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Protein Page:
Bcl-2 (human)

Overview
Bcl-2 a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Apoptosis; Membrane protein, integral
Cellular Component: pore complex; mitochondrial outer membrane; endoplasmic reticulum membrane; nuclear membrane; membrane; mitochondrion; endoplasmic reticulum; cytoplasm; cytosol; nucleus; myelin sheath
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; protein heterodimerization activity; channel activity; sequence-specific DNA binding; ubiquitin protein ligase binding; BH3 domain binding; channel inhibitor activity; transcription factor binding
Biological Process: positive regulation of catalytic activity; focal adhesion formation; developmental growth; pigment granule organization and biogenesis; response to toxin; ear development; female pregnancy; B cell receptor signaling pathway; negative regulation of myeloid cell apoptosis; negative regulation of ossification; regulation of transmembrane transporter activity; negative regulation of neuron apoptosis; response to drug; spleen development; positive regulation of neuron maturation; axon regeneration; cell aging; regulation of calcium ion transport; positive regulation of cell growth; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of osteoblast proliferation; negative regulation of apoptosis; negative regulation of autophagy; positive regulation of smooth muscle cell migration; positive regulation of skeletal muscle fiber development; regulation of viral genome replication; negative regulation of cell migration; transmembrane transport; mesenchymal cell development; CD8-positive, alpha-beta T cell lineage commitment; B cell lineage commitment; positive regulation of peptidyl-serine phosphorylation; humoral immune response; response to UV-B; endoplasmic reticulum calcium ion homeostasis; peptidyl-serine phosphorylation; ureteric bud branching; homeostasis of number of cells within a tissue; innate immune response; negative regulation of cell growth; response to acid; response to nicotine; renal system process; protein polyubiquitination; response to glucocorticoid stimulus; T cell differentiation in the thymus; lymphoid progenitor cell differentiation; positive regulation of multicellular organism growth; glomerulus development; negative regulation of mitochondrial depolarization; post-embryonic development; cochlear nucleus development; cellular response to glucose starvation; cell-cell adhesion; regulation of mitochondrial membrane potential; positive regulation of B cell proliferation; T cell homeostasis; negative regulation of mitotic cell cycle; cell growth; defense response to virus; release of cytochrome c from mitochondria; regulation of protein homodimerization activity; actin filament organization; digestive tract morphogenesis; organ growth; induction of apoptosis via death domain receptors; gland morphogenesis; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; B cell proliferation; regulation of protein heterodimerization activity; behavioral fear response; melanin metabolic process; apoptosis; regulation of cell-matrix adhesion; negative regulation of retinal cell programmed cell death; regulation of protein stability; protein amino acid dephosphorylation; response to radiation; B cell homeostasis; ovarian follicle development; positive regulation of melanocyte differentiation; melanocyte differentiation; response to gamma radiation; response to iron ion; negative regulation of cellular pH reduction; ossification; hair follicle morphogenesis; thymus development; male gonad development; peptidyl-threonine phosphorylation; neuron apoptosis; axonogenesis; response to hydrogen peroxide; response to cytokine stimulus; induction of apoptosis by oxidative stress; response to DNA damage stimulus
Reference #:  P10415 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl-2; BCL2
Gene Symbols: BCL2
Molecular weight: 26,266 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Autophagy Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcl-2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: T56‑p, T69‑p, S70‑p, T74‑p, S87‑p
apoptosis, induced: T56‑p, S70‑p, T74‑p, S87‑p
apoptosis, inhibited: T56‑p, T69‑p, S70‑p, T74‑p, S87‑p
cell cycle regulation: T56‑p
cell growth, altered: S70‑p
activity, inhibited: S70‑p, S87‑p
intracellular localization: S70‑p
molecular association, regulation: T56‑p, T69‑p, S70‑p, S87‑p
protein stabilization: T56‑p, T74‑p, S87‑p
ubiquitination: T56‑p, T74‑p, S87‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y9-p AHAGRTGyDNREIVM
1 0 S24 KYIHYKLSQRGYEWD
11 0 T56-p FSSQPGHtPHPAASR
8 0 T69-p SRDPVARtsPLQtPA
35 1 S70-p RDPVARtsPLQtPAA
4 0 T74-p ARtsPLQtPAAPGAA
17 0 S87-p AAAGPALsPVPPVVH
0 2 Y235-p ACITLGAyLGHK___
2875 : Phospho-Bcl-2 (Thr56) Antibody (Human Specific)
2827 : Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb
2834 : Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
  mouse

 
Y9 AQAGRTGYDNREIVM
S24 KYIHYKLSQRGYEWD
N56 FSFQPESNPMPAVHR
T69-p HRDMAARtsPLRPLV
S70-p RDMAARtsPLRPLVA
P74 ARtsPLRPLVATAGP
S84-p ATAGPALsPVPPVVH
Y232 ACITLGAYLGHK___
  rat

 
Y9 AQAGRTGYDNREIVM
S24-p KYIHYKLsQRGYEWD
N56 FSFQPESNRTPAVHR
T69 HRDTAARTsPLRPLV
S70-p RDTAARTsPLRPLVA
P74 ARTsPLRPLVANAGP
S84-p ANAGPALsPVPPVVH
Y232 ACITLGAYLGHK___
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