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ATF-2 (human)

Overview ATF-2 a transcription factor that is a member of the leucine zipper family. Binds to the cAMP-responsive element (CRE). Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Also possesses histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4 in vitro. Note: This description may include information from UniProtKB. Protein type: Transcription factor; C2H2-type zinc finger protein Cellular Component: nucleoplasm; nucleolus; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; identical protein binding; protein binding; zinc ion binding; cAMP response element binding protein binding; transcription coactivator activity; chromatin binding; transcription factor activity; protein kinase binding Biological Process: fat cell differentiation; transcription from RNA polymerase II promoter; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; response to osmotic stress; positive regulation of transforming growth factor-beta2 production; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; regulation of transcription factor activity; toll-like receptor signaling pathway; innate immune response; toll-like receptor 4 signaling pathway Reference #:  P15336 (UniProtKB) Alt. Names/Synonyms: Activating transcription factor 2; activating transcription factor 2 splice variant ATF2-var2; ATF2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE-BP1; CREB-2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; Cyclic AMP-responsive element-binding protein 2; HB16; MGC111558; TREB7 Gene Symbols: ATF2 Molecular weight: 54,537 Da Basal Isoelectric point: 7.75  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATF-2 1BHI - A=1-38 (human) 1T2K - D=336-396 (human) 4H36 - A=46-400 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1BHI 1T2K 4H36  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: T52‑p carcinogenesis, induced: T52‑p cell cycle regulation: T71‑p cell growth, altered: T71‑p transcription, altered: S62‑p, T69‑p, T71‑p, T73‑p, S121‑p transcription, induced: T52‑p, T69‑p, T71‑p activation: S62‑p, T69‑p, T71‑p, T73‑p intracellular localization: T52‑p, S121‑p, S490‑p, S498‑p protein stabilization: S62‑p, T69‑p, T71‑p, T73‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	1		T52-p	HKHKHEMtLKFGPAR
2	33		S62-p	FGPARNDsVIVADQt
28	70		T69-p	sVIVADQtPtPtRFL
47	56		T71-p	IVADQtPtPtRFLKN
4	10		T73-p	ADQtPtPtRFLKNCE
5	14		S90-p	GLFNELAsPFENEFk
0	1		K97-a	sPFENEFkKASEDDI
0	5		K105-a	KASEDDIkKMPLDLs
0	48		S112-p	kKMPLDLsPLAtPII
1	31		T116-p	LDLsPLAtPIIRsKI
1	0		S121-p	LAtPIIRsKIEEPSV
0	1		S136-p	VETTHQDsPLPHPES
0	2		T283-p	MRLKAALtQQHPPVt
0	2		T290-p	tQQHPPVtNGDTVKG
0	1		T290	tQQHPPVTNGDTVKG
0	4		T305-p	HGSGLVRtQsEESRP
0	7		S307-p	SGLVRtQsEESRPQS
0	1		S310	VRtQsEESRPQSLQQ
0	14		S328-p	STTETPAsPAHTtPQ
0	1		T332	TPAsPAHTtPQtQST
0	2		T333-p	PAsPAHTtPQtQSTs
0	3		T336-p	PAHTtPQtQSTsGRR
2	0		S340-p	tPQtQSTsGRRRRAA
1	0		K357-a	DPDEKRRkFLERNRA
2	0		S367-p	ERNRAAAsRCRQKRk
1	0		K374-a	sRCRQKRkVWVQSLE
0	2		K409-u	RNEVAQLkQLLLAHK
1	0		S490-p	QSTEPALsQIVMAPS
1	0		S498-p	QIVMAPSsQSQPSGS

	mouse
T34	HKHKHEMTLKFGPAR
S44-p	FGPARNDsVIVADQt
T51-p	sVIVADQtPtPtRFL
T53-p	IVADQtPtPtRFLKN
T55-p	ADQtPtPtRFLKNCE
S72-p	GLFNELAsPFENEFK
K79	sPFENEFKKASEDDI
K87	KASEDDIKKMPLDLs
S94-p	KKMPLDLsPLAtPII
T98-p	LDLsPLAtPIIRSKI
S103	LAtPIIRSKIEEPSV
S118	VETTHQDSPLPHPES
T265-p	MRLKAALtQQHPPVt
T272-p	tQQHPPVtNGDTVKG
T272-g	tQQHPPVtNGDTVKG
T287-p	HGSGLVRtQsEEsRP
S289-p	SGLVRtQsEEsRPQS
S292-p	VRtQsEEsRPQSLQQ
S310-p	STTETPAsPAHtTPQ
T314-p	TPAsPAHtTPQTQNT
T315	PAsPAHtTPQTQNTS
T318	PAHtTPQTQNTSGRR
S322	TPQTQNTSGRRRRAA
K339	DPDEKRRKFLERNRA
S349	ERNRAAASRCRQKRK
K356	SRCRQKRKVWVQSLE
K391-u	RNEVAQLkQLLLAHK
S472	QSTEPALSQIVMAPP
S480	QIVMAPPSQAQPSGS

	rat
T34	HKHKHEMTLKFGPAR
S44	FGPARNDSVIVADQt
T51-p	SVIVADQtPtPtRFL
T53-p	IVADQtPtPtRFLKN
T55-p	ADQtPtPtRFLKNCE
S72	GLFNELASPFENEFK
K79	SPFENEFKKASEDDI
K87	KASEDDIKKMPLDLs
S94-p	KKMPLDLsPLATPII
T98	LDLsPLATPIIRSKI
S103	LATPIIRSKIEEPSV
S118	VETTHQDSPLPHPES
T265	MRLKAALTQQHPPVT
T272	TQQHPPVTNGDTVKG
T272	TQQHPPVTNGDTVKG
A287	HGSGLVRAQSEESRP
S289	SGLVRAQSEESRPQS
S292	VRAQSEESRPQSLQQ
S310	STTETPASPAHTTPQ
T314	TPASPAHTTPQTQNT
T315	PASPAHTTPQTQNTS
T318	PAHTTPQTQNTSGRR
S322	TPQTQNTSGRRRRAA
K339	DPDEKRRKFLERNRA
S349	ERNRAAASRCRQKRK
K356	SRCRQKRKVWVQSLE
K391	RNEVAQLKQLLLAHK
S472	QSTEPALSQIVMAPS
S480	QIVMAPSSQAQPSGS

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