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Protein Page:
Bcl-xL (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Bcl-xL an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Membrane protein, integral; Mitochondrial; Apoptosis
Cellular Component: centrosome; nuclear membrane; mitochondrion; synaptic vesicle membrane; integral to membrane; cytosol; mitochondrial outer membrane; mitochondrial matrix; cytoplasm; mitochondrial inner membrane; nucleolus; nucleus; cell junction
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; BH3 domain binding; protein kinase binding
Biological Process: negative regulation of autophagy; positive regulation of apoptosis; apoptosis; cytokinesis; cellular process regulating host cell cycle in response to virus; germ cell development; apoptotic mitochondrial changes; ovarian follicle development; regulation of mitochondrial membrane potential; positive regulation of cell proliferation; negative regulation of neuron apoptosis; release of cytochrome c from mitochondria; in utero embryonic development; mitotic cell cycle checkpoint; male gonad development; suppression by virus of host apoptosis; endocytosis; cell proliferation; neuron apoptosis; fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; response to cycloheximide; innate immune response; spermatogenesis; regulation of mitochondrial membrane permeability; growth; negative regulation of apoptosis
Reference #:  Q07817 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulator Bcl-X; B2CL1; Bcl-2-like protein 1; Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; Bcl2-L-1; BCL2-like 1; BCL2L; BCL2L1; BCLX; BCLXL; BCLXS; DKFZp781P2092
Gene Symbols: BCL2L1
Molecular weight: 26,049 Da
Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcl-xL

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: T47‑p, S62‑p
apoptosis, induced: T47‑p, S62‑p, T115‑p
cell cycle regulation: T47‑p, S49‑p, S62‑p
intracellular localization: S62‑p
molecular association, regulation: S62‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S14 ELVVDFLSYkLSQKG
0 1 K16-ub VVDFLSYkLSQKGYS
3 0 T47-p GTESEMEtPsAINGN
1 0 S49-p ESEMEtPsAINGNPS
11 2 S62-p PSWHLADsPAVNGAT
0 6 K87-ub VIPMAAVkQALREAG
1 0 S106 LRYRRAFSDLTSQLH
2 0 T115-p LTSQLHItPGTAYQS
1 0 S228 AGVVLLGSLFSRK__
  mouse

 
S14-p ELVVDFLsYKLSQKG
K16 VVDFLsYKLSQKGYS
T47 ETEAERETPSAINGN
S49 EAERETPSAINGNPS
S62-p PSWHLADsPAVNGAT
K87-ub VIPMAAVkQALREAG
S106 LRYRRAFSDLTSQLH
T115 LTSQLHITPGTAYQS
S228 AGVVLLGSLFSRK__
  rat

 
S14 ELVVDFLSYKLSQKG
K16 VVDFLSYKLSQKGYS
T47 ETEPERETPSAINGN
S49 EPERETPSAINGNPS
S62-p PSWHLADsPAVNGAT
K87 VIPMAAVKQALREAG
S106-p LRYRRAFsDLTSQLH
T115 LTSQLHITPGTAYQS
S228-p AGVVLLGsLFSRK__
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