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Protein Page:
CHOP (human)

Overview
CHOP a transcriptional-regulatory protein of the bZIP family. Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA. May play an important role in melanoma progression. CK2-mediated phosphorylation inhibits its transcriptional activity. Up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Transcription factor; DNA binding protein
Cellular Component: nucleoplasm; late endosome; nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity; transcription factor binding
Biological Process: regulation of transcription in response to stress; proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; unfolded protein response; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; mRNA transcription from RNA polymerase II promoter; blood vessel maturation; response to unfolded protein; positive regulation of interleukin-8 production; response to starvation; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; regulation of transcription, DNA-dependent; cell redox homeostasis; release of sequestered calcium ion into cytosol; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; cell cycle arrest; response to DNA damage stimulus; ER overload response
Reference #:  P35638 (UniProtKB)
Alt. Names/Synonyms: C/EBP homologous protein; C/EBP zeta; C/EBP-homologous protein; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CEBPZ; CHOP; CHOP-10; CHOP10; DDIT-3; DDIT3; DNA damage-inducible transcript 3 protein; DNA-damage-inducible transcript 3; GADD153; Growth arrest and DNA damage-inducible protein GADD153; growth arrest- and DNA damage-inducible; MGC4154
Gene Symbols: DDIT3
Molecular weight: 19,175 Da
Basal Isoelectric point: 4.61  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHOP

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S79‑p, S82‑p
transcription, inhibited: S14‑p, S15‑p, S30‑p, S31‑p
activity, inhibited: S14‑p, S15‑p, S30‑p, S31‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S14-p PFSFGTLssWELEAW
1 0 S15-p FSFGTLssWELEAWY
1 0 S30-p EDLQEVLssDENGGT
1 0 S31-p DLQEVLssDENGGTY
1 1 S79-p EVTSTSQsPHsPDSS
1 1 S82-p STSQsPHsPDSSQSS
  mouse

 
S14 PFTLETVSSWELEAW
S15 FTLETVSSWELEAWY
S30 EDLQEVLSSDEIGGT
S31 DLQEVLSSDEIGGTY
S78-p EVTRTSQsPRsPDSS
S81-p RTSQsPRsPDSSQSS
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