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Protein Page:
C/EBP-beta (rat)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
C/EBP-beta a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-alpha, -delta and -gamma. Involved in immune and inflammatory responses. Specifically binds to regulatory regions of genes encoding IL-6, other cytokines and several acute-phase proteins. There are two forms of C/EBPbeta, the 38kDa liver activating protein (LAP) and the 20kDa liver inhibitory protein (LIP) which may be products of alternative translation. LAP is a transcriptional activator while LIP may inhibit C/EBPbeta transcriptional activity. Phosphorylated and activated by ERK1/2. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Motility/polarity/chemotaxis; DNA binding protein
Cellular Component: nucleoplasm; nuclear matrix; nuclear chromatin; cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; chromatin binding; transcription factor binding; glucocorticoid receptor binding
Biological Process: fat cell differentiation; neuron differentiation; transcription from RNA polymerase II promoter; positive regulation of osteoblast differentiation; embryonic placenta development; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of interleukin-6 biosynthetic process; brown fat cell differentiation; mammary gland epithelial cell proliferation; positive regulation of fat cell differentiation; response to lipopolysaccharide; positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron apoptosis; negative regulation of transcription, DNA-dependent
Reference #:  P21272 (UniProtKB)
Alt. Names/Synonyms: C/EBP beta; C/EBP-related protein 2; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; Cebpb; Crp2; IL-6DBP; Il6dbp; Interleukin-6-dependent-binding protein; LAP; Liver activating protein (LAP also NF-IL6 nuclear factor-IL6 previously designated TCF5); liver activating protein (LAP); Liver activating protein (LAP, also NF-IL6, nuclear factor-IL6, previously designated TCF5); Liver-enriched transcriptional activator; NF-IL6; nuclear factor-IL6; SF-B; Sfb; Silencer factor B; TCF5
Gene Symbols: Cebpb
Molecular weight: 31,503 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Growth And Differentiation Control by MAPKs  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

C/EBP-beta

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell cycle regulation: S105‑p, S273‑p
cell growth, altered: S64‑p, S105‑p, T189‑p
cell growth, induced: Y109‑p, S111‑p, R114‑m1
transcription, altered: S185‑p, T189‑p
transcription, induced: S64‑p, Y109‑p, S111‑p, R114‑m1, S273‑p
molecular association, regulation: S105‑p, Y109‑p, S111‑p, R114‑m1, S273‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
1 0 R3 _____MHRLLAWDAA
3 0 K39-ac DCLAYGAkAARAAPR
1 0 K39 DCLAYGAKAARAAPR
0 1 A53 RAPAAEPAIGEHERA
7 1 S64-p HERAIDFsPYLEPLA
1 0 Y66 RAIDFsPYLEPLAPA
5 0 S105-p AKPSKKPsDYGyVsL
0 5 Y107 PSKKPsDYGyVsLGr
1 4 Y109-p KKPsDYGyVsLGrAG
1 3 S111-p PsDYGyVsLGrAGAK
0 1 R114-m1 YGyVsLGrAGAKAAP
1 0 K118 sLGrAGAKAAPPACF
2 0 K134 PPPPAALKAEPGFEP
0 1 T170 AYLGYQATPSGSSGs
0 2 S172 LGYQATPSGSSGsLS
0 1 S175 QATPSGSSGsLSTsS
2 1 S177-p TPSGSSGsLSTsSSS
6 1 T180 GSSGsLSTsSSSsPP
2 0 S181-p SSGsLSTsSSSsPPG
1 0 S181 SSGsLSTSSSSsPPG
0 1 S182 SGsLSTsSSSsPPGt
1 0 S182 SGsLSTsSSSsPPGt
0 1 S183 GsLSTsSSSsPPGtP
0 3 S184 sLSTsSSSsPPGtPS
8 7 S185-p LSTsSSSsPPGtPSP
28 5 T189-p SSSsPPGtPSPADAK
0 2 A211 AGPPAAPAKAKAkkA
4 0 K216-ac APAKAKAkkAVDKLS
4 1 K217-ac PAKAKAkkAVDKLSD
4 0 A218 AKAKAkkAVDKLSDE
0 1 K221 KAkkAVDKLSDEYKM
3 0 S240-p NNIAVRKsRDKAKMR
1 2 S273-p QKKVEQLsRELSTLR
1 0 S277 EQLsRELSTLRNLFK
3081 : Phospho-C/EBPbeta (Ser105) Antibody (Rat Specific)
3084 : Phospho-C/EBPbeta (Thr235) Antibody
  human

 
R3-m2 _____MQrLVAWDPA
K43 LAAAYGGKAAPAAPP
K43 LAAAYGGKAAPAAPP
S65-p PPAGELGsIGDHERA
S76-p HERAIDFsPyLEPLG
Y78-p RAIDFsPyLEPLGAP
A135 GKNCKKPAEyGyVsL
Y137-p NCKKPAEyGyVsLGR
Y139-p KKPAEyGyVsLGRLG
S141-p PAEyGyVsLGRLGAA
R144 yGyVsLGRLGAAKGA
K149 LGRLGAAKGALHPGC
K174-sm PPPPAELkAEPGFEP
V216 AYLGYQAVPsGSSGs
S218-p LGYQAVPsGSSGsLS
S221 QAVPsGSSGsLSTSS
S223-p VPsGSSGsLSTSSss
T226 GSSGsLSTSSsssPP
S227 SSGsLSTSSsssPPG
S227 SSGsLSTSSsssPPG
S228 SGsLSTSSsssPPGt
S228 SGsLSTSSsssPPGt
S229-p GsLSTSSsssPPGtP
S230-p sLSTSSsssPPGtPS
S231-p LSTSSsssPPGtPSP
T235-p SsssPPGtPSPADAK
S257-p AGAAPAPsQVKSKAk
K264-ac sQVKSKAkktVDkHS
K265-ac QVKSKAkktVDkHSD
T266-p VKSKAkktVDkHSDE
K269-ac KAkktVDkHSDEYKI
S288-p NNIAVRKsRDKAKMR
S321 QKKVEQLSRELsTLR
S325-p EQLSRELsTLRNLFK
3084 : Phospho-C/EBPbeta (Thr235) Antibody
  mouse

 
R3 _____MHRLLAWDAA
K39-ac DCLAYGAkAARAAPR
K39-me DCLAYGAkAARAAPR
A53 RAPAAEPAIGEHERA
S64-p HERAIDFsPYLEPLA
Y66 RAIDFsPYLEPLAPA
A104 AKPSKKPADYGYVSL
Y106 PSKKPADYGYVSLGR
Y108 KKPADYGYVSLGRAG
S110 PADYGYVSLGRAGAk
R113 YGYVSLGRAGAkAAP
K117-ac SLGRAGAkAAPPACF
K133 PPPPAALKAEPGFEP
T169-p AYLGYQAtPSGSsGs
S171 LGYQAtPSGSsGsLS
S174-p QAtPSGSsGsLStss
S176-p tPSGSsGsLStssSs
T179-p GSsGsLStssSssPP
S180 SsGsLStSsSssPPG
S180-gl SsGsLStssSssPPG
S181-p sGsLStssSssPPGt
S181-gl sGsLStssSssPPGt
S182 GsLStssSssPPGtP
S183-p sLStssSssPPGtPS
S184-p LStssSssPPGtPSP
T188-p sSssPPGtPSPADAK
A210 AGPPAAPAKAKAkkt
K215-ac APAKAKAkktVDKLS
K216-ac PAKAKAkktVDKLSD
T217-p AKAKAkktVDKLSDE
K220 KAkktVDKLSDEYKM
S239 NNIAVRKSRDKAKMR
S272-p QKKVEQLsRELSTLR
S276 EQLsRELSTLRNLFK
3084 : Phospho-C/EBPbeta (Thr235) Antibody
  chicken

 
R3 _____MQRLVAWDAA
K39 DCLAALNKLHPRAAG
K39-me DCLAALNkLHPRAAG
T54 GRSMTELTVGDHERA
S65 HERAIDFSPYLDPLA
Y67 RAIDFSPYLDPLAAS
P120 GSGGGKKPDYTYISL
Y122 GGGKKPDYTYISLTR
Y124 GKKPDYTYISLTRHG
S126 KPDYTYISLTRHGHP
R129 YTYISLTRHGHPCGS
P133 SLTRHGHPCGSQSHK
K156 PPQIVETKVEPVFET
V201 SYLGYQSVPSGSSGN
S203 LGYQSVPSGSSGNLS
S206 QSVPSGSSGNLSTSS
N208 VPSGSSGNLSTSSSS
T211 GSSGNLSTSSSSSPP
S212 SSGNLSTSSSSSPPG
S212 SSGNLSTSSSSSPPG
S213 SGNLSTSSSSSPPGT
S213 SGNLSTSSSSSPPGT
S214 GNLSTSSSSSPPGTP
S215 NLSTSSSSSPPGTPN
S216 LSTSSSSSPPGTPNP
T220 SSSSPPGTPNPSESS
- under review  
K247 PAGKNKPKKCVDKHS
K248 AGKNKPKKCVDKHSD
C249 GKNKPKKCVDKHSDE
K252 KPKKCVDKHSDEYKL
S271 NNIAVRKSRDKAKMR
S304 QKKVEQLSRELSTLR
S308 EQLSRELSTLRNLFK
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