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Protein Page:
K10 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
K10 a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K1. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: extracellular space; keratin filament; cytoplasm; intermediate filament; nucleus
Molecular Function: structural constituent of epidermis
Biological Process: keratinocyte differentiation
Reference #:  P13645 (UniProtKB)
Alt. Names/Synonyms: CK-10; CK10; cytokeratin 10; Cytokeratin-10; K10; K1C10; keratin 10; Keratin, type I cytoskeletal 10; Keratin-10; KPP; KRT10
Gene Symbols: KRT10
Molecular weight: 58,827 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

K10

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S14-p SSKHYSSsRsGGGGG
0 4 S16-p KHYSSsRsGGGGGGG
0 1 S38-p VSSLRISssKGsLGG
0 1 S39-p SSLRISssKGsLGGG
0 1 K40 SLRISssKGsLGGGF
0 1 K40 SLRISssKGsLGGGF
0 4 S42-p RISssKGsLGGGFSS
0 2 S53-p GFSSGGFsGGsFSRG
0 3 S56-p SGGFsGGsFSRGSSG
0 5 S159-p NLNDRLAsyLDkVRA
0 77 Y160-p LNDRLAsyLDkVRAL
0 6 K163-u RLAsyLDkVRALEEs
0 1 S170-p kVRALEEsNyELEGK
0 5 Y172-p RALEEsNyELEGKIK
0 2 Y199-p EPRDYSKyyKTIDDL
0 1 Y200-p PRDYSKyyKTIDDLK
0 8 Y238-p ADDFRLKyENEVALR
0 1 T265 VLDELTLTKADLEMQ
0 3 Y325-p LNNMRSQyEQLAEQN
0 1 N353 ELTTEIDNNIEQISS
0 1 S458-p SLLEGEGssGGGGRG
0 2 S459-p LLEGEGssGGGGRGG
0 2 S573-p HKSSSSGsVGESSsK
0 2 S579-p GsVGESSsKGPRy__
0 3 Y584-p SSsKGPRy_______
  mouse

 
S14 SSSKQFSSSRSGGGG
S17 KQFSSSRSGGGGGGG
S30 GGSVRVSStrGsLGG
T31-p GSVRVSStrGsLGGG
R32-m2 SVRVSStrGsLGGGY
R32-m1 SVRVSStrGsLGGGY
S34-p RVSStrGsLGGGYSS
S45-p GYSSGGFsGGsFSRG
S48-p SGGFsGGsFSRGSSG
S157-p NLNDRLAsYMDKVRA
Y158 LNDRLAsYMDKVRAL
K161 RLAsYMDKVRALEES
S168 KVRALEESNYELEGK
Y170 RALEESNYELEGKIK
Y197 EPRDYSKYYKTIEDL
Y198 PRDYSKYYKTIEDLK
Y236 ADDFRLKYENEVTLR
S263-p VLDELTLsKSDLEMQ
Y323 LNNMRNQYEQLAEKN
S351-p ELTTEIDsNIEQMSS
S456 SLLEGEGSsSGGGGG
S457-p LLEGEGSsSGGGGGR
- gap
S565 SGGGDQSSKGPRY__
Y570 QSSKGPRY_______
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