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Protein Page:
NDRG3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NDRG3 sequence is similar to alpha/beta hydrolases. During development, NDRG3 is expressed at high levels in the spinal cord and the thymic rudiment. NDRG3 is located throughout the mouse cerebrum and cerebellum. NDRG1 and NDRG3 belong to a subfamily, and NDRG2 and NDRG4 to another. In humans, NDRG3 is highly expressed in brain and testis. Unlike Ndr1, Ndr2 and Ndr3 appear not to be controlled by N-myc or c-myc. Three alternately spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 20q11.21-q11.23
Cellular Component: cytoplasm
Biological Process: spermatogenesis; negative regulation of cell growth; cell differentiation
Reference #:  Q9UGV2 (UniProtKB)
Alt. Names/Synonyms: FLJ13556; N-myc downstream-regulated gene 3; NDRG family member 3; NDRG3; Protein NDRG3
Gene Symbols: NDRG3
Molecular weight: 41,409 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NDRG3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K13-ub DVQLTEIkPLLNDKN
0 1 K19 IkPLLNDKNGTRNFQ
0 1 K51 VTIRGLPKGNRPVIL
0 1 Y308-p KLTEAFKyFLQGMGY
0 7 Y315 yFLQGMGYIPsAsMt
0 2 S318-p QGMGYIPsAsMtRLA
0 4 S320-p MGYIPsAsMtRLARs
0 3 T322-p YIPsAsMtRLARsRt
0 188 S327-p sMtRLARsRtHstss
0 151 T329-p tRLARsRtHstsssL
0 678 S331-p LARsRtHstsssLGs
0 164 T332-p ARsRtHstsssLGsG
0 168 S333-p RsRtHstsssLGsGE
0 385 S334-p sRtHstsssLGsGEs
0 416 S335-p RtHstsssLGsGEsP
0 84 S338-p stsssLGsGEsPFsR
0 28 S341-p ssLGsGEsPFsRsVt
0 3 S344-p GsGEsPFsRsVtsNQ
0 6 S346-p GEsPFsRsVtsNQsD
0 12 T348-p sPFsRsVtsNQsDGt
0 14 S349-p PFsRsVtsNQsDGtQ
0 36 S352-p RsVtsNQsDGtQEsC
0 13 T355-p tsNQsDGtQEsCEsP
0 4 S358-p QsDGtQEsCEsPDVL
0 103 S361-p GtQEsCEsPDVLDRH
0 18 T370-p DVLDRHQtMEVsC__
0 5 S374-p RHQtMEVsC______
  NDRG3 iso2  
K13 DVQLTEIKPLLNDKE
K19 IKPLLNDKEHDIETT
K39 VTIRGLPKGNRPVIL
Y296 KLTEAFKYFLQGMGY
Y303 YFLQGMGYIPSASMT
S306 QGMGYIPSASMTRLA
S308 MGYIPSASMTRLARS
T310 YIPSASMTRLARSRT
S315 SMTRLARSRTHSTSS
T317 TRLARSRTHSTSSSL
S319 LARSRTHSTSSSLGS
T320 ARSRTHSTSSSLGSG
S321 RSRTHSTSSSLGSGE
S322 SRTHSTSSSLGSGES
S323 RTHSTSSSLGSGESP
S326 STSSSLGSGESPFSR
S329 SSLGSGESPFSRSVT
S332 GSGESPFSRSVTSNQ
S334 GESPFSRSVTSNQSD
T336 SPFSRSVTSNQSDGT
S337 PFSRSVTSNQSDGTQ
S340 RSVTSNQSDGTQESC
T343 TSNQSDGTQESCESP
S346 QSDGTQESCESPDVL
S349 GTQESCESPDVLDRH
T358 DVLDRHQTMEVSC__
S362 RHQTMEVSC______
  NDRG3 iso3  
K13 DVQLTEIKPLLNDKN
K19 IKPLLNDKNGTRNFQ
N20 KPLLNDKNGTRNFQD
Y219 KLTEAFKYFLQGMGY
Y226 YFLQGMGYIPSASMT
S229 QGMGYIPSASMTRLA
S231 MGYIPSASMTRLARS
T233 YIPSASMTRLARSRT
S238 SMTRLARSRTHSTSS
T240 TRLARSRTHSTSSSL
S242 LARSRTHSTSSSLGS
T243 ARSRTHSTSSSLGSG
S244 RSRTHSTSSSLGSGE
S245 SRTHSTSSSLGSGES
S246 RTHSTSSSLGSGESP
S249 STSSSLGSGESPFSR
S252 SSLGSGESPFSRSVT
S255 GSGESPFSRSVTSNQ
S257 GESPFSRSVTSNQSD
T259 SPFSRSVTSNQSDGT
S260 PFSRSVTSNQSDGTQ
S263 RSVTSNQSDGTQESC
T266 TSNQSDGTQESCESP
S269 QSDGTQESCESPDVL
S272 GTQESCESPDVLDRH
T281 DVLDRHQTMEVSC__
S285 RHQTMEVSC______
  mouse

 
K13 DVQLTEIKPLLNDkN
K19-ub IKPLLNDkNGTRNFQ
K51-ub VTIRGLPkGNRPVIL
Y308 KLTEAFKYFLQGMGY
Y315 YFLQGMGYIPsAsMt
S318-p QGMGYIPsAsMtRLA
S320-p MGYIPsAsMtRLARs
T322-p YIPsAsMtRLARsRt
S327-p sMtRLARsRtHstss
T329-p tRLARsRtHstsssI
S331-p LARsRtHstsssIGs
T332-p ARsRtHstsssIGsG
S333-p RsRtHstsssIGsGE
S334-p sRtHstsssIGsGEs
S335-p RtHstsssIGsGEsP
S338-p stsssIGsGEsPFSR
S341-p ssIGsGEsPFSRsVt
S344 GsGEsPFSRsVtSNQ
S346-p GEsPFSRsVtSNQsD
T348-p sPFSRsVtSNQsDGt
S349 PFSRsVtSNQsDGtQ
S352-p RsVtSNQsDGtQEsC
T355-p tSNQsDGtQEsCEsP
S358-p QsDGtQEsCEsPDVL
S361-p GtQEsCEsPDVLDRH
T370 DVLDRHQTMEVsC__
S374-p RHQTMEVsC______
  rat

 
K13 DVQLTEIKPLLNDKN
K19 IKPLLNDKNGTRNFQ
K51 VTIRGLPKGNRPVIL
Y308 KLTEAFKYFLQGMGy
Y315-p YFLQGMGyIPSASMT
S318 QGMGyIPSASMTRLA
S320 MGyIPSASMTRLARS
T322 yIPSASMTRLARSRT
S327 SMTRLARSRTHsTss
T329 TRLARSRTHsTsssI
S331-p LARSRTHsTsssIGs
T332 ARSRTHsTsssIGsG
S333-p RSRTHsTsssIGsGE
S334-p SRTHsTsssIGsGEs
S335-p RTHsTsssIGsGEsP
S338-p sTsssIGsGEsPFSR
S341-p ssIGsGEsPFSRSVT
S344 GsGEsPFSRSVTSNQ
S346 GEsPFSRSVTSNQSD
T348 sPFSRSVTSNQSDGT
S349 PFSRSVTSNQSDGTQ
S352 RSVTSNQSDGTQESC
T355 TSNQSDGTQESCESP
S358 QSDGTQESCESPDVL
S361 GTQESCESPDVLDRH
T370 DVLDRHQTMEVSC__
S374 RHQTMEVSC______
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