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Protein Page:
SAMHD1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SAMHD1 a protein induced by interferon gamma. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.-
Chromosomal Location of Human Ortholog: 20pter-q12
Cellular Component: nucleolus; plasma membrane; intracellular; nucleus
Molecular Function: protein binding; phosphoric diester hydrolase activity; nucleic acid binding; zinc ion binding; dGTPase activity; RNA binding; dGTP binding
Biological Process: dGTP catabolic process; dATP catabolic process; innate immune response; immune response; defense response to virus; protein homotetramerization; regulation of innate immune response
Reference #:  Q9Y3Z3 (UniProtKB)
Alt. Names/Synonyms: DCIP; Dendritic cell-derived IFNG-induced protein; HDDC1; Monocyte protein 5; MOP-5; MOP5; SAM domain and HD domain 1; SAM domain and HD domain-containing protein 1; SAMH1; SAMHD1; SBBI88
Gene Symbols: SAMHD1
Molecular weight: 72,201 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SAMHD1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S6-p __MQRADsEQPSKRP
0 1 K11 ADsEQPSKRPRCDDs
1 51 S18-p KRPRCDDsPRtPsNt
2 89 T21-p RCDDsPRtPsNtPsA
0 13 S23-p DDsPRtPsNtPsAEA
0 15 N24 DsPRtPsNtPsAEAD
1 36 T25-p sPRtPsNtPsAEADW
0 4 S27-p RtPsNtPsAEADWsP
0 7 E29 PsNtPsAEADWsPGL
2 40 S33-p PsAEADWsPGLELHP
0 1 V63 RGGFEEPVLLkNIRE
0 7 K66-ub FEEPVLLkNIRENEI
0 1 S93-p FENLGVSsLGERKkL
0 1 K99-ub SsLGERKkLLsyIQR
0 1 S102-p GERKkLLsyIQRLVQ
0 1 Y103-p ERKkLLsyIQRLVQI
0 1 T138-p LLVRIIDtPQFQRLR
0 1 Y146-p PQFQRLRyIkQLGGG
0 1 K148-ub FQRLRyIkQLGGGYy
0 1 Y155-p kQLGGGYyVFPGASH
0 1 E255 NGIKPVMEQYGLIPE
0 1 K269 EEDICFIKEQIVGPL
0 14 S278 QIVGPLESPVEDSLW
0 1 E281 GPLESPVEDSLWPYK
0 1 S283 LESPVEDSLWPYKGR
0 1 K294-ac YKGRPENkSFLYEIV
0 1 K294-ub YKGRPENkSFLYEIV
0 4 K304-ub LYEIVSNkRNGIDVD
0 2 K312-ub RNGIDVDkWDyFARD
0 3 Y315-p IDVDkWDyFARDCHH
0 1 K332 IQNNFDYKRFIKFAR
0 1 - gap
0 1 - gap
0 1 Y360 DKEVGNLYDMFHTRN
0 2 T384-p KVGNIIDtMItDAFL
0 2 T387-p NIIDtMItDAFLKAD
0 1 Y419-p AIDDMEAyTKLTDNI
0 1 Y432-p NIFLEILySTDPKLK
0 6 K446-ub KDAREILkQIEYRNL
0 1 K455 IEYRNLFKYVGETQP
0 2 K455-ub IEYRNLFkYVGETQP
0 1 S482-p SLPKEVAsAKPkVLL
0 1 K484 PKEVAsAKPkVLLDV
0 1 K486-ub EVAsAKPkVLLDVKL
0 1 Y507-p VDVINMDyGMQEKNP
0 1 K544 VSQLLPEKFAEQLIR
0 1 K544-ub VSQLLPEkFAEQLIR
0 1 Y553-p AEQLIRVyCKKVDRK
0 1 T579-p WCADRNFtKPQDGDV
7 39 T592-p DVIAPLItPQKKEWN
0 1 T608-p STSVQNPtRLREASK
0 1 S616-p RLREASKsRVQLFKD
  mouse

 
L6 __MQSAPLEQPAkRP
K11-ub APLEQPAkRPRCDGs
S18-p kRPRCDGsPRtPPst
T21-p RCDGsPRtPPstPPA
P23 DGsPRtPPstPPAtA
S24-p GsPRtPPstPPAtAN
T25-p sPRtPPstPPAtANL
P27 RtPPstPPAtANLsA
T29-p PPstPPAtANLsADD
S33-p PPAtANLsADDDFQN
K64-ub NRGFREKkVLDIFRD
D67 FREKkVLDIFRDNKI
S94 LEDLGVSSLEERKKM
K100 SSLEERKKMIECIQQ
E103 EERKKMIECIQQLSQ
C104 ERKKMIECIQQLSQS
T139 LLIRIIDTPQFQRLR
Y147 PQFQRLRYIKQLGGG
K149 FQRLRYIKQLGGGYY
Y156 KQLGGGYYVFPGASH
K256-ac NELKLVMkNYGLVPE
K270-ub EEDITFIkEQIMGPP
T279-p QIMGPPItPVkDsLW
K282-ub GPPItPVkDsLWPYK
S284-p PItPVkDsLWPYKGR
K295 YKGRPATKSFLYEIV
K295 YKGRPATKSFLYEIV
K305-ub LYEIVSNkRNGIDVD
K313-ub RNGIDVDkWDyFARD
Y316-p IDVDkWDyFARDCHH
K333-ac IQNNFDYkRFIKFAR
K347-ub RICEVEYkVKEDkTY
K352-ub EYkVKEDkTYIRKVK
Y372-p EKEVGNLyDMFHTRN
I396 KISNLIDIMITDAFL
T399 NLIDIMITDAFLKAD
F431 AIDDMEAFTKLTDNI
H444 NIFLEVLHSTDPQLS
R458 SEAQSILRNIECRNL
K467-ac IECRNLYkYLGETQP
K467-ub IECRNLYkYLGETQP
K493 RLPQEVAKAkPEKAP
K495-ub PQEVAKAkPEKAPDV
E497 EVAKAkPEKAPDVEL
Y518 VDVINVDYGMEDKNP
K555-ac VSQLLPEkFAEQLIR
K555 VSQLLPEKFAEQLIR
Y564 AEQLIRVYCKKKDGK
T590 WCALRDFTKPQDGDI
T603-p DIIAPLItPLKWNNK
- under review  
V621 CLQEVSKVKTCLKF_
  rat

 
S6 __MQRPDSEQPAKRS
K11 PDSEQPAKRSRCDGs
S18-p KRSRCDGsPRtPPST
T21-p RCDGsPRtPPSTRPA
P23 DGsPRtPPSTRPAAA
S24 GsPRtPPSTRPAAAN
T25 sPRtPPSTRPAAANE
P27 RtPPSTRPAAANESA
A29 PPSTRPAAANESADP
S33 RPAAANESADPESSD
K62 KRGFREKKVLDIFRE
D65 FREKKVLDIFRENKI
S92 LESLGVSSLEQRKKM
K98 SSLEQRKKMIECIQK
E101 EQRKKMIECIQKLNQ
C102 QRKKMIECIQKLNQS
T137 LLIRIIDTPQFQRLR
Y145 PQFQRLRYIKQLGGG
K147 FQRLRYIKQLGGGYY
Y154 KQLGGGYYVFPGASH
K254 NELKLVMKNYGLVPE
K268 EEDITFIKEQIMGPP
S277-p QIMGPPVsPVKDCLW
K280 GPPVsPVKDCLWPYK
C282 PVsPVKDCLWPYKGR
K293 YKGRPAKKSFLYEIV
K293 YKGRPAKKSFLYEIV
K303 LYEIVANKRNGIDVD
K311 RNGIDVDKWDYFARD
Y314 IDVDKWDYFARDCHH
K331 IQNNFDYKRFIKFAR
- gap
- gap
Y365 EKEVGNLYDMFHTRN
I389 KIGNLIDIMITEAFL
T392 NLIDIMITEAFLKAD
F424 AIHDMEAFSKLTDNI
Y437 NIFLEILYSTDPQLS
R451 SEARNILRNIECRNL
K460 IECRNLYKYLGETQP
K460 IECRNLYKYLGETQP
N486 KLAQEVANAKPEIAP
K488 AQEVANAKPEIAPDV
E490 EVANAKPEIAPDVEL
Y511 VDVINMDYGMEDKNP
K548-ac VSQLLPQkFAEQLIR
K548 VSQLLPQKFAEQLIR
Y557 AEQLIRVYYKKKDKK
T583 WCALRDFTKPQDGDI
T596 DIIAPLITPLKWNKK
- under review  
V614 CIEEVSKVKTCLKF_
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