transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor binding; transcription factor activity; DNA bending activity; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; epidermal growth factor receptor signaling pathway; tissue development; muscle development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; negative regulation of smooth muscle cell differentiation; stem cell differentiation; pattern specification process; negative regulation of cell proliferation; embryonic development; negative regulation of angiogenesis; regulation of transcription factor activity; regulation of transcription, DNA-dependent; mitotic cell cycle G2/M transition DNA damage checkpoint; organ development; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; G1 phase of mitotic cell cycle; cell cycle arrest
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.