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C/EBP-beta
a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-alpha, -delta and -gamma. Involved in immune and inflammatory responses. Specifically binds to regulatory regions of genes encoding IL-6, other cytokines and several acute-phase proteins. There are two forms of C/EBPbeta, the 38kDa liver activating protein (LAP) and the 20kDa liver inhibitory protein (LIP) which may be products of alternative translation. LAP is a transcriptional activator while LIP may inhibit C/EBPbeta transcriptional activity. Phosphorylated and activated by ERK1/2. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Transcription factor; DNA binding protein |
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Cellular Component: nuclear matrix; nuclear chromatin; cytoplasm; nucleus
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Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor binding; glucocorticoid receptor binding
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Biological Process: fat cell differentiation; embryonic placenta development; positive regulation of transcription, DNA-dependent; regulation of interleukin-6 biosynthetic process; mammary gland epithelial cell proliferation; response to lipopolysaccharide; neuron differentiation; positive regulation of osteoblast differentiation; regulation of transcription, DNA-dependent; induction of apoptosis; brown fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
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Reference #:
P21272 (UniProtKB)
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| Alt. Names/Synonyms: C/EBP beta; C/EBP-related protein 2; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; Cebpb; Crp2; IL-6DBP; Il6dbp; Interleukin-6-dependent-binding protein; LAP; Liver activating protein (LAP also NF-IL6 nuclear factor-IL6 previously designated TCF5); liver activating protein (LAP); Liver activating protein (LAP, also NF-IL6, nuclear factor-IL6, previously designated TCF5); Liver-enriched transcriptional activator; NF-IL6; nuclear factor-IL6; SF-B; Sfb; Silencer factor B; TCF5 |
| Gene Symbols: Cebpb |
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Molecular weight: 31,503 Da
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Basal Isoelectric point: 8.78
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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MAPK/Erk in Growth and Differentiation
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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