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Bcl-2 (human)

Overview Bcl-2 a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions. Note: This description may include information from UniProtKB. Protein type: Apoptosis; Autophagy; Membrane protein, integral Cellular Component: pore complex; endoplasmic reticulum membrane; mitochondrial outer membrane; nuclear membrane; membrane; mitochondrion; endoplasmic reticulum; cytoplasm; cytosol; nucleus; myelin sheath Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; protein heterodimerization activity; channel activity; sequence-specific DNA binding; ubiquitin protein ligase binding; BH3 domain binding; transcription factor binding Biological Process: positive regulation of catalytic activity; focal adhesion formation; developmental growth; pigment granule organization and biogenesis; response to toxin; ear development; female pregnancy; B cell receptor signaling pathway; negative regulation of myeloid cell apoptosis; regulation of protein localization; negative regulation of ossification; oligodendrocyte differentiation; regulation of transmembrane transporter activity; negative regulation of neuron apoptosis; response to drug; spleen development; positive regulation of neuron maturation; axon regeneration; cell aging; regulation of calcium ion transport; positive regulation of cell growth; response to ethanol; response to heat; response to estrogen stimulus; negative regulation of osteoblast proliferation; G1/S transition of mitotic cell cycle; negative regulation of apoptosis; negative regulation of autophagy; positive regulation of smooth muscle cell migration; response to L-ascorbic acid; response to insulin stimulus; positive regulation of skeletal muscle fiber development; negative regulation of cell migration; response to aluminum ion; mesenchymal cell development; CD8-positive, alpha-beta T cell lineage commitment; B cell lineage commitment; positive regulation of peptidyl-serine phosphorylation; humoral immune response; response to UV-B; endoplasmic reticulum calcium ion homeostasis; peptidyl-serine phosphorylation; response to copper ion; homeostasis of number of cells within a tissue; ureteric bud branching; response to hypoxia; innate immune response; negative regulation of cell growth; response to nicotine; renal system process; protein polyubiquitination; T cell differentiation in the thymus; lymphoid progenitor cell differentiation; positive regulation of multicellular organism growth; glomerulus development; negative regulation of mitochondrial depolarization; response to caffeine; post-embryonic development; cochlear nucleus development; cell-cell adhesion; regulation of mitochondrial membrane potential; response to folic acid; positive regulation of B cell proliferation; negative regulation of mitotic cell cycle; T cell homeostasis; cell growth; defense response to virus; response to corticosterone stimulus; release of cytochrome c from mitochondria; regulation of protein homodimerization activity; actin filament organization; digestive tract morphogenesis; organ growth; organ morphogenesis; gland morphogenesis; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; cell death; B cell proliferation; regulation of protein heterodimerization activity; behavioral fear response; melanin metabolic process; apoptosis; regulation of cell-matrix adhesion; negative regulation of retinal cell programmed cell death; regulation of protein stability; protein amino acid dephosphorylation; response to radiation; B cell homeostasis; ovarian follicle development; positive regulation of melanocyte differentiation; melanocyte differentiation; response to gamma radiation; negative regulation of cellular pH reduction; response to iron ion; ossification; thymus development; male gonad development; peptidyl-threonine phosphorylation; neuron apoptosis; response to hydrogen peroxide; response to cytokine stimulus; response to DNA damage stimulus Reference #:  P10415 (UniProtKB) Alt. Names/Synonyms: Apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl-2; BCL2 Gene Symbols: BCL2 Molecular weight: 26,266 Da Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Autophagy Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Bcl-2 1G5M - A=1-207 (human) 1GJH - A=1-207 (human) 1YSW - A=45-207 (human) 2O21 - A=44-207 (human) 2O22 - A=44-207 (human) 2O2F - A=8-31, A=92-204 (human) 2W3L - A/B=92-206 (human) 2XA0 - A/B=1-207 (human) 4AQ3 - F/A/D/C/E/B=92-207 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1G5M 1GJH 1YSW 2O21 2O22 2O2F 2W3L 2XA0 4AQ3  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: T56‑p, T69‑p, S70‑p, T74‑p, S87‑p apoptosis, induced: T56‑p, S70‑p, T74‑p, S87‑p apoptosis, inhibited: T56‑p, T69‑p, S70‑p, T74‑p, S87‑p cell cycle regulation: T56‑p cell growth, altered: S70‑p inhibition: S70‑p, S87‑p intracellular localization: S70‑p molecular association, regulation: T56‑p, T69‑p, S70‑p, S87‑p protein stabilization: T56‑p, T74‑p, S87‑p ubiquitination: T56‑p, T74‑p, S87‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y9-p	AHAGRTGyDNREIVM
1	0		S24	KYIHYKLSQRGYEWD
10	0		T56-p	FSSQPGHtPHPAASR
8	0		T69-p	SRDPVARtsPLQtPA
34	1		S70-p	RDPVARtsPLQtPAA
4	0		T74-p	ARtsPLQtPAAPGAA
17	0		S87-p	AAAGPALsPVPPVVH
0	2		Y235-p	ACITLGAyLGHK___

	mouse
Y9	AQAGRTGYDNREIVM
S24	KYIHYKLSQRGYEWD
N56	FSFQPESNPMPAVHR
T69-p	HRDMAARtsPLRPLV
S70-p	RDMAARtsPLRPLVA
P74	ARtsPLRPLVATAGP
S84-p	ATAGPALsPVPPVVH
Y232	ACITLGAYLGHK___

	rat
Y9	AQAGRTGYDNREIVM
S24-p	KYIHYKLsQRGYEWD
N56	FSFQPESNRTPAVHR
T69	HRDTAARTsPLRPLV
S70-p	RDTAARTsPLRPLVA
P74	ARTsPLRPLVANAGP
S84-p	ANAGPALsPVPPVVH
Y232	ACITLGAYLGHK___

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