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Protein Page:
CSF2RB (human)

Overview
CSF2RB a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease. Note: This description may include information from UniProtKB.
Protein type: Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: granulocyte macrophage colony-stimulating factor receptor complex; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; interleukin-5 receptor activity; interleukin-3 receptor activity; receptor activity
Biological Process: response to lipopolysaccharide; respiratory gaseous exchange; signal transduction
Reference #:  P32927 (UniProtKB)
Alt. Names/Synonyms: CD131; CDw131; colony stimulating factor 2 receptor, beta; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); colony-stimulating factor-2 receptor, beta, low-affinity; CSF2RB; Cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta subunit; GM-CSF/IL-3/IL-5 receptor common beta-chain; IL3RB; IL5RB; interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
Gene Symbols: CSF2RB
Molecular weight: 97,336 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CSF2RB

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y593‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p
apoptosis, inhibited: S601‑p
cell growth, altered: Y593‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p, Y882‑p
cell motility, altered: Y593‑p, Y628‑p, Y711‑p
transcription, altered: Y593‑p, S601‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p, Y882‑p
activity, induced: Y593‑p, S601‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p, Y882‑p
molecular association, regulation: Y593‑p, S601‑p, Y628‑p, Y711‑p, Y766‑p
phosphorylation: Y593‑p, S601‑p, Y628‑p, Y711‑p
receptor internalization, altered: Y593‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y466-p ALRFCGIyGyRLRRK
1 0 Y468-p RFCGIyGyRLRRKWE
0 1 S491-p SHLFQNGsAELWPPG
12 0 Y593-p SFDFNGPyLGPPHSR
6 0 S601-p LGPPHSRsLPDILGQ
6 0 Y628-p PPPGSLEyLCLPAGG
3 0 Y711-p DPGVASGyVSSADLV
0 5 P753 PGLASGPPGAPGPVK
0 2 A755 LASGPPGAPGPVKSG
6 10 Y766-p VKSGFEGyVELPPIE
0 1 S779 IEGRSPRSPRNNPVP
2 0 Y822-p VLQQVGDyCFLPGLG
0 5 G862 FQVKKPPGQAVPQVP
0 1 A876 PVIQLFKALKQQDyL
2 0 Y882-p KALKQQDyLSLPPWE
  mouse

► Hide Isoforms
 
S469 ILRFGCVSVYRTYRK
Y471 RFGCVSVYRTYRKWK
G494 SLLFQDGGKGLWPPG
Y595-p SFDFNGPyLGPPQSH
S603-p LGPPQSHsLPDLPDQ
Y630 ALPGSLEYMCLPPGG
Y710 GSMMASDYVTPGDPV
S752-p LKLPRVPsGsPALGP
S754-p LPRVPsGsPALGPPG
Y765-p GPPGFEDyVELPPSV
S778-p SVSQAAKsPPGHPAP
Y821 VLQQVGDYCFLPGLG
Y861-p LSVKKFPyQPMPQAP
S875 PAIQFFKSLKHQDYL
Y881 KSLKHQDYLSLPPWD
  CSF2RB iso2  
Y468 ALHFGRVYGYRTYRK
Y470 HFGRVYGYRTYRKWK
G493 SLLFQDGGKGLWPPG
Y595 SFDFNGPYLGPPQSH
S603 LGPPQSHSLPDLPGQ
Y630 ALPGSLEYMCLPPGG
Y710 GSMMASDYVTPGDPV
S752 LKLPRVPSGSPALGP
S754 LPRVPSGSPALGPPG
Y765 GPPGFEDYVELPPSV
S778 SVSQAATSPPGHPAP
Y821 VLQQVGDYCFLPGLG
Y861-p LSVKKFPyQPLPQAP
S875-p PAIQFFKsLKY____
- gap
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