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FOXO4 (human)

Overview FOXO4 transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus; cytosol Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor binding; transcription factor activity; DNA bending activity; protein kinase binding Biological Process: transcription from RNA polymerase II promoter; epidermal growth factor receptor signaling pathway; tissue development; muscle development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; negative regulation of smooth muscle cell differentiation; stem cell differentiation; pattern specification process; negative regulation of cell proliferation; embryonic development; negative regulation of angiogenesis; regulation of transcription factor activity; regulation of transcription, DNA-dependent; mitotic cell cycle G2/M transition DNA damage checkpoint; organ development; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; G1 phase of mitotic cell cycle; cell cycle arrest Reference #:  P98177 (UniProtKB) Alt. Names/Synonyms: AFX; AFX1; Fork head domain transcription factor AFX1; forkhead box O4; Forkhead box protein O4; FOXO4; MGC120490; MLLT7; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 Gene Symbols: FOXO4 Molecular weight: 53,684 Da Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXO4 1E17 - A=86-211 (human) 3BPY - A=97-181 (human) 3L2C - A=86-187 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1E17 3BPY 3L2C  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: S197‑p carcinogenesis, altered: T227‑p, S230‑p cell cycle regulation: T451‑p, T455‑p transcription, altered: T32‑p, S197‑p, T227‑p, S230‑p, S262‑p, T451‑p, T455‑p intracellular localization: T32‑p, S197‑p, S262‑p, T451‑p, T455‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S26-p	DPDFEPQsRPRsCtW
0	3		S30-p	EPQsRPRsCtWPLPR
5	34		T32-p	QsRPRsCtWPLPRPE
0	1		S111-p	QSYAELIsQAIESAP
2	0		K186-a	MLNPEGGkSGkAPRR
2	0		K189-a	PEGGkSGkAPRRRAA
12	5		S197-p	APRRRAAsMDSSSKL
1	0		T227-p	PAPPEGAtPTsPVGH
1	7		S230-p	PEGAtPTsPVGHFAK
0	1		S241-p	HFAKWSGsPCsRNRE
0	1		S244-p	KWSGsPCsRNREEAD
0	7		S261-p	TTFRPRSssNASSVS
3	2		S262-p	TFRPRSssNASSVST
0	1		S272-p	SSVSTRLsPLRPEsE
0	1		S278-p	LsPLRPEsEVLAEEI
0	1		S288-p	LAEEIPAsVSSyAGG
0	1		Y292-p	IPAsVSSyAGGVPPT
2	0		K407-a	GGLPSSSkLATGVGL
3	1		T451-p	PIPKALGtPVLtPPt
3	0		T455-p	ALGtPVLtPPtEAAS
0	2		T458-p	tPVLtPPtEAASQDR

	mouse
S26	DPDFEPQSRPRSCtW
S30	EPQSRPRSCtWPLPR
T32-p	QSRPRSCtWPLPRPD
S111	QSYAELISQAIESAP
K186-a	MLNPDGGkGGkAPRR
K189-a	PDGGkGGkAPRRRAA
S197-p	APRRRAAsMDSSSKL
T227	PAPPEGATPRsPLGH
S230-p	PEGATPRsPLGHFAK
S241	HFAKWSSSPCPRNRE
P244	KWSSSPCPRNREEAD
S261	TTFRPRSSSNASTVS
S262	TFRPRSSSNASTVST
S272	STVSTRLSPMRPESE
S278	LSPMRPESEVLAEEE
S289	AEEEMPASASSYAGG
Y293	MPASASSYAGGVPPT
K408-a	GGMPSSSkLGTGVSL
T452-p	PIPKVLGtPVLASPt
A456	VLGtPVLASPtEDSS
T459-p	tPVLASPtEDSSHDR

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