an integral membrane protein of the connexin family, alpha-type (group II) subfamily. Hexamers of connexin-43 form connexons, which aggregate together to form gap junctions, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; contractile fiber; integral to plasma membrane; lysosome; early endosome; intermediate filament; fascia adherens; cytosol; lipid raft; Golgi membrane; multivesicular body; connexon complex; mitochondrial outer membrane; apical plasma membrane; gap junction; plasma membrane; lateral plasma membrane
Molecular Function: protein binding; signal transducer activity; ion transmembrane transporter activity; beta-tubulin binding; SH3 domain binding; gap junction channel activity; receptor binding; PDZ domain binding
Biological Process: lens development in camera-type eye; adult heart development; ATP transport; response to peptide hormone stimulus; positive regulation of I-kappaB kinase/NF-kappaB cascade; gap junction assembly; in utero embryonic development; apoptosis; epithelial cell maturation; heart development; neuron migration; regulation of bone remodeling; skeletal muscle regeneration; milk ejection; regulation of calcium ion transport; signal transduction; vascular transport; protein oligomerization; osteoblast differentiation; negative regulation of cell proliferation; limb bud formation; cell-cell signaling; muscle contraction; transport; positive regulation of protein catabolic process; blood vessel morphogenesis; positive regulation of striated muscle development; heart looping; regulation of bone mineralization; neurite morphogenesis; response to pH
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.