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Protein Page:
Myc (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Myc a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors.. Seems to activate the transcription of growth-related genes. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: 8q24.21
Cellular Component: nucleoplasm; protein complex; nucleolus; cytosol; nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity
Biological Process: cellular iron ion homeostasis; oxygen transport; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; regulation of telomere maintenance; transcription, DNA-dependent; MAPKKK cascade; negative regulation of cell division; negative regulation of stress-activated MAPK cascade; negative regulation of monocyte differentiation; chromatin remodeling; ureteric bud branching; regulation of gene expression; negative regulation of fibroblast proliferation; energy reserve metabolic process; positive regulation of transcription from RNA polymerase II promoter; gene expression; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis
Disease: Burkitt Lymphoma
Reference #:  P01106 (UniProtKB)
Alt. Names/Synonyms: avian myelocytomatosis viral oncogene homolog; BHLHE39; c-Myc; Class E basic helix-loop-helix protein 39; MRTL; MYC; Myc proto-oncogene protein; myc-related translation/localization regulatory factor; Proto-oncogene c-Myc; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog (avian)
Gene Symbols: MYC
Molecular weight: 48,804 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Myc

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S62‑p, S71‑p
apoptosis, induced: T58‑p, S62‑p, S71‑p
cell differentiation, altered: T58‑p
cell growth, altered: T58‑p, S62‑p
cell growth, induced: S62‑p, Y74‑p
cell growth, inhibited: T58‑p
transcription, altered: T58‑p, S62‑p
transcription, induced: T58‑p, S62‑p
activity, induced: S62‑p
intracellular localization: T58‑p, Y74‑p
molecular association, regulation: T58‑p, S62‑p
O-GlcNAc glycosylation: S62‑p
phosphorylation: T58‑p, S62‑p
protein degradation: T58‑p, S62‑p
protein stabilization: S62‑p, S71‑p
ubiquitination: T58‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 7 S6-p __MPLNVsFtNRNyD
1 1 T8-p MPLNVsFtNRNyDLD
1 0 Y12-p VsFtNRNyDLDyDSV
1 2 Y16-p NRNyDLDyDSVQPyF
1 0 Y22-p DyDSVQPyFYCDEEE
1 0 Y32-p CDEEENFyQQQQQSE
0 1 K52-ub PSEDIWKkFELLPtP
1 0 K52-sm PSEDIWKkFELLPtP
47 46 T58-p KkFELLPtPPLsPsR
2 0 T58-gl KkFELLPtPPLsPsR
40 47 S62-p LLPtPPLsPsRRsGL
1 14 S64-p PtPPLsPsRRsGLCs
2 4 S67-p PLsPsRRsGLCsPSy
6 6 S71-p sRRsGLCsPSyVAVt
0 1 S73 RsGLCsPSyVAVtPF
2 1 Y74-p sGLCsPSyVAVtPFs
0 3 T78-p sPSyVAVtPFsLRGD
1 1 S81-p yVAVtPFsLRGDNDG
0 1 S136 IIQDCMWSGFSAAAk
0 1 S139 DCMWSGFSAAAkLVS
2 0 K143-ac SGFSAAAkLVSEkLA
3 23 K148-ac AAkLVSEkLASYQAA
0 55 K148-ub AAkLVSEkLASYQAA
1 0 K148-sm AAkLVSEkLASYQAA
3 0 K157-ac ASYQAARkDSGsPNP
1 1 K157-ub ASYQAARkDSGsPNP
1 0 K157-sm ASYQAARkDSGsPNP
0 2 S161-p AARkDSGsPNPARGH
0 1 N163 RkDSGsPNPARGHSV
1 0 S249-p EETPPTTssDsEEEQ
1 0 S250-p ETPPTTssDsEEEQE
2 0 S252-p PPTTssDsEEEQEDE
2 0 K275-ac EKRQAPGkRsEsGsP
0 1 S277-p RQAPGkRsEsGsPSA
0 1 S279-p APGkRsEsGsPSAGG
0 2 S281-p GkRsEsGsPSAGGHs
0 1 S288-p sPSAGGHsKPPHsPL
1 13 S293-p GHsKPPHsPLVLKRC
2 0 K317-ac AAPPSTRkDYPAAkR
1 0 K317-sm AAPPSTRkDYPAAkR
4 5 K323-ac RkDYPAAkRVkLDSV
0 1 K323-ub RkDYPAAkRVkLDSV
1 0 K323-sm RkDYPAAkRVkLDSV
2 0 K326-sm YPAAkRVkLDSVRVL
1 0 K326-ub YPAAkRVkLDSVRVL
1 0 S329 AkRVkLDSVRVLRQI
0 1 S337-p VRVLRQIsNNRKCts
1 1 T343-p IsNNRKCtsPRssDt
1 4 S344-p sNNRKCtsPRssDtE
2 0 S347-p RKCtsPRssDtEENV
2 3 S348-p KCtsPRssDtEENVk
0 2 T350-p tsPRssDtEENVkRR
0 1 K355-ub sDtEENVkRRtHNVL
4 0 T358-p EENVkRRtHNVLERQ
2 0 K371-ac RQRRNELkRsFFALR
6 1 S373-p RRNELkRsFFALRDQ
0 4 K389-ub PELENNEkAPkVVIL
1 0 K389-sm PELENNEkAPkVVIL
1 0 K392-sm ENNEkAPkVVILKkA
1 0 K398-sm PkVVILKkAtAYILs
4 0 T400-p VVILKkAtAYILsVQ
0 1 S405-p kAtAYILsVQAEEQk
0 1 K412-ub sVQAEEQkLISEEDL
1 0 E417 EQkLISEEDLLRKRR
1 0 K430-sm RREQLKHkLEQLRNS
13748 : Phospho-c-Myc (Ser62) (E1J4K) Rabbit mAb
  Myc iso2  
S21 ATMPLNVSFTNRNYD
T23 MPLNVSFTNRNYDLD
Y27 VSFTNRNYDLDYDSV
Y31 NRNYDLDYDSVQPYF
Y37 DYDSVQPYFYCDEEE
Y47 CDEEENFYQQQQQSE
K67 PSEDIWKKFELLPTP
K67 PSEDIWKKFELLPTP
T73 KKFELLPTPPLSPSR
T73 KKFELLPTPPLSPSR
S77 LLPTPPLSPSRRSGL
S79 PTPPLSPSRRSGLCS
S82 PLSPSRRSGLCSPSY
S86 SRRSGLCSPSYVAVT
S88 RSGLCSPSYVAVTPF
Y89 SGLCSPSYVAVTPFS
T93 SPSYVAVTPFSLRGD
S96 YVAVTPFSLRGDNDG
S151 IIQDCMWSGFSAAAK
S154 DCMWSGFSAAAKLVS
K158 SGFSAAAKLVSEKLA
K163 AAKLVSEKLASYQAA
K163 AAKLVSEKLASYQAA
K163 AAKLVSEKLASYQAA
K172 ASYQAARKDSGSPNP
K172 ASYQAARKDSGSPNP
K172 ASYQAARKDSGSPNP
S176 AARKDSGSPNPARGH
N178 RKDSGSPNPARGHSV
S264 EETPPTTSSDSEEEQ
S265 ETPPTTSSDSEEEQE
S267 PPTTSSDSEEEQEDE
K290 EKRQAPGKRSESGSP
S292 RQAPGKRSESGSPSA
S294 APGKRSESGSPSAGG
S296 GKRSESGSPSAGGHS
S303 SPSAGGHSKPPHSPL
S308 GHSKPPHSPLVLKRC
K332 AAPPSTRKDYPAAKR
K332 AAPPSTRKDYPAAKR
K338 RKDYPAAKRVKLDSV
K338 RKDYPAAKRVKLDSV
K338 RKDYPAAKRVKLDSV
K341 YPAAKRVKLDSVRVL
K341 YPAAKRVKLDSVRVL
S344 AKRVKLDSVRVLRQI
S352 VRVLRQISNNRKCTS
T358 ISNNRKCTSPRSSDT
S359 SNNRKCTSPRSSDTE
S362 RKCTSPRSSDTEENV
S363 KCTSPRSSDTEENVK
T365 TSPRSSDTEENVKRR
K370 SDTEENVKRRTHNVL
T373 EENVKRRTHNVLERQ
K386 RQRRNELKRSFFALR
S388 RRNELKRSFFALRDQ
K404 PELENNEKAPKVVIL
K404 PELENNEKAPKVVIL
K407 ENNEKAPKVVILKKA
K413 PKVVILKKATAYILS
T415 VVILKKATAYILSVQ
S420 KATAYILSVQAEEQK
K427 SVQAEEQKLISEEDL
E432 EQKLISEEDLLRKRR
K445 RREQLKHKLEQLRNS
  mouse

 
N6 __MPLNVNFTNRNYD
T8 MPLNVNFTNRNYDLD
Y12 VNFTNRNYDLDYDSV
Y16 NRNYDLDYDSVQPYF
Y22 DYDSVQPYFICDEEE
Y32 CDEEENFYHQQQQSE
K52 PSEDIWKKFELLPtP
K52 PSEDIWKKFELLPtP
T58-p KKFELLPtPPLsPsR
T58 KKFELLPTPPLsPsR
S62-p LLPtPPLsPsRRsGL
S64-p PtPPLsPsRRsGLCS
S67-p PLsPsRRsGLCSPsy
S71 sRRsGLCSPsyVAVA
S73-p RsGLCSPsyVAVAtS
Y74-p sGLCSPsyVAVAtSF
T79-p PsyVAVAtSFSPRED
S82 VAVAtSFSPREDDDG
S137-p IIQDCMWsGFsAAAK
S140-p DCMWsGFsAAAKLVS
K144 sGFsAAAKLVSEkLA
K149-ac AAKLVSEkLASYQAA
K149-ub AAKLVSEkLASYQAA
K149 AAKLVSEKLASYQAA
K158 ASYQAARKDSTSLsP
K158 ASYQAARKDSTSLsP
K158 ASYQAARKDSTSLsP
S162 AARKDSTSLsPARGH
S164-p RKDSTSLsPARGHSV
S249 EETPPTTSSDSEEEQ
S250 ETPPTTSSDSEEEQE
S252 PPTTSSDSEEEQEDE
K275 EKRQTPAKRSESGSS
S277 RQTPAKRSESGSSPS
S279 TPAKRSESGSSPSRG
S281 AKRSESGSSPSRGHS
S288 SSPSRGHSKPPHsPL
S293-p GHSKPPHsPLVLKRC
K317 AAPPSTRKDYPAAkR
K317 AAPPSTRKDYPAAkR
K323-ac RKDYPAAkRAKLDsG
K323 RKDYPAAKRAKLDsG
K323 RKDYPAAKRAKLDsG
K326 YPAAkRAKLDsGRVL
K326 YPAAkRAKLDsGRVL
S329-p AkRAKLDsGRVLKQI
S337 GRVLKQISNNRKCSS
S343 ISNNRKCSSPRSSDT
S344 SNNRKCSSPRSSDTE
S347 RKCSSPRSSDTEEND
S348 KCSSPRSSDTEENDK
T350 SSPRSSDTEENDKRR
K355 SDTEENDKRRtHNVL
T358-p EENDKRRtHNVLERQ
K371 RQRRNELKRsFFALR
S373-p RRNELKRsFFALRDQ
K389 PELENNEKAPKVVIL
K389 PELENNEKAPKVVIL
K392 ENNEKAPKVVILKKA
K398 PKVVILKKAtAYILS
T400-p VVILKKAtAYILSIQ
S405 KAtAYILSIQADEHK
K412 SIQADEHKLTSEkDL
K417-ac EHKLTSEkDLLRKRR
K430 RREQLKHKLEQLRNS
13748 : Phospho-c-Myc (Ser62) (E1J4K) Rabbit mAb
  rat

 
S6 __MPLNVSFANRNYD
A8 MPLNVSFANRNYDLD
Y12 VSFANRNYDLDYDSV
Y16 NRNYDLDYDSVQPYF
Y22 DYDSVQPYFICDEEE
Y32 CDEEENFYHQQQQSE
K52 PSEDIWKKFELLPtP
K52 PSEDIWKKFELLPtP
T58-p KKFELLPtPPLSPSR
T58 KKFELLPTPPLSPSR
S62 LLPtPPLSPSRRSGL
S64 PtPPLSPSRRSGLCS
S67 PLSPSRRSGLCSPSY
S71 SRRSGLCSPSYVAVA
S73 RSGLCSPSYVAVATS
Y74 SGLCSPSYVAVATSF
T79 PSYVAVATSFSPRED
S82 VAVATSFSPREDDDG
S137 IIQDCMWSGFSAAAK
S140 DCMWSGFSAAAKLVS
K144 SGFSAAAKLVSEkLA
K149-ac AAKLVSEkLASYQAA
K149 AAKLVSEKLASYQAA
K149 AAKLVSEKLASYQAA
K158 ASYQAARKDSTSLSP
K158 ASYQAARKDSTSLSP
K158 ASYQAARKDSTSLSP
S162 AARKDSTSLSPARGH
S164 RKDSTSLSPARGHSV
S249 EETPPTTSSDSEEEQ
S250 ETPPTTSSDSEEEQD
S252 PPTTSSDSEEEQDDE
K275 EKRQPPAKRSESGSS
S277 RQPPAKRSESGSSPS
S279 PPAKRSESGSSPSRG
S281 AKRSESGSSPSRGHS
S288 SSPSRGHSKPPHSPL
S293 GHSKPPHSPLVLKRC
K317 AAPPSTRKDYPAAKR
K317 AAPPSTRKDYPAAKR
K323 RKDYPAAKRAKLDSG
K323 RKDYPAAKRAKLDSG
K323 RKDYPAAKRAKLDSG
K326 YPAAKRAKLDSGRVL
K326 YPAAKRAKLDSGRVL
S329 AKRAKLDSGRVLKQI
S337 GRVLKQISNNRKCSS
S343 ISNNRKCSSPRSSDT
S344 SNNRKCSSPRSSDTE
S347 RKCSSPRSSDTEEND
S348 KCSSPRSSDTEENDK
T350 SSPRSSDTEENDKRR
K355 SDTEENDKRRTHNVL
T358 EENDKRRTHNVLERQ
K371 RQRRNELKRSFFALR
S373 RRNELKRSFFALRDQ
K389 PELENNEKAPKVVIL
K389 PELENNEKAPKVVIL
K392 ENNEKAPKVVILKKA
K398 PKVVILKKATAYILS
T400 VVILKKATAYILSVQ
S405 KATAYILSVQADEHK
K412 SVQADEHKLISEKDL
K417 EHKLISEKDLLRKRR
K430 RREQLKHKLEQLRNS
13748 : Phospho-c-Myc (Ser62) (E1J4K) Rabbit mAb
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