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Protein Page:
Bcr (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Bcr a protein with serine/threonine protein kinase activity and is a GTPase-activating protein (GAP) for RAC1 and CDC42. The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain and a region that binds SH2 domains. The middle of the protein has a PH domain and a region of sequence similarity to the guanine nucleotide exchange factors for the Rho family of GTP binding proteins. The carboxy-terminal region promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. A breakpoint cluster region protein that participates in a t(9;22)(q34;q11) chromosomal translocation that produces a BCR-ABL oncogene responsible for chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The function of wild type Bcr in cells remains unclear. PDGF receptor may use Bcr as a downstream signaling mediator. Tyr177 of human Bcr, phosphorylated in the Bcr-Abl fusion protein, provides a docking site for Gab2 and GRB2, and is important in the transforming activity of Bcr-Abl. Sequence variants of the Bcr protein may be associated with bipolar disorder. Two alternatively spliced isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, atypical; GAPs; EC 2.7.11.1; GAPs, Rac/Rho; GEFs, Rac/Rho; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; BCR family
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: protein complex; membrane; plasma membrane; cytosol
Molecular Function: protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; protein binding; enzyme binding; protein-tyrosine kinase activity; Rac GTPase activator activity; kinase activity; ATP binding; GTPase activator activity
Biological Process: inner ear morphogenesis; peptidyl-tyrosine phosphorylation; regulation of cell cycle; protein amino acid autophosphorylation; response to lipopolysaccharide; platelet-derived growth factor receptor signaling pathway; signal transduction; protein amino acid phosphorylation; regulation of small GTPase mediated signal transduction; negative regulation of neutrophil degranulation; small GTPase mediated signal transduction; positive regulation of phagocytosis; negative regulation of inflammatory response; positive regulation of Rac GTPase activity; brain development; actin cytoskeleton organization and biogenesis; neuromuscular process controlling balance; negative regulation of cell migration
Reference #:  P11274 (UniProtKB)
Alt. Names/Synonyms: ALL; BCR; BCR1; breakpoint cluster region; Breakpoint cluster region protein; CML; D22S11; D22S662; FLJ16453; PHL; Renal carcinoma antigen NY-REN-26
Gene Symbols: BCR
Molecular weight: 142,819 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcr

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S354‑p
apoptosis, inhibited: Y177‑p
carcinogenesis, induced: Y177‑p
cell growth, altered: Y177‑p
cell motility, altered: Y177‑p
enzymatic activity, induced: Y328‑p, Y360‑p
molecular association, regulation: Y177‑p, S354‑p
phosphorylation: Y177‑p, Y360‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S18-p WKAQFPDsEPPRMEL
0 104 Y58-p QERFRMIyLQTLLAK
0 1 S88-p AQAPDGAsEPRASAS
0 17 S122-p ARPDGEGsPGKARPG
0 3 G124 PDGEGsPGKARPGtA
0 3 T130-p PGKARPGtARRPGAA
0 2 S139-p RRPGAAAsGERDDRG
13 1009 Y177-p ADAEKPFyVNVEFHH
0 1 K194-ac GLVKVNDkEVSDRIs
0 1 S197 KVNDkEVSDRIssLG
0 2 S201-p kEVSDRIssLGsQAM
0 13 S202-p EVSDRIssLGsQAMQ
0 14 S205-p DRIssLGsQAMQMER
0 1 K213-ac QAMQMERkKsQHGAG
0 22 S215-p MQMERkKsQHGAGss
0 1 S221-p KsQHGAGssVGDAsR
0 29 S222-p sQHGAGssVGDAsRP
0 7 S227-p GssVGDAsRPPyRGR
0 149 Y231-p GDAsRPPyRGRssES
0 3 S235-p RPPyRGRssESsCGV
0 9 S236-p PPyRGRssESsCGVD
0 2 S239-p RGRssESsCGVDGDy
1 324 Y246-p sCGVDGDyEDAELNP
0 1 S267-p LIDANGGsRPPWPPL
1 14 Y276-p PPWPPLEyQPyQsIy
1 129 Y279-p PPLEyQPyQsIyVGG
0 61 S281-p LEyQPyQsIyVGGMM
2 90 Y283-p yQPyQsIyVGGMMEG
0 27 S299-p GKGPLLRsQstsEQE
0 240 S301-p GPLLRsQstsEQEKR
0 27 T302-p PLLRsQstsEQEKRL
0 5 S303-p LLRsQstsEQEKRLt
0 3 T310-p sEQEKRLtWPRRSYs
0 2 S317-p tWPRRSYsPRSFEDC
2 0 Y328-p FEDCGGGyTPDCSSN
3 64 S354-p SGQSSRVsPsPTTyR
0 15 S356-p QSSRVsPsPTTyRMF
4 29 Y360-p VsPsPTTyRMFRDKS
0 1 S374-p SRSPSQNsQQsFDSS
0 1 S377-p PSQNsQQsFDSSSPP
0 1 S382 QQsFDSSSPPTPQCH
0 1 T385 FDSSSPPTPQCHKRH
0 38 S429-p FHGDADGsFGtPPGy
0 52 T432-p DADGsFGtPPGyGCA
0 219 Y436-p sFGtPPGyGCAADRA
0 134 Y455-p RHQDGLPyIDDsPss
0 36 S459-p GLPyIDDsPsssPHL
0 1 S461-p PyIDDsPsssPHLsS
0 3 S462-p yIDDsPsssPHLsSK
0 10 S463-p IDDsPsssPHLsSKG
0 2 S467-p PsssPHLsSKGRGsR
0 4 R471 PHLsSKGRGsRDALV
0 10 S473-p LsSKGRGsRDALVSG
0 1 K486-ub SGALESTkAsELDLE
0 1 S488-p ALESTkAsELDLEkG
0 1 K494-ub AsELDLEkGLEMRKW
0 11 Y513-p ILASEETyLsHLEAL
0 1 S515-p ASEETyLsHLEALLL
0 1 S540-p TSQPVLTsQQIETIF
0 164 Y554-p FFKVPELyEIHKEFy
0 122 Y561-p yEIHKEFyDGLFPRV
0 1 S572-p FPRVQQWsHQQRVGD
0 5 K583-ub RVGDLFQkLASQLGV
0 257 Y591-p LASQLGVyRAFVDNy
0 258 Y598-p yRAFVDNyGVAMEMA
0 1 S626-p SENLRARsNKDAKDP
0 1 T634-p NKDAKDPttKNsLEt
0 8 T635-p KDAKDPttKNsLEtL
0 21 S638-p KDPttKNsLEtLLyK
0 18 T641-p ttKNsLEtLLyKPVD
0 320 Y644-p NsLEtLLyKPVDRVt
0 1 T651-p yKPVDRVtRsTLVLH
0 1 S653-p PVDRVtRsTLVLHDL
0 15 T693-p SSINEEItPRRQsMT
0 4 S698-p EItPRRQsMTVKKGE
0 2 Y756-p QQYDCKWyIPLTDLS
0 5 S843-p VHSRNGKsyTFLISS
0 32 Y844-p HSRNGKsyTFLISSD
0 30 Y852-p TFLISSDyERAEWRE
0 1 S871 QQKKCFRSFSLTSVE
0 2 S873 KKCFRSFSLTSVELQ
0 1 S876 FRSFSLTSVELQMLT
0 1 T883 SVELQMLTNSCVKLQ
0 1 S885 ELQMLTNSCVKLQTV
0 2 S894-p VKLQTVHsIPLTINK
0 58 S906-p INKEDDEsPGLyGFL
0 188 Y910-p DDEsPGLyGFLNVIV
0 1 T921-p NVIVHSAtGFKQSSN
0 1 K985 EKCYNKTKIPKEDGE
0 1 T1018-p QDRDWQRtVIAMNGI
0 1 S1030-p NGIEVKLsVKFNsRE
0 2 S1035-p KLsVKFNsREFsLKR
0 1 S1039-p KFNsREFsLKRMPSR
0 7 T1049-p RMPSRKQtGVFGVKI
0 2 Y1089-p GMEEVGIyRVSGVAT
0 1 S1260 EAIPAPDSKRQsILF
0 14 S1264-p APDSKRQsILFSTEV
3901 : Phospho-Bcr (Tyr177) Antibody
  mouse

 
S18 WRAQFPDSEPPRMEL
Y58-p QERFRMIyLQTLLAK
A88 AQPPDGAAEPRASAP
S122-p ARPDGEGsPsKGRSA
S124-p PDGEGsPsKGRSASA
S130 PsKGRSASARRPAAA
S139-p RRPAAAAsADRDDRG
Y178-p ADAEKPFyVNVEFHH
K195 GLVKVNDKEVsDRIS
S198-p KVNDKEVsDRISSLG
S202 KEVsDRISSLGSQAM
S203 EVsDRISSLGSQAMQ
S206 DRISSLGSQAMQMER
K214 QAMQMERKKsQQSAG
S216-p MQMERKKsQQSAGQG
- gap
- gap
- gap
Y232 GEAPRPHYRGRSsES
S236 RPHYRGRSsESSCGL
S237-p PHYRGRSsESSCGLD
S240 RGRSsESSCGLDGDy
Y247-p SCGLDGDyEDAELNP
N268 LINANGGNRPPWPPL
Y277 PPWPPLEYQPYQSIY
Y280 PPLEYQPYQSIYVGG
S282 LEYQPYQSIYVGGMM
Y284 YQPYQSIYVGGMMVE
S301-p GKSPLLRsQstSEQE
S303-p SPLLRsQstSEQEKR
T304-p PLLRsQstSEQEKRL
S305 LLRsQstSEQEKRLT
T312 SEQEKRLTWPRRSYs
S319-p TWPRRSYsPRSFEDS
Y330 FEDSGGGYTPDCSSN
S356-p SGQSSRVsPSPTTyR
S358 QSSRVsPSPTTyRMF
Y362-p VsPSPTTyRMFRDKS
S376 SRSPSQNSQQSFDSS
S379 PSQNSQQSFDSSsPP
S384-p QQSFDSSsPPtPQCQ
T387-p FDSSsPPtPQCQKRH
S431 FQGEADSSFGTPPGY
T434 EADSSFGTPPGYGCA
Y438 SFGTPPGYGCAADQA
Y457 RHQDGLPYIDDsPss
S461-p GLPYIDDsPsssPHL
S463-p PYIDDsPsssPHLSS
S464-p YIDDsPsssPHLSSK
S465-p IDDsPsssPHLSSKG
S469 PsssPHLSSKGrGsL
R473-m1 PHLSSKGrGsLASGA
S475-p LSSKGrGsLASGALD
K485 SGALDPTKVSELDLE
S487 ALDPTKVSELDLEKG
K493 VSELDLEKGLEMRKW
Y512 ILASEETYLSHLEAL
S514 ASEETYLSHLEALLL
S539 TSQPVLTSQQIETIF
Y553-p FFKVPELyEIHKEFy
Y560-p yEIHKEFyDGLFPRV
S571 FPRVQQWSHQQRVGD
K582 RVGDLFQKLASQLGV
Y590-p LASQLGVyRAFVDNY
Y597 yRAFVDNYGVAMETA
S625 SENLRARSNKDVKDS
T633 NKDVKDSTTKNSLET
T634 KDVKDSTTKNSLETL
S637 KDSTTKNSLETLLyK
T640 TTKNSLETLLyKPVD
Y643-p NSLETLLyKPVDRVT
T650 yKPVDRVTRSTLVLH
S652 PVDRVTRSTLVLHDL
T692 SSINEEITPRRQSMT
S697 EITPRRQSMTVKKGE
Y755-p QQYDCKWyIPLTDLS
S842 VHSRNGKSyTFLISS
Y843-p HSRNGKSyTFLISSD
Y851-p TFLISSDyERAEWRE
S870 QQKKCFKSFsLTSVE
S872-p KKCFKSFsLTSVELQ
S875 FKSFsLTSVELQMLt
T882-p SVELQMLtNSCVKLQ
S884 ELQMLtNSCVKLQTV
H893 VKLQTVHHIPLTINK
S905 INKEDDESPGLYGFL
Y909 DDESPGLYGFLHVIV
T920 HVIVHSATGFKQSSN
K984-ac EKCYNKMkMTKEDGE
T1017 QDRDWQRTVIDMNGI
S1029 NGIEVKLSVKFTSRE
S1034 KLSVKFTSREFSLKR
S1038 KFTSREFSLKRMPSR
T1048 RMPSRKQTGVFGVKI
Y1088 GMEEVGIYRVSGVAT
S1259-p EAIPAPDsKRQsILF
S1263-p APDsKRQsILFSTEV
  rat

 
S18 WRAQFPDSEPPRMEL
Y58 QERFRMIYLQTLLAK
A88 EQPPDGAAEHRASAP
S122 ERPIXEGSPNKEQPA
N124 PIXEGSPNKEQPATA
T130 PNKEQPATASRPADV
- gap
Y178-p ADAEKPFyVNVEFHH
K195 GLVKVNDKEVSDRIS
S198 KVNDKEVSDRISSLG
S202 KEVSDRISSLGSQAM
S203 EVSDRISSLGSQAMQ
S206 DRISSLGSQAMQMER
K214 QAMQMERKKSQQSAG
S216 MQMERKKSQQSAGQG
- gap
- gap
- gap
Y232 GEAPRPHYRGRSSES
S236 RPHYRGRSSESSCGL
S237 PHYRGRSSESSCGLD
S240 RGRSSESSCGLDGDY
Y247 SCGLDGDYEDAELNP
N268 LINANGGNRPPWPPL
Y277 PPWPPLEYQPYQSIY
Y280 PPLEYQPYQSIYVGG
S282 LEYQPYQSIYVGGMM
Y284 YQPYQSIYVGGMMVE
S301 GKSPLLRSQSTSEQE
S303 SPLLRSQSTSEQEKR
T304 PLLRSQSTSEQEKRL
S305 LLRSQSTSEQEKRLT
T312 SEQEKRLTWPRRSYs
S319-p TWPRRSYsPRSFEDS
Y330 FEDSGGGYTPDCSSN
S356 SGQSSRVSPSPTTYR
S358 QSSRVSPSPTTYRMF
Y362 VSPSPTTYRMFRDKS
S376 SRSPSQNSQQSFDSS
S379 PSQNSQQSFDSSSPP
S384 QQSFDSSSPPTPQCQ
T387 FDSSSPPTPQCQKRH
S431 FQGEADSSFGTPPGY
T434 EADSSFGTPPGYGCA
Y438 SFGTPPGYGCAADQA
Y457 RHQDGLPYIDDsPSS
S461-p GLPYIDDsPSSsPHL
S463 PYIDDsPSSsPHLSS
S464 YIDDsPSSsPHLSSK
S465-p IDDsPSSsPHLSSKG
S469 PSSsPHLSSKGRGsP
R473 PHLSSKGRGsPASGA
S475-p LSSKGRGsPASGALE
K485 SGALEPTKASELDLE
S487 ALEPTKASELDLEKG
K493 ASELDLEKGLEMRKW
Y512 ILASEETYLSHLEAL
S514 ASEETYLSHLEALLL
S539 TSQPVLTSQQIETIF
Y553 FFKVPELYEIHKEFY
Y560 YEIHKEFYDGLFPRV
S571 FPRVQQWSHQQRVGD
K582 RVGDLFQKLASQLGV
Y590 LASQLGVYRAFVDNY
Y597 YRAFVDNYGVAMETA
S625 SENLRARSNKDVKDS
T633 NKDVKDSTTKNSLET
T634 KDVKDSTTKNSLETL
S637 KDSTTKNSLETLLYK
T640 TTKNSLETLLYKPVD
Y643 NSLETLLYKPVDRVT
T650 YKPVDRVTRSTLVLH
S652 PVDRVTRSTLVLHDL
T692 SSINEEITPRRQSMT
S697 EITPRRQSMTVKKGE
Y755 QQYDCKWYIPLTDLS
S842 VHSRNGKSYTFLISS
Y843 HSRNGKSYTFLISSD
Y851 TFLISSDYERAEWRE
S870-p QQKKCFKsFsLTsVE
S872-p KKCFKsFsLTsVELQ
S875-p FKsFsLTsVELQMLT
T882 sVELQMLTNsCVKLQ
S884-p ELQMLTNsCVKLQTV
H893 VKLQTVHHIPLTINK
S905 INKEDDESPGLYGFL
Y909 DDESPGLYGFLHAIV
T920 HAIVHSATGFKQSSN
K984 EKCYNKMKMAKEDGE
T1017 QDRDWQRTVIDMNGI
S1029 NGIEVKLSVKFTSRE
S1034 KLSVKFTSREFSLKR
S1038 KFTSREFSLKRMPSR
T1048 RMPSRKQTGVFGVKI
Y1088 GMEEVGIYRVSGVAT
S1259 EAIPAPDSKRQSILF
S1263 APDSKRQSILFSTEV
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