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K10 (human)

Overview K10 a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K1. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: keratin filament; cytoplasm; intermediate filament Molecular Function: structural constituent of epidermis; structural molecule activity Biological Process: keratinocyte differentiation; epidermis development Reference #:  P13645 (UniProtKB) Alt. Names/Synonyms: CK-10; CK10; cytokeratin 10; Cytokeratin-10; K10; K1C10; keratin 10; Keratin, type I cytoskeletal 10; Keratin-10; KPP; KRT10 Gene Symbols: KRT10 Molecular weight: 58,827 Da Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below K10 3ASW - B=473-487 (human) 4F1Z - Q=473-486 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3ASW 4F1Z  |  DISEASE 113800 148080 600648 607602  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S2-p	______MsVRYSSSK
0	1		K9	sVRYSSSKHySSSRs
0	1		Y11-p	RYSSSKHySSSRsGG
0	3		S16-p	KHySSSRsGGGGGGG
0	3		S42-p	RISSSKGsLGGGFSS
0	1		S53	GFSSGGFSGGSFSRG
0	2		S56	SGGFSGGSFSRGSSG
0	4		S159-p	NLNDRLAsyLDkVRA
0	77		Y160-p	LNDRLAsyLDkVRAL
0	6		K163-u	RLAsyLDkVRALEES
0	5		Y172-p	RALEESNyELEGKIK
0	2		Y199-p	EPRDYSKyyKTIDDL
0	1		Y200-p	PRDYSKyyKTIDDLK
0	8		Y238-p	ADDFRLKyENEVALR
0	1		T265	VLDELTLTKADLEMQ
0	1		T277-p	EMQIESLtEELAyLK
0	1		Y282-p	SLtEELAyLKKNHEE
0	3		Y325-p	LNNMRSQyEQLAEQN
0	1		N353	ELTTEIDNNIEQISS
0	1		S459	LLEGEGSSGGGGRGG
0	1		S535-p	GGYGGGSsGGGGGGY
0	1		S546-p	GGGYGGGsSGGGSSS
0	1		Y557-p	GSSSGGGyGGGSSSG
0	1		S568-p	SSSGGHKssSsGsVG
0	1		S569-p	SSGGHKssSsGsVGE
0	1		S571-p	GGHKssSsGsVGEss
0	2		S573-p	HKssSsGsVGEsssK
0	1		S577-p	SsGsVGEsssKGPRy
0	1		S578-p	sGsVGEsssKGPRy_
0	2		S579-p	GsVGEsssKGPRy__
0	3		Y584-p	sssKGPRy_______

	mouse
S2	______MSVLYSSSS
K10-a	VLYSSSSkQFSSSRS
F12	YSSSSkQFSSSRSGG
S17	kQFSSSRSGGGGGGG
S34-p	RVSSTRGsLGGGYSS
S45-p	GYSSGGFsGGsFSRG
S48-p	SGGFsGGsFSRGSSG
S157-p	NLNDRLAsYMDKVRA
Y158	LNDRLAsYMDKVRAL
K161	RLAsYMDKVRALEES
Y170	RALEESNYELEGKIK
Y197	EPRDYSKYYKTIEDL
Y198	PRDYSKYYKTIEDLK
Y236	ADDFRLKYENEVTLR
S263-p	VLDELTLsKSDLEMQ
N275	EMQIESLNEELAYLK
Y280	SLNEELAYLKKNHEE
Y323	LNNMRNQYEQLAEKN
S351-p	ELTTEIDsNIEQMSS
S457-p	LLEGEGSsSGGGGGR
S525	GGYGGGSSSGGAGGH
S535	GAGGHGGSSGGGYGG
Y540	GGSSGGGYGGGSSSG
G551	SSSGGQGGSGGFKSS
S552	SSGGQGGSGGFKSSG
-	gap
-	gap
Q563	KSSGGGDQSSKGPRY
S564	SSGGGDQSSKGPRY_
S565	SGGGDQSSKGPRY__
Y570	QSSKGPRY_______

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