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Bcl-xL (human)

Overview Bcl-xL an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: Autophagy; Membrane protein, integral; Apoptosis; Mitochondrial Cellular Component: centrosome; mitochondrial outer membrane; nuclear membrane; mitochondrion; cytoplasm; integral to membrane; cytosol Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; BH3 domain binding; protein kinase binding Biological Process: negative regulation of autophagy; release of cytochrome c from mitochondria; in utero embryonic development; apoptosis; positive regulation of apoptosis; male gonad development; cytokinesis; cellular process regulating host cell cycle in response to virus; germ cell development; cell proliferation; apoptotic mitochondrial changes; fertilization; ovarian follicle development; regulation of mitochondrial membrane potential; response to cytokine stimulus; positive regulation of cell proliferation; innate immune response; response to cycloheximide; spermatogenesis; regulation of mitochondrial membrane permeability; negative regulation of neuron apoptosis; negative regulation of apoptosis; growth Reference #:  Q07817 (UniProtKB) Alt. Names/Synonyms: Apoptosis regulator Bcl-X; B2CL1; Bcl-2-like protein 1; Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; Bcl2-L-1; BCL2-like 1; BCL2L; BCL2L1; BCLX; BCLXL; BCLXS; DKFZp781P2092 Gene Symbols: BCL2L1 Molecular weight: 26,049 Da Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Bcl-xL 1BXL - A=1-209 (human) 1G5J - A=1-209 (human) 1G5M (human) 1GJH (human) 1LXL - A=1-209 (human) 1MAZ - A=1-209 (human) 1R2D - A=1-211 (human) 1R2E - A=1-211 (human) 1R2G - A=1-211 (human) 1R2H - A=1-211 (human) 1R2I - A=1-211 (human) 1YSG - A=1-209 (human) 1YSI - A=1-209 (human) 1YSN - A=1-209 (human) 2B48 - A=1-211 (human) 2LP8 - A=85-209 (human) 2LPC - A=85-209 (human) 2M03 - A=1-209 (human) 2M04 - A=1-209 (human) 2O1Y - A=1-209 (human) 2O2M - A=73-196 (human) 2O2N - A=73-196 (human) 2P1L - A/C/E/G=83-209 (human) 2YJ1 - A/C=83-209 (human) 2YQ6 - A=83-209 (human) 2YQ7 - A=83-209 (human) 2YXJ - A/B=1-209 (human) 3CVA - X=1-211 (human) 3FDL - A=83-209 (human) 3FDM - A/C/B=83-209 (human) 3INQ - A/B=83-209 (human) 3IO8 - A/C=83-209 (human) 3PL7 - A/B=1-209 (human) 3QKD - A/B=1-209 (human) 3R85 - A/D/C/B=83-197 (human) 3SP7 - A=85-209 (human) 3SPF - A=85-209 (human) 4A1U - A=83-209 (human) 4A1W - A/D/C/B=83-209 (human) 4AQ3 - F/A/D/C/E/B=29-44 (human) 4EHR - A=1-209 (human) 4HNJ - A/B=1-209 (human) 1PQ0 - A=1-196 (mouse) 1PQ1 - A=1-196 (mouse) 2BZW - A=1-211 (mouse) 3IHC - A=1-196 (mouse) 3IHD - A=1-196 (mouse) 3IHE - A=1-196 (mouse) 3IHF - A/D/C/B=1-196 (mouse) 3IIG - A=1-196 (mouse) 3IIH - A=1-196 (mouse) 3ILB - A/N=1-196 (mouse) 3ILC - A=1-196 (mouse) 1AF3 - A=1-196 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BXL 1G5J 1G5M 1GJH 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2O1Y 2O2M 2O2N 2P1L 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 4A1U 4A1W 4AQ3 4EHR 4HNJ  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature A000371 A000372 A000373  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: T47‑p, S62‑p apoptosis, induced: T47‑p, S62‑p, T115‑p cell cycle regulation: T47‑p, S49‑p, S62‑p intracellular localization: S62‑p molecular association, regulation: S62‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K16-u	VVDFLSYkLSQKGYS
3	0		T47-p	GTESEMEtPsAINGN
1	0		S49-p	ESEMEtPsAINGNPS
9	2		S62-p	PSWHLADsPAVNGAT
0	6		K87-u	VIPMAAVkQALREAG
1	0		S106	LRYRRAFSDLTSQLH
2	0		T115-p	LTSQLHItPGTAYQS
1	0		S228	AGVVLLGSLFSRK__

	mouse
K16	VVDFLSYKLSQKGYS
T47	ETEAERETPSAINGN
S49	EAERETPSAINGNPS
S62	PSWHLADSPAVNGAT
K87-u	VIPMAAVkQALREAG
S106	LRYRRAFSDLTSQLH
T115	LTSQLHITPGTAYQS
S228	AGVVLLGSLFSRK__

	rat
K16	VVDFLSYKLSQKGYS
T47	ETEPERETPSAINGN
S49	EPERETPSAINGNPS
S62-p	PSWHLADsPAVNGAT
K87	VIPMAAVKQALREAG
S106-p	LRYRRAFsDLTSQLH
T115	LTSQLHITPGTAYQS
S228-p	AGVVLLGsLFSRK__

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