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CSF2RB (human)

Overview CSF2RB a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease. Note: This description may include information from UniProtKB. Protein type: Receptor, cytokine; Membrane protein, integral Cellular Component: granulocyte macrophage colony-stimulating factor receptor complex; integral to plasma membrane; plasma membrane Molecular Function: protein binding; interleukin-5 receptor activity; interleukin-3 receptor activity; receptor activity Biological Process: respiratory gaseous exchange; signal transduction Reference #:  P32927 (UniProtKB) Alt. Names/Synonyms: CD131; CDw131; colony stimulating factor 2 receptor, beta; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); colony-stimulating factor-2 receptor, beta, low-affinity; CSF2RB; Cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta subunit; GM-CSF/IL-3/IL-5 receptor common beta-chain; IL3RB; IL5RB; interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity) Gene Symbols: CSF2RB Molecular weight: 97,336 Da Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states CST Pathways:  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CSF2RB 1C8P - A=338-438 (human) 1EGJ - A=338-438 (human) 1GH7 - A/B=25-437 (human) 3CXE - A=25-438 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1C8P 1EGJ 1GH7 3CXE  |  Phospho3D  |  DISEASE 138981 265120  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: Y593‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p apoptosis, inhibited: S601‑p cell growth, altered: Y593‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p, Y882‑p cell motility, altered: Y593‑p, Y628‑p, Y711‑p transcription, altered: Y593‑p, S601‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p, Y882‑p activation: Y593‑p, S601‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p, Y882‑p molecular association, regulation: Y593‑p, S601‑p, Y628‑p, Y711‑p, Y766‑p phosphorylation: Y593‑p, S601‑p, Y628‑p, Y711‑p receptor internalization, altered: Y593‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		Y466-p	ALRFCGIyGyRLRRK
1	0		Y468-p	RFCGIyGyRLRRKWE
0	1		S491-p	SHLFQNGsAELWPPG
12	0		Y593-p	SFDFNGPyLGPPHSR
6	0		S601-p	LGPPHSRsLPDILGQ
6	0		Y628-p	PPPGSLEyLCLPAGG
3	0		Y711-p	DPGVASGyVSSADLV
0	5		P753	PGLASGPPGAPGPVK
0	2		A755	LASGPPGAPGPVKSG
6	10		Y766-p	VKSGFEGyVELPPIE
0	1		S779	IEGRSPRSPRNNPVP
2	0		Y822-p	VLQQVGDyCFLPGLG
0	5		G862	FQVKKPPGQAVPQVP
0	1		A876	PVIQLFKALKQQDyL
2	0		Y882-p	KALKQQDyLSLPPWE

	mouse ► Hide Isoforms
S469	ILRFGCVSVYRTYRK
Y471	RFGCVSVYRTYRKWK
G494	SLLFQDGGKGLWPPG
Y595-p	SFDFNGPyLGPPQSH
S603-p	LGPPQSHsLPDLPDQ
Y630	ALPGSLEYMCLPPGG
Y710	GSMMASDYVTPGDPV
S752-p	LKLPRVPsGsPALGP
S754-p	LPRVPsGsPALGPPG
Y765-p	GPPGFEDyVELPPSV
S778-p	SVSQAAKsPPGHPAP
Y821	VLQQVGDYCFLPGLG
Y861-p	LSVKKFPyQPMPQAP
S875	PAIQFFKSLKHQDYL
Y881	KSLKHQDYLSLPPWD

	CSF2RB iso2
Y468	ALHFGRVYGYRTYRK
Y470	HFGRVYGYRTYRKWK
G493	SLLFQDGGKGLWPPG
Y595	SFDFNGPYLGPPQSH
S603	LGPPQSHSLPDLPGQ
Y630	ALPGSLEYMCLPPGG
Y710	GSMMASDYVTPGDPV
S752	LKLPRVPSGSPALGP
S754	LPRVPSGSPALGPPG
Y765	GPPGFEDYVELPPSV
S778	SVSQAATSPPGHPAP
Y821	VLQQVGDYCFLPGLG
Y861-p	LSVKKFPyQPLPQAP
S875-p	PAIQFFKsLKY____
-	gap

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