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Protein Page:
MPO (human)

Overview
MPO Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.11.2.2; EC 1.11.1.7
Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule
Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding
Biological Process: response to food; respiratory burst during defense response; removal of superoxide radicals; response to mechanical stimulus; hydrogen peroxide catabolic process; defense response; response to lipopolysaccharide; response to yeast; response to oxidative stress; defense response to fungus; negative regulation of apoptosis; aging
Reference #:  P05164 (UniProtKB)
Alt. Names/Synonyms: 84 kDa myeloperoxidase; 89 kDa myeloperoxidase; MPO; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain; PERM
Gene Symbols: MPO
Molecular weight: 83,869 Da
Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MPO

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 T428-p REHNRLAtELKSLNP
0 1 Y482-p YLPTYRSyNDSVDPR
0 3 Y500-p VFTNAFRyGHTLIQP
0 2 Y723-p NIFMSNSyPRDFVNC
  mouse

 
T402 REHNRLATQLKRLNP
Y456 YLPQYRSYNDSVDPR
Y474 VFTNAFRYGHTLIQP
Y697 NIFMSNTYPRDFVSC
  rat

 
T142 REHNRLATELKRLNP
Y196 YLPQYRSYNDSVDPR
Y214-p VFTNAFRyGHTLIQP
H437 NIFMSNSHPRDFVSC
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