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Jun (human)

Overview Jun the protooncogene c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The Jun Kinases (JNKs) binds to the N-terminal region of c-Jun and phosphorylate it in response to extracellular signals including growth factors, cytokines and stress, regulating its transcriptional activity. Note: This description may include information from UniProtKB. Protein type: Transcription factor Cellular Component: nucleoplasm; nuclear chromosome; transcription factor complex; transcriptional repressor complex; cytosol Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein homodimerization activity; DNA binding; transcription coactivator activity; double-stranded DNA binding; Rho GTPase activator activity; transcription factor activity; transcription factor binding Biological Process: positive regulation of monocyte differentiation; circadian rhythm; response to cAMP; regulation of cell cycle; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; microglial cell activation; response to lipopolysaccharide; SMAD protein nuclear translocation; toll-like receptor 3 signaling pathway; negative regulation of cell proliferation; response to radiation; positive regulation of fibroblast proliferation; regulation of transcription factor activity; transforming growth factor beta receptor signaling pathway; positive regulation of neuron apoptosis; negative regulation of protein amino acid autophosphorylation; negative regulation of neuron apoptosis; angiogenesis; toll-like receptor 4 signaling pathway; aging; response to drug; release of cytochrome c from mitochondria; monocyte differentiation; leading edge cell differentiation; axon regeneration; MyD88-independent toll-like receptor signaling pathway; learning; liver development; Toll signaling pathway; negative regulation of DNA binding; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; membrane depolarization; cellular response to potassium ion starvation; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of Rho GTPase activity; positive regulation of DNA replication Reference #:  P05412 (UniProtKB) Alt. Names/Synonyms: Activator protein 1; AP-1; AP1; c-Jun; enhancer-binding protein AP1; JUN; Jun activation domain binding protein; jun oncogene; p39; Proto-oncogene c-Jun; Transcription factor AP-1; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog Gene Symbols: JUN Molecular weight: 35,676 Da Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Jun 1A02 - J=254-308 (human) 1FOS - F=257-313, H=256-313 (human) 1JNM - A/B=254-315 (human) 1JUN - A/B=276-314 (human) 1S9K - E=257-308 (human) 1T2K - C=254-314 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A02 1FOS 1JNM 1JUN 1S9K 1T2K  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: S63‑p, T95‑p apoptosis, induced: S63‑p carcinogenesis, altered: T2‑p, T8‑p, T89‑p, T93‑p, T286‑p cell growth, altered: T2‑p, T8‑p, S63‑p, S73‑p, T89‑p, T93‑p, T286‑p transcription, altered: S63‑p, S73‑p, T91‑p, T93‑p, T95‑p, T231‑p, S243‑p, S249‑p activation: S63‑p, S73‑p, T95‑p inhibition: T231‑p, S243‑p, S249‑p molecular association, regulation: S63‑p, S73‑p, T91‑p, T93‑p, Y170‑p, T231‑p, T239‑p, S243‑p, S249‑p phosphorylation: S243‑p protein stabilization: S63‑p, S73‑p ubiquitination: T239‑p, S243‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		T2-p	______MtAKMETtF
1	0		T8-p	MtAKMETtFYDDALN
0	1		S37-p	NPKILKQsMTLNLAD
0	1		S48-p	NLADPVGsLkPHLRA
0	1		K50-u	ADPVGsLkPHLRAKN
0	1		K56	LkPHLRAKNsDLLts
0	6		S58-p	PHLRAKNsDLLtsPD
0	2		T62-p	AKNsDLLtsPDVGLL
98	20		S63-p	KNsDLLtsPDVGLLK
62	41		S73-p	VGLLKLAsPELERLI
1	0		T89-p	QSSNGHItTtPtPtQ
7	0		T91-p	SNGHItTtPtPtQFL
8	0		T93-p	GHItTtPtPtQFLCP
1	0		T95-p	ItTtPtPtQFLCPKN
1	0		Y170-p	LHSEPPVyANLSNFN
5	0		K226-s	HPRLQALkEEPQtVP
3	0		T231-p	ALkEEPQtVPEMPGE
5	17		T239-p	VPEMPGEtPPLsPID
10	19		S243-p	PGEtPPLsPIDMEsQ
3	1		S249-p	LsPIDMEsQERIkAE
2	0		K254-s	MEsQERIkAERKRMR
1	0		K268-a	RNRIAASkCRkRkLE
2	0		K271-a	IAASkCRkRkLERIA
1	0		K273-a	ASkCRkRkLERIARL
1	1		T286-p	RLEEKVKtLKAQNSE
0	1		K309-u	REQVAQLkQKVMNHV

	mouse
T2	______MTAKMETTF
T8	MTAKMETTFYDDALN
S37	NPKILKQSMTLNLAD
S48	NLADPVGSLKPHLRA
K50	ADPVGSLKPHLRAkN
K56-u	LKPHLRAkNsDLLts
S58-p	PHLRAkNsDLLtsPD
T62-p	AkNsDLLtsPDVGLL
S63-p	kNsDLLtsPDVGLLK
S73-p	VGLLKLAsPELERLI
T89	QSSNGHITTtPtPTQ
T91-p	SNGHITTtPtPTQFL
T93-p	GHITTtPtPTQFLCP
T95	ITTtPtPTQFLCPKN
Y170	LHSEPPVYANLSNFN
K229-s	HPRLQALkEEPQTVP
T234	ALkEEPQTVPEMPGE
T242-p	VPEMPGEtPPLsPID
S246-p	PGEtPPLsPIDMESQ
S252	LsPIDMESQERIkAE
K257-s	MESQERIkAERKRMR
K271	RNRIAASKCRKRKLE
K274	IAASKCRKRKLERIA
K276	ASKCRKRKLERIARL
T289	RLEEKVKTLKAQNSE
K312	REQVAQLKQKVMNHV

	rat
T2	______MTAKMETTF
T8	MTAKMETTFYDDALN
S37	NPKILKQSMTLNLAD
N48	NLADPVGNLKPHLRA
K50	ADPVGNLKPHLRAKN
K56	LKPHLRAKNSDLLts
S58	PHLRAKNSDLLtsPD
T62-p	AKNSDLLtsPDVGLL
S63-p	KNSDLLtsPDVGLLK
S73-p	VGLLKLAsPELERLI
T89	QSSNGHITTTPTPTQ
T91	SNGHITTTPTPTQFL
T93	GHITTTPTPTQFLCP
T95	ITTTPTPTQFLCPKN
Y170	LHSEPPVYANLSNFN
K229	HPRLQALKEEPQTVP
T234	ALKEEPQTVPEMPGE
T242	VPEMPGETPPLsPID
S246-p	PGETPPLsPIDMESQ
S252	LsPIDMESQERIKAE
K257	MESQERIKAERKRMR
K271	RNRIAASKCRKRKLE
K274	IAASKCRKRKLERIA
K276	ASKCRKRKLERIARL
T289	RLEEKVKTLKAQNSE
K312	REQVAQLKQKVMNHV

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