an integral membrane protein of the connexin family, alpha-type (group II) subfamily. Hexamers of connexin-43 form connexons, which aggregate together to form gap junctions, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Channel, misc.; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q22.31
Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; lysosome; integral to plasma membrane; early endosome; fascia adherens; lipid raft; Golgi membrane; connexon complex; multivesicular body; mitochondrial outer membrane; plasma membrane; gap junction
Molecular Function: signal transducer activity; protein binding; ion transmembrane transporter activity; SH3 domain binding; gap junction channel activity; PDZ domain binding
Biological Process: ATP transport; response to peptide hormone stimulus; chronic inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; gap junction assembly; apoptosis; heart development; regulation of calcium ion transport; positive regulation of vasodilation; signal transduction; vascular transport; protein oligomerization; elevation of cytosolic calcium ion concentration; cell-cell signaling; muscle contraction; positive regulation of glomerular filtration; transport; negative regulation of cardiac muscle cell proliferation; positive regulation of protein catabolic process; positive regulation of vasoconstriction; transmembrane transport; neurite morphogenesis; response to pH
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.