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Protein Page:
TXN (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TXN Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA- binding activity in a redox-dependent manner. Up-regulated by ionizing radiation. Belongs to the thioredoxin family. Note: This description may include information from UniProtKB.
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; protein disulfide oxidoreductase activity; peptide disulfide oxidoreductase activity
Biological Process: negative regulation of protein export from nucleus; transcription, DNA-dependent; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; negative regulation of transcription from RNA polymerase II promoter; signal transduction; glycerol ether metabolic process; cell proliferation; response to radiation; cell-cell signaling; cell redox homeostasis; regulation of protein import into nucleus, translocation; innate immune response; cell motility; positive regulation of DNA binding
Reference #:  P10599 (UniProtKB)
Alt. Names/Synonyms: ADF; ATL-derived factor; DKFZp686B1993; MGC61975; SASP; Surface-associated sulphydryl protein; THIO; Thioredoxin; TRDX; TRX; TRX1; TXN
Gene Symbols: TXN
Molecular weight: 11,737 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TXN

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: T100‑p
intracellular localization: T100‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K3-ac _____MVkQIESktA
0 2 K8 MVkQIESKtAFQEAL
0 2 K8-ub MVkQIESktAFQEAL
0 1 K8-sc MVkQIESktAFQEAL
0 1 T9-p VkQIESktAFQEALD
0 11 K39-ac CGPCKMIkPFFHSLS
0 4 K39-ub CGPCKMIkPFFHSLS
0 1 K39-sc CGPCKMIkPFFHSLS
0 1 S67-p DDCQDVAsECEVKCM
1 1 T76-p CEVKCMPtFQFFkKG
0 4 K81-ac MPtFQFFkKGQkVGE
0 1 K85-sc QFFkKGQkVGEFSGA
0 4 K94-ac GEFSGANkEkLEAtI
0 1 K94-ub GEFSGANkEkLEAtI
0 1 K94-sc GEFSGANkEkLEAtI
0 1 K96 FSGANkEKLEAtINE
0 12 K96-ub FSGANkEkLEAtINE
1 1 T100-p NkEkLEAtINELV__
  mouse

 
K3 _____MVKLIESkEA
K8-ac MVKLIESkEAFQEAL
K8-ub MVKLIESkEAFQEAL
K8-sc MVKLIESkEAFQEAL
E9 VKLIESkEAFQEALA
K39-ac CGPCKMIkPFFHSLC
K39-ub CGPCKMIkPFFHSLC
K39 CGPCKMIKPFFHSLC
A67 DDCQDVAADCEVKCM
T76 CEVKCMPTFQFYkKG
K81-ac MPTFQFYkKGQKVGE
K85 QFYkKGQKVGEFSGA
K94-ac GEFSGANkEkLEASI
K94 GEFSGANKEkLEASI
K94 GEFSGANKEkLEASI
K96-ac FSGANkEkLEASITE
K96-ub FSGANkEkLEASITE
S100 NkEkLEASITEYA__
  rat

 
K3 _____MVKLIESKEA
K8 MVKLIESKEAFQEAL
K8 MVKLIESKEAFQEAL
K8 MVKLIESKEAFQEAL
E9 VKLIESKEAFQEALA
K39 CGPCKMIKPFFHSLC
K39 CGPCKMIKPFFHSLC
K39 CGPCKMIKPFFHSLC
A67 DDCQDVAADCEVKCM
T76 CEVKCMPTFQFYKKG
K81 MPTFQFYKKGQKVGE
K85 QFYKKGQKVGEFSGA
K94 GEFSGANKEKLEATI
K94 GEFSGANKEKLEATI
K94 GEFSGANKEKLEATI
K96 FSGANKEKLEATITE
K96 FSGANKEKLEATITE
T100 NKEKLEATITEFA__
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