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Protein Page:
Bcr (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Bcr a protein with serine/threonine protein kinase activity and is a GTPase-activating protein (GAP) for RAC1 and CDC42. The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain and a region that binds SH2 domains. The middle of the protein has a PH domain and a region of sequence similarity to the guanine nucleotide exchange factors for the Rho family of GTP binding proteins. The carboxy-terminal region promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. A breakpoint cluster region protein that participates in a t(9;22)(q34;q11) chromosomal translocation that produces a BCR-ABL oncogene responsible for chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The function of wild type Bcr in cells remains unclear. PDGF receptor may use Bcr as a downstream signaling mediator. Tyr177 of human Bcr, phosphorylated in the Bcr-Abl fusion protein, provides a docking site for Gab2 and GRB2, and is important in the transforming activity of Bcr-Abl. Sequence variants of the Bcr protein may be associated with bipolar disorder. Two alternatively spliced isoforms of the human protein have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, ATYPICAL; GTPase activating protein, Rac/Rho; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; ATYPICAL group; BCR family
Cellular Component: plasma membrane; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; Rho guanyl-nucleotide exchange factor activity; Rac GTPase activator activity; protein-tyrosine kinase activity; phospholipid binding; kinase activity; ATP binding; GTPase activator activity
Biological Process: inner ear morphogenesis; regulation of cell cycle; response to lipopolysaccharide; signal transduction; protein amino acid phosphorylation; negative regulation of neutrophil degranulation; regulation of small GTPase mediated signal transduction; positive regulation of phagocytosis; negative regulation of inflammatory response; small GTPase mediated signal transduction; brain development; actin cytoskeleton organization and biogenesis; neuromuscular process controlling balance; negative regulation of cell migration
Reference #:  P11274 (UniProtKB)
Alt. Names/Synonyms: ALL; BCR; BCR1; breakpoint cluster region; Breakpoint cluster region protein; CML; D22S11; D22S662; FLJ16453; PHL; Renal carcinoma antigen NY-REN-26
Gene Symbols: BCR
Molecular weight: 142,819 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcr
Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
apoptosis, induced: S354‑p
apoptosis, inhibited: Y177‑p
carcinogenesis, induced: Y177‑p
cell growth, altered: Y177‑p
cell motility, altered: Y177‑p
enzymatic activity, induced: Y328‑p, Y360‑p
molecular association, regulation: Y177‑p, S354‑p
phosphorylation: Y177‑p, Y360‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S18-p WKAQFPDsEPPRMEL
0 102 Y58-p QERFRMIyLQTLLAK
0 11 S122-p ARPDGEGsPGKARPG
0 3 G124 PDGEGsPGKARPGtA
0 3 T130-p PGKARPGtARRPGAA
0 1 S139 RRPGAAASGERDDRG
13 970 Y177-p ADAEKPFyVNVEFHH
0 1 K194-a GLVKVNDkEVSDRIs
0 1 S197 KVNDkEVSDRIssLG
0 2 S201-p kEVSDRIssLGsQAM
0 8 S202-p EVSDRIssLGsQAMQ
0 9 S205-p DRIssLGsQAMQMER
0 1 K213-a QAMQMERkKsQHGAG
0 17 S215-p MQMERkKsQHGAGSS
0 150 Y231-p GDASRPPyRGRssES
0 3 S235-p RPPyRGRssESSCGV
0 8 S236-p PPyRGRssESSCGVD
1 333 Y246-p SCGVDGDyEDAELNP
0 1 S267-p LIDANGGsRPPWPPL
0 12 Y276-p PPWPPLEyQPyQsIy
0 123 Y279-p PPLEyQPyQsIyVGG
0 55 S281-p LEyQPyQsIyVGGMM
1 87 Y283-p yQPyQsIyVGGMMEG
0 27 S299-p GKGPLLRsQstsEQE
0 237 S301-p GPLLRsQstsEQEKR
0 27 T302-p PLLRsQstsEQEKRL
0 5 S303-p LLRsQstsEQEKRLt
0 2 T310-p sEQEKRLtWPRRSYs
0 2 S317-p tWPRRSYsPRSFEDC
2 0 Y328-p FEDCGGGyTPDCSSN
3 59 S354-p SGQSSRVsPSPTTyR
4 29 Y360-p VsPSPTTyRMFRDKS
0 1 S374-p SRSPSQNsQQSFDSS
0 1 S382 QQSFDSSSPPTPQCH
0 1 T385 FDSSSPPTPQCHKRH
0 37 S429-p FHGDADGsFGtPPGy
0 47 T432-p DADGsFGtPPGyGCA
0 214 Y436-p sFGtPPGyGCAADRA
0 133 Y455-p RHQDGLPyIDDsPss
0 25 S459-p GLPyIDDsPsssPHL
0 1 S461-p PyIDDsPsssPHLSS
0 2 S462-p yIDDsPsssPHLSSK
0 7 S463-p IDDsPsssPHLSSKG
0 3 R471 PHLSSKGRGsRDALV
0 5 S473-p LSSKGRGsRDALVSG
0 1 K486-u SGALESTkASELDLE
0 1 K494-u ASELDLEkGLEMRKW
0 8 Y513-p ILASEETyLSHLEAL
0 1 S540-p TSQPVLTsQQIETIF
0 163 Y554-p FFKVPELyEIHKEFy
0 118 Y561-p yEIHKEFyDGLFPRV
0 1 S572-p FPRVQQWsHQQRVGD
0 5 K583-u RVGDLFQkLASQLGV
0 259 Y591-p LASQLGVyRAFVDNy
0 258 Y598-p yRAFVDNyGVAMEMA
0 1 S626-p SENLRARsNKDAKDP
0 1 T634-p NKDAKDPttKNsLEt
0 6 T635-p KDAKDPttKNsLEtL
0 18 S638-p KDPttKNsLEtLLyK
0 16 T641-p ttKNsLEtLLyKPVD
0 319 Y644-p NsLEtLLyKPVDRVt
0 1 T651-p yKPVDRVtRsTLVLH
0 1 S653-p PVDRVtRsTLVLHDL
0 12 T693-p SSINEEItPRRQsMT
0 4 S698-p EItPRRQsMTVKKGE
0 2 Y756-p QQYDCKWyIPLTDLS
0 34 Y844-p HSRNGKSyTFLISSD
0 29 Y852-p TFLISSDyERAEWRE
0 1 S871 QQKKCFRSFSLTSVE
0 1 S873 KKCFRSFSLTSVELQ
0 1 S876 FRSFSLTSVELQMLT
0 1 S885 ELQMLTNSCVKLQTV
0 55 S906-p INKEDDEsPGLyGFL
0 187 Y910-p DDEsPGLyGFLNVIV
0 1 K985 EKCYNKTKIPKEDGE
0 1 T1018-p QDRDWQRtVIAMNGI
0 1 S1030-p NGIEVKLsVKFNsRE
0 1 S1035-p KLsVKFNsREFSLKR
0 1 Y1089-p GMEEVGIyRVSGVAT
0 1 S1260 EAIPAPDSKRQsILF
0 11 S1264-p APDSKRQsILFSTEV
3901 : Phospho-Bcr (Tyr177) Antibody
  mouse

 
S18 WRAQFPDSEPPRMEL
Y58-p QERFRMIyLQTLLAK
S122-p ARPDGEGsPsKGRSA
S124-p PDGEGsPsKGRSASA
S130 PsKGRSASARRPAAA
S139-p RRPAAAAsADRDDRG
Y178-p ADAEKPFyVNVEFHH
K195 GLVKVNDKEVsDRIS
S198-p KVNDKEVsDRISSLG
S202 KEVsDRISSLGSQAM
S203 EVsDRISSLGSQAMQ
S206 DRISSLGSQAMQMER
K214 QAMQMERKKsQQSAG
S216-p MQMERKKsQQSAGQG
Y232 GEAPRPHYRGRSsES
S236 RPHYRGRSsESSCGL
S237-p PHYRGRSsESSCGLD
Y247-p SCGLDGDyEDAELNP
N268 LINANGGNRPPWPPL
Y277 PPWPPLEYQPYQSIY
Y280 PPLEYQPYQSIYVGG
S282 LEYQPYQSIYVGGMM
Y284 YQPYQSIYVGGMMVE
S301-p GKSPLLRsQstSEQE
S303-p SPLLRsQstSEQEKR
T304-p PLLRsQstSEQEKRL
S305 LLRsQstSEQEKRLT
T312 SEQEKRLTWPRRSYs
S319-p TWPRRSYsPRSFEDS
Y330 FEDSGGGYTPDCSSN
S356-p SGQSSRVsPSPTTyR
Y362-p VsPSPTTyRMFRDKS
S376 SRSPSQNSQQSFDSS
S384-p QQSFDSSsPPtPQCQ
T387-p FDSSsPPtPQCQKRH
S431 FQGEADSSFGTPPGY
T434 EADSSFGTPPGYGCA
Y438 SFGTPPGYGCAADQA
Y457 RHQDGLPYIDDsPss
S461-p GLPYIDDsPsssPHL
S463-p PYIDDsPsssPHLSS
S464-p YIDDsPsssPHLSSK
S465-p IDDsPsssPHLSSKG
R473-m1 PHLSSKGrGsLASGA
S475-p LSSKGrGsLASGALD
K485 SGALDPTKVSELDLE
K493 VSELDLEKGLEMRKW
Y512 ILASEETYLSHLEAL
S539 TSQPVLTSQQIETIF
Y553-p FFKVPELyEIHKEFy
Y560-p yEIHKEFyDGLFPRV
S571 FPRVQQWSHQQRVGD
K582 RVGDLFQKLASQLGV
Y590-p LASQLGVyRAFVDNY
Y597 yRAFVDNYGVAMETA
S625 SENLRARSNKDVKDS
T633 NKDVKDSTTKNSLET
T634 KDVKDSTTKNSLETL
S637 KDSTTKNSLETLLyK
T640 TTKNSLETLLyKPVD
Y643-p NSLETLLyKPVDRVT
T650 yKPVDRVTRSTLVLH
S652 PVDRVTRSTLVLHDL
T692 SSINEEITPRRQSMT
S697 EITPRRQSMTVKKGE
Y755-p QQYDCKWyIPLTDLS
Y843-p HSRNGKSyTFLISSD
Y851-p TFLISSDyERAEWRE
S870 QQKKCFKSFSLTSVE
S872 KKCFKSFSLTSVELQ
S875 FKSFSLTSVELQMLT
S884 ELQMLTNSCVKLQTV
S905 INKEDDESPGLYGFL
Y909 DDESPGLYGFLHVIV
K984-a EKCYNKMkMTKEDGE
T1017 QDRDWQRTVIDMNGI
S1029 NGIEVKLSVKFTSRE
S1034 KLSVKFTSREFSLKR
Y1088 GMEEVGIYRVSGVAT
S1259-p EAIPAPDsKRQsILF
S1263-p APDsKRQsILFSTEV
  rat

 
S18 WRAQFPDSEPPRMEL
Y58 QERFRMIYLQTLLAK
S122 ERPIXEGSPNKEQPA
N124 PIXEGSPNKEQPATA
T130 PNKEQPATASRPADV
- gap
Y178-p ADAEKPFyVNVEFHH
K195 GLVKVNDKEVSDRIS
S198 KVNDKEVSDRISSLG
S202 KEVSDRISSLGSQAM
S203 EVSDRISSLGSQAMQ
S206 DRISSLGSQAMQMER
K214 QAMQMERKKSQQSAG
S216 MQMERKKSQQSAGQG
Y232 GEAPRPHYRGRSSES
S236 RPHYRGRSSESSCGL
S237 PHYRGRSSESSCGLD
Y247 SCGLDGDYEDAELNP
N268 LINANGGNRPPWPPL
Y277 PPWPPLEYQPYQSIY
Y280 PPLEYQPYQSIYVGG
S282 LEYQPYQSIYVGGMM
Y284 YQPYQSIYVGGMMVE
S301 GKSPLLRSQSTSEQE
S303 SPLLRSQSTSEQEKR
T304 PLLRSQSTSEQEKRL
S305 LLRSQSTSEQEKRLT
T312 SEQEKRLTWPRRSYS
S319 TWPRRSYSPRSFEDS
Y330 FEDSGGGYTPDCSSN
S356 SGQSSRVSPSPTTYR
Y362 VSPSPTTYRMFRDKS
S376 SRSPSQNSQQSFDSS
S384 QQSFDSSSPPTPQCQ
T387 FDSSSPPTPQCQKRH
S431 FQGEADSSFGTPPGY
T434 EADSSFGTPPGYGCA
Y438 SFGTPPGYGCAADQA
Y457 RHQDGLPYIDDsPSS
S461-p GLPYIDDsPSSSPHL
S463 PYIDDsPSSSPHLSS
S464 YIDDsPSSSPHLSSK
S465 IDDsPSSSPHLSSKG
R473 PHLSSKGRGSPASGA
S475 LSSKGRGSPASGALE
K485 SGALEPTKASELDLE
K493 ASELDLEKGLEMRKW
Y512 ILASEETYLSHLEAL
S539 TSQPVLTSQQIETIF
Y553 FFKVPELYEIHKEFY
Y560 YEIHKEFYDGLFPRV
S571 FPRVQQWSHQQRVGD
K582 RVGDLFQKLASQLGV
Y590 LASQLGVYRAFVDNY
Y597 YRAFVDNYGVAMETA
S625 SENLRARSNKDVKDS
T633 NKDVKDSTTKNSLET
T634 KDVKDSTTKNSLETL
S637 KDSTTKNSLETLLYK
T640 TTKNSLETLLYKPVD
Y643 NSLETLLYKPVDRVT
T650 YKPVDRVTRSTLVLH
S652 PVDRVTRSTLVLHDL
T692 SSINEEITPRRQSMT
S697 EITPRRQSMTVKKGE
Y755 QQYDCKWYIPLTDLS
Y843 HSRNGKSYTFLISSD
Y851 TFLISSDYERAEWRE
S870-p QQKKCFKsFsLTsVE
S872-p KKCFKsFsLTsVELQ
S875-p FKsFsLTsVELQMLT
S884-p ELQMLTNsCVKLQTV
S905 INKEDDESPGLYGFL
Y909 DDESPGLYGFLHAIV
K984 EKCYNKMKMAKEDGE
T1017 QDRDWQRTVIDMNGI
S1029 NGIEVKLSVKFTSRE
S1034 KLSVKFTSREFSLKR
Y1088 GMEEVGIYRVSGVAT
S1259 EAIPAPDSKRQSILF
S1263 APDSKRQSILFSTEV
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