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CHOP (human)

Overview CHOP a transcriptional-regulatory protein of the bZIP family. Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA. May play an important role in melanoma progression. CK2-mediated phosphorylation inhibits its transcriptional activity. Up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein; Autophagy Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity; transcription corepressor activity; transcription factor binding Biological Process: regulation of transcription in response to stress; proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; unfolded protein response; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; mRNA transcription from RNA polymerase II promoter; response to unfolded protein; positive regulation of interleukin-8 production; unfolded protein response, activation of signaling protein activity; regulation of transcription, DNA-dependent; cell redox homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cell cycle arrest; response to DNA damage stimulus Reference #:  P35638 (UniProtKB) Alt. Names/Synonyms: C/EBP homologous protein; C/EBP zeta; C/EBP-homologous protein; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CEBPZ; CHOP; CHOP-10; CHOP10; DDIT-3; DDIT3; DNA damage-inducible transcript 3 protein; DNA-damage-inducible transcript 3; GADD153; Growth arrest and DNA damage-inducible protein GADD153; growth arrest- and DNA damage-inducible; MGC4154 Gene Symbols: DDIT3 Molecular weight: 19,175 Da Basal Isoelectric point: 4.61  Predict pI for various phosphorylation states CST Pathways:  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CHOP

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 126337 151900  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S14‑p, S15‑p, S30‑p, S31‑p, S79‑p, S82‑p inhibition: S14‑p, S15‑p, S30‑p, S31‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S14-p	PFSFGTLssWELEAW
1	0		S15-p	FSFGTLssWELEAWY
1	0		S30-p	EDLQEVLssDENGGT
1	0		S31-p	DLQEVLssDENGGTY
0	1		S49-p	PGNEEEEsKIFTtLD
0	1		T54-p	EEsKIFTtLDPASLA
0	1		T64-p	PASLAWLtEEEPEPA
1	1		S79-p	EVTSTSQsPHsPDSS
1	1		S82-p	STSQsPHsPDSSQSS
0	1		K121-u	RAGKQRMkEKEQENE

	mouse
S14	PFTLETVSSWELEAW
S15	FTLETVSSWELEAWY
S30	EDLQEVLSSDEIGGT
S31	DLQEVLSSDEIGGTY
S49	PGNEEEESKTFTTLD
T54	EESKTFTTLDPASLA
T64	PASLAWLTEEPGPTE
S78-p	EVTRTSQsPRsPDSS
S81-p	RTSQsPRsPDSSQSS
K120-u	RPGKQRMkEKEQENE

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