a transcription factor that is a member of the leucine zipper family. Binds to the cAMP-responsive element (CRE). Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Also possesses histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4 in vitro. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; C2H2-type zinc finger protein
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; identical protein binding; protein binding; zinc ion binding; cAMP response element binding protein binding; transcription coactivator activity; chromatin binding; transcription factor activity; protein kinase binding
Biological Process: fat cell differentiation; transcription from RNA polymerase II promoter; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; response to osmotic stress; positive regulation of transforming growth factor-beta2 production; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; regulation of transcription factor activity; toll-like receptor signaling pathway; innate immune response; toll-like receptor 4 signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.