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Protein Page:
BIK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BIK accelerates programmed cell death. Binding to the apoptosis repressors Bcl-xL, Bcl-2, or BHRF1 (the Epstein-Barr virus homolog of Bcl-2) suppresses its death-promoting activity. Contains 1 Bcl-2 homology 3 (BH3) domain. Does not interact with Bax. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Apoptosis; Mitochondrial
Cellular Component: mitochondrial membrane; integral to membrane; endomembrane system
Molecular Function: BH domain binding; protein binding; protein heterodimerization activity
Biological Process: apoptotic mitochondrial changes; positive regulation of protein homooligomerization; apoptosis; male gonad development; spermatogenesis
Reference #:  Q13323 (UniProtKB)
Alt. Names/Synonyms: Apoptosis inducer NBK; apoptosis-inducing NBK; Bcl-2-interacting killer; BCL2-interacting killer (apoptosis-inducing); BIK; BIP1; BP4; NBK
Gene Symbols: BIK
Molecular weight: 18,016 Da
Basal Isoelectric point: 4.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BIK

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: T33‑p, S35‑p
molecular association, regulation: T33‑p, S35‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 - gap
3 0 T33-p TMEVLGMtDsEEDLD
3 0 S35-p EVLGMtDsEEDLDPM
0 1 K115-ub MDGFTTLkENIMRFW
1 0 S124-p NIMRFWRsPNPGSWV
1 0 N126 MRFWRsPNPGSWVSC
  mouse

 
K33-ub ASETPSMkEPVRDVD
- gap
- gap
R106 IRSLTNLRENIWSWR
V114 ENIWSWRVLtPGAWV
T116-p IWSWRVLtPGAWVSP
  rat

 
K33 VSGAPSMKEPVGVED
- gap
- gap
R114 IGSLTNLRENIWSWR
V122 ENIWSWRVFTPGAWV
T124 IWSWRVFTPGAWVSP
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