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Protein Page:
FOXO4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXO4 transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; epidermal growth factor receptor signaling pathway; muscle development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; stem cell differentiation; negative regulation of smooth muscle cell differentiation; negative regulation of cell proliferation; negative regulation of angiogenesis; regulation of transcription, DNA-dependent; mitotic cell cycle G2/M transition DNA damage checkpoint; insulin receptor signaling pathway; innate immune response; cell cycle arrest
Reference #:  P98177 (UniProtKB)
Alt. Names/Synonyms: AFX; AFX1; Fork head domain transcription factor AFX1; forkhead box O4; Forkhead box protein O4; FOXO4; MGC120490; MLLT7; translocated to, 7
Gene Symbols: FOXO4
Molecular weight: 53,684 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXO4

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S197‑p
carcinogenesis, altered: T227‑p, S230‑p
cell cycle regulation: T451‑p, T455‑p
transcription, altered: T227‑p, S230‑p
transcription, induced: T451‑p, T455‑p
transcription, inhibited: T32‑p, S197‑p, S262‑p
intracellular localization: T32‑p, S197‑p, S262‑p, T451‑p, T455‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S26-p DPDFEPQsRPRsCtW
0 3 S30-p EPQsRPRsCtWPLPR
5 38 T32-p QsRPRsCtWPLPRPE
0 1 S111-p QSYAELIsQAIESAP
2 0 K186-ac MLNPEGGkSGkAPRR
3 0 K189-ac PEGGkSGkAPRRRAA
12 7 S197-p APRRRAAsMDsSSKL
0 1 S200-p RRAAsMDsSSKLLRG
1 1 T227-p PAPPEGAtPTsPVGH
1 6 S230-p PEGAtPTsPVGHFAK
0 1 S241-p HFAKWSGsPCsRNRE
0 1 S244-p KWSGsPCsRNREEAD
0 7 S261-p TTFRPRSssNASSVS
3 2 S262-p TFRPRSssNASSVST
0 2 S272-p SSVSTRLsPLRPEsE
0 1 S278-p LsPLRPEsEVLAEEI
0 1 S288-p LAEEIPAsVSSyAGG
0 1 Y292-p IPAsVSSyAGGVPPT
2 0 K407-ac GGLPSSSkLATGVGL
3 1 T451-p PIPKALGtPVLtPPt
3 0 T455-p ALGtPVLtPPtEAAS
0 2 T458-p tPVLtPPtEAASQDR
2599 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32)/FoxO4 (Thr28) (4G6) Rabbit mAb
9471 : Phospho-FoxO4 (Ser193) Antibody
  mouse

 
S26 DPDFEPQSRPRSCtW
S30 EPQSRPRSCtWPLPR
T32-p QSRPRSCtWPLPRPD
S111 QSYAELISQAIESAP
K186-ac MLNPDGGkGGkAPRR
K189-ac PDGGkGGkAPRRRAA
S197-p APRRRAAsMDSSSKL
S200 RRAAsMDSSSKLLRG
T227 PAPPEGATPRsPLGH
S230-p PEGATPRsPLGHFAK
S241 HFAKWSSSPCPRNRE
P244 KWSSSPCPRNREEAD
S261 TTFRPRSSSNASTVS
S262 TFRPRSSSNASTVST
S272 STVSTRLSPMRPESE
S278 LSPMRPESEVLAEEE
S289 AEEEMPASASSYAGG
Y293 MPASASSYAGGVPPT
K408-ac GGMPSSSkLGTGVSL
T452-p PIPKVLGtPVLASPt
A456 VLGtPVLASPtEDSS
T459-p tPVLASPtEDSSHDR
9471 : Phospho-FoxO4 (Ser193) Antibody
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