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Protein Page:
TORC3 (human)

Overview
TORC3 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N- terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription. Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. Belongs to the TORC family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: cAMP response element binding protein binding
Biological Process: transcription, DNA-dependent; viral reproduction; activation of CREB transcription factor; protein homotetramerization
Reference #:  Q6UUV7 (UniProtKB)
Alt. Names/Synonyms: CREB regulated transcription coactivator 3; CREB-regulated transcription coactivator 3; CRTC3; FLJ21868; TORC-3; TORC3; Transducer of CREB protein 3; transducer of regulated cAMP response element-binding protein (CREB) 3; Transducer of regulated cAMP response element-binding protein 3; transducer of regulated CREB protein 3
Gene Symbols: CRTC3
Molecular weight: 66,959 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TORC3

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S4-p ____MAAsPGSGSAN
0 1 T56-p KLQQLRLtQyHGGsL
0 2 Y58-p QQLRLtQyHGGsLPN
0 12 S62-p LtQyHGGsLPNVSQL
0 2 S162-p SALNRTNsDSALHTS
0 1 S238-p TKEIQSLsGRPRSCD
0 29 S329-p SGLQSSRsNPsIQAT
0 2 S332-p QSSRsNPsIQATLNK
0 5 S363-p NASALHPsLRLFsLs
0 7 S368-p HPsLRLFsLsNPsLs
0 57 S370-p sLRLFsLsNPsLsTT
0 1 S373-p LFsLsNPsLsTTNLS
0 1 S375-p sLsNPsLsTTNLSGP
0 38 S391-p RRRQPPVsPLtLsPG
0 9 T394-p QPPVsPLtLsPGPEA
0 25 S396-p PVsPLtLsPGPEAHQ
0 4 S406-p PEAHQGFsRQLssts
0 18 S410-p QGFsRQLsstsPLAP
0 6 S411-p GFsRQLsstsPLAPY
0 6 T412-p FsRQLsstsPLAPYP
0 17 S413-p sRQLsstsPLAPYPT
0 1 S432-p SSDRSQLsFLPtEAQ
0 1 T436-p SQLsFLPtEAQAQVs
0 16 S443-p tEAQAQVsPPPPYPA
0 3 S524-p VPLVQQGsRELQDSF
  TORC3 iso3  
S4 ____MAASPGSGSAN
T56 KLQQLRLTQYHGGSL
Y58 QQLRLTQYHGGSLPN
S62 LTQYHGGSLPNVSQL
S162 SALNRTNSDSALHTS
S238 TKEIQSLSGRPRSCD
S329 SGLQSSRSNPSIQAT
S332 QSSRSNPSIQATLNK
S363 NASALHPSLRLFSLS
S368 HPSLRLFSLSNPSLS
S370 SLRLFSLSNPSLSTT
S373 LFSLSNPSLSTTNLS
S375 SLSNPSLSTTNLSGP
S391 RRRQPPVSPLTLSPG
T394 QPPVSPLTLSPGPEA
S396 PVSPLTLSPGPEAHQ
S406 PEAHQGFSRQLSSTS
S410 QGFSRQLSSTSPLAP
S411 GFSRQLSSTSPLAPY
T412 FSRQLSSTSPLAPYP
S413 SRQLSSTSPLAPYPT
S432 SSDRSQLSFLPTEAQ
T436 SQLSFLPTEAQAQVS
S443 TEAQAQVSPPPPYPA
S524 VPLVQQGSRELQDSF
  mouse

 
S4 ____MAASPGSGSAN
T56-p KLQQLRLtQyHGGsL
Y58-p QQLRLtQyHGGsLPN
S62-p LtQyHGGsLPNVSQL
S162 SALNRTNSDSALHTS
S238 SKEIQSLSGRPRSCD
S329-p SGLQSSRsNPsIQAT
S332-p QSSRsNPsIQATLSK
S363 NASALHPSLRLFsLs
S368-p HPSLRLFsLsNPsLS
S370-p SLRLFsLsNPsLSTT
S373-p LFsLsNPsLSTTNLS
S375 sLsNPsLSTTNLSGP
S391-p RRRQPPVsPLTLsPG
T394 QPPVsPLTLsPGPEA
S396-p PVsPLTLsPGPEAHQ
S406 PEAHQGFSRQLsATS
S410-p QGFSRQLsATSPLNP
A411 GFSRQLsATSPLNPY
T412 FSRQLsATSPLNPYP
S413 SRQLsATSPLNPYPA
S432 TSEQSPLSFLPTDAQ
T436 SPLSFLPTDAQAQVS
S443 TDAQAQVSPPPPYPT
H524 VPLVQQSHREPQDSF
  rat

 
S4 ____MAASPGSGSAN
T56 RLQQLRLTQHHGGsL
H58 QQLRLTQHHGGsLPN
S62-p LTQHHGGsLPNVSQL
S162 SALNRTNSDSALHTS
S238 TKEIQSLSGRPRSCD
S329 SGLQSSRSNPSIQAT
S332 QSSRSNPSIQATLNK
S363 NASALHPSLRLFSLS
S368 HPSLRLFSLSNPSLS
S370 SLRLFSLSNPSLSTT
S373 LFSLSNPSLSTTNLS
S375 SLSNPSLSTTNLSGP
S391 RRRQPPVSPLTLSPG
T394 QPPVSPLTLSPGPEA
S396 PVSPLTLSPGPEAHQ
N406 PEAHQGFNRQLSATS
S410 QGFNRQLSATSPLNP
A411 GFNRQLSATSPLNPY
T412 FNRQLSATSPLNPYP
S413 NRQLSATSPLNPYPA
S432 TSEQSPLSFLPTDAQ
T436 SPLSFLPTDAQAQVS
S443 TDAQAQVSPPPPYPT
H524 VPLVQQSHREPQDSF
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