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Protein Page:
Jun (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Jun the protooncogene c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The Jun Kinases (JNKs) binds to the N-terminal region of c-Jun and phosphorylate it in response to extracellular signals including growth factors, cytokines and stress, regulating its transcriptional activity. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: nucleoplasm; nuclear chromosome; transcription factor complex; transcriptional repressor complex; cytosol
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; transcription coactivator activity; double-stranded DNA binding; Rho GTPase activator activity; transcription factor binding; transcription factor activity
Biological Process: circadian rhythm; positive regulation of monocyte differentiation; response to cAMP; regulation of cell cycle; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; stress-activated MAPK cascade; microglial cell activation; response to lipopolysaccharide; SMAD protein nuclear translocation; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; negative regulation of cell proliferation; response to radiation; positive regulation of fibroblast proliferation; regulation of transcription factor activity; positive regulation of neuron apoptosis; transforming growth factor beta receptor signaling pathway; negative regulation of protein amino acid autophosphorylation; negative regulation of neuron apoptosis; angiogenesis; toll-like receptor 4 signaling pathway; aging; response to drug; release of cytochrome c from mitochondria; monocyte differentiation; leading edge cell differentiation; axon regeneration; MyD88-independent toll-like receptor signaling pathway; learning; liver development; negative regulation of DNA binding; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; membrane depolarization; cellular response to potassium ion starvation; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; toll-like receptor 9 signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of Rho GTPase activity; positive regulation of DNA replication
Reference #:  P05412 (UniProtKB)
Alt. Names/Synonyms: Activator protein 1; AP-1; AP1; c-Jun; enhancer-binding protein AP1; JUN; Jun activation domain binding protein; jun oncogene; p39; Proto-oncogene c-Jun; Transcription factor AP-1; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
Gene Symbols: JUN
Molecular weight: 35,676 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Jun

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: S63‑p, T95‑p
apoptosis, induced: S63‑p
carcinogenesis, altered: T2‑p, T8‑p, T89‑p, T93‑p, T286‑p
cell growth, altered: T2‑p, T8‑p, S63‑p, S73‑p, T89‑p, T93‑p, T286‑p
transcription, altered: S63‑p, S73‑p, T91‑p, T93‑p, T95‑p, T231‑p, S243‑p, S249‑p
transcription, induced: S63‑p, S73‑p
activity, induced: S63‑p, S73‑p, T95‑p
activity, inhibited: T231‑p, S243‑p, S249‑p
molecular association, regulation: S63‑p, S73‑p, T91‑p, T93‑p, Y170‑p, T231‑p, T239‑p, S243‑p, S249‑p
phosphorylation: S243‑p
protein stabilization: S63‑p, S73‑p
ubiquitination: T239‑p, S243‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T2-p ______MtAKMETtF
1 0 T8-p MtAKMETtFYDDALN
0 1 K50-u ADPVGSLkPHLRAKN
0 7 S58-p PHLRAKNsDLLtsPD
0 2 T62-p AKNsDLLtsPDVGLL
101 22 S63-p KNsDLLtsPDVGLLK
65 47 S73-p VGLLKLAsPELERLI
1 0 T89-p QSSNGHItTtPtPtQ
7 0 T91-p SNGHItTtPtPtQFL
8 0 T93-p GHItTtPtPtQFLCP
1 0 T95-p ItTtPtPtQFLCPKN
1 0 Y170-p LHSEPPVyANLSNFN
5 0 K226-s HPRLQALkEEPQtVP
3 0 T231-p ALkEEPQtVPEMPGE
5 18 T239-p VPEMPGEtPPLsPID
10 23 S243-p PGEtPPLsPIDMEsQ
3 1 S249-p LsPIDMEsQERIkAE
2 0 K254-s MEsQERIkAERKRMR
1 0 K268-a RNRIAASkCRkRkLE
2 0 K271-a IAASkCRkRkLERIA
1 0 K273-a ASkCRkRkLERIARL
1 1 T286-p RLEEKVKtLKAQNSE
2361 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb
2363 : Phospho-c-Jun (Ser63) (58A6) Mouse mAb
5464 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb (Biotinylated)
9261 : Phospho-c-Jun (Ser63) II Antibody
3270 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb
8752 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (PE Conjugate)
9164 : Phospho-c-Jun (Ser73) Antibody
12714 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2303 : Phospho-c-Jun (Thr91) Antibody
2993 : Phospho-c-Jun (Thr93) Antibody
2994 : Phospho-c-Jun (Ser243) Antibody
  mouse

 
T2 ______MTAKMETTF
T8 MTAKMETTFYDDALN
K50 ADPVGSLKPHLRAKN
S58-p PHLRAKNsDLLtsPD
T62-p AKNsDLLtsPDVGLL
S63-p KNsDLLtsPDVGLLK
S73-p VGLLKLAsPELERLI
T89 QSSNGHITTtPtPtQ
T91-p SNGHITTtPtPtQFL
T93-p GHITTtPtPtQFLCP
T95-p ITTtPtPtQFLCPKN
Y170 LHSEPPVYANLSNFN
K229-s HPRLQALkEEPQTVP
T234 ALkEEPQTVPEMPGE
T242-p VPEMPGEtPPLsPID
S246-p PGEtPPLsPIDMESQ
S252 LsPIDMESQERIkAE
K257-s MESQERIkAERKRMR
K271 RNRIAASKCRKRKLE
K274 IAASKCRKRKLERIA
K276 ASKCRKRKLERIARL
T289 RLEEKVKTLKAQNSE
2361 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb
2363 : Phospho-c-Jun (Ser63) (58A6) Mouse mAb
5464 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb (Biotinylated)
9261 : Phospho-c-Jun (Ser63) II Antibody
3270 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb
8752 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (PE Conjugate)
9164 : Phospho-c-Jun (Ser73) Antibody
12714 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2303 : Phospho-c-Jun (Thr91) Antibody
2993 : Phospho-c-Jun (Thr93) Antibody
2994 : Phospho-c-Jun (Ser243) Antibody
  rat

 
T2 ______MTAKMETTF
T8 MTAKMETTFYDDALN
K50 ADPVGNLKPHLRAKN
S58 PHLRAKNSDLLtsPD
T62-p AKNSDLLtsPDVGLL
S63-p KNSDLLtsPDVGLLK
S73-p VGLLKLAsPELERLI
T89 QSSNGHITTTPTPTQ
T91 SNGHITTTPTPTQFL
T93 GHITTTPTPTQFLCP
T95 ITTTPTPTQFLCPKN
Y170 LHSEPPVYANLSNFN
K229 HPRLQALKEEPQTVP
T234 ALKEEPQTVPEMPGE
T242 VPEMPGETPPLsPID
S246-p PGETPPLsPIDMESQ
S252 LsPIDMESQERIKAE
K257 MESQERIKAERKRMR
K271 RNRIAASKCRKRKLE
K274 IAASKCRKRKLERIA
K276 ASKCRKRKLERIARL
T289 RLEEKVKTLKAQNSE
2361 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb
2363 : Phospho-c-Jun (Ser63) (58A6) Mouse mAb
5464 : Phospho-c-Jun (Ser63) (54B3) Rabbit mAb (Biotinylated)
9261 : Phospho-c-Jun (Ser63) II Antibody
3270 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb
8752 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (PE Conjugate)
9164 : Phospho-c-Jun (Ser73) Antibody
12714 : Phospho-c-Jun (Ser73) (D47G9) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
2303 : Phospho-c-Jun (Thr91) Antibody
2993 : Phospho-c-Jun (Thr93) Antibody
2994 : Phospho-c-Jun (Ser243) Antibody
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