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Protein Page:
UVRAG (human)

Overview
UVRAG Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Highly expressed in brain, lung, kidney and liver. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Autophagy
Cellular Component: protein complex; lysosome; early endosome; late endosome; cytoplasm
Molecular Function: protein binding; SH3 domain binding
Biological Process: DNA repair; positive regulation of autophagy
Reference #:  Q9P2Y5 (UniProtKB)
Alt. Names/Synonyms: DHTX; disrupted in heterotaxy; p63; UV radiation resistance associated gene; UV radiation resistance-associated gene protein; UVRAG
Gene Symbols: UVRAG
Molecular weight: 78,151 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UVRAG

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S83-p IYKEFYRsEVIKNSL
0 3 S96-p SLNPTWRsLDFGIMP
0 2 T108-p IMPDRLDtSVSCFVV
0 2 Y427 LQFDYGVYLLNKNIA
0 1 S482-p IPVPKRQssIFGGAD
0 3 S483-p PVPKRQssIFGGADV
0 2 I484 VPKRQssIFGGADVG
0 3 S493 GGADVGFSGGIPsPD
0 26 S498-p GFSGGIPsPDKGHRK
0 1 S508-p KGHRKRAsSENERLQ
0 6 Y516-p SENERLQyKtPPPsy
0 39 T518-p NERLQyKtPPPsyNS
0 2 S522-p QyKtPPPsyNSALAQ
0 3 Y523-p yKtPPPsyNSALAQP
0 4 T545-p GETERKItSLSssLD
0 1 S549-p RKItSLSssLDTsLD
0 6 S550-p KItSLSssLDTsLDF
0 4 S554-p LSssLDTsLDFsKEN
0 3 S558-p LDTsLDFsKENKKKG
0 1 S571-p KGEDLVGsLNGGHAN
0 36 Y681-p EEFSRRIyALNENVS
0 14 S689-p ALNENVSsFRRPRRs
0 55 S696-p sFRRPRRssDK____
0 16 S697-p FRRPRRssDK_____
  mouse

 
S83 IFKEFYRSEVIKNSL
S96 SLNPTWRSLDFGIMP
T108 IMPDRLDTSVSCFVV
Y426-p LQFDYGVyLLNKNIA
S481 IPVPKRQSstFGGAD
S482-p PVPKRQSstFGGADG
T483-p VPKRQSstFGGADGG
S492-p GGADGGFsAGIPsPD
S497-p GFsAGIPsPDKVHRK
S507 KVHRKRASSENERLQ
Y515-p SENERLQyKtPPPsy
T517-p NERLQyKtPPPsyNS
S521-p QyKtPPPsyNSALTQ
Y522-p yKtPPPsyNSALTQP
A544 GDSERKVAPLSSsLD
S548 RKVAPLSSsLDTsLD
S549-p KVAPLSSsLDTsLDF
S553-p LSSsLDTsLDFSKEN
S557 LDTsLDFSKENKKAG
S570 AGVDLGSSVSGDHGN
Y680 EEFSRRIYALSENVS
S688-p ALSENVSsFRRPRRs
S695-p sFRRPRRsSDK____
S696 FRRPRRsSDK_____
  rat

 
S83 ICKEFYRSEVIKNSL
S96 SLNPTWRSLDFGIMP
T108 IMPDRLDTSVSCFVV
Y426 LQFDYGVYLLNKNIA
S481 IPVPKRQSSTFRGAD
S482 PVPKRQSSTFRGADV
T483 VPKRQSSTFRGADVG
S492 RGADVGLSTGVPsPD
S497-p GLSTGVPsPDNVHRK
S507 NVHRKRASSENERLQ
Y515 SENERLQYKTPPPSY
T517 NERLQYKTPPPSYNS
S521 QYKTPPPSYNSALTQ
Y522 YKTPPPSYNSALTQH
T544 GDSERKVTPLSssLD
S548-p RKVTPLSssLDTSLD
S549-p KVTPLSssLDTSLDF
S553 LSssLDTSLDFSKES
S557 LDTSLDFSKESKKTG
S570 TGVDLGNSVSGDHRN
Y680 EEFSRRIYALSENVS
S688 ALSENVSSFRRPRRs
S695-p SFRRPRRsSDK____
S696 FRRPRRsSDK_____
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