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Protein Page:
STIM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STIM1 Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1. Forms homooligomers and heterooligomers with STIM2. Interacts with ORAI1. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and ORAI1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with TMEM66/SARAF, promoting a slow inactivation of STIM1-dependent SOCE activity, possibly by facilitating the deoligomerization of STIM1. Ubiquitously expressed in various human primary cells and tumor cell lines. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding protein; Endoplasmic reticulum; Membrane protein, integral
Cellular Component: microtubule; endoplasmic reticulum membrane; growth cone; endoplasmic reticulum; integral to plasma membrane; integral to endoplasmic reticulum membrane
Molecular Function: microtubule plus-end binding; identical protein binding; store-operated calcium channel activity; protein binding; calcium channel regulator activity; calcium ion binding
Biological Process: activation of store-operated calcium channel activity; regulation of calcium ion transport; detection of calcium ion; blood coagulation
Reference #:  Q13586 (UniProtKB)
Alt. Names/Synonyms: D11S4896E; GOK; STIM1; Stromal interaction molecule 1
Gene Symbols: STIM1
Molecular weight: 77,423 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STIM1

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S628‑p, S668‑p
activity, inhibited: S486‑p, S668‑p
intracellular localization: S628‑p, S668‑p
molecular association, regulation: S575‑p, S628‑p, S668‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T175 AVTNTTMTGTVLKMT
0 1 Y236-p FAYIQNRySKEHMKK
0 1 K246-ub EHMKKMMkDLEGLHR
0 30 S257-p GLHRAEQsLHDLQER
0 1 K267-ub DLQERLHkAQEEHRT
0 2 K315-ub ENERSRQkYAEEELE
0 1 K333 EALRKAEKELESHSS
0 1 Y361 THEVEVQYYNIKKQN
0 1 T393-p KRNTLFGtFHVAHSS
0 2 K413 DHKILTAKQALSEVt
0 2 K413-ub DHKILTAkQALSEVt
0 1 T420-p kQALSEVtAALRERL
1 0 S486-p DMDEEIVsPLSMQsP
0 1 S492-p VsPLSMQsPSLQSsV
0 1 S498-p QsPSLQSsVRQRLTE
0 10 T504 SsVRQRLTEPQHGLG
0 46 S512-p EPQHGLGsQRDLtHs
0 1 R514 QHGLGsQRDLtHsDs
0 3 T517-p LGsQRDLtHsDsEss
0 25 S519-p sQRDLtHsDsEssLH
0 22 S521-p RDLtHsDsEssLHMs
0 3 S523-p LtHsDsEssLHMsDR
0 8 S524-p tHsDsEssLHMsDRQ
0 2 S528-p sEssLHMsDRQRVAP
0 1 S553-p EALNAMTsNGSHRLI
0 6 S567-p IEGVHPGsLVEKLPD
5 49 S575-p LVEKLPDsPALAKKA
0 3 S595-p HGLDKAHsLMELsPs
0 2 S600-p AHsLMELsPsAPPGG
0 2 S602-p sLMELsPsAPPGGsP
4 8 S608-p PsAPPGGsPHLDSSR
0 6 S616-p PHLDSSRsHsPssPD
0 12 S618-p LDSSRsHsPssPDPD
0 6 S620-p SSRsHsPssPDPDtP
4 6 S621-p SRsHsPssPDPDtPs
0 8 T626-p PssPDPDtPsPVGDS
1 8 S628-p sPDPDtPsPVGDSRA
0 10 S660-p VAEEDNGsIGEEtDS
0 3 T665-p NGsIGEEtDSsPGRK
0 1 S667 sIGEEtDSsPGRKKF
2 13 S668-p IGEEtDSsPGRKKFP
0 1 K677-ub GRKKFPLkIFkkPLK
0 1 K680-ac KFPLkIFkkPLKK__
0 1 K681-ac FPLkIFkkPLKK___
  mouse

 
T175-p AVTNTTMtGTVLKMT
Y236 FAYIQNRYSKEHMKK
K246 EHMKKMMKDLEGLHR
S257-p GLHRAEQsLHDLQER
K267 DLQERLHKAQEEHRT
K315 ENERSRQKYAEEELE
K333-ub EALRKAEkELESHSS
Y361-p THEVEVQyYNIKKQN
T393 KRNTLFGTFHVAHSS
K413-ac DHKILTAkQALSEVT
K413-ub DHKILTAkQALSEVT
T420 kQALSEVTAALRERL
S486 DMDEEIVSPLSMQSP
S492 VSPLSMQSPSLQSSV
S498 QSPSLQSSVRQRLtE
T504-p SSVRQRLtEPQLGLG
S512-p EPQLGLGsQrDLtHs
R514-m1 QLGLGsQrDLtHsDs
T517-p LGsQrDLtHsDsEss
S519-p sQrDLtHsDsEssLH
S521-p rDLtHsDsEssLHMs
S523-p LtHsDsEssLHMsDR
S524-p tHsDsEssLHMsDRQ
S528-p sEssLHMsDRQRVAP
S553 EALNAMPSNGSHRLI
S567-p IEGVHPGsLVEKLPD
S575-p LVEKLPDsPALAKKT
S595-p HGLDKAHsLMELNPS
N600 AHsLMELNPSVPPGG
S602 sLMELNPSVPPGGsP
S608-p PSVPPGGsPLLDSSH
S616 PLLDSSHSLSPSsPD
S618 LDSSHSLSPSsPDPD
S620 SSHSLSPSsPDPDTP
S621-p SHSLSPSsPDPDTPs
T626 PSsPDPDTPsPVGDN
S628-p sPDPDTPsPVGDNRA
S660-p MAEEDNGsIGEEtDs
T665-p NGsIGEEtDssPGRK
S667-p sIGEEtDssPGRKKF
S668-p IGEEtDssPGRKKFP
K677 GRKKFPLKIFKKPLK
K680 KFPLKIFKKPLKK__
K681 FPLKIFKKPLKK___
  rat

 
T175 AVTNTTMTGTVLKMT
Y236 FAYIQNRYSKEHMKK
K246 EHMKKMMKDLEGLHR
S257-p GLHRAEQsLHDLQER
K267 DLQERLHKAQEEHRT
K315 ENERSRQKYAEEELE
K333 EALRKAEKELESHSS
Y361 THEVEVQYYNIKKQN
T393 KRNTLFGTFHVAHSS
K413 DHKILTAKQALSEVT
K413 DHKILTAKQALSEVT
T420 KQALSEVTAALRERL
S486 DMDEEIVSPLSMQSP
S492 VSPLSMQSPSLQSSV
S498 QSPSLQSSVRQRLTE
T504 SSVRQRLTEPQHGLG
S512-p EPQHGLGsQRDLtHs
R514 QHGLGsQRDLtHsDs
T517-p LGsQRDLtHsDsESS
S519-p sQRDLtHsDsESSLH
S521-p RDLtHsDsESSLHTS
S523 LtHsDsESSLHTSDR
S524 tHsDsESSLHTSDRQ
S528 sESSLHTSDRQRVAP
S553 EALNATSSNGSHRLI
S567-p IEGVHPGsLVEKLPD
S575-p LVEKLPDsPALAKKT
S595 HGLDKAHSLMELNPS
N600 AHSLMELNPSVPPGG
S602 SLMELNPSVPPGGSP
S608 PSVPPGGSPLLDSSH
S616 PLLDSSHSHSPSSPD
S618 LDSSHSHSPSSPDPD
S620 SSHSHSPSSPDPDTP
S621 SHSHSPSSPDPDTPS
T626 PSSPDPDTPSPVGDS
S628 SPDPDTPSPVGDSRA
S660-p MAEEDNGsIGEETDS
T665 NGsIGEETDSsPGRK
S667 sIGEETDSsPGRKKF
S668-p IGEETDSsPGRKKFP
K677 GRKKFPLKIFKKPLK
K680 KFPLKIFKKPLKK__
K681 FPLKIFKKPLKK___
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