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Protein Page:
PBX1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PBX1 Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1. Expressed in all tissues except in cells of the B and T lineage. Belongs to the TALE/PBX homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; DNA binding protein; Transcription factor
Cellular Component: transcription factor complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor binding; transcription factor activity
Biological Process: spleen development; thymus development; transcription, DNA-dependent; adrenal gland development; embryonic hemopoiesis; negative regulation of transcription factor activity; embryonic skeletal development; anterior/posterior pattern formation; organ morphogenesis; negative regulation of neuron differentiation; ureteric bud branching; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of ossification; sex differentiation; steroid biosynthetic process; proximal/distal pattern formation; embryonic limb morphogenesis
Reference #:  P40424 (UniProtKB)
Alt. Names/Synonyms: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; PBX1; Pre-B cell leukemia transcription factor-1; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1; PRL
Gene Symbols: PBX1
Molecular weight: 46,626 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PBX1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S126-p GPEKGGGsAAAAAAA
0 2 S136-p AAAAAAAsGGAGsDN
0 1 S141-p AAsGGAGsDNsVEHS
0 1 S144-p GGAGsDNsVEHSDYR
0 1 K287 VSNWFGNKRIRYKKN
0 1 Y305-p FQEEANIyAAKTAVT
0 7 S325 AHGSQANSPSTPNSA
0 1 S327 GSQANSPSTPNSAGS
0 1 T328 SQANSPSTPNSAGSS
0 2 S331 NSPSTPNSAGSSSSF
0 1 - gap
0 4 - gap
  PBX1 iso2  
S126 GPEKGGGSAAAAAAA
S136 AAAAAAASGGAGSDN
S141 AASGGAGSDNSVEHS
S144 GGAGSDNSVEHSDYR
K287 VSNWFGNKRIRYKKN
Y305 FQEEANIYAAKTAVT
S325-p AHGSQANsPStPNsA
S327 GSQANsPStPNsAGG
T328-p SQANsPStPNsAGGy
S331-p NsPStPNsAGGyPsP
Y335-p tPNsAGGyPsPCYQP
S337-p NsAGGyPsPCYQPDR
  mouse

► Hide Isoforms
 
S126 GPEKGGGSAAAAAAA
S136 AAAAAAASGGAGSDN
S141 AASGGAGSDNSVEHS
S144 GGAGSDNSVEHSDYR
K287-ac VSNWFGNkRIRYKKN
Y305 FQEEANIYAAKTAVT
S325 AHGSQANSPSTPNSA
S327 GSQANSPSTPNSAGS
T328 SQANSPSTPNSAGSS
S331 NSPSTPNSAGSSSSF
- gap
- gap
  PBX1 iso2  
S126 GPEKGGGSAAAAAAA
S136 AAAAAAASGGAGSDN
S141 AASGGAGSDNSVEHS
S144 GGAGSDNSVEHSDYR
K287 VSNWFGNKRIRYKKN
Y305 FQEEANIYAAKTAVT
S325-p AHGSQANsPsTPNsA
S327-p GSQANsPsTPNsAGG
T328 SQANsPsTPNsAGGY
S331-p NsPsTPNsAGGYPsP
Y335 TPNsAGGYPsPCYQP
S337-p NsAGGYPsPCYQPDR
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