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Protein Page:
AR (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
AR a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein; Nuclear receptor
Cellular Component: nucleoplasm; protein complex; axon; cytoplasm; dendrite; nuclear chromatin; plasma membrane; nucleus
Molecular Function: protein dimerization activity; protein binding; ligand-dependent nuclear receptor activity; androgen receptor activity; enzyme binding; DNA binding; androgen receptor binding; zinc ion binding; androgen binding; sequence-specific DNA binding; beta-catenin binding; chromatin binding; transcription factor binding; transcription factor activity; receptor binding
Biological Process: cell death; positive regulation of insulin-like growth factor receptor signaling pathway; prostate gland development; positive regulation of transcription, DNA-dependent; positive regulation of estrogen receptor signaling pathway; signal transduction; response to insulin stimulus; activation of NF-kappaB transcription factor; negative regulation of integrin biosynthetic process; cell-cell signaling; positive regulation of MAPKKK cascade; regulation of catalytic activity; transport; positive regulation of cell proliferation; male genitalia morphogenesis; positive regulation of integrin biosynthetic process; cell growth; negative regulation of epithelial cell proliferation; transcription initiation from RNA polymerase II promoter; regulation of developmental growth; organ formation; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; in utero embryonic development; male gonad development; protein oligomerization; cell proliferation; androgen receptor signaling pathway; regulation of systemic arterial blood pressure; positive regulation of transcription from RNA polymerase III promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; male somatic sex determination; sex differentiation; positive regulation of phosphorylation
Reference #:  P10275 (UniProtKB)
Alt. Names/Synonyms: AIS; ANDR; Androgen receptor; AR; DHTR; Dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM
Gene Symbols: AR
Molecular weight: 98,989 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AR

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S791‑p
apoptosis, inhibited: S213‑p, S791‑p
cell cycle regulation: Y534‑p
cell growth, altered: Y267‑p, T280‑p, S291‑p, Y363‑p
cell growth, induced: S81‑p
cell growth, inhibited: S791‑p
transcription, altered: S81‑p, S94‑p, S213‑p, S256‑p, T280‑p, S291‑p, S308‑p, S424‑p, S515‑p, Y534‑p, S650‑p, S791‑p
transcription, induced: Y223‑p, Y267‑p, Y363‑p, S515‑p, S578‑p
activity, induced: T280‑p, S291‑p
activity, inhibited: S213‑p
intracellular localization: S81‑p, S213‑p, Y534‑p, S578‑p, S650‑p, S791‑p
molecular association, regulation: S81‑p, Y267‑p, T280‑p, S291‑p, S578‑p
protein degradation: S515‑p
protein stabilization: S81‑p
ubiquitination: S515‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
3 1 S16-p RVYPRPPsKTYRGAF
8 1 S81-p QQQQQETsPRQQQQQ
7 4 S94-p QQQGEDGsPQAHRRG
8 0 S213-p SGRAREAsGAPTSSK
1 1 Y223-p PTSSKDNyLGGTSTI
3 2 S256-p VEALEHLsPGEQLRG
3 2 Y267-p QLRGDCMyAPLLGVP
1 0 T280-p VPPAVRPtPCAPLAE
1 0 S291-p PLAECKGsLLDDSAG
0 1 Y307-p STEDTAEysPFKGGY
7 2 S308-p TEDTAEysPFKGGYT
0 1 Y346-p LPSTLSLyKSGALDE
0 1 Y357-p ALDEAAAyQSRDyyN
0 1 Y362-p AAyQSRDyyNFPLAL
1 2 Y363-p AyQSRDyyNFPLALA
4 0 K386-s PHPHARIkLENPLDy
0 1 Y393-p kLENPLDyGSAWAAA
1 0 R405-p AAAAAQCrYGDLASL
3 1 S424-p AAGPGSGsPSAAASS
4 1 S515-p VSRVPYPsPTCVkSE
4 0 K520-s YPsPTCVkSEMGPWM
2 1 Y534-p MDSYSGPyGDMRLET
0 1 Y551-p DHVLPIDyYFPPQKT
2 0 S578-p YGALTCGsCKVFFKR
8 0 K630-a GMTLGARkLkkLGNL
1 0 K630-m GMTLGARkLkkLGNL
7 0 K632-a TLGARkLkkLGNLKL
6 0 K633-a LGARkLkkLGNLKLQ
8 3 S650-p GEASSTTsPTEETTQ
0 1 K720 VHVVKWAKALPGFRN
5 0 S791-p CVRMRHLsQEFGWLQ
1 0 K845-u LDRIIACkRkNPtSC
1 0 K847-u RIIACkRkNPtSCSR
1 1 T850-p ACkRkNPtSCSRRFY
0 1 Y915-p SGKVKPIyFHTQ___
  mouse

 
S16 RVYPRPPSKTYRGAF
S61 LQQRQETSPRRRRRQ
S75 QQHTEDGSPQAHIRG
T208 SARAREATGAPSSSK
Y218 PSSSKDSYLGGNSTI
S251 VEALEHLSPGEQLRG
Y262 QLRGDCMYASLLGGP
T275 GPPAVRPTPCAPLPE
L286 PLPECKGLPLDEGPG
Y302 STEETAEYSSFKGGY
S303 TEETAEYSSFKGGYA
Y341 IPSSLSLYKSGALDE
Y352 ALDEAAAYQNRDYYN
Y357 AAYQNRDYYNFPLAL
Y358 AYQNRDYYNFPLALS
K381 THPHARIKLENPLDY
Y388 KLENPLDYGSAWAAA
R400 AAAAAQCRYGDLGSL
S419 VAGPSTGSPPATTSS
S495 VNRVPYPSPNCVKSE
K500 YPSPNCVKSEMGPWM
Y514 MENYSGPYGDMRLDS
Y531 DHVLPIDYYFPPQKT
S558 YGALTCGSCKVFFKR
K610 GMTLGARKLKKLGNL
K610 GMTLGARKLKKLGNL
K612 TLGARKLKKLGNLKL
K613 LGARKLKKLGNLKLQ
S630-p GENSNAGsPTEDPSQ
K700-u VHVVKWAkALPGFRN
S771 CVRMRHLSQEFGWLQ
K825 LDRIIACKRKNPTSC
K827 RIIACKRKNPTSCSR
T830 ACKRKNPTSCSRRFY
Y895 SGKVKPIYFHTQ___
  rat

 
S16 RVYPRPPSKTYRGAF
S61 LQQRQETSPRRRRRQ
S75 QQHPEDGSPQAHIRG
T211 SVRAREATGAPSSSK
Y221 PSSSKDSYLGGNSTI
S254 VEALEHLSPGEQLRG
Y265 QLRGDCMYASLLGGP
T278 GPPAVRPTPCAPLAE
L289 PLAECKGLSLDEGPG
Y305 GTEETAEYSSFKGGY
S306 TEETAEYSSFKGGYA
Y344 IPSSLSLYKSGAVDE
Y355 AVDEAAAYQNRDYYN
Y360 AAYQNRDYYNFPLAL
Y361 AYQNRDYYNFPLALS
K384 THPHARIKLENPSDY
Y391 KLENPSDYGSAWAAA
R403 AAAAAQCRYGDLASL
S422 VAGPSTGSPPATASS
S498 VNRVPYPSPSCVKSE
K503 YPSPSCVKSEMGPWM
Y517 MENYSGPYGDMRLDS
Y534 DHVLPIDYYFPPQKT
S561 YGALTCGSCKVFFKR
K613 GMTLGARKLKKLGNL
K613 GMTLGARKLKKLGNL
K615 TLGARKLKKLGNLKL
K616 LGARKLKKLGNLKLQ
S633 GENSSAGSPTEDPSQ
K703 VHVVKWAKALPGFRN
S774 CVRMRHLSQEFGWLQ
K828 LDRIIACKRKNPTSC
K830 RIIACKRKNPTSCSR
T833 ACKRKNPTSCSRRFY
Y898 SGKVKPIYFHTQ___
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