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Protein Page:
CHOP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CHOP a transcriptional-regulatory protein of the bZIP family. Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA. May play an important role in melanoma progression. CK2-mediated phosphorylation inhibits its transcriptional activity. Up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Transcription factor; DNA binding protein
Cellular Component: nucleoplasm; late endosome; nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor binding; transcription factor activity
Biological Process: regulation of transcription in response to stress; proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; unfolded protein response; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; mRNA transcription from RNA polymerase II promoter; blood vessel maturation; response to unfolded protein; positive regulation of interleukin-8 production; response to starvation; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; regulation of transcription, DNA-dependent; cell redox homeostasis; positive regulation of neuron apoptosis; release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; cell cycle arrest; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; response to DNA damage stimulus; ER overload response
Reference #:  P35638 (UniProtKB)
Alt. Names/Synonyms: C/EBP homologous protein; C/EBP zeta; C/EBP-homologous protein; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CEBPZ; CHOP; CHOP-10; CHOP10; DDIT-3; DDIT3; DNA damage-inducible transcript 3 protein; DNA-damage-inducible transcript 3; GADD153; Growth arrest and DNA damage-inducible protein GADD153; growth arrest- and DNA damage-inducible; MGC4154
Gene Symbols: DDIT3
Molecular weight: 19,175 Da
Basal Isoelectric point: 4.61  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHOP

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S79‑p, S82‑p
transcription, inhibited: S14‑p, S15‑p, S30‑p, S31‑p
activity, inhibited: S14‑p, S15‑p, S30‑p, S31‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S14-p PFSFGTLssWELEAW
1 0 S15-p FSFGTLssWELEAWY
1 0 S30-p EDLQEVLssDENGGT
1 0 S31-p DLQEVLssDENGGTY
0 1 S49-p PGNEEEEsKIFTtLD
0 1 T54-p EEsKIFTtLDPASLA
0 1 T64-p PASLAWLtEEEPEPA
1 1 S79-p EVTSTSQsPHsPDSS
1 1 S82-p STSQsPHsPDSSQSS
0 1 K121 RAGKQRMKEKEQENE
  mouse

 
S14 PFTLETVSSWELEAW
S15 FTLETVSSWELEAWY
S30 EDLQEVLSSDEIGGT
S31 DLQEVLSSDEIGGTY
S49 PGNEEEESKTFTTLD
T54 EESKTFTTLDPASLA
T64 PASLAWLTEEPGPTE
S78-p EVTRTSQsPRsPDSS
S81-p RTSQsPRsPDSSQSS
K120-ub RPGKQRMkEKEQENE
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