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UCHL1
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Monomer. Homodimer. Interacts with SNCA. Interacts with COPS5. Found in neuronal cell bodies and processes throughout the neocortex. Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Belongs to the peptidase C12 family. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system; Ligase; EC 3.4.19.12; EC 6.-.-.-; Cell development/differentiation; Protease |
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Cellular Component: endoplasmic reticulum membrane; cytoplasm; plasma membrane; nucleolus; nucleus
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Molecular Function: ubiquitin thiolesterase activity; protein binding; ubiquitin binding; omega peptidase activity; cysteine-type endopeptidase activity; alpha-2A adrenergic receptor binding; ligase activity
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Biological Process: ubiquitin-dependent protein catabolic process; cell death; negative regulation of MAP kinase activity; protein deubiquitination
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Reference #:
P09936 (UniProtKB)
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| Alt. Names/Synonyms: Neuron cytoplasmic protein 9.5; PARK5; PGP 9.5; PGP9.5; PGP95; ubiquitin C-terminal hydrolase; ubiquitin carboxyl-terminal esterase L1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; UCH-L1; UCHL1 |
| Gene Symbols: UCHL1 |
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Molecular weight: 24,824 Da
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Basal Isoelectric point: 5.33
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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