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Protein Page:
UCHL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UCHL1 Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Monomer. Homodimer. Interacts with SNCA. Interacts with COPS5. Found in neuronal cell bodies and processes throughout the neocortex. Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Belongs to the peptidase C12 family. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Protease; Cell development/differentiation; EC 3.4.19.12; EC 6.-.-.-; Ligase
Cellular Component: endoplasmic reticulum membrane; cell soma; axon; cytoplasm; nucleolus; plasma membrane; nucleus; cytosol
Molecular Function: ubiquitin thiolesterase activity; omega peptidase activity; ubiquitin binding; protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; alpha-2A adrenergic receptor binding; ligase activity
Biological Process: cell death; ubiquitin-dependent protein catabolic process; negative regulation of MAP kinase activity; cell proliferation; axon transport of mitochondrion; protein deubiquitination; axon target recognition; eating behavior; neuromuscular process; sensory perception of pain; muscle fiber development; adult walking behavior
Reference #:  P09936 (UniProtKB)
Alt. Names/Synonyms: Neuron cytoplasmic protein 9.5; PARK5; PGP 9.5; PGP9.5; PGP95; ubiquitin C-terminal hydrolase; ubiquitin carboxyl-terminal esterase L1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; UCH-L1; UCHL1
Gene Symbols: UCHL1
Molecular weight: 24,824 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UCHL1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K4-ac ____MQLkPMEINPE
0 44 K4-ub ____MQLkPMEINPE
0 3 K15-ub INPEMLNkVLSRLGV
0 1 R19 MLNkVLSRLGVAGQW
0 4 K64-ub AQHENFRkkQIEELk
0 17 K65-ub QHENFRkkQIEELkG
0 42 K71-ub kkQIEELkGQEVSPk
0 5 K78-ub kGQEVSPkVYFMkQT
0 5 K83-ub SPkVYFMkQTIGNSC
0 5 K105-ub AVANNQDkLGFEDGS
0 8 K115-ub FEDGSVLkQFLSETE
0 14 K123-ub QFLSETEkMSPEDRA
0 2 S125 LSETEkMSPEDRAKC
0 39 K135-ub DRAKCFEkNEAIQAA
0 41 K157-ub GQCRVDDkVNFHFIL
0 1 S188-p FPVNHGAssEDtLLk
0 1 S189-p PVNHGAssEDtLLkD
0 1 T192-p HGAssEDtLLkDAAK
0 3 K195-ub ssEDtLLkDAAKVCR
0 1 K195-ac ssEDtLLkDAAKVCR
0 1 K221-ub FSAVALCkAA_____
  mouse

 
K4 ____MQLKPMEINPE
K4-ub ____MQLkPMEINPE
K15-ub INPEMLNkVLAkLGV
K19-ub MLNkVLAkLGVAGQW
K64 AQHENFRKkQIEELk
K65-ub QHENFRKkQIEELkG
K71-ub KkQIEELkGQEVSPk
K78-ub kGQEVSPkVYFMKQT
K83 SPkVYFMKQTIGNSC
K105 AVANNQDKLEFEDGS
K115 FEDGSVLKQFLSETE
K123-ub QFLSETEkLsPEDRA
S125-p LSETEkLsPEDRAKC
K135-ub DRAKCFEkNEAIQAA
K157-ub GQCRVDDkVNFHFIL
S188 FPVNHGASSEDSLLQ
S189 PVNHGASSEDSLLQD
S192 HGASSEDSLLQDAAK
Q195 SSEDSLLQDAAKVCR
Q195 SSEDSLLQDAAKVCR
K221 FSAVALCKAA_____
  rat

 
K4-ac ____MQLkPMEINPE
K4-ub ____MQLkPMEINPE
K15 INPEMLNKVLAKLGV
K19 MLNKVLAKLGVAGQW
K64-ub AQHENFRkKQIEELk
K65 QHENFRkKQIEELkG
K71-ub kKQIEELkGQEVSPK
K78 kGQEVSPKVYFMKQT
K83 SPKVYFMKQTIGNSC
K105 AVANNQDKLEFEDGS
K115 FEDGSVLKQFLSETE
K123-ub QFLSETEkLsPEDRA
S125-p LSETEkLsPEDRAKC
K135-ub DRAKCFEkNEAIQAA
K157-ub GQCRVDDkVNFHFIL
S188 FPVNHGASSEDSLLQ
S189 PVNHGASSEDSLLQD
S192 HGASSEDSLLQDAAK
Q195 SSEDSLLQDAAKVCR
Q195 SSEDSLLQDAAKVCR
K221 FSAVALCKAA_____
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