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ACO2 (human)

Overview ACO2 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Monomer. Belongs to the aconitase/IPM isomerase family. Note: This description may include information from UniProtKB. Protein type: Mitochondrial; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Lyase; EC 4.2.1.3; Carbohydrate Metabolism - citrate (TCA) cycle Cellular Component: mitochondrion; mitochondrial matrix; nucleus Molecular Function: 4 iron, 4 sulfur cluster binding; iron ion binding; 3 iron, 4 sulfur cluster binding Biological Process: cell death; isocitrate metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle; citrate metabolic process Reference #:  Q99798 (UniProtKB) Alt. Names/Synonyms: ACO2; ACON; Aconitase; aconitase 2, mitochondrial; Aconitate hydratase, mitochondrial; ACONM; Citrate hydro-lyase; MGC20605; MGC33908 Gene Symbols: ACO2 Molecular weight: 85,425 Da Basal Isoelectric point: 7.36  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ACO2 1B0J - A=28-781 (pig) 1B0K - A=29-781 (pig) 1B0M - A=29-781 (pig) 5ACN - A=29-781 (pig) 6ACN - A=29-781 (pig) 7ACN - A=29-781 (pig) 1ACO - A=29-779 (cow) 1AMI - A=28-779 (cow) 1AMJ - A=28-779 (cow) 1C96 - A=29-779 (cow) 1C97 - A=29-779 (cow) 1FGH - A=29-779 (cow) 1NIS - A=29-779 (cow) 1NIT - A=29-779 (cow) 8ACN - A=29-779 (cow)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K31-a	SVLCQRAkVAMSHFE
0	1		K31	SVLCQRAKVAMSHFE
0	3		Y42-p	SHFEPNEyIHYDLLE
0	10		K50-a	IHYDLLEkNINIVRK
0	1		K50	IHYDLLEKNINIVRK
0	1		T64	KRLNRPLTLSEKIVY
2	0		Y71	TLSEKIVYGHLDDPA
0	1		S87-p	QEIERGKsYLRLRPD
0	2		Y88	EIERGKsYLRLRPDR
0	1		K138-a	EAQVGGEkDLRRAKD
0	2		K144	EkDLRRAKDINQEVY
0	2		K144	EkDLRRAKDINQEVY
0	2		Y151	KDINQEVYNFLATAG
0	1		K160-a	FLATAGAkYGVGFWK
0	1		K225	AGIPWELKCPkVIGV
0	2		K228-a	PWELKCPkVIGVkLT
0	2		K233-a	CPkVIGVkLTGSLSG
0	1		S237	IGVkLTGSLSGWSSP
0	2		K304-a	FPYNHRMkkYLSKTG
0	5		K305-a	PYNHRMkkYLSKTGR
0	1		S308	HRMkkYLSKTGREDI
0	1		K370-u	EVGKVAEkEGWPLDI
0	1		Y390-p	GSCTNSSyEDMGRSA
0	2		K401-a	GRSAAVAkQALAHGL
0	1		K401	GRSAAVAKQALAHGL
0	2		K409-a	QALAHGLkCkSQFTI
0	1		K409	QALAHGLKCkSQFTI
0	4		K411-a	LAHGLkCkSQFTITP
0	3		Y432-p	ATIERDGyAQILRDL
0	2		K458-a	CIGQWDRkDIkkGEk
0	1		K461-a	QWDRkDIkkGEkNtI
0	2		K462-a	WDRkDIkkGEkNtIV
0	2		K465-a	kDIkkGEkNtIVtsY
0	1		T467-p	IkkGEkNtIVtsYNR
0	1		T470-p	GEkNtIVtsYNRNFt
0	1		S471-p	EkNtIVtsYNRNFtG
0	2		T477-p	tsYNRNFtGRNDANP
0	1		T497	VTSPEIVTALAIAGT
0	54		Y513-p	KFNPETDyLTGTDGk
0	5		T517	ETDyLTGTDGkkFRL
0	1		T517	ETDyLTGTDGkkFRL
0	164		K520-a	yLTGTDGkkFRLEAP
0	8		K521-a	LTGTDGkkFRLEAPD
0	2		R523	GTDGkkFRLEAPDAD
2	0		Y544	FDPGQDTYQHPPkDS
0	1		K549-a	DTYQHPPkDSSGQHV
0	1		K549	DTYQHPPKDSSGQHV
0	4		S559-p	SGQHVDVsPtSQRLQ
0	2		T561-p	QHVDVsPtSQRLQLL
0	4		K573-a	QLLEPFDkWDGkDLE
0	1		K573	QLLEPFDKWDGkDLE
0	28		K577-a	PFDkWDGkDLEDLQI
0	1		K591-a	ILIKVKGkCTTDHIS
0	1		T593	IKVKGkCTTDHISAA
0	1		T594	KVKGkCTTDHISAAG
0	13		K605-a	SAAGPWLkFRGHLDN
0	3		K628-a	AINIENGkANSVRNA
0	1		K651-a	PDTARYYkkHGIRWV
0	1		K652-a	DTARYYkkHGIRWVV
2	1		Y665	VVIGDENYGEGssRE
0	2		S669-p	DENYGEGssREHAAL
0	2		S670-p	ENYGEGssREHAALE
0	4		K689-a	GGRAIITkSFARIHE
0	22		K700-a	RIHETNLkKQGLLPL
0	1		K701	IHETNLkKQGLLPLT
0	1		A713	PLTFADPADYNKIHP
0	1		K723	NKIHPVDKLTIQGLk
0	1		K723	NKIHPVDKLTIQGLk
0	4		K730-a	KLTIQGLkDFTPGKP
0	1		K736	LkDFTPGKPLKCIIk
0	1		K736	LkDFTPGKPLKCIIk
0	1		K739	FTPGKPLKCIIkHPN
0	13		K743-a	KPLKCIIkHPNGTQE

	mouse
K31-a	SVLCQRAkVAMSHFE
K31-u	SVLCQRAkVAMSHFE
Y42	SHFEPSEYIRYDLLE
K50-a	IRYDLLEkNINIVRK
K50-u	IRYDLLEkNINIVRK
T64-p	KRLNRPLtLSEKIVY
Y71	tLSEKIVYGHLDDPA
T87	QEIERGKTYLRLRPD
Y88	EIERGKTYLRLRPDR
K138-a	EAQVGGEkDLRRAkD
K144-a	EkDLRRAkDINQEVY
K144-u	EkDLRRAkDINQEVY
Y151	kDINQEVYNFLATAG
K160-a	FLATAGAkYGVGFWR
K225-a	AGIPWELkCPkVIGV
K228-a	PWELkCPkVIGVkLT
K233-a	CPkVIGVkLTGsLSG
S237-p	IGVkLTGsLSGWTSP
K304-a	FPYNHRMkkYLsKTG
K305-a	PYNHRMkkYLsKTGR
S308-p	HRMkkYLsKTGRTDI
K370	DVGTVAEKEGWPLDI
Y390	GSCTNSSYEDMGRSA
K401-a	GRSAAVAkQALAHGL
K401-u	GRSAAVAkQALAHGL
K409-a	QALAHGLkCkSQFTI
K409-m1	QALAHGLkCkSQFTI
K411-a	LAHGLkCkSQFTITP
Y432	ATIERDGYAQILRDV
K458-a	CIGQWDRkDIkkGEk
K461-a	QWDRkDIkkGEkNTI
K462-a	WDRkDIkkGEkNTIV
K465-a	kDIkkGEkNTIVTSY
T467	IkkGEkNTIVTSYNR
T470	GEkNTIVTSYNRNFt
S471	EkNTIVTSYNRNFtG
T477-p	TSYNRNFtGRNDANP
T497-p	VTSPEIVtALAIAGT
F513	KFNPETDFLTGkDGk
K517-a	ETDFLTGkDGkkFkL
K517-u	ETDFLTGkDGkkFkL
K520-a	FLTGkDGkkFkLEAP
K521-a	LTGkDGkkFkLEAPD
K523-a	GkDGkkFkLEAPDAD
Y544	FDPGQDTYQHPPkDS
K549	DTYQHPPKDSSGQRV
K549-u	DTYQHPPkDSSGQRV
S559-p	SGQRVDVsPtSQRLQ
T561-p	QRVDVsPtSQRLQLL
K573-a	QLLEPFDkWDGkDLE
K573-u	QLLEPFDkWDGkDLE
K577-a	PFDkWDGkDLEDLQI
K591-a	ILIKVKGkCttDHIS
T593-p	IKVKGkCttDHISAA
T594-p	KVKGkCttDHISAAG
K605-a	SAAGPWLkFRGHLDN
K628-a	AINIENGkANSVRNA
K651-a	PDTARYYkkHGIRWV
K652-a	DTARYYkkHGIRWVV
Y665-p	VVIGDENyGEGssRE
S669-p	DENyGEGssREHAAL
S670-p	ENyGEGssREHAALE
K689-a	GGRAIITkSFARIHE
K700-a	RIHETNLkkQGLLPL
K701-u	IHETNLkkQGLLPLT
S713-p	PLTFADPsDYNKIHP
K723-a	NKIHPVDkLTIQGLk
K723-u	NKIHPVDkLTIQGLk
K730-a	kLTIQGLkDFAPGkP
K736-a	LkDFAPGkPLkCVIk
K736-u	LkDFAPGkPLkCVIk
K739-a	FAPGkPLkCVIkHPN
K743-a	kPLkCVIkHPNGTQE

	rat
K31	SALCQRAKVAMSHFE
K31	SALCQRAKVAMSHFE
Y42	SHFEPSEYIRYDLLE
K50	IRYDLLEKNINIVRK
K50	IRYDLLEKNINIVRK
T64	KRLNRPLTLSEKIVy
Y71-p	TLSEKIVyGHLDDPA
T87	QEIERGKTyLRLRPD
Y88-p	EIERGKTyLRLRPDR
K138	EAQLGGEKDLRRAKD
K144	EKDLRRAKDINQEVy
K144	EKDLRRAKDINQEVy
Y151-p	KDINQEVyNFLATAG
K160	FLATAGAKYGVGFWR
K225	AGIPWELKCPKVIGV
K228	PWELKCPKVIGVKLT
K233	CPKVIGVKLTGTLSG
T237	IGVKLTGTLSGWTSP
K304	FPYNHRMKKYLSKTG
K305	PYNHRMKKYLSKTGR
S308	HRMKKYLSKTGRADI
K370	DVGTVAEKEGWPLDI
Y390	GSCTNSSYEDMGRSA
K401	GRSAAVAKQALAHGL
K401	GRSAAVAKQALAHGL
K409	QALAHGLKCKSQFTI
K409	QALAHGLKCKSQFTI
K411	LAHGLKCKSQFTITP
Y432	ATIERDGYAQILRDV
K458	CIGQWDRKDIKKGEK
K461	QWDRKDIKKGEKNTI
K462	WDRKDIKKGEKNTIV
K465	KDIKKGEKNTIVTSY
T467	IKKGEKNTIVTSYNR
T470	GEKNTIVTSYNRNFT
S471	EKNTIVTSYNRNFTG
T477	TSYNRNFTGRNDANP
T497	VTSPEIVTALAIAGT
F513	KFNPETDFLTGKDGK
K517	ETDFLTGKDGKKFKL
K517	ETDFLTGKDGKKFKL
K520	FLTGKDGKKFKLEAP
K521	LTGKDGKKFKLEAPD
K523	GKDGKKFKLEAPDAD
Y544-p	FDPGQDTyQHPPKDS
K549	DTyQHPPKDSSGQRV
K549	DTyQHPPKDSSGQRV
S559-p	SGQRVDVsPTSQRLQ
T561	QRVDVsPTSQRLQLL
K573	QLLEPFDKWDGKDLE
K573	QLLEPFDKWDGKDLE
K577	PFDKWDGKDLEDLQI
K591	ILIKVKGKCTTDHIS
T593	IKVKGKCTTDHISAA
T594	KVKGKCTTDHISAAG
K605	SAAGPWLKFRGHLDN
K628	AINIENGKANSVRNA
K651	PDTARYYKKHGIRWV
K652	DTARYYKKHGIRWVV
Y665-p	VVIGDENyGEGsSRE
S669-p	DENyGEGsSREHAAL
S670	ENyGEGsSREHAALE
K689	GGRAIITKSFARIHE
K700	RIHETNLKKQGLLPL
K701	IHETNLKKQGLLPLT
S713	PLTFADPSDYNKIHP
K723	NKIHPVDKLTIQGLk
K723	NKIHPVDKLTIQGLk
K730-a	KLTIQGLkDFAPGKP
K736	LkDFAPGKPLNCIIK
K736	LkDFAPGKPLNCIIK
N739	FAPGKPLNCIIKHPN
K743	KPLNCIIKHPNGTQE

	pig
K31	SVLCQRAKVAMSHFE
K31	SVLCQRAKVAMSHFE
Y42	SHFEPHEYIRYDLLE
K50	IRYDLLEKNIDIVRK
K50	IRYDLLEKNIDIVRK
T64	KRLNRPLTLSEKIVY
Y71	TLSEKIVYGHLDDPA
T87	QEIERGKTYLRLRPD
Y88	EIERGKTYLRLRPDR
K138	EAQLGGEKDLRRAKD
K144	EKDLRRAKDINQEVY
K144	EKDLRRAKDINQEVY
Y151	KDINQEVYNFLATAG
K160	FLATAGAKYGVGFWR
K225	AGIPWELKCPKVIGV
K228	PWELKCPKVIGVKLT
K233	CPKVIGVKLTGSLSG
S237	IGVKLTGSLSGWTSP
K304	FPYNHRMKKYLSKTG
K305	PYNHRMKKYLSKTGR
S308	HRMKKYLSKTGRADI
K370	EVGSVAEKEGWPLDI
Y390	GSCTNSSYEDMGRSA
K401	GRSAAVAKQALAHGL
K401	GRSAAVAKQALAHGL
K409	QALAHGLKCKSQFTI
K409	QALAHGLKCKSQFTI
K411	LAHGLKCKSQFTITP
Y432	ATIERDGYAQVLRDV
K458	CIGQWDRKDIKKGEK
K461	QWDRKDIKKGEKNTI
K462	WDRKDIKKGEKNTIV
K465	KDIKKGEKNTIVTSY
T467	IKKGEKNTIVTSYNR
T470	GEKNTIVTSYNRNFT
S471	EKNTIVTSYNRNFTG
T477	TSYNRNFTGRNDANP
T497	VTSPEIVTALAIAGT
F513	KFNPETDFLTGKDGK
K517	ETDFLTGKDGKKFKL
K517	ETDFLTGKDGKKFKL
K520	FLTGKDGKKFKLEAP
K521	LTGKDGKKFKLEAPD
K523	GKDGKKFKLEAPDAD
Y544	FDPGQDTYQHPPKDS
K549	DTYQHPPKDSSGQRV
K549	DTYQHPPKDSSGQRV
S559	SGQRVDVSPTSQRLQ
T561	QRVDVSPTSQRLQLL
K573	QLLEPFDKWDGKDLE
K573	QLLEPFDKWDGKDLE
K577	PFDKWDGKDLEDLQI
K591	ILIKVKGKCTTDHIS
T593	IKVKGKCTTDHISAA
T594	KVKGKCTTDHISAAG
K605	SAAGPWLKFRGHLDN
K628	AINIENRKANSVRNA
K651	PDTARYYKQHGIRWV
Q652	DTARYYKQHGIRWVV
Y665	VVIGDENYGEGSSRE
S669	DENYGEGSSREHRAL
S670	ENYGEGSSREHRALE
K689	GGRAIITKSFARIHE
K700	RIHETNLKKQGLLPL
K701	IHETNLKKQGLLPLT
A713	PLTFADPADYNKIHP
K723	NKIHPVDKLTIQGLK
K723	NKIHPVDKLTIQGLK
K730	KLTIQGLKDFAPGKP
K736	LKDFAPGKPLKCIIK
K736	LKDFAPGKPLKCIIK
K739	FAPGKPLKCIIKHPN
K743	KPLKCIIKHPNGTQE

	cow
K31	SVLCQRAKVAMSHFE
K31	SVLCQRAKVAMSHFE
Y42	SHFEPNEYIRYDLLE
K50	IRYDLLEKNINIVRK
K50	IRYDLLEKNINIVRK
T64	KRLNRPLTLSEKIVY
Y71	TLSEKIVYGHLDDPA
T87	QEIERGKTYLRLRPD
Y88	EIERGKTYLRLRPDR
K138	EAQLGGEKDLRRAKD
K144	EKDLRRAKDINQEVY
K144	EKDLRRAKDINQEVY
Y151	KDINQEVYNFLATAG
K160	FLATAGAKYGVGFWR
K225	AGIPWELKCPKVIGV
K228	PWELKCPKVIGVKLT
K233	CPKVIGVKLTGSLSG
S237	IGVKLTGSLSGWTSP
K304	FPYNHRMKKYLSKTG
K305	PYNHRMKKYLSKTGR
S308	HRMKKYLSKTGRADI
K370	EVGSVAEKEGWPLDI
Y390	GSCTNSSYEDMGRSA
K401	GRSAAVAKQALAHGL
K401	GRSAAVAKQALAHGL
Q409	QALAHGLQCKSQFTI
Q409	QALAHGLQCKSQFTI
K411	LAHGLQCKSQFTITP
Y432	ATIERDGYAQILRDV
K458	CIGQWDRKDIKKGEK
K461	QWDRKDIKKGEKNTI
K462	WDRKDIKKGEKNTIV
K465	KDIKKGEKNTIVTSY
T467	IKKGEKNTIVTSYNR
T470	GEKNTIVTSYNRNFT
S471	EKNTIVTSYNRNFTG
T477	TSYNRNFTGRNDANP
T497	VTSPEIVTALAIAGT
F513	KFNPETDFLTGKDGK
K517	ETDFLTGKDGKKFKL
K517	ETDFLTGKDGKKFKL
K520	FLTGKDGKKFKLEAP
K521	LTGKDGKKFKLEAPD
K523	GKDGKKFKLEAPDAD
Y544	FDPGQDTYQHPPKDS
K549	DTYQHPPKDSSGQQV
K549	DTYQHPPKDSSGQQV
S559	SGQQVDVSPTSQRLQ
T561	QQVDVSPTSQRLQLL
K573	QLLEPFDKWDGRDLE
K573	QLLEPFDKWDGRDLE
R577	PFDKWDGRDLEDLQI
K591	ILIKVKGKCTTDHIS
T593	IKVKGKCTTDHISAA
T594	KVKGKCTTDHISAAG
K605	SAAGPWLKFRGHLDN
K628	AINVENGKANSVRNA
K651	PDTARYYKKHGIRWV
K652	DTARYYKKHGIRWVV
Y665	VVIGDENYGEGSSRE
S669	DENYGEGSSREHAAL
S670	ENYGEGSSREHAALE
K689	GGRAIITKSFARIHE
K700	RIHETNLKKQGLLPL
K701	IHETNLKKQGLLPLT
A713	PLTFADPADYNKIHP
K723	NKIHPVDKLTIKGLK
K723	NKIHPVDKLTIKGLK
K730	KLTIKGLKDFAPGKP
K736	LKDFAPGKPLTCIIK
K736	LKDFAPGKPLTCIIK
T739	FAPGKPLTCIIKHPN
K743	KPLTCIIKHPNGTQE

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