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Protein Page:
CLTC (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CLTC a major protein component of the cytoplasmic face of coated vesicles and coated pits. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle protein
Cellular Component: clathrin coat of trans-Golgi network vesicle; clathrin coat; mitochondrion; clathrin-coated vesicle; plasma membrane; melanosome; spindle; trans-Golgi network membrane; cytosol; clathrin coat of coated pit
Molecular Function: protein binding; structural molecule activity
Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; intracellular protein transport; mitosis; receptor-mediated endocytosis; axon guidance; nerve growth factor receptor signaling pathway; receptor internalization; antigen processing and presentation of exogenous peptide antigen via MHC class II; transferrin transport; post-Golgi vesicle-mediated transport; membrane organization and biogenesis
Reference #:  Q00610 (UniProtKB)
Alt. Names/Synonyms: CHC; CHC17; Clathrin heavy chain 1; Clathrin heavy chain on chromosome 17; clathrin, heavy chain (Hc); clathrin, heavy polypeptide (Hc); clathrin, heavy polypeptide-like 2; CLH-17; CLH1; CLH17; CLTC; CLTCL2; Hc; KIAA0034
Gene Symbols: CLTC
Molecular weight: 191,615 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CLTC
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
intracellular localization: Y1477‑p
molecular association, regulation: Y1477‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 K43 KFICIREKVGEQAQV
0 2 S67-p NPIRRPIsADSAIMN
0 1 K78-u AIMNPASkVIALKAG
0 2 K96-u QIFNIEMkSKMKAHT
0 4 T105-p KMKAHTMtDDVTFWK
0 3 T158-p CQIINYRtDAKQkWL
0 1 K163-u YRtDAKQkWLLLTGI
0 9 Y184 VVGAMQLYSVDRKVS
0 1 K189 QLYSVDRKVSQPIEG
0 1 K227 VRGQAGGKLHIIEVG
0 1 T235-p LHIIEVGtPPtGNQP
0 1 T238-p IEVGtPPtGNQPFPk
0 3 K245-a tGNQPFPkkAVDVFF
1 1 K245 tGNQPFPKkAVDVFF
0 1 K245 tGNQPFPKkAVDVFF
1 1 K246 GNQPFPkKAVDVFFP
0 1 K246-u GNQPFPkkAVDVFFP
0 1 S299 CIYMNRISGETIFVT
0 1 T302 MNRISGETIFVTAPH
0 6 K367-u AEELFARkFNALFAQ
0 1 K382 GNYSEAAKVAANAPk
0 9 K389-u KVAANAPkGILRtPD
0 13 T394-p APkGILRtPDtIRRF
0 2 T397-p GILRtPDtIRRFQSV
0 1 T411 VPAQPGQTSPLLQYF
0 2 K450-u GRKQLLEkWLkEDkL
0 21 K453-u QLLEkWLkEDkLECS
0 8 K456-a EkWLkEDkLECSEEL
0 3 K456-u EkWLkEDkLECSEEL
0 2 T473-p LVKSVDPtLALSVYL
0 1 K500-u AETGQVQkIVLYAKk
0 1 K506 QkIVLYAKkVGyTPD
0 55 K507-u kIVLYAKkVGyTPDW
0 1 Y510-p LYAKkVGyTPDWIFL
0 2 Y556-p IVDVFMEyNLIQQCT
0 2 S576 ALKNNRPSEGPLQTR
0 2 K619-a HIAQLCEkAGLLQRA
0 45 K619-u HIAQLCEkAGLLQRA
0 1 T631 QRALEHFTDLyDIkR
0 1056 Y634-p LEHFTDLyDIkRAVV
0 10 K637-a FTDLyDIkRAVVHTH
0 6 K637-u FTDLyDIkRAVVHTH
0 1 K737-u KYIQAACkTGQIkEV
0 2 K742-u ACkTGQIkEVERICR
0 2 K760 CYDPERVKNFLKEAK
0 1 T769 FLKEAKLTDQLPLII
0 3 K798-u LYRNNLQkYIEIYVQ
0 2 K806-u YIEIYVQkVNPSRLP
0 2 K851 ELVAEVEKRNRLkLL
0 1 K851 ELVAEVEKRNRLkLL
0 1 K856-a VEKRNRLkLLLPWLE
0 3 K856-u VEKRNRLkLLLPWLE
0 12 K881-u ATHNALAkIyIDSNN
0 2 Y883-p HNALAkIyIDSNNNP
0 1 S886 LAkIyIDSNNNPERF
0 752 Y899-p RFLRENPyyDsRVVG
0 110 Y900-p FLRENPyyDsRVVGk
0 3 S902-p RENPyyDsRVVGkYC
0 2 K907-a yDsRVVGkYCEKRDP
0 1 K907 yDsRVVGKYCEKRDP
0 1 K911 VVGkYCEKRDPHLAC
0 31 K941-u CNENSLFkSLSRYLV
0 6 K1034-u LLILTAIkADRTRVM
0 2 K1074-u EAFAIFRkFDVNTSA
0 82 Y1096-p IGNLDRAyEFAERCN
0 1 K1130-u EAIDSYIkADDPSSY
0 1 K1155-a GNWEELVkYLQMARK
0 2 S1167 ARKKARESYVETELI
0 2 K1179-u ELIFALAktNRLAEL
0 1 T1180-p LIFALAktNRLAELE
0 109 Y1206-p QQVGDRCyDEkMyDA
0 2 K1209-a GDRCyDEkMyDAAkL
0 1 K1209 GDRCyDEKMyDAAkL
0 293 Y1211-p RCyDEkMyDAAkLLy
0 8 K1215-u EkMyDAAkLLyNNVs
0 12 Y1218-p yDAAkLLyNNVsNFG
0 3 S1222-p kLLyNNVsNFGRLAs
0 5 S1229-p sNFGRLAstLVHLGE
0 1 T1230-p NFGRLAstLVHLGEy
0 11 Y1237-p tLVHLGEyQAAVDGA
0 1 K1254 ANSTRTWKEVCFACV
0 1 S1341 EHLELFWSRVNIPKV
0 1 Y1368 LVFLYDKYEEYDNAI
0 1 Y1371 LYDKYEEYDNAIITM
0 1 T1377 EYDNAIITMMNHPTD
0 1 T1396-p GQFKDIItkVANVEL
0 1 K1397-u QFKDIItkVANVELY
0 1 T1433 LSPRLDHTRAVNyFs
0 134 Y1438-p DHTRAVNyFskVkQL
0 2 S1440-p TRAVNyFskVkQLPL
0 1 K1441-a RAVNyFskVkQLPLV
0 67 K1441-u RAVNyFskVkQLPLV
0 14 K1443-u VNyFskVkQLPLVKP
0 2 K1461-u SVQNHNNkSVNESLN
2 165 Y1477-p LFITEEDyQALRtSI
0 1 T1482-p EDyQALRtSIDAyDN
0 101 Y1487-p LRtSIDAyDNFDNIs
0 8 S1494-p yDNFDNIsLAQRLEk
0 1 K1501-a sLAQRLEkHELIEFR
0 4 K1501-u sLAQRLEkHELIEFR
0 8 Y1513-p EFRRIAAyLFKGNNR
0 1 K1516 RIAAyLFKGNNRWkQ
0 1 R1520 yLFKGNNRWkQSVEL
0 1 K1522-u FKGNNRWkQSVELCK
0 2 K1535-u CKKDSLYkDAMQYAS
0 1 T1608-p QVMKEYLtkVDkLDA
0 15 K1609-u VMKEYLtkVDkLDAS
0 2 K1612-u EYLtkVDkLDASEsL
0 1 S1618-p DkLDASEsLRkEEEQ
0 1 K1621-a DASEsLRkEEEQATE
0 7 Y1634-p TETQPIVyGQPQLML
0 1 Y1657-p PPQAPFGyGytAPPy
0 1 Y1659-p QAPFGyGytAPPyGQ
0 1 T1660-p APFGyGytAPPyGQP
0 1 Y1664-p yGytAPPyGQPQPGF
0 3 Y1673-p QPQPGFGySM_____
  mouse

► Hide Isoforms 		 
K43-u KFICIREkVGEQAQV
S67-p NPIRRPIsADSAIMN
K78 AIMNPASKVIALKAG
K96-u QIFNIEMkSKMKAHT
T105-p KMKAHTMtDDVTFWK
T158 CQIINYRTDAKQKWL
K163 YRTDAKQKWLLLTGI
Y184-p VVGAMQLySVDRkVS
K189-u QLySVDRkVSQPIEG
K227-u VRGQAGGkLHIIEVG
T235-p LHIIEVGtPPtGNQP
T238-p IEVGtPPtGNQPFPk
K245 tGNQPFPKKAVDVFF
K245 tGNQPFPKKAVDVFF
K245-u tGNQPFPkKAVDVFF
K246 GNQPFPkKAVDVFFP
K246 GNQPFPkKAVDVFFP
S299-p CIYMNRIsGEtIFVT
T302-p MNRIsGEtIFVTAPH
K367-u AEELFARkFNALFAQ
K382-u GNYSEAAkVAANAPk
K389-u kVAANAPkGILRtPD
T394-p APkGILRtPDtIRRF
T397-p GILRtPDtIRRFQSV
T411-p VPAQPGQtSPLLQYF
K450-u GRKQLLEkWLkEDkL
K453-u QLLEkWLkEDkLECS
K456 EkWLkEDKLECSEEL
K456-u EkWLkEDkLECSEEL
T473-p LVKSVDPtLALSVYL
K500 AETGQVQKIVLYAkk
K506-u QKIVLYAkkVGYTPD
K507-u KIVLYAkkVGYTPDW
Y510 LYAkkVGYTPDWIFL
Y556 IVDVFMEYNLIQQCT
S576-p ALKNNRPsEGPLQTR
K619 HIAQLCEKAGLLQRA
K619-u HIAQLCEkAGLLQRA
T631-p QRALEHFtDLyDIkR
Y634-p LEHFtDLyDIkRAVV
K637-a FtDLyDIkRAVVHTH
K637-u FtDLyDIkRAVVHTH
K737 KYIQAACKTGQIKEV
K742 ACKTGQIKEVERICR
K760 CYDPERVKNFLKEAK
T769-p FLKEAKLtDQLPLII
K798-u LYRNNLQkYIEIYVQ
K806-u YIEIYVQkVNPSRLP
K851 ELVAEVEKRNRLkLL
K851-u ELVAEVEkRNRLkLL
K856 VEkRNRLKLLLPWLE
K856-u VEkRNRLkLLLPWLE
K881-u ATHNALAkIYIDsNN
Y883 HNALAkIYIDsNNNP
S886-p LAkIYIDsNNNPERF
Y899-p RFLRENPyyDSRVVG
Y900-p FLRENPyyDSRVVGk
S902 RENPyyDSRVVGkYC
K907 yDSRVVGKYCEkRDP
K907-u yDSRVVGkYCEkRDP
K911-u VVGkYCEkRDPHLAC
K941-u CNENSLFkSLSRYLV
K1034-u LLILTAIkADRTRVM
K1074-u EAFAIFRkFDVNTSA
Y1096-p IGNLDRAyEFAERCN
K1130 EAIDSYIKADDPSSY
K1155 GNWEELVKYLQMARK
S1167-p ARKKAREsYVETELI
K1179 ELIFALAKTNRLAEL
T1180 LIFALAKTNRLAELE
Y1206-p QQVGDRCyDEkMyDA
K1209 GDRCyDEKMyDAAkL
K1209-u GDRCyDEkMyDAAkL
Y1211-p RCyDEkMyDAAkLLY
K1215-u EkMyDAAkLLYNNVs
Y1218 yDAAkLLYNNVsNFG
S1222-p kLLYNNVsNFGRLAS
S1229 sNFGRLASTLVHLGE
T1230 NFGRLASTLVHLGEY
Y1237 TLVHLGEYQAAVDGA
K1254-u ANSTRTWkEVCFACV
S1341-p EHLELFWsRVNIPKV
Y1368-p LVFLYDKyEEyDNAI
Y1371-p LYDKyEEyDNAIItM
T1377-p EyDNAIItMMNHPTD
T1396 GQFKDIITKVANVEL
K1397 QFKDIITKVANVELY
T1433-p LSPRLDHtRAVNyFS
Y1438-p DHtRAVNyFSkVkQL
S1440 tRAVNyFSkVkQLPL
K1441 RAVNyFSKVkQLPLV
K1441-u RAVNyFSkVkQLPLV
K1443-u VNyFSkVkQLPLVKP
K1461-u SVQNHNNkSVNESLN
Y1477-p LFITEEDyQALRTSI
T1482 EDyQALRTSIDAyDN
Y1487-p LRTSIDAyDNFDNIs
S1494-p yDNFDNIsLAQRLEk
K1501 sLAQRLEKHELIEFR
K1501-u sLAQRLEkHELIEFR
Y1513 EFRRIAAYLFkGNNr
K1516-u RIAAYLFkGNNrWKQ
R1520-m2 YLFkGNNrWKQSVEL
K1522 FkGNNrWKQSVELCK
K1535-u CKKDSLYkDAMQYAS
T1608 QVMKEYLTkVDkLDA
K1609-u VMKEYLTkVDkLDAS
K1612-u EYLTkVDkLDASESL
S1618 DkLDASESLRKEEEQ
K1621 DASESLRKEEEQATE
Y1634 TETQPIVYGQPQLML
Y1657 PPQAPFGYGYTAPPY
Y1659 QAPFGYGYTAPPYGQ
T1660 APFGYGYTAPPYGQP
Y1664 YGYTAPPYGQPQPGF
Y1673 QPQPGFGYSM_____
  CLTC iso3  
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Y10 LFITEEDYQALRTSI
T15 EDYQALRTSIDAYDN
Y20 LRTSIDAYDNFDNIS
S27 YDNFDNISLAQRLEK
K34 SLAQRLEKHELIEFR
K34 SLAQRLEKHELIEFR
Y46 EFRRIAAYLFKGNNR
K49 RIAAYLFKGNNRWKQ
R53 YLFKGNNRWKQSVEL
K55 FKGNNRWKQSVELCK
K68 CKKDSLYKDAMQYAS
T141 QVMKEYLTkVDAIKE
K142-u VMKEYLTkVDAIKEK
K152 AIKEKVDKLDASESL
S158 DKLDASESLRKEEEQ
K161 DASESLRKEEEQATE
Y174 TETQPIVYGQPQLML
Y197 PPQAPFGYGYTAPPY
Y199 QAPFGYGYTAPPYGQ
T200 APFGYGYTAPPYGQP
Y204 YGYTAPPYGQPQPGF
Y213 QPQPGFGYSM_____
  rat

 
K43 KFICIREKVGEQAQV
S67 NPIRRPISADSAIMN
K78 AIMNPASKVIALKAG
K96 QIFNIEMKSKMKAHT
T105 KMKAHTMTDDVTFWK
T158 CQIINYRTDAKQKWL
K163 YRTDAKQKWLLLTGI
Y184-p VVGAMQLySVDRKVS
K189 QLySVDRKVSQPIEG
K227 VRGQAGGKLHIIEVG
T235 LHIIEVGTPPTGNQP
T238 IEVGTPPTGNQPFPk
K245-a TGNQPFPkkAVDVFF
K245-m2 TGNQPFPkkAVDVFF
K245 TGNQPFPKkAVDVFF
K246-m2 GNQPFPkkAVDVFFP
K246 GNQPFPkKAVDVFFP
S299 CIYMNRISGETIFVT
T302 MNRISGETIFVTAPH
K367 AEELFARKFNALFAQ
K382 GNYSEAAKVAANAPK
K389 KVAANAPKGILRTPD
T394 APKGILRTPDTIRRF
T397 GILRTPDTIRRFQSV
T411 VPAQPGQTSPLLQYF
K450 GRKQLLEKWLKEDKL
K453 QLLEKWLKEDKLECS
K456 EKWLKEDKLECSEEL
K456 EKWLKEDKLECSEEL
T473 LVKSVDPTLALSVYL
K500 AETGQVQKIVLYAKK
K506 QKIVLYAKKVGYTPD
K507 KIVLYAKKVGYTPDW
Y510 LYAKKVGYTPDWIFL
Y556 IVDVFMEYNLIQQCT
S576 ALKNNRPSEGPLQTR
K619-a HIAQLCEkAGLLQRA
K619-u HIAQLCEkAGLLQRA
T631 QRALEHFTDLyDIkR
Y634-p LEHFTDLyDIkRAVV
K637-a FTDLyDIkRAVVHTH
K637 FTDLyDIKRAVVHTH
K737 KYIQAACKTGQIKEV
K742 ACKTGQIKEVERICR
K760-a CYDPERVkNFLKEAK
T769 FLKEAKLTDQLPLII
K798 LYRNSLQKYIEIYVQ
K806 YIEIYVQKVNPSRLP
K851-a ELVAEVEkRNRLkLL
K851 ELVAEVEKRNRLkLL
K856 VEkRNRLKLLLPWLE
K856-u VEkRNRLkLLLPWLE
K881-u ATHNALAkIYIDSNN
Y883 HNALAkIYIDSNNNP
S886 LAkIYIDSNNNPERF
Y899-p RFLRENPyyDSRVVG
Y900-p FLRENPyyDSRVVGK
S902 RENPyyDSRVVGKYC
K907 yDSRVVGKYCEKRDP
K907 yDSRVVGKYCEKRDP
K911 VVGKYCEKRDPHLAC
K941-u CNENSLFkSLSRYLV
K1034 LLILTAIKADRTRVM
K1074 EAFAIFRKFDVNTSA
Y1096-p IGNLDRAyEFAERCN
K1130 EAIDSYIKADDPSSY
K1155 GNWEELVKYLQMARK
S1167 ARKKARESYVETELI
K1179 ELIFALAKTNRLAEL
T1180 LIFALAKTNRLAELE
Y1206-p QQVGDRCyDEKMyDA
K1209 GDRCyDEKMyDAAKL
K1209 GDRCyDEKMyDAAKL
Y1211-p RCyDEKMyDAAKLLY
K1215 EKMyDAAKLLYNNVS
Y1218 yDAAKLLYNNVSNFG
S1222 KLLYNNVSNFGRLAS
S1229 SNFGRLASTLVHLGE
T1230 NFGRLASTLVHLGEY
Y1237 TLVHLGEYQAAVDGA
K1254 ANSTRTWKEVCFACV
S1341 EHLELFWSRVNIPKV
Y1368 LVFLYDKYEEYDNAI
Y1371 LYDKYEEYDNAIITM
T1377 EYDNAIITMMNHPTD
T1396 GQFKDIITKVANVEL
K1397 QFKDIITKVANVELY
T1433 LSPRLAHTRAVNyFS
Y1438-p AHTRAVNyFSkVKQL
S1440 TRAVNyFSkVKQLPL
K1441 RAVNyFSKVKQLPLV
K1441-u RAVNyFSkVKQLPLV
K1443 VNyFSkVKQLPLVKP
K1461 SVQNHNNKSVNESLN
Y1477-p LFITEEDyQALRTSI
T1482 EDyQALRTSIDAyDN
Y1487-p LRTSIDAyDNFDNIS
S1494 yDNFDNISLAQRLEK
K1501 SLAQRLEKHELIEFR
K1501 SLAQRLEKHELIEFR
Y1513-p EFRRIAAyLFKGNNR
K1516 RIAAyLFKGNNRWKQ
R1520 yLFKGNNRWKQSVEL
K1522 FKGNNRWKQSVELCK
K1535 CKKDSLYKDAMQYAS
T1608 QVMKEYLTKVDKLDA
K1609 VMKEYLTKVDKLDAS
K1612 EYLTKVDKLDASESL
S1618 DKLDASESLRKEEEQ
K1621 DASESLRKEEEQATE
Y1634 TETQPIVYGQPQLML
Y1657 PPQAPFGYGYTAPPY
Y1659 QAPFGYGYTAPPYGQ
T1660 APFGYGYTAPPYGQP
Y1664 YGYTAPPYGQPQPGF
Y1673 QPQPGFGYSM_____
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