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Protein Page:
FOXO4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
FOXO4 transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; DNA bending activity; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; epidermal growth factor receptor signaling pathway; tissue development; muscle development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; stem cell differentiation; negative regulation of smooth muscle cell differentiation; negative regulation of stress-activated MAPK cascade; pattern specification process; negative regulation of cell proliferation; embryonic development; negative regulation of angiogenesis; regulation of transcription, DNA-dependent; mitotic cell cycle G2/M transition DNA damage checkpoint; insulin receptor signaling pathway; innate immune response; cell cycle arrest; negative regulation of apoptosis
Reference #:  P98177 (UniProtKB)
Alt. Names/Synonyms: AFX; AFX1; Fork head domain transcription factor AFX1; forkhead box O4; Forkhead box protein O4; FOXO4; MGC120490; MLLT7; translocated to, 7
Gene Symbols: FOXO4
Molecular weight: 53,684 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXO4

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S197‑p
carcinogenesis, altered: T227‑p, S230‑p
cell cycle regulation: T451‑p, T455‑p
transcription, altered: T227‑p, S230‑p
transcription, induced: T451‑p, T455‑p
transcription, inhibited: T32‑p, S197‑p, S262‑p
intracellular localization: T32‑p, S197‑p, S262‑p, T451‑p, T455‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S30-p EPQSRPRsCtWPLPR
5 34 T32-p QSRPRsCtWPLPRPE
0 1 S111-p QSYAELIsQAIESAP
2 0 K186-a MLNPEGGkSGkAPRR
3 0 K189-a PEGGkSGkAPRRRAA
12 5 S197-p APRRRAAsMDSSSKL
1 1 T227-p PAPPEGAtPTsPVGH
1 7 S230-p PEGAtPTsPVGHFAK
0 7 S261-p TTFRPRSssNASSVS
3 2 S262-p TFRPRSssNASSVST
2 0 K407-a GGLPSSSkLATGVGL
3 1 T451-p PIPKALGtPVLtPPt
3 0 T455-p ALGtPVLtPPtEAAS
0 2 T458-p tPVLtPPtEAASQDR
2599 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32)/FoxO4 (Thr28) (4G6) Rabbit mAb
9471 : Phospho-FoxO4 (Ser193) Antibody
  mouse

 
S30 EPQSRPRSCtWPLPR
T32-p QSRPRSCtWPLPRPD
S111 QSYAELISQAIESAP
K186-a MLNPDGGkGGkAPRR
K189-a PDGGkGGkAPRRRAA
S197-p APRRRAAsMDSSSKL
T227 PAPPEGATPRsPLGH
S230-p PEGATPRsPLGHFAK
S261 TTFRPRSSSNASTVS
S262 TFRPRSSSNASTVST
K408-a GGMPSSSkLGTGVSL
T452-p PIPKVLGtPVLASPt
A456 VLGtPVLASPtEDSS
T459-p tPVLASPtEDSSHDR
9471 : Phospho-FoxO4 (Ser193) Antibody
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