accelerates programmed cell death. Binding to the apoptosis repressors Bcl-xL, Bcl-2, or BHRF1 (the Epstein-Barr virus homolog of Bcl-2) suppresses its death-promoting activity. Contains 1 Bcl-2 homology 3 (BH3) domain. Does not interact with Bax. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Apoptosis; Mitochondrial
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: mitochondrial membrane; integral to membrane; endomembrane system
Molecular Function: BH domain binding; protein binding; protein heterodimerization activity
Biological Process: apoptotic mitochondrial changes; positive regulation of protein homooligomerization; apoptosis; male gonad development; spermatogenesis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.