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Protein Page:
UVRAG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UVRAG Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Highly expressed in brain, lung, kidney and liver. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Autophagy
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component: protein complex; lysosome; early endosome; cytoplasm; late endosome
Molecular Function: protein binding; SH3 domain binding
Biological Process: DNA repair; positive regulation of autophagy
Reference #:  Q9P2Y5 (UniProtKB)
Alt. Names/Synonyms: DHTX; disrupted in heterotaxy; p63; UV radiation resistance associated gene; UV radiation resistance-associated gene protein; UVRAG
Gene Symbols: UVRAG
Molecular weight: 78,151 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UVRAG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S83-p IYKEFYRsEVIKNSL
0 3 S96-p SLNPTWRsLDFGIMP
0 2 T108-p IMPDRLDtsVSCFVV
0 1 S109-p MPDRLDtsVSCFVVK
0 1 K139 KVCLDGLKYLGQQIH
0 1 T212-p AIKQTQVtVQkIGKE
0 1 K215-m3 QTQVtVQkIGKEIEE
0 1 T229 EKLRLTSTSNELKKK
0 1 S230 KLRLTSTSNELKKKS
0 1 K255 QNELERQKKALGREV
0 2 Y427 LQFDYGVYLLNKNIA
0 2 S482-p IPVPKRQssIFGGAD
0 4 S483-p PVPKRQssIFGGADV
0 3 I484 VPKRQssIFGGADVG
0 4 S493 GGADVGFSGGIPsPD
0 35 S498-p GFSGGIPsPDKGHRK
0 2 S508-p KGHRKRAssENERLQ
0 1 S509-p GHRKRAssENERLQy
0 6 Y516-p sENERLQyKtPPPsy
0 40 T518-p NERLQyKtPPPsyNS
0 2 S522-p QyKtPPPsyNSALAQ
0 3 Y523-p yKtPPPsyNSALAQP
0 1 S525 tPPPsyNSALAQPVT
0 1 T533-p ALAQPVTtVPSMGET
0 3 T545-p GETERKItSLSssLD
0 2 S549-p RKItSLSssLDTsLD
0 10 S550-p KItSLSssLDTsLDF
0 1 T553 SLSssLDTsLDFsKE
0 4 S554-p LSssLDTsLDFsKEN
0 2 S558-p LDTsLDFsKENKKKG
0 1 K559 DTsLDFsKENKKKGE
0 2 S571-p KGEDLVGsLNGGHAN
0 36 Y681-p EEFSRRIyALNENVs
0 1 S688-p yALNENVssFRRPRR
0 15 S689-p ALNENVssFRRPRRs
0 55 S696-p sFRRPRRssDK____
0 16 S697-p FRRPRRssDK_____
  mouse

 
S83 IFKEFYRSEVIKNSL
S96 SLNPTWRSLDFGIMP
T108 IMPDRLDTSVSCFVV
S109 MPDRLDTSVSCFVVK
K139-ac KVYLDGLkYLGQQIH
T211 AIKQTQVTVQRLGKE
R214 QTQVTVQRLGKEIEE
T228-p EKLRLTStsNELKKE
S229-p KLRLTStsNELKKES
K254-ac RNELERQkKALGREV
Y426-p LQFDYGVyLLNKNIA
S481 IPVPKRQSstFGGAD
S482-p PVPKRQSstFGGADG
T483-p VPKRQSstFGGADGG
S492-p GGADGGFsAGIPsPD
S497-p GFsAGIPsPDKVHRK
S507 KVHRKRASSENERLQ
S508 VHRKRASSENERLQy
Y515-p SENERLQyKtPPPsy
T517-p NERLQyKtPPPsyNs
S521-p QyKtPPPsyNsALTQ
Y522-p yKtPPPsyNsALTQP
S524-p tPPPsyNsALTQPGV
A532 ALTQPGVAMPTSGDS
A544 GDSERKVAPLSSsLD
S548 RKVAPLSSsLDtsLD
S549-p KVAPLSSsLDtsLDF
T552-p PLSSsLDtsLDFSkE
S553-p LSSsLDtsLDFSkEN
S557 LDtsLDFSkENKKAG
K558-ub DtsLDFSkENKKAGV
S570 AGVDLGSSVSGDHGN
Y680 EEFSRRIYALSENVS
S687 YALSENVSsFRRPRR
S688-p ALSENVSsFRRPRRs
S695-p sFRRPRRsSDK____
S696 FRRPRRsSDK_____
  rat

 
S83 ICKEFYRSEVIKNSL
S96 SLNPTWRSLDFGIMP
T108 IMPDRLDTSVSCFVV
S109 MPDRLDTSVSCFVVK
K139 KVYLDGLKYLGQQIH
T211 AIKQTQVTVQRIGKE
R214 QTQVTVQRIGKEIEE
T228 EKLRLTSTSNELKKE
S229 KLRLTSTSNELKKES
K254 RNELERQKKALGREV
Y426 LQFDYGVYLLNKNIA
S481 IPVPKRQSSTFRGAD
S482 PVPKRQSSTFRGADV
T483 VPKRQSSTFRGADVG
S492 RGADVGLSTGVPsPD
S497-p GLSTGVPsPDNVHRK
S507 NVHRKRASSENERLQ
S508 VHRKRASSENERLQY
Y515 SENERLQYKTPPPSY
T517 NERLQYKTPPPSYNS
S521 QYKTPPPSYNSALTQ
Y522 YKTPPPSYNSALTQH
S524 TPPPSYNSALTQHGV
A532 ALTQHGVAMPTLGDS
T544 GDSERKVTPLSssLD
S548-p RKVTPLSssLDTSLD
S549-p KVTPLSssLDTSLDF
T552 PLSssLDTSLDFSKE
S553 LSssLDTSLDFSKES
S557 LDTSLDFSKESKKTG
K558 DTSLDFSKESKKTGV
S570 TGVDLGNSVSGDHRN
Y680 EEFSRRIYALSENVS
S687 YALSENVSSFRRPRR
S688 ALSENVSSFRRPRRs
S695-p SFRRPRRsSDK____
S696 FRRPRRsSDK_____
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