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Protein Page:
K18 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
K18 a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Cytoskeletal protein
Cellular Component: perinuclear region of cytoplasm; cytoplasm; keratin filament; nucleolus; microtubule organizing center; intermediate filament
Molecular Function: protein binding; structural molecule activity
Biological Process: anatomical structure morphogenesis; tumor necrosis factor-mediated signaling pathway; viral reproduction; intermediate filament cytoskeleton organization and biogenesis; cell cycle; negative regulation of apoptosis; Golgi to plasma membrane CFTR protein transport
Reference #:  P05783 (UniProtKB)
Alt. Names/Synonyms: Cell proliferation-inducing gene 46 protein; cell proliferation-inducing protein 46; CK-18; CYK18; cytokeratin 18; Cytokeratin-18; K18; K1C18; keratin 18; Keratin, type I cytoskeletal 18; Keratin-18; KRT18
Gene Symbols: KRT18
Molecular weight: 48,058 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

K18

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S34‑p, S51‑p, S53‑p
intracellular localization: S34‑p, S51‑p, S53‑p
molecular association, regulation: S34‑p
protein processing: S53‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 12 S7-p _MSFTTRstFstNyR
0 2 - gap
0 7 T8-p MSFTTRstFstNyRs
0 6 S10-p FTTRstFstNyRsLG
0 2 T11-p TTRstFstNyRsLGs
0 131 Y13-p RstFstNyRsLGsVQ
0 8 S15-p tFstNyRsLGsVQAP
0 6 S18-p tNyRsLGsVQAPsyG
0 1 A21 RsLGsVQAPsyGARP
0 5 S23-p LGsVQAPsyGARPVs
0 76 Y24-p GsVQAPsyGARPVss
0 4 R27 QAPsyGARPVssAAs
0 9 S30-p syGARPVssAAsVyA
3 0 S30-gl syGARPVssAAsVyA
0 15 S31-p yGARPVssAAsVyAG
3 1 S31-gl yGARPVssAAsVyAG
12 25 S34-p RPVssAAsVyAGAGG
0 263 Y36-p VssAAsVyAGAGGsG
0 9 S42-p VyAGAGGsGsrIsVs
0 2 S44-p AGAGGsGsrIsVsrs
0 2 R45-m1 GAGGsGsrIsVsrst
0 1 R45-m2 GAGGsGsrIsVsrst
0 2 S47-p GGsGsrIsVsrstsF
0 3 S49-p sGsrIsVsrstsFrG
3 0 S49-gl sGsrIsVsrstsFrG
0 2 R50-m1 GsrIsVsrstsFrGG
1 14 S51-p srIsVsrstsFrGGM
0 4 T52-p rIsVsrstsFrGGMG
14 20 S53-p IsVsrstsFrGGMGs
0 13 R55-m1 VsrstsFrGGMGsGG
0 1 G57 rstsFrGGMGsGGLA
0 15 S60-p sFrGGMGsGGLAtGI
0 9 T65-p MGsGGLAtGIAGGLA
0 3 K81-ac MGGIQNEkETMQsLN
0 3 K81-ub MGGIQNEkETMQsLN
0 5 S86-p NEkETMQsLNDRLAs
0 3 S93-p sLNDRLAsyLDRVRs
0 27 Y94-p LNDRLAsyLDRVRsL
0 1 R97 RLAsyLDRVRsLETE
0 5 S100-p syLDRVRsLETENRR
0 4 S110-p TENRRLEskIREHLE
0 1 K111-ac ENRRLEskIREHLEk
0 2 K118-ub kIREHLEkKGPQVRD
0 2 S127-p GPQVRDWsHyFkIIE
0 11 Y129-p QVRDWsHyFkIIEDL
0 1 K131-ac RDWsHyFkIIEDLRA
0 8 K131-ub RDWsHyFkIIEDLRA
0 2 T144 RAQIFANTVDNARIV
0 1 K167-ac AADDFRVkyETELAM
0 4 K167-ub AADDFRVkyETELAM
0 36 Y168-p ADDFRVkyETELAMR
0 4 S177-p TELAMRQsVENDIHG
1 2 K187-ac NDIHGLRkVIDDtNI
0 1 K187 NDIHGLRKVIDDtNI
0 1 K187-sc NDIHGLRkVIDDtNI
0 2 T192-p LRkVIDDtNItRLQL
0 1 T195-p VIDDtNItRLQLEtE
0 1 T201-p ItRLQLEtEIEALkE
0 1 K207 EtEIEALKEELLFMk
0 1 K207-ub EtEIEALkEELLFMk
1 0 K207-sm EtEIEALkEELLFMk
0 1 K214-ac kEELLFMkkNHEEEV
0 1 K215-ub EELLFMkkNHEEEVk
0 1 K222-ac kNHEEEVkGLQAQIA
0 1 S230-p GLQAQIAsSGLTVEV
0 2 K241-ub TVEVDAPksQDLAkI
0 4 S242-p VEVDAPksQDLAkIM
0 2 K247-ac PksQDLAkIMADIRA
0 5 K247-ub PksQDLAkIMADIRA
0 1 K247-sc PksQDLAkIMADIRA
0 37 Y256-p MADIRAQyDELARKN
0 1 K262 QyDELARKNREELDK
0 1 K269 KNREELDKyWSQQIE
0 2 Y270-p NREELDKyWSQQIEE
0 1 Q285 STTVVTTQSAEVGAA
0 5 T302-p TLTELRRtVQsLEID
0 5 S305-p ELRRtVQsLEIDLDS
0 1 K317-ac LDSMRNLkAsLENsL
0 4 K317-ub LDSMRNLkAsLENsL
0 1 K317-sc LDSMRNLkAsLENsL
0 3 S319-p SMRNLkAsLENsLRE
0 6 S323-p LkAsLENsLREVEAR
0 2 Y331-p LREVEARyALQMEQL
0 5 Y363-p GQRQAQEyEALLNIk
0 2 K370-ub yEALLNIkVkLEAEI
0 1 K372-ub ALLNIkVkLEAEIAt
1 0 K372-sm ALLNIkVkLEAEIAt
0 1 T379-p kLEAEIAtYRRLLED
0 2 N391 LEDGEDFNLGDALDs
0 9 S398-p NLGDALDssNsMQtI
0 8 S399-p LGDALDssNsMQtIQ
0 9 S401-p DALDssNsMQtIQkT
0 3 T404-p DssNsMQtIQkTtTR
0 2 K407-ub NsMQtIQkTtTRRIV
0 1 T409-p MQtIQkTtTRRIVDG
0 3 K417-ac TRRIVDGkVVsEtND
0 7 K417-ub TRRIVDGkVVsEtND
0 1 K417-sc TRRIVDGkVVsEtND
0 4 S420-p IVDGkVVsEtNDTkV
0 1 T422-p DGkVVsEtNDTkVLR
0 2 K426-ac VsEtNDTkVLRH___
0 17 K426-ub VsEtNDTkVLRH___
0 1 K426-sc VsEtNDTkVLRH___
  mouse

 
S7-p _MSFTTRsttFsTNy
T8-p MSFTTRsttFsTNyR
T9-p SFTTRsttFsTNyRS
S11-p TTRsttFsTNyRSLG
T12 TRsttFsTNyRSLGs
Y14-p sttFsTNyRSLGsVR
S16 tFsTNyRSLGsVRtP
S19-p TNyRSLGsVRtPsQR
T22-p RSLGsVRtPsQRVrP
S24-p LGsVRtPsQRVrPAs
Q25 GsVRtPsQRVrPAss
R28-m1 RtPsQRVrPAssAAs
S31-p sQRVrPAssAAsVyA
S31 sQRVrPASsAAsVyA
S32-p QRVrPAssAAsVyAG
S32 QRVrPAsSAAsVyAG
S35-p rPAssAAsVyAGAGG
Y37-p AssAAsVyAGAGGsG
S43-p VyAGAGGsGsrISVS
S45-p AGAGGsGsrISVSRS
R46-m1 GAGGsGsrISVSRSV
R46 GAGGsGsRISVSRSV
S48 GGsGsrISVSRSVWG
S50 sGsrISVSRSVWGGs
S50 sGsrISVSRSVWGGs
R51 GsrISVSRSVWGGsV
S52 srISVSRSVWGGsVG
- gap
V53 rISVSRSVWGGsVGs
G55 SVSRSVWGGsVGsAG
S57-p SRSVWGGsVGsAGLA
S60-p VWGGsVGsAGLAGMG
- gap
K73 MGGIQTEKETMQDLN
K73 MGGIQTEKETMQDLN
D78 TEKETMQDLNDRLAS
S85 DLNDRLASYLDkVKS
Y86 LNDRLASYLDkVKSL
K89-ub RLASYLDkVKSLETE
S92 SYLDkVKSLETENRR
S102 TENRRLESKIREHLE
K103 ENRRLESKIREHLEK
K110 KIREHLEKKGPQGVR
G120 PQGVRDWGHYFkIIE
Y122 GVRDWGHYFkIIEDL
K124 RDWGHYFKIIEDLRA
K124-ub RDWGHYFkIIEDLRA
S137-p RAQIFANsVDNARIV
K160 AADDFRVKYETELAM
K160-ub AADDFRVkYETELAM
Y161 ADDFRVkYETELAMR
S170-p TELAMRQsVESDIHG
K180-ac SDIHGLRkVVDDTNI
K180-ub SDIHGLRkVVDDTNI
K180 SDIHGLRKVVDDTNI
T185 LRkVVDDTNITRLQL
T188 VVDDTNITRLQLETE
T194 ITRLQLETEIEALkE
K200-ac ETEIEALkEELLFMK
K200 ETEIEALKEELLFMK
K200 ETEIEALKEELLFMK
K207 kEELLFMKKNHEEEV
K208 EELLFMKKNHEEEVQ
Q215 KNHEEEVQGLEAQIA
S223 GLEAQIASSGLTVEV
K234-ub TVEVDAPkSQDLSkI
S235 VEVDAPkSQDLSkIM
K240-ac PkSQDLSkIMADIRA
K240-ub PkSQDLSkIMADIRA
K240 PkSQDLSKIMADIRA
Y249 MADIRAQYEALAQkN
K255-ub QYEALAQkNREELDk
K262-ub kNREELDkYWSQQIE
Y263 NREELDkYWSQQIEE
K278-ub STTVVTTkSAEIRDA
T295 TLTELRRTLQTLEID
T298 ELRRTLQTLEIDLDS
N310 LDSMKNQNINLENsL
N310 LDSMKNQNINLENsL
N310 LDSMKNQNINLENsL
N312 SMKNQNINLENsLGD
S316-p QNINLENsLGDVEAR
Y324 LGDVEARYKAQMEQL
Y356 GQRQAQEYEALLNIk
K363-ub YEALLNIkVKLEAEI
K365 ALLNIkVKLEAEIAT
K365 ALLNIkVKLEAEIAT
T372 KLEAEIATYRRLLED
S384-p LEDGEDFsLNDALDs
S391-p sLNDALDsSNsMQtV
S392 LNDALDsSNsMQtVQ
S394-p DALDsSNsMQtVQkT
T397-p DsSNsMQtVQkTTTR
K400-ub NsMQtVQkTTTRKIV
T402 MQtVQkTTTRKIVDG
R410 TRKIVDGRVVsETND
R410 TRKIVDGRVVsETND
R410 TRKIVDGRVVsETND
S413-p IVDGRVVsETNDTRV
T415 DGRVVsETNDTRVLR
R419 VsETNDTRVLRH___
R419 VsETNDTRVLRH___
R419 VsETNDTRVLRH___
  rat

 
S7-p _MSFTTRstTFSTNY
T8-p MSFTTRstTFSTNYR
T9 SFTTRstTFSTNYRS
S11 TTRstTFSTNYRSLG
T12 TRstTFSTNYRSLGs
Y14 stTFSTNYRSLGsVR
S16 TFSTNYRSLGsVRTP
S19-p TNYRSLGsVRTPSQR
T22 RSLGsVRTPSQRVRP
S24 LGsVRTPSQRVRPAs
Q25 GsVRTPSQRVRPAss
R28 RTPSQRVRPAssAAs
S31-p SQRVRPAssAAsVyA
S31 SQRVRPASsAAsVyA
S32-p QRVRPAssAAsVyAG
S32 QRVRPAsSAAsVyAG
S35-p RPAssAAsVyAGAGG
Y37-p AssAAsVyAGAGGsG
S43-p VyAGAGGsGSRISVs
S45 AGAGGsGSRISVsRS
R46 GAGGsGSRISVsRSV
R46 GAGGsGSRISVsRSV
S48 GGsGSRISVsRSVWG
S50-p sGSRISVsRSVWGGs
S50 sGSRISVSRSVWGGs
R51 GSRISVsRSVWGGsV
S52 SRISVsRSVWGGsVG
- gap
V53 RISVsRSVWGGsVGS
G55 SVsRSVWGGsVGSAG
S57-p sRSVWGGsVGSAGLA
S60 VWGGsVGSAGLAGMG
- gap
K73 MGGVQTEKETMQDLN
K73 MGGVQTEKETMQDLN
D78 TEKETMQDLNDRLAs
S85-p DLNDRLAsYLDKVKN
Y86 LNDRLAsYLDKVKNL
K89 RLAsYLDKVKNLETE
N92 sYLDKVKNLETENRR
S102 TENRRLESkIREYLE
K103-ac ENRRLESkIREYLEK
K110 kIREYLEKRGPQGVR
G120 PQGVRDWGHYFkTIE
Y122 GVRDWGHYFkTIEDL
K124-ac RDWGHYFkTIEDLRA
K124 RDWGHYFKTIEDLRA
S137 RAQIFANSVDNARIV
K160 AADDFRVKYETELAM
K160 AADDFRVKYETELAM
Y161 ADDFRVKYETELAMR
S170 TELAMRQSVESDIHG
K180-ac SDIHGLRkVVDDtNI
K180 SDIHGLRKVVDDtNI
K180 SDIHGLRKVVDDtNI
T185-p LRkVVDDtNITRLQL
T188 VVDDtNITRLQLETE
T194 ITRLQLETEIEALKE
K200 ETEIEALKEELLFMK
K200 ETEIEALKEELLFMK
K200 ETEIEALKEELLFMK
K207 KEELLFMKKNHEEEV
K208 EELLFMKKNHEEEVQ
Q215 KNHEEEVQGLEAQIA
S223 GLEAQIASSGLTVEV
K234 TVEVDAPKSQDLSkI
S235 VEVDAPKSQDLSkIM
K240-ac PKSQDLSkIMADIRA
K240 PKSQDLSKIMADIRA
K240 PKSQDLSKIMADIRA
Y249 MADIRAQYEQLAQKN
K255 QYEQLAQKNREELDK
K262 KNREELDKYWSQQIE
Y263 NREELDKYWSQQIEE
K278 STTVVTTKSAEIRDA
T295 TLLELRRTLQTLEID
T298 ELRRTLQTLEIDLDS
N310 LDSMKNQNINLENNL
N310 LDSMKNQNINLENNL
N310 LDSMKNQNINLENNL
N312 SMKNQNINLENNLGE
N316 QNINLENNLGEVEAR
Y324 LGEVEARYRVQMEQL
Y356 GQRQTQEYEALLNIK
K363 YEALLNIKVKLEAEI
K365 ALLNIKVKLEAEIAT
K365 ALLNIKVKLEAEIAT
T372 KLEAEIATYRRLLED
S384 LEDGDDFSLNDALDS
S391 SLNDALDSsNSMQTV
S392-p LNDALDSsNSMQTVQ
S394 DALDSsNSMQTVQRT
T397 DSsNSMQTVQRTTTR
R400 NSMQTVQRTTTRKVV
T402 MQTVQRTTTRKVVDG
K410-ac TRKVVDGkVVSETND
K410 TRKVVDGKVVSETND
K410 TRKVVDGKVVSETND
S413 VVDGkVVSETNDTRV
T415 DGkVVSETNDTRVLR
R419 VSETNDTRVLRH___
R419 VSETNDTRVLRH___
R419 VSETNDTRVLRH___
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