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Protein Page:
Bcr (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Bcr a protein with serine/threonine protein kinase activity and is a GTPase-activating protein (GAP) for RAC1 and CDC42. The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain and a region that binds SH2 domains. The middle of the protein has a PH domain and a region of sequence similarity to the guanine nucleotide exchange factors for the Rho family of GTP binding proteins. The carboxy-terminal region promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. A breakpoint cluster region protein that participates in a t(9;22)(q34;q11) chromosomal translocation that produces a BCR-ABL oncogene responsible for chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The function of wild type Bcr in cells remains unclear. PDGF receptor may use Bcr as a downstream signaling mediator. Tyr177 of human Bcr, phosphorylated in the Bcr-Abl fusion protein, provides a docking site for Gab2 and GRB2, and is important in the transforming activity of Bcr-Abl. Sequence variants of the Bcr protein may be associated with bipolar disorder. Two alternatively spliced isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
Protein type: GAPs, Rac/Rho; Protein kinase, atypical; GAPs; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; BCR family
Cellular Component: protein complex; plasma membrane; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; Rho guanyl-nucleotide exchange factor activity; enzyme binding; protein-tyrosine kinase activity; Rac GTPase activator activity; kinase activity; GTPase activator activity; ATP binding
Biological Process: inner ear morphogenesis; peptidyl-tyrosine phosphorylation; regulation of cell cycle; protein amino acid autophosphorylation; response to lipopolysaccharide; platelet-derived growth factor receptor signaling pathway; signal transduction; protein amino acid phosphorylation; negative regulation of neutrophil degranulation; regulation of small GTPase mediated signal transduction; negative regulation of inflammatory response; positive regulation of phagocytosis; small GTPase mediated signal transduction; brain development; neuromuscular process controlling balance; actin cytoskeleton organization and biogenesis; negative regulation of cell migration
Reference #:  P11274 (UniProtKB)
Alt. Names/Synonyms: ALL; BCR; BCR1; breakpoint cluster region; Breakpoint cluster region protein; CML; D22S11; D22S662; FLJ16453; PHL; Renal carcinoma antigen NY-REN-26
Gene Symbols: BCR
Molecular weight: 142,819 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcr

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
apoptosis, induced: S354‑p
apoptosis, inhibited: Y177‑p
carcinogenesis, induced: Y177‑p
cell growth, altered: Y177‑p
cell motility, altered: Y177‑p
enzymatic activity, induced: Y328‑p, Y360‑p
molecular association, regulation: Y177‑p, S354‑p
phosphorylation: Y177‑p, Y360‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S18-p WKAQFPDsEPPRMEL
0 102 Y58-p QERFRMIyLQTLLAK
0 13 S122-p ARPDGEGsPGKARPG
0 3 G124 PDGEGsPGKARPGtA
0 3 T130-p PGKARPGtARRPGAA
0 2 S139-p RRPGAAAsGERDDRG
13 972 Y177-p ADAEKPFyVNVEFHH
0 2 S201-p KEVSDRIssLGsQAM
0 9 S202-p EVSDRIssLGsQAMQ
0 10 S205-p DRIssLGsQAMQMER
0 18 S215-p MQMERKKsQHGAGss
0 1 S221-p KsQHGAGssVGDAsR
0 29 S222-p sQHGAGssVGDAsRP
0 7 S227-p GssVGDAsRPPyRGR
0 150 Y231-p GDAsRPPyRGRssES
0 3 S235-p RPPyRGRssESSCGV
0 8 S236-p PPyRGRssESSCGVD
1 333 Y246-p SCGVDGDyEDAELNP
0 12 Y276-p PPWPPLEyQPyQsIy
0 123 Y279-p PPLEyQPyQsIyVGG
0 55 S281-p LEyQPyQsIyVGGMM
1 87 Y283-p yQPyQsIyVGGMMEG
0 27 S299-p GKGPLLRsQstsEQE
0 238 S301-p GPLLRsQstsEQEKR
0 27 T302-p PLLRsQstsEQEKRL
0 5 S303-p LLRsQstsEQEKRLt
0 3 T310-p sEQEKRLtWPRRSYs
0 2 S317-p tWPRRSYsPRSFEDC
2 0 Y328-p FEDCGGGyTPDCSSN
3 61 S354-p SGQSSRVsPsPTTyR
0 13 S356-p QSSRVsPsPTTyRMF
4 29 Y360-p VsPsPTTyRMFRDKS
0 1 S377-p PSQNSQQsFDSSSPP
0 1 S382 QQsFDSSSPPTPQCH
0 1 T385 FDSSSPPTPQCHKRH
0 37 S429-p FHGDADGsFGtPPGy
0 48 T432-p DADGsFGtPPGyGCA
0 214 Y436-p sFGtPPGyGCAADRA
0 133 Y455-p RHQDGLPyIDDsPss
0 29 S459-p GLPyIDDsPsssPHL
0 1 S461-p PyIDDsPsssPHLSS
0 3 S462-p yIDDsPsssPHLSSK
0 8 S463-p IDDsPsssPHLSSKG
0 4 R471 PHLSSKGRGsRDALV
0 7 S473-p LSSKGRGsRDALVSG
0 1 S488-p ALESTKAsELDLEKG
0 8 Y513-p ILASEETyLSHLEAL
0 164 Y554-p FFKVPELyEIHKEFy
0 118 Y561-p yEIHKEFyDGLFPRV
0 5 K583-u RVGDLFQkLASQLGV
0 260 Y591-p LASQLGVyRAFVDNy
0 259 Y598-p yRAFVDNyGVAMEMA
0 6 T635-p KDAKDPTtKNsLEtL
0 19 S638-p KDPTtKNsLEtLLyK
0 17 T641-p TtKNsLEtLLyKPVD
0 320 Y644-p NsLEtLLyKPVDRVT
0 13 T693-p SSINEEItPRRQsMT
0 4 S698-p EItPRRQsMTVKKGE
0 2 Y756-p QQYDCKWyIPLTDLS
0 34 Y844-p HSRNGKSyTFLISSD
0 29 Y852-p TFLISSDyERAEWRE
0 1 S871 QQKKCFRSFSLTSVE
0 2 S873 KKCFRSFSLTSVELQ
0 1 S876 FRSFSLTSVELQMLT
0 1 T883 SVELQMLTNSCVKLQ
0 1 S885 ELQMLTNSCVKLQTV
0 2 S894-p VKLQTVHsIPLTINK
0 55 S906-p INKEDDEsPGLyGFL
0 187 Y910-p DDEsPGLyGFLNVIV
0 1 S1030-p NGIEVKLsVKFNsRE
0 1 S1035-p KLsVKFNsREFSLKR
0 13 S1264-p APDSKRQsILFSTEV
3901 : Phospho-Bcr (Tyr177) Antibody
  mouse

 
S18 WRAQFPDSEPPRMEL
Y58-p QERFRMIyLQTLLAK
S122-p ARPDGEGsPsKGRSA
S124-p PDGEGsPsKGRSASA
S130 PsKGRSASARRPAAA
S139-p RRPAAAAsADRDDRG
Y178-p ADAEKPFyVNVEFHH
S202 KEVSDRISSLGSQAM
S203 EVSDRISSLGSQAMQ
S206 DRISSLGSQAMQMER
S216-p MQMERKKsQQSAGQG
- gap
- gap
- gap
Y232 GEAPRPHYRGRSsES
S236 RPHYRGRSsESSCGL
S237-p PHYRGRSsESSCGLD
Y247-p SCGLDGDyEDAELNP
Y277 PPWPPLEYQPYQSIY
Y280 PPLEYQPYQSIYVGG
S282 LEYQPYQSIYVGGMM
Y284 YQPYQSIYVGGMMVE
S301-p GKSPLLRsQstSEQE
S303-p SPLLRsQstSEQEKR
T304-p PLLRsQstSEQEKRL
S305 LLRsQstSEQEKRLT
T312 SEQEKRLTWPRRSYs
S319-p TWPRRSYsPRSFEDS
Y330 FEDSGGGYTPDCSSN
S356-p SGQSSRVsPSPTTyR
S358 QSSRVsPSPTTyRMF
Y362-p VsPSPTTyRMFRDKS
S379 PSQNSQQSFDSSsPP
S384-p QQSFDSSsPPtPQCQ
T387-p FDSSsPPtPQCQKRH
S431 FQGEADSSFGTPPGY
T434 EADSSFGTPPGYGCA
Y438 SFGTPPGYGCAADQA
Y457 RHQDGLPYIDDsPss
S461-p GLPYIDDsPsssPHL
S463-p PYIDDsPsssPHLSS
S464-p YIDDsPsssPHLSSK
S465-p IDDsPsssPHLSSKG
R473-m1 PHLSSKGrGsLASGA
S475-p LSSKGrGsLASGALD
S487 ALDPTKVSELDLEKG
Y512 ILASEETYLSHLEAL
Y553-p FFKVPELyEIHKEFy
Y560-p yEIHKEFyDGLFPRV
K582 RVGDLFQKLASQLGV
Y590-p LASQLGVyRAFVDNY
Y597 yRAFVDNYGVAMETA
T634 KDVKDSTTKNSLETL
S637 KDSTTKNSLETLLyK
T640 TTKNSLETLLyKPVD
Y643-p NSLETLLyKPVDRVT
T692 SSINEEITPRRQSMT
S697 EITPRRQSMTVKKGE
Y755-p QQYDCKWyIPLTDLS
Y843-p HSRNGKSyTFLISSD
Y851-p TFLISSDyERAEWRE
S870 QQKKCFKSFsLTSVE
S872-p KKCFKSFsLTSVELQ
S875 FKSFsLTSVELQMLt
T882-p SVELQMLtNSCVKLQ
S884 ELQMLtNSCVKLQTV
H893 VKLQTVHHIPLTINK
S905 INKEDDESPGLYGFL
Y909 DDESPGLYGFLHVIV
S1029 NGIEVKLSVKFTSRE
S1034 KLSVKFTSREFSLKR
S1263-p APDSKRQsILFSTEV
  rat

 
S18 WRAQFPDSEPPRMEL
Y58 QERFRMIYLQTLLAK
S122 ERPIXEGSPNKEQPA
N124 PIXEGSPNKEQPATA
T130 PNKEQPATASRPADV
- gap
Y178-p ADAEKPFyVNVEFHH
S202 KEVSDRISSLGSQAM
S203 EVSDRISSLGSQAMQ
S206 DRISSLGSQAMQMER
S216 MQMERKKSQQSAGQG
- gap
- gap
- gap
Y232 GEAPRPHYRGRSSES
S236 RPHYRGRSSESSCGL
S237 PHYRGRSSESSCGLD
Y247 SCGLDGDYEDAELNP
Y277 PPWPPLEYQPYQSIY
Y280 PPLEYQPYQSIYVGG
S282 LEYQPYQSIYVGGMM
Y284 YQPYQSIYVGGMMVE
S301 GKSPLLRSQSTSEQE
S303 SPLLRSQSTSEQEKR
T304 PLLRSQSTSEQEKRL
S305 LLRSQSTSEQEKRLT
T312 SEQEKRLTWPRRSYS
S319 TWPRRSYSPRSFEDS
Y330 FEDSGGGYTPDCSSN
S356 SGQSSRVSPSPTTYR
S358 QSSRVSPSPTTYRMF
Y362 VSPSPTTYRMFRDKS
S379 PSQNSQQSFDSSSPP
S384 QQSFDSSSPPTPQCQ
T387 FDSSSPPTPQCQKRH
S431 FQGEADSSFGTPPGY
T434 EADSSFGTPPGYGCA
Y438 SFGTPPGYGCAADQA
Y457 RHQDGLPYIDDsPSS
S461-p GLPYIDDsPSSSPHL
S463 PYIDDsPSSSPHLSS
S464 YIDDsPSSSPHLSSK
S465 IDDsPSSSPHLSSKG
R473 PHLSSKGRGsPASGA
S475-p LSSKGRGsPASGALE
S487 ALEPTKASELDLEKG
Y512 ILASEETYLSHLEAL
Y553 FFKVPELYEIHKEFY
Y560 YEIHKEFYDGLFPRV
K582 RVGDLFQKLASQLGV
Y590 LASQLGVYRAFVDNY
Y597 YRAFVDNYGVAMETA
T634 KDVKDSTTKNSLETL
S637 KDSTTKNSLETLLYK
T640 TTKNSLETLLYKPVD
Y643 NSLETLLYKPVDRVT
T692 SSINEEITPRRQSMT
S697 EITPRRQSMTVKKGE
Y755 QQYDCKWYIPLTDLS
Y843 HSRNGKSYTFLISSD
Y851 TFLISSDYERAEWRE
S870-p QQKKCFKsFsLTsVE
S872-p KKCFKsFsLTsVELQ
S875-p FKsFsLTsVELQMLT
T882 sVELQMLTNsCVKLQ
S884-p ELQMLTNsCVKLQTV
H893 VKLQTVHHIPLTINK
S905 INKEDDESPGLYGFL
Y909 DDESPGLYGFLHAIV
S1029 NGIEVKLSVKFTSRE
S1034 KLSVKFTSREFSLKR
S1263 APDSKRQSILFSTEV
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