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Protein Page:
HMGN2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HMGN2 Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Belongs to the HMGN family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: cytoplasm; chromatin; nucleus
Molecular Function: nucleosomal DNA binding
Reference #:  P05204 (UniProtKB)
Alt. Names/Synonyms: High mobility group nucleosome-binding domain-containing protein 2; high mobility group protein N2; high-mobility group (nonhistone chromosomal) protein 17; high-mobility group nucleosomal binding domain 2; HMG17; HMGN2; MGC5629; MGC88718; Non-histone chromosomal protein HMG-17; nonhistone chromosomal protein HMG-17
Gene Symbols: HMGN2
Molecular weight: 9,393 Da
Basal Isoelectric point: 10  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HMGN2

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S25‑p, S29‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 K3-a _____MPkRkAEGDA
1 0 K5-a ___MPkRkAEGDAkG
1 75 K11-a RkAEGDAkGDKAKVK
1 13 S25-p KDEPQRRsARLsAkP
2 11 S29-p QRRsARLsAkPAPPk
0 44 K31-a RsARLsAkPAPPkPE
0 16 K31-u RsARLsAkPAPPkPE
0 19 K36-a sAkPAPPkPEPKPKK
0 2 K36-u sAkPAPPkPEPKPKK
1 8 K54-a KKGEKVPkGkkGkAD
1 8 K56-a GEKVPkGkkGkADAG
0 4 K57-a EKVPkGkkGkADAGk
1 6 K59-a VPkGkkGkADAGkEG
0 14 K64-a kGkADAGkEGNNPAE
0 7 K64-u kGkADAGkEGNNPAE
0 9 K76-u PAENGDAkTDQAQkA
0 8 K82-a AkTDQAQkAEGAGDA
0 17 K82-u AkTDQAQkAEGAGDA
0 232 K90-a AEGAGDAk_______
  mouse

 
K3 _____MPKRKAEGDA
K5 ___MPKRKAEGDAkG
K11-a RKAEGDAkGDKTKVK
S25-p KDEPQRRsARLsAkP
S29-p QRRsARLsAkPAPPK
K31-a RsARLsAkPAPPKPE
K31 RsARLsAKPAPPKPE
K36 sAkPAPPKPEPKPKK
K36 sAkPAPPKPEPKPKK
K54 KKGEKVPKGKKGKAD
K56 GEKVPKGKKGKADAG
K57 EKVPKGKKGKADAGk
K59 VPKGKKGKADAGkDA
K64-a KGKADAGkDANNPAE
K64 KGKADAGKDANNPAE
K76-u PAENGDAkTDQAQkA
K82 AkTDQAQKAEGAGDA
K82-u AkTDQAQkAEGAGDA
K90-a AEGAGDAk_______
  rat

 
K3 _____MPKRNAEGDA
N5 ___MPKRNAEGDAKG
K11 RNAEGDAKGDKAKVK
S25 KDEPQRRSARLSAKP
S29 QRRSARLSAKPAPPk
K31 RSARLSAKPAPPkPE
K31 RSARLSAKPAPPkPE
K36 SAKPAPPKPEPKPKK
K36-u SAKPAPPkPEPKPKK
K54 KKGEKVPKGKKGKAD
K56 GEKVPKGKKGKADAG
K57 EKVPKGKKGKADAGK
K59 VPKGKKGKADAGKDA
K64 KGKADAGKDANNPAE
K64 KGKADAGKDANNPAE
K76 PAEDGDAKTDQAQKA
K82 AKTDQAQKADGAGDA
K82 AKTDQAQKADGAGDA
K90 ADGAGDAK_______
  cow

 
K3 _____MPKRKAEGDA
K5 ___MPKRKAEGDAEG
E11 RKAEGDAEGDKAKVK
S25 KDEPQRRSARLsAKP
S29-p QRRSARLsAKPAPPK
K31 RSARLsAKPAPPKPE
K31 RSARLsAKPAPPKPE
K36 sAKPAPPKPEPKPKK
K36 sAKPAPPKPEPKPKK
K54 KKGEKVPKGKKGKAD
K56 GEKVPKGKKGKADAG
K57 EKVPKGKKGKADAGK
K59 VPKGKKGKADAGKDG
K64 KGKADAGKDGNNPAE
K64 KGKADAGKDGNNPAE
K76 PAENGDAKTDQAQKA
K82 AKTDQAQKAEGAGDA
K82 AKTDQAQKAEGAGDA
K90 AEGAGDAK_______
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