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Protein Page:
CASP9 (human)

Overview
CASP9 a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two isoforms. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.4.22.62; Apoptosis
Chromosomal Location of Human Ortholog: 1p36.21
Cellular Component: mitochondrion; nucleus; cytosol; apoptosome
Molecular Function: peptidase activity; protein binding; cysteine-type endopeptidase activity; enzyme activator activity; protein kinase binding; SH3 domain binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of apoptosis; DNA damage response, signal transduction; response to lipopolysaccharide; proteolysis; response to estradiol stimulus; regulation of apoptosis; response to antibiotic; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of neuron apoptosis; response to cobalt ion; innate immune response; caspase activation via cytochrome c; platelet formation; response to DNA damage stimulus; aging
Reference #:  P55211 (UniProtKB)
Alt. Names/Synonyms: APAF-3; APAF3; apoptotic protease activating factor 3; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; CASP-9; CASP9; caspase 9, apoptosis-related cysteine peptidase; caspase 9, apoptosis-related cysteine protease; Caspase-9; Caspase-9 subunit p10; Caspase-9 subunit p35; CASPASE-9c; ICE-LAP6; ICE-like apoptotic protease 6; MCH6
Gene Symbols: CASP9
Molecular weight: 46,281 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CASP9

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: T125‑p, S144‑p
apoptosis, induced: T125‑p, Y153‑p, S196‑p
activity, induced: Y153‑p
activity, inhibited: T125‑p, S144‑p, S196‑p
enzymatic activity, inhibited: S183‑p
molecular association, regulation: Y153‑p, S183‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S99-p NRQAAKLsKPTLENL
0 1 T107-p KPTLENLtPVVLRPE
6 5 T125-p PEVLRPEtPRPVDIG
0 1 S133-p PRPVDIGsGGFGDVG
1 0 S144-p GDVGALEsLRGNADL
1 0 Y153-p RGNADLAyILSMEPC
0 1 S175-p NVNFCREsGLRTRTG
1 0 S183-p GLRTRTGsNIDCEKL
1 1 S195-p EKLRRRFssLHFMVE
3 1 S196-p KLRRRFssLHFMVEV
0 1 T208-p VEVKGDLtAKKMVLA
0 1 T301-p HGFEVAStsPEDEsP
0 2 S302-p GFEVAStsPEDEsPG
0 5 S307-p StsPEDEsPGsNPEP
1 5 S310-p PEDEsPGsNPEPDAT
0 2 P312 DEsPGsNPEPDATPF
  mouse

 
S132 RVVKLEPSQPAVGNL
T140 QPAVGNLTPVVLGPE
T163-p PEVLRPEtPRPVDIG
S171 PRPVDIGSGGAHDVC
K182 HDVCVPGKIRGHADM
Y191 RGHADMAYTLDSDPC
S213 NVNFCPSSGLGTRTG
S221 GLGTRTGSNLDRDKL
R233 DKLEHRFRWLRFMVE
W234 KLEHRFRWLRFMVEV
T246 VEVKNDLTAKKMVTA
T339 HGFEVACTSSQGRTL
S340 GFEVACTSSQGRTLD
T345 CTSSQGRTLDsDSEP
S348-p SQGRTLDsDSEPDAV
S350 GRTLDsDSEPDAVPY
  rat

 
S132 KVVKLDPSQPALGNL
T140 QPALGNLTPVVLGPE
T163 PEVLTPETPRPVDIG
S171 PRPVDIGSGRAHDVC
K182 HDVCTPGKIERHADM
Y191 ERHADMAYTLDSDPC
S213 NVNFCPSSGLSTRIG
S221 GLSTRIGSHVDCEKL
C233 EKLQHRFCWLRFMVE
W234 KLQHRFCWLRFMVEV
T246 VEVKNDLTAKKMVTA
T339 HGFEVAFTSSQDKAF
S340 GFEVAFTSSQDKAFD
A345 FTSSQDKAFDsDsEP
S348-p SQDKAFDsDsEPDAV
S350-p DKAFDsDsEPDAVPY
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