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AML2 (human)

Overview AML2 CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA- binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: cytoplasm; nuclear chromatin; nucleus Molecular Function: protein binding; transcription factor activity; ATP binding Biological Process: peripheral nervous system neuron development; transcription from RNA polymerase II promoter; axon guidance; hair follicle morphogenesis; regulation of transcription, DNA-dependent; cell maturation; induction of apoptosis; interferon-gamma production; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; negative regulation of cell cycle; negative regulation of epithelial cell proliferation Reference #:  Q13761 (UniProtKB) Alt. Names/Synonyms: Acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; AML2; CBF-alpha-3; CBFA3; Core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; FLJ34510; MGC16070; Oncogene AML-2; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2-alpha C; PEBP2A3; PEBP2aC; Polyomavirus enhancer-binding protein 2 alpha C subunit; Runt-related transcription factor 3; RUNX3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2 Gene Symbols: RUNX3 Molecular weight: 44,356 Da Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AML2

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	Sites Implicated In
cell cycle regulation: S149‑p, T151‑p, T153‑p, T155‑p transcription, altered: S149‑p, T151‑p, T153‑p, T155‑p, S356‑p intracellular localization: S149‑p, T151‑p, T153‑p, T155‑p protein degradation: S356‑p protein stabilization: S149‑p, T151‑p, T153‑p, T155‑p ubiquitination: S356‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	7		S17-p	SRRFTPPsPAFPCGG
1	0		K94-u	KTLPVAFkVVALGDV
0	8		K129-u	RNASAVMkNQVARFN
1	0		K148-u	VGRSGRGksFtLtIt
1	2		S149-p	GRSGRGksFtLtItV
1	1		T151-p	SGRGksFtLtItVFT
1	1		T153-p	RGksFtLtItVFTNP
1	1		T155-p	ksFtLtItVFTNPTQ
1	0		T209-p	ERLRMRVtPstPsPR
0	4		S211-p	LRMRVtPstPsPRGS
1	4		T212-p	RMRVtPstPsPRGSL
1	8		S214-p	RVtPstPsPRGSLST
0	1		T222-p	PRGSLSTtSHFSsQP
0	1		S227-p	STtSHFSsQPQtPIQ
1	16		T231-p	HFSsQPQtPIQGTSE
0	1		S243-p	TSELNPFsDPRQFDR
0	1		T254-p	QFDRSFPtLPTLTEs
0	1		S261-p	tLPTLTEsRFPDPRM
1	0		S356-p	SSSGGDRsPTRMLAS

	mouse
S17	SRRFTPPSTAFPCGG
K95	KTLPVAFKVVALGDV
K130	RNASAVMKNQVARFN
K149	VGRSGRGKSFTLTIT
S150	GRSGRGKSFTLTITV
T152	SGRGKSFTLTITVFT
T154	RGKSFTLTITVFTNP
T156	KSFTLTITVFTNPTQ
T207	GDLRMRVTPStPsPR
S209	LRMRVTPStPsPRGS
T210-p	RMRVTPStPsPRGSL
S212-p	RVTPStPsPRGSLST
T220	PRGSLSTTSHFSSQA
S225	STTSHFSSQAQTPIQ
T229	HFSSQAQTPIQGSSD
S241	SSDLNPFSDPRQFDR
T252	QFDRSFPTLQSLTES
S259	TLQSLTESRFPDPRM
S352	AAGGGERSPTRMLTS

	rat
S17	SRRFTPPSTAFPCGG
K95	KTLPVAFKVVALGDV
K130	RNASAVMKNQVARFN
K149	VGRSGRGKSFTLTIT
S150	GRSGRGKSFTLTITV
T152	SGRGKSFTLTITVFT
T154	RGKSFTLTITVFTNP
T156	KSFTLTITVFTNPTQ
T207	GDLRMRVTPSTPSPR
S209	LRMRVTPSTPSPRGS
T210	RMRVTPSTPSPRGSL
S212	RVTPSTPSPRGSLST
T220	PRGSLSTTSHFSSQA
S225	STTSHFSSQAQTPIQ
T229	HFSSQAQTPIQGSSD
S241	SSDLNPFSDPRQFDR
T252	QFDRSFPTLQSLTES
S259	TLQSLTESRFPEGRM
S352	AAGGGERSPTRMLTS

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