an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Membrane protein, integral; Mitochondrial; Autophagy
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; BH3 domain binding; protein kinase binding
Biological Process: negative regulation of autophagy; release of cytochrome c from mitochondria; in utero embryonic development; apoptosis; mitotic cell cycle checkpoint; suppression by virus of host apoptosis; male gonad development; cytokinesis; endocytosis; cellular process regulating host cell cycle in response to virus; germ cell development; cell proliferation; neuron apoptosis; apoptotic mitochondrial changes; fertilization; regulation of mitochondrial membrane potential; DNA damage response, signal transduction resulting in induction of apoptosis; ovarian follicle development; response to cytokine stimulus; positive regulation of cell proliferation; innate immune response; response to cycloheximide; spermatogenesis; negative regulation of neuron apoptosis; regulation of mitochondrial membrane permeability; growth; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.