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Protein Page:
KHSRP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KHSRP an RNA binding and processing protein that binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3' untranslated regions, possibly by recruiting degradation machinery to ARE-containing mRNAs. Interacts with APC which is part of the apolipoprotein B mRNA editing enzyme complex. The interaction is not required for activity of the catalytic component, APOBEC1, but may confer stability on the complex. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein
Cellular Component: nucleoplasm; stress granule; nucleolus; cytosol; nucleus
Molecular Function: DNA binding
Biological Process: RNA splicing, via transesterification reactions; mRNA transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA metabolic process; RNA splicing; gene expression; mRNA processing; mRNA metabolic process
Reference #:  Q92945 (UniProtKB)
Alt. Names/Synonyms: Far upstream element-binding protein 2; FBP2; FUBP2; FUSE binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KH-type splicing regulatory protein; KHSRP; KSRP; MGC99676; p75
Gene Symbols: KHSRP
Molecular weight: 73,115 Da
Basal Isoelectric point: 6.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KHSRP

Protein Structure Not Found.


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Sites Implicated In
RNA stability, altered: T692‑p
transcription, altered: S193‑p
activity, induced: S132‑p, S274‑p, S670‑p
intracellular localization: S193‑p
molecular association, regulation: S132‑p, S193‑p, S274‑p, S670‑p
protein conformation: S193‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T6-p __MSDYStGGPPPGP
0 1 R40 GPPGAGDRGGGGPGG
0 1 K71 GGGPGIRKDAFADAV
0 4 K87-ac RARQIAAkIGGDAAt
0 1 K87 RARQIAAKIGGDAAt
0 2 T94-p kIGGDAAttVNNstP
0 3 T95-p IGGDAAttVNNstPd
0 3 S99-p AAttVNNstPdFGFG
0 71 T100-p AttVNNstPdFGFGG
0 1 D102-ca tVNNstPdFGFGGQk
0 61 K109-ac dFGFGGQkRQLEDGD
0 22 K109-ub dFGFGGQkRQLEDGD
0 10 K121-ac DGDQPESkkLAsQGd
0 1 K122-ac GDQPESkkLAsQGds
0 1 K122 GDQPESkKLAsQGds
0 12 S125-p PESkkLAsQGdsIss
0 1 D128-ca kkLAsQGdsIssQLG
0 15 S129-p kLAsQGdsIssQLGP
0 8 S131-p AsQGdsIssQLGPIH
1 11 S132-p sQGdsIssQLGPIHP
0 1 Y149-p RTSMTEEyRVPDGMV
0 1 K169 RGGEQINKIQQDsGC
0 1 S174-p INKIQQDsGCKVQIs
0 44 S181-p sGCKVQIsPDsGGLP
0 10 S184-p KVQIsPDsGGLPERS
2 9 S193-p GLPERSVsLTGAPEs
0 1 S200-p sLTGAPEsVQKAkMM
0 1 K203 GAPEsVQKAkMMLDD
0 1 K205-ub PEsVQKAkMMLDDIV
0 1 T234-p ANGGQNGtVQEIMIP
0 6 K251-ub KAGLVIGkGGETIkQ
0 2 K257-ub GkGGETIkQLQERAG
0 1 K266 LQERAGVKMILIQDG
1 11 S274-p MILIQDGsQNtNVDK
0 3 T277-p IQDGsQNtNVDKPLR
0 1 K281 sQNtNVDKPLRIIGD
1 56 Y317-p GFGDRNEyGsRIGGG
0 4 S319-p GDRNEyGsRIGGGID
0 1 K359-sm AGVRIQFkQDDGTGP
0 42 R411-m1 PGMPPGGrGrGrGQG
0 13 R411-m2 PGMPPGGrGrGrGQG
0 28 R413-m1 MPPGGrGrGrGQGNW
0 12 R413-m2 MPPGGrGrGrGQGNW
0 27 R415-m1 PGGrGrGrGQGNWGP
0 13 R415-m2 PGGrGrGrGQGNWGP
0 43 R442-m1 KCGLVIGrGGENVKA
0 2 R442-m2 KCGLVIGrGGENVKA
0 1 K448 GrGGENVKAINQQTG
0 1 S461-p TGAFVEIsRQLPPNG
0 15 S480-p KLFIIRGsPQQIDHA
0 1 K488-ac PQQIDHAkQLIEEKI
0 1 K488-ub PQQIDHAkQLIEEKI
1 0 Y583-p WAAYYSHyYQQPPGP
0 3 K627-ac KAWEEYYkkIGQQPQ
0 1 K628-ub AWEEYYkkIGQQPQQ
0 1 Y644-p GAPPQQDyTkAWEEY
0 1 K646-ub PPQQDyTkAWEEYyk
0 1 Y652-p TkAWEEYykkQAQVA
0 3 K653-ac kAWEEYykkQAQVAT
0 1 K654-ub AWEEYykkQAQVATG
1 3 S670-p GPGAPPGsQPDySAA
0 3 Y674-p PPGsQPDySAAWAEY
1 2 Y688-p YYRQQAAyYGQtPGP
1 0 T692-p QAAyYGQtPGPGGPQ
  mouse

 
T6 __MSDYNTGGPPPGP
R40-m1 GPPGAGDrGGGGPGG
K72-ub GGGPGIRkDAFADAV
K88 RARQIAAKIGGDAAT
K88-ub RARQIAAkIGGDAAT
T95 kIGGDAATTVNNNtP
T96 IGGDAATTVNNNtPD
N100 AATTVNNNtPDFGFG
T101-p ATTVNNNtPDFGFGG
D103 TVNNNtPDFGFGGQk
K110-ac DFGFGGQkRQLEDGD
K110-ub DFGFGGQkRQLEDGD
K122 DGDQPDSKkLASQGD
K123 GDQPDSKKLASQGDS
K123-ub GDQPDSKkLASQGDS
S126 PDSKkLASQGDSIGS
D129 KkLASQGDSIGSQLG
S130 kLASQGDSIGSQLGP
G132 ASQGDSIGSQLGPIH
S133 SQGDSIGSQLGPIHP
Y150 RTSMTEEYRVPDGMV
K170-ub RGGEQINkIQQDSGC
S175 INkIQQDSGCKVQIs
S182-p SGCKVQIsPDsGGLP
S185-p KVQIsPDsGGLPERS
S194-p GLPERSVsLTGAPES
S201 sLTGAPESVQkAKMM
K204-ub GAPESVQkAKMMLDD
K206 PESVQkAKMMLDDIV
T235 ANGGQNGTVQEIMIP
K252-ub KAGLVIGkGGETIkQ
K258-ub GkGGETIkQLQERAG
K267-ub LQERAGVkMILIQDG
S275 MILIQDGSQNTNVDk
T278 IQDGSQNTNVDkPLR
K282-ub SQNTNVDkPLRIIGD
Y318 GFGDRNEYGSRVGGG
S320 GDRNEYGSRVGGGID
K360 AGVRIQFKQDDGTGP
R412-m1 PGMPPGGrGrGrGQG
R412-m2 PGMPPGGrGrGrGQG
R414-m1 MPPGGrGrGrGQGNW
R414-m2 MPPGGrGrGrGQGNW
R416-m1 PGGrGrGrGQGNWGP
R416-m2 PGGrGrGrGQGNWGP
R443-m1 KCGLVIGrGGENVkA
R443-m2 KCGLVIGrGGENVkA
K449-ub GrGGENVkAINQQTG
S462 TGAFVEISRQLPPNG
S481-p KLFVIRGsPQQIDHA
K489 PQQIDHAKQLIEEKI
K489 PQQIDHAKQLIEEKI
Y584 WAAYYSHYYQQPPGP
K628 KAWEEYYKKIGQQPQ
K629 AWEEYYKKIGQQPQQ
Y645 GAPPQQDYTKAWEEY
K647 PPQQDYTKAWEEYYK
Y653 TKAWEEYYKKQAQVA
K654 KAWEEYYKKQAQVAT
K655 AWEEYYKKQAQVATG
S671 GPGAPPGSQPDYSAA
Y675 PPGSQPDYSAAWAEY
Y689 YYRQQAAYYGQTPGP
T693 QAAYYGQTPGPGGPQ
  rat

 
T6 __MSDYSTGGPPPGP
R40 GPPGAGDRGGGGPGG
K72 GGGPGIRKDAFADAV
K88 RARQIAAKIGGDAAT
K88 RARQIAAKIGGDAAT
T95 KIGGDAATTVNNNTP
T96 IGGDAATTVNNNTPD
N100 AATTVNNNTPDFGFG
T101 ATTVNNNTPDFGFGG
D103 TVNNNTPDFGFGGQK
K110 DFGFGGQKRQLEDGD
K110 DFGFGGQKRQLEDGD
K122 DGDQPDSKKLASQGD
K123 GDQPDSKKLASQGDS
K123 GDQPDSKKLASQGDS
S126 PDSKKLASQGDSIGS
D129 KKLASQGDSIGSQLG
S130 KLASQGDSIGSQLGP
G132 ASQGDSIGSQLGPIH
S133 SQGDSIGSQLGPIHP
Y150 RTSMTEEYRVPDGMV
K170 RGGEQINKIQQDSGC
S175 INKIQQDSGCKVQIs
S182-p SGCKVQIsPDsGGLP
S185-p KVQIsPDsGGLPERS
S194 GLPERSVSLTGAPES
S201 SLTGAPESVQKAKMM
K204 GAPESVQKAKMMLDD
K206 PESVQKAKMMLDDIV
T235 ANGGQNGTVQEIMIP
K252 KAGLVIGKGGETIKQ
K258 GKGGETIKQLQERAG
K267 LQERAGVKMILIQDG
S275 MILIQDGSQNTNVDK
T278 IQDGSQNTNVDKPLR
K282 SQNTNVDKPLRIIGD
Y318 GFGDRNEYGSRVGGG
S320 GDRNEYGSRVGGGID
K360 AGVRIQFKQDDGTGP
R412-m1 PGMPPGGrGrGrGQG
R412 PGMPPGGRGrGrGQG
R414-m1 MPPGGrGrGrGQGNW
R414 MPPGGrGRGrGQGNW
R416-m1 PGGrGrGrGQGNWGP
R416 PGGrGrGRGQGNWGP
R443-m1 KCGLVIGrGGENVKA
R443 KCGLVIGRGGENVKA
K449 GrGGENVKAINQQTG
S462 TGAFVEISRQLPPNG
S481-p KLFVIRGsPQQIDHA
K489 PQQIDHAKQLIEEKI
K489 PQQIDHAKQLIEEKI
Y584 WAAYYSHYYQQPPGP
K628 KAWEEYYKKIGQQPQ
K629 AWEEYYKKIGQQPQQ
Y645 GAPPQQDYTKAWEEY
K647 PPQQDYTKAWEEYYK
Y653 TKAWEEYYKKQAQVA
K654 KAWEEYYKKQAQVAT
K655 AWEEYYKKQAQVATG
S671 GPGAPPGSQPDYSAA
Y675 PPGSQPDYSAAWAEY
Y689 YYRQQAAYYGQTPGP
T693 QAAYYGQTPGPGGPQ
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