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Protein Page:
PRICKLE1 (human)

Overview
PRICKLE1 Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. Defects in PRICKLE1 are the cause of progressive myoclonic epilepsy type 1B (EPM1B). EPM1B is an autosomal recessive disorder characterized by myoclonus that progresses in severity over time, tonic-clonic seizures and ataxia. Defects in PRICKLE1 may be a cause of susceptibility to neural tube defects (NTD). Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. Belongs to the prickle / espinas / testin family. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: nuclear membrane; nucleus; cytosol
Molecular Function: protein binding; zinc ion binding
Biological Process: positive regulation of protein ubiquitination; protein import into nucleus; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; neural tube closure; negative regulation of transcription, DNA-dependent
Reference #:  Q96MT3 (UniProtKB)
Alt. Names/Synonyms: EPM1B; FLJ31627; FLJ31937; MGC138902; MGC138903; PRIC1; prickle homolog 1 (Drosophila); prickle-like 1; Prickle-like protein 1; PRICKLE1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein; REST/NRSF-interacting LIM domain protein 1; RILP
Gene Symbols: PRICKLE1
Molecular weight: 94,300 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Select Structure to View Below

PRICKLE1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T21-p FGCQRSStSDDDSGC
0 1 S315 LGEDVHASDSSDSAF
0 1 S317 EDVHASDSSDSAFQS
0 2 S476 SDMYWAQSQDGLGDS
0 4 S591 NSSMLHRSAESLKSL
0 2 S594 MLHRSAESLKSLSSE
0 1 S597 RSAESLKSLSSELCP
0 4 S624 PVLRRSKSQSRPQQV
0 6 Y661 ERTRRRVYNFEERGS
0 2 S681-p RRRRSRKsRsDNALN
0 4 S683-p RRSRKsRsDNALNLV
  mouse

 
T21 FGCQRSSTSDDDSGC
S315-p LGEDIHAsDsSDSAF
S317-p EDIHAsDsSDSAFQS
S477-p SDMYWAQsQDGLGDS
S592-p NSSMLHRsAEsLQsL
S595-p MLHRsAEsLQsLNSG
S598-p RsAEsLQsLNSGLCP
S625-p PVLRRSKsQSRPQQV
Y662 ERTRRRAYHFEERGS
S682-p RHRRSRKsRsDNALN
S684-p RRSRKsRsDNALNLV
  rat

 
T21 FGCQRSSTSDDDSGC
S315 LGEDIHASDSSDSAF
S317 EDIHASDSSDSAFQS
S476-p SDMYWAQsQDGLGDS
S591 NSSMLHRSAESLKSL
S594 MLHRSAESLKSLNSE
S597 RSAESLKSLNSELCP
S624 PVLRRSKSQSRPQQV
Y661-p ERTRRRVyHFEERGS
S681 RHRRSRKSRSDNALN
S683 RRSRKSRSDNALNLV
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