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Protein Page:
ATF-2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ATF-2 a transcription factor that is a member of the leucine zipper family. Binds to the cAMP-responsive element (CRE). Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Also possesses histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4 in vitro. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor
Cellular Component: nucleoplasm; mitochondrial outer membrane; cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; histone acetyltransferase activity; protein heterodimerization activity; metal ion binding; transcription coactivator activity; cAMP response element binding protein binding; chromatin binding; protein kinase binding; transcription factor activity
Biological Process: fat cell differentiation; transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; positive regulation of transforming growth factor-beta2 production; response to osmotic stress; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; regulation of transcription from RNA polymerase II promoter; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; regulation of transcription factor activity; intra-S DNA damage checkpoint; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription factor activity; toll-like receptor 9 signaling pathway; histone acetylation; response to DNA damage stimulus; toll-like receptor 4 signaling pathway
Reference #:  P15336 (UniProtKB)
Alt. Names/Synonyms: Activating transcription factor 2; activating transcription factor 2 splice variant ATF2-var2; ATF2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE-BP1; CREB-2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; Cyclic AMP-responsive element-binding protein 2; HB16; MGC111558; TREB7
Gene Symbols: ATF2
Molecular weight: 54,537 Da
Basal Isoelectric point: 7.75  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATF-2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: T52‑p
carcinogenesis, induced: T52‑p
cell cycle regulation: T71‑p
cell growth, altered: T71‑p
transcription, altered: T69‑p, T71‑p
transcription, induced: T52‑p, S62‑p, T69‑p, T71‑p, T73‑p, S121‑p
activity, induced: S62‑p, T69‑p, T71‑p, T73‑p
intracellular localization: T52‑p, S121‑p, S490‑p, S498‑p
protein stabilization: S62‑p, T69‑p, T71‑p, T73‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 T52-p HKHKHEMtLKFGPAR
2 34 S62-p FGPARNDsVIVADQt
28 76 T69-p sVIVADQtPtPtRFL
47 60 T71-p IVADQtPtPtRFLKN
4 10 T73-p ADQtPtPtRFLKNCE
5 14 S90-p GLFNELAsPFENEFK
0 5 K105-a KASEDDIkKMPLDLs
0 54 S112-p kKMPLDLsPLAtPII
1 31 T116-p LDLsPLAtPIIRsKI
1 0 S121-p LAtPIIRsKIEEPSV
0 2 S136-p VETTHQDsPLPHPES
0 2 T283-p MRLKAALtQQHPPVt
0 2 T290-p tQQHPPVtNGDTVKG
0 1 T290 tQQHPPVTNGDTVKG
0 5 T305-p HGSGLVRtQsEESRP
0 7 S307-p SGLVRtQsEESRPQS
0 1 S310 VRtQsEESRPQSLQQ
0 16 S328-p STTETPAsPAHTtPQ
0 1 T332 TPAsPAHTtPQtQST
0 2 T333-p PAsPAHTtPQtQSTs
0 3 T336-p PAHTtPQtQSTsGRR
2 1 S340-p tPQtQSTsGRRRRAA
1 0 K357-a DPDEKRRkFLERNRA
2 0 S367-p ERNRAAAsRCRQKRk
1 0 K374-a sRCRQKRkVWVQSLE
0 2 K409-u RNEVAQLkQLLLAHK
1 0 S490-p QSTEPALsQIVMAPS
1 0 S498-p QIVMAPSsQSQPSGS
9225 : Phospho-ATF-2 (Thr69/71) Antibody
4036 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb (Biotinylated)
5112 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb
9221 : Phospho-ATF-2 (Thr71) Antibody
9225 : Phospho-ATF-2 (Thr69/71) Antibody
  mouse

 
T34 HKHKHEMTLKFGPAR
S44-p FGPARNDsVIVADQt
T51-p sVIVADQtPtPtRFL
T53-p IVADQtPtPtRFLKN
T55-p ADQtPtPtRFLKNCE
S72-p GLFNELAsPFENEFK
K87 KASEDDIKKMPLDLs
S94-p KKMPLDLsPLAtPII
T98-p LDLsPLAtPIIRSKI
S103 LAtPIIRSKIEEPSV
S118 VETTHQDSPLPHPES
T265-p MRLKAALtQQHPPVt
T272-p tQQHPPVtNGDTVKG
T272-gl tQQHPPVtNGDTVKG
T287-p HGSGLVRtQsEEsRP
S289-p SGLVRtQsEEsRPQS
S292-p VRtQsEEsRPQSLQQ
S310-p STTETPAsPAHtTPQ
T314-p TPAsPAHtTPQTQNT
T315 PAsPAHtTPQTQNTs
T318 PAHtTPQTQNTsGRR
S322-p TPQTQNTsGRRRRAA
K339 DPDEKRRKFLERNRA
S349 ERNRAAASRCRQKRK
K356 SRCRQKRKVWVQSLE
K391-u RNEVAQLkQLLLAHK
S472 QSTEPALSQIVMAPP
S480 QIVMAPPSQAQPSGS
9225 : Phospho-ATF-2 (Thr69/71) Antibody
4036 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb (Biotinylated)
5112 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb
9221 : Phospho-ATF-2 (Thr71) Antibody
9225 : Phospho-ATF-2 (Thr69/71) Antibody
  rat

 
T34 HKHKHEMTLKFGPAR
S44 FGPARNDSVIVADQt
T51-p SVIVADQtPtPtRFL
T53-p IVADQtPtPtRFLKN
T55-p ADQtPtPtRFLKNCE
S72 GLFNELASPFENEFK
K87 KASEDDIKKMPLDLs
S94-p KKMPLDLsPLATPII
T98 LDLsPLATPIIRSKI
S103 LATPIIRSKIEEPSV
S118 VETTHQDSPLPHPES
T265 MRLKAALTQQHPPVT
T272 TQQHPPVTNGDTVKG
T272 TQQHPPVTNGDTVKG
A287 HGSGLVRAQSEESRP
S289 SGLVRAQSEESRPQS
S292 VRAQSEESRPQSLQQ
S310-p STTETPAsPAHTTPQ
T314 TPAsPAHTTPQTQNT
T315 PAsPAHTTPQTQNTS
T318 PAHTTPQTQNTSGRR
S322 TPQTQNTSGRRRRAA
K339 DPDEKRRKFLERNRA
S349 ERNRAAASRCRQKRK
K356 SRCRQKRKVWVQSLE
K391 RNEVAQLKQLLLAHK
S472 QSTEPALSQIVMAPS
S480 QIVMAPSSQAQPSGS
9225 : Phospho-ATF-2 (Thr69/71) Antibody
4036 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb (Biotinylated)
5112 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb
9221 : Phospho-ATF-2 (Thr71) Antibody
9225 : Phospho-ATF-2 (Thr69/71) Antibody
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