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Protein Page:
HIP (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HIP One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90. Interacts (via the C-terminus 303- 319 AA) with GRK5. Belongs to the FAM10 family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: protein complex; cytoplasm; cytosol
Molecular Function: protein binding, bridging; protein domain specific binding; identical protein binding; protein binding; chaperone binding; unfolded protein binding; protein complex binding; dATP binding; Hsp70 protein binding
Biological Process: protein folding; protein homooligomerization
Reference #:  P50502 (UniProtKB)
Alt. Names/Synonyms: AAG2; aging-associated protein 2; F10A1; FAM10A1; FAM10A4; FLJ27260; heat shock 70kD protein binding protein; HIP; HOP; Hsc70-interacting protein; Hsp70-interacting protein; HSPABP; HSPABP1; MGC129952; P48; PRO0786; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; SNC6; ST13; suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein); Suppression of tumorigenicity 13 protein
Gene Symbols: ST13
Molecular weight: 41,332 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HIP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 17 K14-u NELRAFVkMCKQDPS
0 2 K41-u WVESMGGkVPPATQK
0 4 K50-u PPATQKAkSEENTkE
0 6 K56-u AkSEENTkEEkPDSK
0 1 K59-u EENTkEEkPDSKKVE
0 13 S75-p DLKADEPssEEsDLE
1 16 S76-p LKADEPssEEsDLEI
1 18 S79-p DEPssEEsDLEIDKE
0 3 K118-u MDQANDKkVAAIEAL
0 8 K142-u DLFTDAIkLNPRLAI
0 8 K153-a RLAILYAkRAsVFVk
0 5 K153-u RLAILYAkRAsVFVk
0 1 S156-p ILYAkRAsVFVkLQk
0 1 K160 kRAsVFVKLQkPNAA
0 7 K160-u kRAsVFVkLQkPNAA
0 1 K163-u sVFVkLQkPNAAIRD
0 3 S181-p AIEINPDsAQPYkWR
0 4 K186-u PDsAQPYkWRGKAHR
0 1 K222-u EDASAMLkEVQPRAQ
1 0 S346-p AQNPANMskYQSNPk
0 17 K347-u QNPANMskYQSNPkV
0 23 K353-u skYQSNPkVMNLISk
0 14 K360-u kVMNLISkLSAkFGG
0 60 K364-u LISkLSAkFGGQA__
  mouse

 
K14-u SELRAFVkMCRQDPS
K41 WVESMGGKVPPATHK
K50 PPATHKAKSEENTKE
K56 AKSEENTKEEKRDKT
K59 EENTKEEKRDKTTEE
S74 NIKTEELSSEESDLE
S75 IKTEELSSEESDLEI
S78 EELSSEESDLEIDNE
K117-u MDEANEKkGAAIEAL
K141-u DLFTDAIkLNPRLAI
K152-a RLAILYAkRASVFVk
K152-u RLAILYAkRASVFVk
S155 ILYAkRASVFVkLQK
K159-a kRASVFVkLQKPNAA
K159-u kRASVFVkLQKPNAA
K162 SVFVkLQKPNAAIRD
S180 AIEINPDSAQPYkWR
K185-u PDSAQPYkWRGKAHR
R221 EDASAMLREVQPRAQ
S348 AQNPSNMSkYQSNPk
K349-u QNPSNMSkYQSNPkV
K355-u SkYQSNPkVMNLISk
K362-u kVMNLISkLSAkFGG
K366-u LISkLSAkFGGQS__
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