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Protein Page:
ACO2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ACO2 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Monomer. Belongs to the aconitase/IPM isomerase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; EC 4.2.1.3; Lyase
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: iron ion binding; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; 3 iron, 4 sulfur cluster binding
Biological Process: isocitrate metabolic process; cell death; cellular metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle; citrate metabolic process
Reference #:  Q99798 (UniProtKB)
Alt. Names/Synonyms: ACO2; ACON; Aconitase; aconitase 2, mitochondrial; Aconitate hydratase, mitochondrial; ACONM; Citrate hydro-lyase; MGC20605; MGC33908
Gene Symbols: ACO2
Molecular weight: 85,425 Da
Basal Isoelectric point: 7.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACO2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K31 SVLCQRAKVAMSHFE
0 3 Y42-p SHFEPNEyIHYDLLE
0 10 K50-a IHYDLLEkNINIVRK
0 1 K50 IHYDLLEKNINIVRK
2 0 Y71 TLSEKIVYGHLDDPA
0 2 Y88 EIERGKSYLRLRPDR
0 2 K144 EKDLRRAKDINQEVY
0 2 K144 EKDLRRAKDINQEVY
0 2 Y151 KDINQEVYNFLATAG
0 1 K225 AGIPWELKCPKVIGV
0 2 K228 PWELKCPKVIGVkLT
0 2 K233-a CPKVIGVkLTGSLSG
0 1 S237 IGVkLTGSLSGWSSP
0 2 K304 FPYNHRMKKYLSKtG
0 5 K305 PYNHRMKKYLSKtGR
0 1 S308 HRMKKYLSKtGREDI
0 1 T310-p MKKYLSKtGREDIAN
0 1 K370-u EVGKVAEkEGWPLDI
0 2 K401 GRSAAVAKQALAHGL
0 1 K401 GRSAAVAKQALAHGL
0 2 K409 QALAHGLKCKSQFTI
0 4 K411 LAHGLKCKSQFTITP
0 3 Y432-p ATIERDGyAQILRDL
0 2 K458 CIGQWDRKDIKKGEK
0 2 K462 WDRKDIKKGEKNTIV
0 2 K465 KDIKKGEKNTIVTSY
0 2 T477-p TSYNRNFtGRNDANP
0 1 T497 VTSPEIVTALAIAGT
0 54 Y513-p KFNPETDyLTGTDGk
0 5 T517 ETDyLTGTDGkkFRL
0 1 T517 ETDyLTGTDGkkFRL
0 164 K520-a yLTGTDGkkFRLEAP
0 8 K521-a LTGTDGkkFRLEAPD
0 2 R523 GTDGkkFRLEAPDAD
0 1 G535 DADELPKGEFDPGQD
2 0 Y544 FDPGQDTYQHPPkDS
0 1 K549-a DTYQHPPkDSSGQHV
0 1 K549 DTYQHPPKDSSGQHV
0 5 S559-p SGQHVDVsPTSQRLQ
0 2 T561 QHVDVsPTSQRLQLL
0 4 K573-a QLLEPFDkWDGkDLE
0 1 K573 QLLEPFDKWDGkDLE
0 28 K577-a PFDkWDGkDLEDLQI
0 1 T593 IKVKGKCTTDHISAA
0 1 T594 KVKGKCTTDHISAAG
0 13 K605-a SAAGPWLkFRGHLDN
0 3 K628 AINIENGKANSVRNA
0 1 R648 GPVPDTARYYKKHGI
2 1 Y665 VVIGDENYGEGssRE
0 2 S669-p DENYGEGssREHAAL
0 2 S670-p ENYGEGssREHAALE
0 4 K689-a GGRAIITkSFARIHE
0 22 K700-a RIHETNLkKQGLLPL
0 1 K701 IHETNLkKQGLLPLT
0 1 A713 PLTFADPADYNKIHP
0 1 K723 NKIHPVDKLTIQGLK
0 1 K723 NKIHPVDKLTIQGLK
0 4 K730 KLTIQGLKDFTPGKP
0 1 K736 LKDFTPGKPLKCIIk
0 1 K736 LKDFTPGKPLKCIIk
0 1 K739 FTPGKPLKCIIkHPN
0 13 K743-a KPLKCIIkHPNGTQE
  mouse

 
K31-u SVLCQRAkVAMSHFE
Y42 SHFEPSEYIRYDLLE
K50-a IRYDLLEkNINIVRK
K50-u IRYDLLEkNINIVRK
Y71 TLSEKIVYGHLDDPA
Y88 EIERGKTYLRLRPDR
K144-a EKDLRRAkDINQEVY
K144-u EKDLRRAkDINQEVY
Y151 kDINQEVYNFLATAG
K225-a AGIPWELkCPkVIGV
K228-a PWELkCPkVIGVkLT
K233-a CPkVIGVkLTGsLSG
S237-p IGVkLTGsLSGWTSP
K304-a FPYNHRMkkYLsKTG
K305-a PYNHRMkkYLsKTGR
S308-p HRMkkYLsKTGRTDI
T310 MkkYLsKTGRTDIAN
K370 DVGTVAEKEGWPLDI
K401-a GRSAAVAkQALAHGL
K401-u GRSAAVAkQALAHGL
K409-a QALAHGLkCkSQFTI
K411-a LAHGLkCkSQFTITP
Y432 ATIERDGYAQILRDV
K458-a CIGQWDRkDIKkGEk
K462-a WDRkDIKkGEkNTIV
K465-a kDIKkGEkNTIVTSY
T477-p TSYNRNFtGRNDANP
T497-p VTSPEIVtALAIAGT
F513 KFNPETDFLTGkDGk
K517-a ETDFLTGkDGkkFkL
K517-u ETDFLTGkDGkkFkL
K520-a FLTGkDGkkFkLEAP
K521-a LTGkDGkkFkLEAPD
K523-a GkDGkkFkLEAPDAD
S535-p DADELPRsDFDPGQD
Y544 FDPGQDTYQHPPkDS
K549 DTYQHPPKDSSGQRV
K549-u DTYQHPPkDSSGQRV
S559-p SGQRVDVsPtSQRLQ
T561-p QRVDVsPtSQRLQLL
K573-a QLLEPFDkWDGkDLE
K573-u QLLEPFDkWDGkDLE
K577-a PFDkWDGkDLEDLQI
T593-p IKVKGKCttDHISAA
T594-p KVKGKCttDHISAAG
K605-a SAAGPWLkFRGHLDN
K628-a AINIENGkANSVRNA
R648-m2 GPVPDTArYYKKHGI
Y665-p VVIGDENyGEGssRE
S669-p DENyGEGssREHAAL
S670-p ENyGEGssREHAALE
K689-a GGRAIITkSFARIHE
K700-a RIHETNLkkQGLLPL
K701-u IHETNLkkQGLLPLT
S713-p PLTFADPsDYNKIHP
K723-a NKIHPVDkLTIQGLk
K723-u NKIHPVDkLTIQGLk
K730-a kLTIQGLkDFAPGkP
K736-a LkDFAPGkPLkCVIk
K736-u LkDFAPGkPLkCVIk
K739-a FAPGkPLkCVIkHPN
K743-a kPLkCVIkHPNGTQE
  rat

 
K31 SALCQRAKVAMSHFE
Y42 SHFEPSEYIRYDLLE
K50 IRYDLLEKNINIVRK
K50 IRYDLLEKNINIVRK
Y71-p TLSEKIVyGHLDDPA
Y88-p EIERGKTyLRLRPDR
K144 EKDLRRAKDINQEVy
K144 EKDLRRAKDINQEVy
Y151-p KDINQEVyNFLATAG
K225 AGIPWELKCPKVIGV
K228 PWELKCPKVIGVKLT
K233 CPKVIGVKLTGTLSG
T237 IGVKLTGTLSGWTSP
K304 FPYNHRMKKYLSKTG
K305 PYNHRMKKYLSKTGR
S308 HRMKKYLSKTGRADI
T310 MKKYLSKTGRADIAN
K370 DVGTVAEKEGWPLDI
K401 GRSAAVAKQALAHGL
K401 GRSAAVAKQALAHGL
K409 QALAHGLKCKSQFTI
K411 LAHGLKCKSQFTITP
Y432 ATIERDGYAQILRDV
K458 CIGQWDRKDIKKGEK
K462 WDRKDIKKGEKNTIV
K465 KDIKKGEKNTIVTSY
T477 TSYNRNFTGRNDANP
T497 VTSPEIVTALAIAGT
F513 KFNPETDFLTGKDGK
K517 ETDFLTGKDGKKFKL
K517 ETDFLTGKDGKKFKL
K520 FLTGKDGKKFKLEAP
K521 LTGKDGKKFKLEAPD
K523 GKDGKKFKLEAPDAD
S535 DADELPRSDFDPGQD
Y544-p FDPGQDTyQHPPKDS
K549 DTyQHPPKDSSGQRV
K549 DTyQHPPKDSSGQRV
S559-p SGQRVDVsPTSQRLQ
T561 QRVDVsPTSQRLQLL
K573 QLLEPFDKWDGKDLE
K573 QLLEPFDKWDGKDLE
K577 PFDKWDGKDLEDLQI
T593 IKVKGKCTTDHISAA
T594 KVKGKCTTDHISAAG
K605 SAAGPWLKFRGHLDN
K628 AINIENGKANSVRNA
R648 GPVPDTARYYKKHGI
Y665-p VVIGDENyGEGsSRE
S669-p DENyGEGsSREHAAL
S670 ENyGEGsSREHAALE
K689 GGRAIITKSFARIHE
K700 RIHETNLKKQGLLPL
K701 IHETNLKKQGLLPLT
S713 PLTFADPSDYNKIHP
K723 NKIHPVDKLTIQGLk
K723 NKIHPVDKLTIQGLk
K730-a KLTIQGLkDFAPGKP
K736 LkDFAPGKPLNCIIK
K736 LkDFAPGKPLNCIIK
N739 FAPGKPLNCIIKHPN
K743 KPLNCIIKHPNGTQE
  pig

 
K31 SVLCQRAKVAMSHFE
Y42 SHFEPHEYIRYDLLE
K50 IRYDLLEKNIDIVRK
K50 IRYDLLEKNIDIVRK
Y71 TLSEKIVYGHLDDPA
Y88 EIERGKTYLRLRPDR
K144 EKDLRRAKDINQEVY
K144 EKDLRRAKDINQEVY
Y151 KDINQEVYNFLATAG
K225 AGIPWELKCPKVIGV
K228 PWELKCPKVIGVKLT
K233 CPKVIGVKLTGSLSG
S237 IGVKLTGSLSGWTSP
K304 FPYNHRMKKYLSKTG
K305 PYNHRMKKYLSKTGR
S308 HRMKKYLSKTGRADI
T310 MKKYLSKTGRADIAN
K370 EVGSVAEKEGWPLDI
K401 GRSAAVAKQALAHGL
K401 GRSAAVAKQALAHGL
K409 QALAHGLKCKSQFTI
K411 LAHGLKCKSQFTITP
Y432 ATIERDGYAQVLRDV
K458 CIGQWDRKDIKKGEK
K462 WDRKDIKKGEKNTIV
K465 KDIKKGEKNTIVTSY
T477 TSYNRNFTGRNDANP
T497 VTSPEIVTALAIAGT
F513 KFNPETDFLTGKDGK
K517 ETDFLTGKDGKKFKL
K517 ETDFLTGKDGKKFKL
K520 FLTGKDGKKFKLEAP
K521 LTGKDGKKFKLEAPD
K523 GKDGKKFKLEAPDAD
A535 DADELPRAEFDPGQD
Y544 FDPGQDTYQHPPKDS
K549 DTYQHPPKDSSGQRV
K549 DTYQHPPKDSSGQRV
S559 SGQRVDVSPTSQRLQ
T561 QRVDVSPTSQRLQLL
K573 QLLEPFDKWDGKDLE
K573 QLLEPFDKWDGKDLE
K577 PFDKWDGKDLEDLQI
T593 IKVKGKCTTDHISAA
T594 KVKGKCTTDHISAAG
K605 SAAGPWLKFRGHLDN
K628 AINIENRKANSVRNA
R648 GPVPDTARYYKQHGI
Y665 VVIGDENYGEGSSRE
S669 DENYGEGSSREHRAL
S670 ENYGEGSSREHRALE
K689 GGRAIITKSFARIHE
K700 RIHETNLKKQGLLPL
K701 IHETNLKKQGLLPLT
A713 PLTFADPADYNKIHP
K723 NKIHPVDKLTIQGLK
K723 NKIHPVDKLTIQGLK
K730 KLTIQGLKDFAPGKP
K736 LKDFAPGKPLKCIIK
K736 LKDFAPGKPLKCIIK
K739 FAPGKPLKCIIKHPN
K743 KPLKCIIKHPNGTQE
  cow

 
K31 SVLCQRAKVAMSHFE
Y42 SHFEPNEYIRYDLLE
K50 IRYDLLEKNINIVRK
K50 IRYDLLEKNINIVRK
Y71 TLSEKIVYGHLDDPA
Y88 EIERGKTYLRLRPDR
K144 EKDLRRAKDINQEVY
K144 EKDLRRAKDINQEVY
Y151 KDINQEVYNFLATAG
K225 AGIPWELKCPKVIGV
K228 PWELKCPKVIGVKLT
K233 CPKVIGVKLTGSLSG
S237 IGVKLTGSLSGWTSP
K304 FPYNHRMKKYLSKTG
K305 PYNHRMKKYLSKTGR
S308 HRMKKYLSKTGRADI
T310 MKKYLSKTGRADIAN
K370 EVGSVAEKEGWPLDI
K401 GRSAAVAKQALAHGL
K401 GRSAAVAKQALAHGL
Q409 QALAHGLQCKSQFTI
K411 LAHGLQCKSQFTITP
Y432 ATIERDGYAQILRDV
K458 CIGQWDRKDIKKGEK
K462 WDRKDIKKGEKNTIV
K465 KDIKKGEKNTIVTSY
T477 TSYNRNFTGRNDANP
T497 VTSPEIVTALAIAGT
F513 KFNPETDFLTGKDGK
K517 ETDFLTGKDGKKFKL
K517 ETDFLTGKDGKKFKL
K520 FLTGKDGKKFKLEAP
K521 LTGKDGKKFKLEAPD
K523 GKDGKKFKLEAPDAD
A535 DADELPRAEFDPGQD
Y544 FDPGQDTYQHPPKDS
K549 DTYQHPPKDSSGQQV
K549 DTYQHPPKDSSGQQV
S559 SGQQVDVSPTSQRLQ
T561 QQVDVSPTSQRLQLL
K573 QLLEPFDKWDGRDLE
K573 QLLEPFDKWDGRDLE
R577 PFDKWDGRDLEDLQI
T593 IKVKGKCTTDHISAA
T594 KVKGKCTTDHISAAG
K605 SAAGPWLKFRGHLDN
K628 AINVENGKANSVRNA
R648 GPVPDTARYYKKHGI
Y665 VVIGDENYGEGSSRE
S669 DENYGEGSSREHAAL
S670 ENYGEGSSREHAALE
K689 GGRAIITKSFARIHE
K700 RIHETNLKKQGLLPL
K701 IHETNLKKQGLLPLT
A713 PLTFADPADYNKIHP
K723 NKIHPVDKLTIKGLK
K723 NKIHPVDKLTIKGLK
K730 KLTIKGLKDFAPGKP
K736 LKDFAPGKPLTCIIK
K736 LKDFAPGKPLTCIIK
T739 FAPGKPLTCIIKHPN
K743 KPLTCIIKHPNGTQE
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