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AR (human)

Overview AR a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Nuclear receptor; DNA binding protein; Transcription factor Cellular Component: nucleoplasm; protein complex; axon; nuclear chromatin; cytoplasm; dendrite; nucleus Molecular Function: protein dimerization activity; identical protein binding; ligand-dependent nuclear receptor activity; zinc ion binding; androgen binding; beta-catenin binding; transcription factor binding; androgen receptor activity; protein binding; enzyme binding; DNA binding; androgen receptor binding; sequence-specific DNA binding; chromatin binding; transcription factor activity; receptor binding Biological Process: cell death; prostate gland development; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of estrogen receptor signaling pathway; signal transduction; response to insulin stimulus; activation of NF-kappaB transcription factor; negative regulation of integrin biosynthetic process; positive regulation of MAPKKK cascade; cell-cell signaling; transport; regulation of catalytic activity; positive regulation of cell proliferation; male genitalia morphogenesis; positive regulation of integrin biosynthetic process; cell growth; negative regulation of epithelial cell proliferation; transcription initiation from RNA polymerase II promoter; regulation of developmental growth; organ formation; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; in utero embryonic development; male gonad development; protein oligomerization; cell proliferation; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase III promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter; male somatic sex determination; sex differentiation; positive regulation of phosphorylation; negative regulation of apoptosis Reference #:  P10275 (UniProtKB) Alt. Names/Synonyms: AIS; ANDR; Androgen receptor; AR; DHTR; Dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM Gene Symbols: AR Molecular weight: 98,989 Da Basal Isoelectric point: 6  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below AR 1E3G - A=657-919 (human) 1GS4 - A=670-917 (human) 1T5Z - A=669-919 (human) 1T63 - A=669-919 (human) 1T65 - A=669-919 (human) 1XJ7 - A=663-919 (human) 1XOW - A=671-919, B=20-30 (human) 1XQ3 - A=671-919 (human) 1Z95 - A=672-917 (human) 2AM9 - A=654-919 (human) 2AMA - A=654-919 (human) 2AMB - A=654-919 (human) 2AO6 - A=671-919 (human) 2AX6 - A=664-919 (human) 2AX7 - A=664-919 (human) 2AX8 - A=664-919 (human) 2AX9 - A=664-919 (human) 2AXA - A=664-919 (human) 2HVC - A=669-918 (human) 2OZ7 - A=671-919 (human) 2PIO - A=669-919 (human) 2PIP - L=669-919 (human) 2PIQ - A=669-919 (human) 2PIR - A=669-919 (human) 2PIT - A=669-919 (human) 2PIU - A=669-919 (human) 2PIV - A=669-919 (human) 2PIW - A=669-919 (human) 2PIX - A=669-919 (human) 2PKL - A=669-919 (human) 2PNU - A=654-919 (human) 2Q7I - A=663-919 (human) 2Q7J - A=663-919 (human) 2Q7K - A=663-919 (human) 2Q7L - A=663-919 (human) 2YHD - A=671-919 (human) 2YLO - A=664-919 (human) 2YLP - A=664-919 (human) 2YLQ - A=664-919 (human) 3B5R - A=671-919 (human) 3B65 - A=671-919 (human) 3B66 - A=671-919 (human) 3B67 - A=671-919 (human) 3B68 - A=671-919 (human) 3BTR - B=621-635 (human) 3L3X - A=670-918 (human) 3L3Z - A=670-918 (human) 3RLJ - A=671-917 (human) 3RLL - A=671-917 (human) 3V49 - A=654-919 B=21-31 (human) 3V4A - A=671-919 B=21-31 (human) 3ZQT - A=664-919 (human) 4HLW - A=664-919 (human) 2QPY - A=649-899 (mouse) 1I37 (rat) 1I38 (rat) 1R4I (rat) 1XNN (rat) 2IHQ (rat) 2NW4 (rat) 3G0W (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1E3G 1GS4 1T5Z 1T63 1T65 1XJ7 1XOW 1XQ3 1Z95 2AM9 2AMA 2AMB 2AO6 2AX6 2AX7 2AX8 2AX9 2AXA 2HVC 2OZ7 2PIO 2PIP 2PIQ 2PIR 2PIT 2PIU 2PIV 2PIW 2PIX 2PKL 2PNU 2Q7I 2Q7J 2Q7K 2Q7L 2YHD 2YLO 2YLP 2YLQ 3B5R 3B65 3B66 3B67 3B68 3BTR 3L3X 3L3Z 3RLJ 3RLL 3V49 3V4A 3ZQT 4HLW  |  Phospho3D  |  DISEASE 176807 300068 300633 308370 312300 313200 313700  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: S213‑p, S791‑p cell cycle regulation: Y534‑p cell growth, altered: Y267‑p, T280‑p, S291‑p, Y363‑p cell growth, induced: S81‑p transcription, altered: S81‑p, S94‑p, S213‑p, S256‑p, Y267‑p, T280‑p, S291‑p, S308‑p, Y363‑p, S424‑p, S515‑p, Y534‑p, S578‑p, S650‑p, S791‑p activation: T280‑p, S291‑p inhibition: S213‑p intracellular localization: S81‑p, S213‑p, Y534‑p, S578‑p, S650‑p, S791‑p molecular association, regulation: S81‑p, Y267‑p, T280‑p, S291‑p, S578‑p protein degradation: S515‑p protein stabilization: S81‑p ubiquitination: S515‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
3	1		S16-p	RVYPRPPsKTYRGAF
8	1		S81-p	QQQQQETsPRQQQQQ
6	4		S94-p	QQQGEDGsPQAHRRG
8	0		S213-p	SGRAREAsGAPtSSK
0	1		T217-p	REAsGAPtSSKDNyL
0	1		Y223-p	PtSSKDNyLGGTSTI
0	1		S231-p	LGGTSTIsDNAKELC
0	1		S242-p	KELCKAVsVsMGLGV
0	1		S244-p	LCKAVsVsMGLGVEA
3	2		S256-p	VEALEHLsPGEQLRG
3	2		Y267-p	QLRGDCMyAPLLGVP
1	0		T280-p	VPPAVRPtPCAPLAE
1	0		S291-p	PLAECKGsLLDDSAG
0	1		Y307-p	STEDTAEysPFKGGY
6	2		S308-p	TEDTAEysPFKGGYT
0	1		Y346-p	LPSTLSLyKSGALDE
0	1		Y357-p	ALDEAAAyQSRDyyN
0	1		Y362-p	AAyQSRDyyNFPLAL
1	2		Y363-p	AyQSRDyyNFPLALA
4	0		K386-s	PHPHARIkLENPLDy
0	1		Y393-p	kLENPLDyGSAWAAA
1	0		R405-p	AAAAAQCrYGDLASL
3	1		S424-p	AAGPGSGsPSAAASS
4	1		S515-p	VSRVPYPsPTCVkSE
4	0		K520-s	YPsPTCVkSEMGPWM
2	1		Y534-p	MDSYSGPyGDMRLET
0	1		Y551-p	DHVLPIDyYFPPQKT
2	0		S578-p	YGALTCGsCKVFFKR
8	0		K630-a	GMTLGARkLkkLGNL
7	0		K632-a	TLGARkLkkLGNLKL
6	0		K633-a	LGARkLkkLGNLKLQ
7	3		S650-p	GEASSTTsPTEETTQ
0	1		K720	VHVVKWAKALPGFRN
4	0		S791-p	CVRMRHLsQEFGWLQ
0	1		K825-u	VDGLKNQkFFDELRM
0	1		K836-a	ELRMNYIkELDRIIA
1	0		K845-u	LDRIIACkRkNPtSC
1	0		K847-u	RIIACkRkNPtSCSR
1	1		T850-p	ACkRkNPtSCSRRFy
0	1		Y857-p	tSCSRRFyQLTKLLD
0	1		Y915-p	SGKVKPIyFHTQ___

	mouse
S16	RVYPRPPSKTYRGAF
S61	LQQRQETSPRRRRRQ
S75	QQHTEDGSPQAHIRG
T208	SARAREATGAPSSSK
S212	REATGAPSSSKDSYL
Y218	PSSSKDSYLGGNSTI
S226	LGGNSTISDSAKELC
S237	KELCKAVSVSMGLGV
S239	LCKAVSVSMGLGVEA
S251	VEALEHLSPGEQLRG
Y262	QLRGDCMYASLLGGP
T275	GPPAVRPTPCAPLPE
L286	PLPECKGLPLDEGPG
Y302	STEETAEYSSFKGGY
S303	TEETAEYSSFKGGYA
Y341	IPSSLSLYKSGALDE
Y352	ALDEAAAYQNRDYYN
Y357	AAYQNRDYYNFPLAL
Y358	AYQNRDYYNFPLALS
K381	THPHARIKLENPLDY
Y388	KLENPLDYGSAWAAA
R400	AAAAAQCRYGDLGSL
S419	VAGPSTGSPPATTSS
S495	VNRVPYPSPNCVKSE
K500	YPSPNCVKSEMGPWM
Y514	MENYSGPYGDMRLDS
Y531	DHVLPIDYYFPPQKT
S558	YGALTCGSCKVFFKR
K610	GMTLGARKLKKLGNL
K612	TLGARKLKKLGNLKL
K613	LGARKLKKLGNLKLQ
S630-p	GENSNAGsPTEDPSQ
K700-u	VHVVKWAkALPGFRN
S771	CVRMRHLSQEFGWLQ
K805	VDGLKNQKFFDELRM
K816	ELRMNYIKELDRIIA
K825	LDRIIACKRKNPTSC
K827	RIIACKRKNPTSCSR
T830	ACKRKNPTSCSRRFY
Y837	TSCSRRFYQLTKLLD
Y895	SGKVKPIYFHTQ___

	rat
S16	RVYPRPPSKTYRGAF
S61	LQQRQETSPRRRRRQ
S75	QQHPEDGSPQAHIRG
T211	SVRAREATGAPSSSK
S215	REATGAPSSSKDSYL
Y221	PSSSKDSYLGGNSTI
S229	LGGNSTISDSAKELC
S240	KELCKAVSVSMGLGV
S242	LCKAVSVSMGLGVEA
S254	VEALEHLSPGEQLRG
Y265	QLRGDCMYASLLGGP
T278	GPPAVRPTPCAPLAE
L289	PLAECKGLSLDEGPG
Y305	GTEETAEYSSFKGGY
S306	TEETAEYSSFKGGYA
Y344	IPSSLSLYKSGAVDE
Y355	AVDEAAAYQNRDYYN
Y360	AAYQNRDYYNFPLAL
Y361	AYQNRDYYNFPLALS
K384	THPHARIKLENPSDY
Y391	KLENPSDYGSAWAAA
R403	AAAAAQCRYGDLASL
S422	VAGPSTGSPPATASS
S498	VNRVPYPSPSCVKSE
K503	YPSPSCVKSEMGPWM
Y517	MENYSGPYGDMRLDS
Y534	DHVLPIDYYFPPQKT
S561	YGALTCGSCKVFFKR
K613	GMTLGARKLKKLGNL
K615	TLGARKLKKLGNLKL
K616	LGARKLKKLGNLKLQ
S633	GENSSAGSPTEDPSQ
K703	VHVVKWAKALPGFRN
S774	CVRMRHLSQEFGWLQ
K808	VDGLKNQKFFDELRM
K819	ELRMNYIKELDRIIA
K828	LDRIIACKRKNPTSC
K830	RIIACKRKNPTSCSR
T833	ACKRKNPTSCSRRFY
Y840	TSCSRRFYQLTKLLD
Y898	SGKVKPIYFHTQ___

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