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C/EBP-alpha (human)

Overview C/EBP-alpha a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-beta and CEBP-gamma. Binds to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: Rb-E2F complex; nuclear matrix; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein domain specific binding; protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; protein complex binding; transcription factor activity; transcription factor binding Biological Process: transcription from RNA polymerase II promoter; embryonic placenta development; macrophage differentiation; cell maturation; response to glucocorticoid stimulus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; response to vitamin B2; acute-phase response; inner ear development; cholesterol metabolic process; mitochondrion organization and biogenesis; generation of precursor metabolites and energy; organ regeneration; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; liver development; positive regulation of osteoblast differentiation; virus-host interaction; white fat cell differentiation; brown fat cell differentiation; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of transcription from RNA polymerase II promoter; myeloid cell differentiation; urea cycle; lung development Reference #:  P49715 (UniProtKB) Alt. Names/Synonyms: C/EBP alpha; C/EBP-alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer-binding protein alpha; CEBP; CEBPA Gene Symbols: CEBPA Molecular weight: 37,561 Da Basal Isoelectric point: 7.27  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below C/EBP-alpha 1NWQ - A/C=281-340 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 116897 601626  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept

	Sites Implicated In
cell differentiation, altered: S21‑p transcription, altered: S21‑p activation: S21‑p inhibition: S21‑p molecular association, regulation: S21‑p protein conformation: S21‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
7	0		S21-p	PMSSHLQsPPHAPSS
0	1		K161-a	ALRPLVIkQEPREED
0	1		K161-u	ALRPLVIkQEPREED
1	0		K161	ALRPLVIKQEPREED
6	0		P197	SHPHPHPPPAHLAAP
6	0		T226	HLQPGHPTPPPTPVP
6	0		T230	GHPTPPPTPVPsPHP
3	0		S234-p	PPPTPVPsPHPAPAL
2	0		A252	GLPGPGSALKGLGAA
0	1		K313-u	RNVETQQkVLELTSD
0	1		S332-p	RKRVEQLsRELDTLR

	mouse
S21-p	PMSSHLQsPPHAPSN
K159	ALRPLVIKQEPREED
K159	ALRPLVIKQEPREED
K159-s	ALRPLVIkQEPREED
S193-p	PPPHPHAsPAHLAAP
T222-p	HLQPGHPtPPPtPVP
T226-p	GHPtPPPtPVPsPHA
S230-p	PPPtPVPsPHAAPAL
A248	GLPGPGSALKGLAGA
K314	RNVETQQKVLELTSD
S333	RKRVEQLSRELDTLR

	rat
S21-p	PMSSHLQsPPHAPSN
K159	ALRPLVIKQEPREED
K159	ALRPLVIKQEPREED
K159	ALRPLVIKQEPREED
S193	PPPHPHASPAHLAAP
T222-p	HLQPGHPtPPPtPVP
T226-p	GHPtPPPtPVPsPHP
S230-p	PPPtPVPsPHPAPAM
S248-p	GLPGPGGsLKGLAGP
K313	RNVETQQKVLELTSD
S332	RKRVEQLSRELDTLR

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