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PBX1 (human)

Overview PBX1 Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1. Expressed in all tissues except in cells of the B and T lineage. Belongs to the TALE/PBX homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Transcription factor; DNA binding protein Cellular Component: transcription factor complex; cytoplasm; nucleolus; nucleus Molecular Function: protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor binding; transcription factor activity Biological Process: spleen development; transcription, DNA-dependent; thymus development; adrenal gland development; embryonic hemopoiesis; embryonic skeletal development; negative regulation of transcription factor activity; anterior/posterior pattern formation; negative regulation of neuron differentiation; organ morphogenesis; ureteric bud branching; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of ossification; steroid biosynthetic process; sex differentiation; proximal/distal pattern formation; embryonic limb morphogenesis Reference #:  P40424 (UniProtKB) Alt. Names/Synonyms: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; PBX1; Pre-B cell leukemia transcription factor-1; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1; PRL Gene Symbols: PBX1 Molecular weight: 46,626 Da Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PBX1 1B72 - B=233-319 (human) 1PUF - B=233-305 (human) 1DU6 - A=241-294 (mouse) 1LFU - P=233-313 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1B72 1PUF  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K287	VSNWFGNKRIRYKKN
0	1		Y305-p	FQEEANIyAAKTAVT
0	7		S325	AHGSQANSPSTPNSA
0	1		S327	GSQANSPSTPNSAGS
0	1		T328	SQANSPSTPNSAGSS
0	2		S331	NSPSTPNSAGSSSSF
0	1		-	gap
0	4		-	gap

	PBX1 iso2
K287	VSNWFGNKRIRYKKN
Y305	FQEEANIYAAKTAVT
S325-p	AHGSQANsPStPNsA
S327	GSQANsPStPNsAGG
T328-p	SQANsPStPNsAGGy
S331-p	NsPStPNsAGGyPsP
Y335-p	tPNsAGGyPsPCYQP
S337-p	NsAGGyPsPCYQPDR

	mouse ► Hide Isoforms
K287-a	VSNWFGNkRIRYKKN
Y305	FQEEANIYAAKTAVT
S325	AHGSQANSPSTPNSA
S327	GSQANSPSTPNSAGS
T328	SQANSPSTPNSAGSS
S331	NSPSTPNSAGSSSSF
-	gap
-	gap

	PBX1 iso2
K287	VSNWFGNKRIRYKKN
Y305	FQEEANIYAAKTAVT
S325-p	AHGSQANsPsTPNsA
S327-p	GSQANsPsTPNsAGG
T328	SQANsPsTPNsAGGY
S331-p	NsPsTPNsAGGYPsP
Y335	TPNsAGGYPsPCYQP
S337-p	NsAGGYPsPCYQPDR

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