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Protein Page:
CSF2RB (human)

Overview
CSF2RB a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Cellular Component: granulocyte macrophage colony-stimulating factor receptor complex; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; interleukin-5 receptor activity; interleukin-3 receptor activity; receptor activity
Biological Process: response to lipopolysaccharide; respiratory gaseous exchange; signal transduction
Reference #:  P32927 (UniProtKB)
Alt. Names/Synonyms: CD131; CDw131; colony stimulating factor 2 receptor, beta; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); colony-stimulating factor-2 receptor, beta, low-affinity; CSF2RB; Cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta subunit; GM-CSF/IL-3/IL-5 receptor common beta-chain; IL3RB; IL5RB; interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
Gene Symbols: CSF2RB
Molecular weight: 97,336 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CSF2RB

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y593‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p
apoptosis, inhibited: S601‑p
cell growth, altered: Y593‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p, Y882‑p
cell motility, altered: Y593‑p, Y628‑p, Y711‑p
transcription, altered: Y593‑p, S601‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p, Y882‑p
activity, induced: Y593‑p, S601‑p, Y628‑p, Y711‑p, Y766‑p, Y822‑p, Y882‑p
molecular association, regulation: Y593‑p, S601‑p, Y628‑p, Y711‑p, Y766‑p
phosphorylation: Y593‑p, S601‑p, Y628‑p, Y711‑p
receptor internalization, altered: Y593‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y466-p ALRFCGIyGyRLRRK
1 0 Y468-p RFCGIyGyRLRRKWE
12 0 Y593-p SFDFNGPyLGPPHSR
6 0 S601-p LGPPHSRsLPDILGQ
6 0 Y628-p PPPGSLEyLCLPAGG
3 0 Y711-p DPGVASGyVSSADLV
0 5 P753 PGLASGPPGAPGPVK
0 2 A755 LASGPPGAPGPVKSG
6 10 Y766-p VKSGFEGyVELPPIE
0 1 S779 IEGRSPRSPRNNPVP
2 0 Y822-p VLQQVGDyCFLPGLG
0 5 G862 FQVKKPPGQAVPQVP
0 1 A876 PVIQLFKALKQQDyL
2 0 Y882-p KALKQQDyLSLPPWE
  mouse

► Hide Isoforms
 
S469 ILRFGCVSVYRTYRK
Y471 RFGCVSVYRTYRKWK
Y595-p SFDFNGPyLGPPQSH
S603-p LGPPQSHsLPDLPDQ
Y630 ALPGSLEYMCLPPGG
Y710 GSMMASDYVTPGDPV
S752-p LKLPRVPsGsPALGP
S754-p LPRVPsGsPALGPPG
Y765-p GPPGFEDyVELPPSV
S778-p SVSQAAKsPPGHPAP
Y821 VLQQVGDYCFLPGLG
Y861-p LSVKKFPyQPMPQAP
S875 PAIQFFKSLKHQDYL
Y881 KSLKHQDYLSLPPWD
  CSF2RB iso2  
Y468 ALHFGRVYGYRTYRK
Y470 HFGRVYGYRTYRKWK
Y595 SFDFNGPYLGPPQSH
S603 LGPPQSHSLPDLPGQ
Y630 ALPGSLEYMCLPPGG
Y710 GSMMASDYVTPGDPV
S752 LKLPRVPSGSPALGP
S754 LPRVPSGSPALGPPG
Y765 GPPGFEDYVELPPSV
S778 SVSQAATSPPGHPAP
Y821 VLQQVGDYCFLPGLG
Y861-p LSVKKFPyQPLPQAP
S875-p PAIQFFKsLKY____
- gap
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