from nucleus; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; negative regulation of transcription from RNA polymerase II promoter; signal transduction; glycerol ether metabolic process; cell proliferation; response to radiation; cell-cell signaling; cell redox homeostasis; innate immune response; regulation of protein import into nucleus, translocation; cell motility; positive regulation of DNA binding Reference #:  P10599 (UniProtKB) Alt. Names/Synonyms: ADF; ATL-derived factor; DKFZp686B1993; MGC61975; SASP; Surface-associated sulphydryl protein; THIO; Thioredoxin; TRDX; TRX; TRX1; TXN Gene Symbols: TXN Molecular weight: 11,737 Da Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TXN 1AIU - A=1-105 (human) 1AUC - A=1-105 (human) 1CQG - A=1-105 (human) 1CQH - A=1-105 (human) 1ERT - A=1-105 (human) 1ERU - A=1-105 (human) 1ERV - A=1-105 (human) 1ERW - A=1-105 (human) 1M7T - A=1-101 (human) 1MDI - A=1-105 (human) 1MDJ - A=1-105 (human) 1MDK - A=1-105 (human) 1TRS - A=1-105 (human) 1TRU - A=1-105 (human) 1TRV - A=1-105 (human) 1TRW - A=1-105 (human) 1W1C - C=1-105 (human) 1W1E - C=1-105 (human) 2HSH - A=1-105 (human) 2HXK - A/B/C=1-105 (human) 2IFQ - A/B/C=1-105 (human) 2IIY - A=1-105 (human) 3E3E - A/B=1-105 (human) 3KD0 - A=1-105 (human) 3M9J - A/B=1-105 (human) 3M9K - A/B=1-105 (human) 3QFA - D/C=2-105 (human) 3QFB - D/C=2-105 (human) 3TRX - A=1-105 (human) 4TRX - A=1-105 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4TRX  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: T100‑p intracellular localization: T100‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K3-a	_____MVkQIESkTA
0	2		K8-u	MVkQIESkTAFQEAL
0	1		K8	MVkQIESKTAFQEAL
0	10		K39-a	CGPCKMIkPFFHSLS
0	4		K39-u	CGPCKMIkPFFHSLS
0	4		K81-a	MPTFQFFkKGQKVGE
0	3		K94-a	GEFSGANkEkLEAtI
0	1		K94-u	GEFSGANkEkLEAtI
0	12		K96-u	FSGANkEkLEAtINE
0	1		K96	FSGANkEKLEAtINE
1	1		T100-p	NkEkLEAtINELV__

	mouse
K3	_____MVKLIESkEA
K8-u	MVKLIESkEAFQEAL
K8-a	MVKLIESkEAFQEAL
K39-a	CGPCKMIkPFFHSLC
K39-u	CGPCKMIkPFFHSLC
K81-a	MPTFQFYkKGQKVGE
K94-a	GEFSGANkEkLEASI
K94	GEFSGANKEkLEASI
K96-u	FSGANkEkLEASITE
K96-a	FSGANkEkLEASITE
S100	NkEkLEASITEYA__

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