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Protein Page:
PBX1 (human)

Overview
PBX1 Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1. Expressed in all tissues except in cells of the B and T lineage. Belongs to the TALE/PBX homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor; Motility/polarity/chemotaxis
Cellular Component: transcription factor complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription factor binding; transcription factor activity
Biological Process: spleen development; thymus development; embryonic hemopoiesis; adrenal gland development; negative regulation of transcription factor activity; embryonic skeletal development; anterior/posterior pattern formation; negative regulation of neuron differentiation; organ morphogenesis; ureteric bud branching; positive regulation of cell proliferation; regulation of ossification; steroid biosynthetic process; sex differentiation; proximal/distal pattern formation; embryonic limb morphogenesis
Reference #:  P40424 (UniProtKB)
Alt. Names/Synonyms: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; PBX1; Pre-B cell leukemia transcription factor-1; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1; PRL
Gene Symbols: PBX1
Molecular weight: 46,626 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PBX1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 7 S325 AHGSQANSPSTPNSA
0 2 S331 NSPSTPNSAGSSSSF
0 4 - gap
  PBX1 iso2  
S325-p AHGSQANsPSTPNsA
S331-p NsPSTPNsAGGYPsP
S337-p NsAGGYPsPCYQPDR
  mouse

► Hide Isoforms
 
S325 AHGSQANSPSTPNSA
S331 NSPSTPNSAGSSSSF
- gap
  PBX1 iso2  
S325-p AHGSQANsPSTPNsA
S331-p NsPSTPNsAGGYPsP
S337-p NsAGGYPsPCYQPDR
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