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Protein Page:
ATF-2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATF-2 a transcription factor that is a member of the leucine zipper family. Binds to the cAMP-responsive element (CRE). Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Also possesses histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4 in vitro. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; EC 2.3.1.48; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 2q32
Cellular Component: nucleoplasm; mitochondrial outer membrane; cytoplasm; nucleolus; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; histone acetyltransferase activity; protein heterodimerization activity; metal ion binding; transcription coactivator activity; cAMP response element binding protein binding; chromatin binding; transcription factor activity; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; fat cell differentiation; establishment and/or maintenance of chromatin architecture; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; response to osmotic stress; positive regulation of transforming growth factor-beta2 production; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; regulation of transcription from RNA polymerase II promoter; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription, DNA-dependent; regulation of transcription factor activity; intra-S DNA damage checkpoint; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; histone acetylation; toll-like receptor 4 signaling pathway; response to DNA damage stimulus
Reference #:  P15336 (UniProtKB)
Alt. Names/Synonyms: Activating transcription factor 2; activating transcription factor 2 splice variant ATF2-var2; ATF2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE-BP1; CREB-2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; Cyclic AMP-responsive element-binding protein 2; HB16; MGC111558; TREB7
Gene Symbols: ATF2
Molecular weight: 54,537 Da
Basal Isoelectric point: 7.75  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATF-2

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: T52‑p
carcinogenesis, induced: T52‑p
cell cycle regulation: T71‑p
cell growth, altered: T71‑p
transcription, altered: T69‑p, T71‑p
transcription, induced: T52‑p, S62‑p, T69‑p, T71‑p, T73‑p, S121‑p
activity, induced: S62‑p, T69‑p, T71‑p, T73‑p
intracellular localization: T52‑p, S121‑p, S490‑p, S498‑p
protein stabilization: S62‑p, T69‑p, T71‑p, T73‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 T52-p HKHKHEMtLKFGPAR
2 35 S62-p FGPARNDsVIVADQt
28 85 T69-p sVIVADQtPtPtRFL
47 70 T71-p IVADQtPtPtRFLKN
4 12 T73-p ADQtPtPtRFLKNCE
5 18 S90-p GLFNELAsPFENEFk
0 1 K97-ac sPFENEFkKASEDDI
0 5 K105-ac KASEDDIkKMPLDLs
0 64 S112-p kKMPLDLsPLAtPII
1 33 T116-p LDLsPLAtPIIRsKI
1 0 S121-p LAtPIIRsKIEEPSV
0 3 S136-p VETTHQDsPLPHPES
0 1 S266 PGIPGPSSPQPVQSE
0 2 T283-p MRLKAALtQQHPPVt
0 2 T290-p tQQHPPVtNGDTVKG
0 1 T290 tQQHPPVTNGDTVKG
0 5 T305-p HGSGLVRtQsEEsRP
0 7 S307-p SGLVRtQsEEsRPQS
0 3 S310-p VRtQsEEsRPQSLQQ
0 1 T325-p PATSTTEtPAsPAHT
0 18 S328-p STTEtPAsPAHTtPQ
0 2 T332 tPAsPAHTtPQtQST
0 2 T333-p PAsPAHTtPQtQSTs
0 4 T336-p PAHTtPQtQSTsGRR
2 1 S340-p tPQtQSTsGRRRRAA
1 0 K357-ac DPDEKRRkFLERNRA
2 0 S367-p ERNRAAAsRCRQKRk
1 0 K374-ac sRCRQKRkVWVQSLE
0 2 K409-ub RNEVAQLkQLLLAHK
0 1 T431-p QKKSGYHtADKDDSs
0 1 S438-p tADKDDSsEDIsVPS
0 1 S442-p DDSsEDIsVPSsPHt
0 1 S446-p EDIsVPSsPHtEAIQ
0 1 T449-p sVPSsPHtEAIQHSS
1 0 S490-p QSTEPALsQIVMAPS
1 0 S498-p QIVMAPSsQSQPSGS
9225 : Phospho-ATF-2 (Thr69/71) Antibody
4036 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb (Biotinylated)
5112 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb
9221 : Phospho-ATF-2 (Thr71) Antibody
9225 : Phospho-ATF-2 (Thr69/71) Antibody
13850 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb (PE Conjugate)
  mouse

 
T34 HKHKHEMTLKFGPAR
S44-p FGPARNDsVIVADQt
T51-p sVIVADQtPtPtRFL
T53-p IVADQtPtPtRFLKN
T55-p ADQtPtPtRFLKNCE
S72-p GLFNELAsPFENEFK
K79 sPFENEFKKASEDDI
K87 KASEDDIKKMPLDLs
S94-p KKMPLDLsPLAtPII
T98-p LDLsPLAtPIIRSKI
S103 LAtPIIRSKIEEPSV
S118 VETTHQDSPLPHPES
S248-p PGIPGPSsPQPVQSE
T265-p MRLKAALtQQHPPVt
T272-p tQQHPPVtNGDTVKG
T272-gl tQQHPPVtNGDTVKG
T287-p HGSGLVRtQsEEsRP
S289-p SGLVRtQsEEsRPQS
S292-p VRtQsEEsRPQSLQQ
T307 PATSTTETPAsPAHt
S310-p STTETPAsPAHtTPQ
T314-p TPAsPAHtTPQTQNT
T315 PAsPAHtTPQTQNTs
T318 PAHtTPQTQNTsGRR
S322-p TPQTQNTsGRRRRAA
K339 DPDEKRRKFLERNRA
S349 ERNRAAASRCRQKRK
K356 SRCRQKRKVWVQSLE
K391-ub RNEVAQLkQLLLAHK
T413 QKKSGYHTADKDDSS
S420 TADKDDSSEDLSVPS
S424 DDSSEDLSVPSSPHT
S428 EDLSVPSSPHTEAIQ
T431 SVPSSPHTEAIQHSS
S472 QSTEPALSQIVMAPP
S480 QIVMAPPSQAQPSGS
9225 : Phospho-ATF-2 (Thr69/71) Antibody
4036 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb (Biotinylated)
5112 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb
9221 : Phospho-ATF-2 (Thr71) Antibody
9225 : Phospho-ATF-2 (Thr69/71) Antibody
13850 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb (PE Conjugate)
  rat

 
T34 HKHKHEMTLKFGPAR
S44 FGPARNDSVIVADQt
T51-p SVIVADQtPtPtRFL
T53-p IVADQtPtPtRFLKN
T55-p ADQtPtPtRFLKNCE
S72 GLFNELASPFENEFK
K79 SPFENEFKKASEDDI
K87 KASEDDIKKMPLDLs
S94-p KKMPLDLsPLATPII
T98 LDLsPLATPIIRSKI
S103 LATPIIRSKIEEPSV
S118 VETTHQDSPLPHPES
S248 PGIPGPSSPQPVQSE
T265 MRLKAALTQQHPPVT
T272 TQQHPPVTNGDTVKG
T272 TQQHPPVTNGDTVKG
A287 HGSGLVRAQSEESRP
S289 SGLVRAQSEESRPQS
S292 VRAQSEESRPQSLQQ
T307 PATSTTETPAsPAHT
S310-p STTETPAsPAHTTPQ
T314 TPAsPAHTTPQTQNT
T315 PAsPAHTTPQTQNTS
T318 PAHTTPQTQNTSGRR
S322 TPQTQNTSGRRRRAA
K339 DPDEKRRKFLERNRA
S349 ERNRAAASRCRQKRK
K356 SRCRQKRKVWVQSLE
K391 RNEVAQLKQLLLAHK
T413 QKKSGYHTADKDDSS
S420 TADKDDSSEDLSVPS
S424 DDSSEDLSVPSSPHT
S428 EDLSVPSSPHTEAIQ
T431 SVPSSPHTEAIQHSS
S472 QSTEPALSQIVMAPS
S480 QIVMAPSSQAQPSGS
9225 : Phospho-ATF-2 (Thr69/71) Antibody
4036 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb (Biotinylated)
5112 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb
9221 : Phospho-ATF-2 (Thr71) Antibody
9225 : Phospho-ATF-2 (Thr69/71) Antibody
13850 : Phospho-ATF-2 (Thr71) (11G2) Rabbit mAb (PE Conjugate)
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