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Protein Page:
MPO (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MPO Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 1.11.1.7; EC 1.11.2.2; Oxidoreductase
Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule
Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding
Biological Process: respiratory burst during defense response; response to food; removal of superoxide radicals; response to mechanical stimulus; hydrogen peroxide catabolic process; response to lipopolysaccharide; defense response; response to yeast; response to oxidative stress; defense response to fungus; aging; negative regulation of apoptosis
Reference #:  P05164 (UniProtKB)
Alt. Names/Synonyms: 84 kDa myeloperoxidase; 89 kDa myeloperoxidase; MPO; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain; PERM
Gene Symbols: MPO
Molecular weight: 83,869 Da
Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MPO

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K103-ac MELLSYFkQPVAATR
0 1 S315 DCIPFFRSCPACPGS
0 1 P320 FRSCPACPGSNITIR
0 3 T428-p REHNRLAtELKsLNP
0 1 S432-p RLAtELKsLNPRWDG
0 1 Y482-p YLPTYRSyNDSVDPR
0 2 Y500-p VFTNAFRyGHTLIQP
0 1 Y516-p MFRLDNRyQPMEPNP
0 1 S528-p PNPRVPLsRVFFASW
0 1 S720-p SKNNIFMsNSyPRDF
0 2 Y723-p NIFMsNSyPRDFVNC
  mouse

 
K77 TELLFYFKQPVAGTR
S289-p DCIPFFRsCPACtRN
T294-p FRsCPACtRNNITIR
T402 REHNRLATQLKRLNP
R406 RLATQLKRLNPRWNG
Y456 YLPQYRSYNDSVDPR
Y474 VFTNAFRYGHTLIQP
Y490 MFRLNNQYRPTGPNP
S502 PNPRVPLSKVFFASW
S694 SKNNIFMSNTYPRDF
Y697 NIFMSNTYPRDFVSC
  rat

 
K77 MELLSYFKQPVAGTR
- gap
- gap
T142 REHNRLATELKRLNP
R146 RLATELKRLNPRWNG
Y196 YLPQYRSYNDSVDPR
Y214 VFTNAFRYGHTLIQP
Y230 MFRLDNQYRSTGPNP
S242 PNPRVPLSRVFFASW
S434 SKNNIFMSNSHPRDF
H437 NIFMSNSHPRDFVSC
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